#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32610	uniprotkb:Q00582	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710970|imex:IM-26166-6700	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610|ensembl:YEL051W(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:FDE93E1FAF0AEC5B	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 0.00200243136042494 ) paralog2 (YML121W)-prey (YEL051W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:soKKV2qGwYOaxDvB8CyKAeIKFBs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39968	uniprotkb:Q00582	intact:EBI-20212|uniprotkb:D3DLN6|uniprotkb:Q549T0|ensemblfungi:YEL013W	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:vac8_yeast(display_long)|uniprotkb:VAC8(gene name)|psi-mi:VAC8(display_short)|uniprotkb:YEB3(gene name synonym)|uniprotkb:YEL013W(locus name)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710958|imex:IM-26166-6440	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000739|refseq:NP_010903.3|mint:P39968|ensemblfungi:YEL013W(gene)|ensemblfungi:YEL013W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000425"(pexophagy)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045121"(membrane raft)|go:"GO:0071255"(Cvt vesicle assembly)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0071562"(nucleus-vacuole junction assembly)|go:"GO:0071563"(Myo2p-Vac17p-Vac8p transport complex)|go:"GO:1903044"(protein localization to membrane raft)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:5XJG|rcsb pdb:6KBM|rcsb pdb:6KBN|dip:DIP-5121N|ensembl:YEL013W(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:B2E75774B47E5933	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 4.41430729991231E-09 ) paralog2 (YML121W)-prey (YEL013W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:vxnzgu1OVqdfbmAB+Z6s9UbZSM0559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:SgzleXUY9fbB7o5AHP6WKesgMGg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32610	uniprotkb:P53290	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710982|imex:IM-26166-6500	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610|ensembl:YEL051W(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	crc64:FDE93E1FAF0AEC5B	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 9.78450747243705E-05 ) paralog2 (YGR163W)-prey (YEL051W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:K7dutMAQ1VVdz/kTPgMqNCtm3gM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38247	uniprotkb:Q00582	intact:EBI-21507|uniprotkb:D6VQ76|ensemblfungi:YBR077C	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:slm4_yeast(display_long)|uniprotkb:YBR077C(locus name)|uniprotkb:YBR0723(orf name)|uniprotkb:GSE complex subunit 1(gene name synonym)|uniprotkb:EGO complex subunit 3(gene name synonym)|uniprotkb:SLM4(gene name)|psi-mi:SLM4(display_short)|uniprotkb:EGO3(gene name synonym)|uniprotkb:GSE1(gene name synonym)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710946|imex:IM-26166-6640	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009633.3|sgd:S000000281|mint:P38247|dip:DIP-1763N|ensemblfungi:YBR077C(gene)|ensemblfungi:YBR077C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0071986"(Ragulator complex)|interpro:IPR020233|rcsb pdb:3LGO|rcsb pdb:4FTX|rcsb pdb:4FUW|rcsb pdb:4XPM|rcsb pdb:6JWP|ensembl:YBR077C(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:D64ABDE1CDF265FD	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 1.33008766105435E-08 ) paralog2 (YML121W)-prey (YBR077C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:BCEWjA3PQvwm3n08QwY0D//TpbA559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:5Uz2fclUqECnT3JNoK8c5THRvFg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00582	uniprotkb:Q00582	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711018|imex:IM-26166-6782	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:B79CE7FE7AD2FDBE	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 7.21023033069775E-08 ) paralog2 (YML121W)-prey (YML121W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:KjSw0W1AN3DYfR8cXCDDj2wlcYY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39968	uniprotkb:P53290	intact:EBI-20212|uniprotkb:D3DLN6|uniprotkb:Q549T0|ensemblfungi:YEL013W	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:vac8_yeast(display_long)|uniprotkb:VAC8(gene name)|psi-mi:VAC8(display_short)|uniprotkb:YEB3(gene name synonym)|uniprotkb:YEL013W(locus name)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711006|imex:IM-26166-6702	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000739|refseq:NP_010903.3|mint:P39968|ensemblfungi:YEL013W(gene)|ensemblfungi:YEL013W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000425"(pexophagy)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045121"(membrane raft)|go:"GO:0071255"(Cvt vesicle assembly)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0071562"(nucleus-vacuole junction assembly)|go:"GO:0071563"(Myo2p-Vac17p-Vac8p transport complex)|go:"GO:1903044"(protein localization to membrane raft)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:5XJG|rcsb pdb:6KBM|rcsb pdb:6KBN|dip:DIP-5121N|ensembl:YEL013W(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	crc64:B2E75774B47E5933	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 1.48455912034593E-06 ) paralog2 (YGR163W)-prey (YEL013W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:vxnzgu1OVqdfbmAB+Z6s9UbZSM0559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:GkKr8flw+r3U8eq3m3BpYmmlE44	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36076	uniprotkb:P30402	intact:EBI-26778|uniprotkb:D6VXK0|ensemblfungi:YKL088W	intact:EBI-14402|uniprotkb:D6W097|ensemblfungi:YMR271C	psi-mi:cab3_yeast(display_long)|uniprotkb:YKL088W(locus name)|uniprotkb:CAB3(gene name)|psi-mi:CAB3(display_short)	psi-mi:pyrx_yeast(display_long)|uniprotkb:YM8156.13C(orf name)|uniprotkb:YMR271C(locus name)|uniprotkb:URA10(gene name)|psi-mi:URA10(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710994|imex:IM-26166-6780	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012835.1|sgd:S000001571|mint:P36076|dip:DIP-4475N|ensemblfungi:YKL088W(gene)|ensemblfungi:YKL088W_mRNA(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|reactome:R-SCE-196783|ensembl:YKL088W(identity)	refseq:NP_013998.1|sgd:S000004884|ensemblfungi:YMR271C(gene)|ensemblfungi:YMR271C_mRNA(transcript)|go:"GO:0004588"(orotate phosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006221"(pyrimidine nucleotide biosynthetic process)|go:"GO:0046132"(pyrimidine ribonucleoside biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR004467(Orotate phosphoribosyl transferase)|interpro:IPR023031|interpro:IPR029057|go:"GO:0044205"('de novo' UMP biosynthetic process)|mint:P30402|dip:DIP-2790N|ensembl:YMR271C(identity)	-	-	-	comment:"paralog1 (YML106W) depletion signifcantly decreases (FDR-corrected p-value: 6.80747349303081E-05 ) paralog2 (YMR271C)-prey (YKL088W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Li7vZOassm4PC5fW111/j5ivgEc559292	rogid:AwF6gBvEBSY5IxWsw73yPixiItk559292	rigid:QRwtZt9c1X1AKcuiyiH8gl8jQrs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:P53278	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711126|imex:IM-26166-6720	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 2.46819093971251E-05 ) paralog2 (YGR130C)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:UC04YNWQHLlJaZq/cZHGgzYO214	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:Q00582	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711090|imex:IM-26166-6940	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:8ABA71761B512242	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 9.62180936987784E-07 ) paralog2 (YML121W)-prey (YMR120C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:/W3LMho64fkpqOJganWEZRYdRiU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41807	uniprotkb:P53290	intact:EBI-20281|uniprotkb:D6W446|ensemblfungi:YPR036W	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:vath_yeast(display_long)|uniprotkb:YP3085.02(orf name)|uniprotkb:VMA13(gene name)|psi-mi:VMA13(display_short)|uniprotkb:CLS11(gene name synonym)|uniprotkb:YPR036W(locus name)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 54 kDa subunit(gene name synonym)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711102|imex:IM-26166-6860	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015361.1|sgd:S000006240|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|rcsb pdb:1HO8|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YPR036W(gene)|ensemblfungi:YPR036W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-6640N|mint:P41807|ensembl:YPR036W(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	crc64:54131FF9C2C87594	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 2.22761193636521E-05 ) paralog2 (YGR163W)-prey (YPR036W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:kEXWvOsnTk0WdgGOny+mufz4lTo559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:mq9Re07KhUMiyCRM8EmhRFpP374	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05359	uniprotkb:Q04651	intact:EBI-6581|uniprotkb:D6VPL7|uniprotkb:E9P8S8|ensemblfungi:YAR002C-A	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:erp1_yeast(display_long)|uniprotkb:ERP1(gene name)|psi-mi:ERP1(display_short)|uniprotkb:YAR002A(orf name)|uniprotkb:YAR002C-A(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711114|imex:IM-26166-6942	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009402.1|sgd:S000002129|mint:Q05359|dip:DIP-5147N|ensemblfungi:YAR002C-A(gene)|ensemblfungi:YAR002C-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YAR002C-A(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.00668922856211015 ) paralog2 (YML067C)-prey (YAR002C-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:RX3ynMqEVNp4bRTVb16YoXaQW3U559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:1ntoILMlT15KqY7tAIconqUYIEc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87284	uniprotkb:Q04651	intact:EBI-13555|uniprotkb:D6VSQ7|ensemblfungi:YDR276C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:pmp3_yeast(display_long)|uniprotkb:PMP3(gene name)|psi-mi:PMP3(display_short)|uniprotkb:SNA1(gene name synonym)|uniprotkb:YDR276C(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711078|imex:IM-26166-6644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010562.1|sgd:S000002684|ensemblfungi:YDR276C(gene)|ensemblfungi:YDR276C_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000612(Protein of unknown function UPF0057)|dip:DIP-7280N|ensembl:YDR276C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 7.93205279720005E-06 ) paralog2 (YML067C)-prey (YDR276C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6uTuY0fyQfxrzyVqcLiNdDF5oRs559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:0mcR/h3OpMm7dqTh500buiJQINw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53290	uniprotkb:P53290	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711066|imex:IM-26166-6444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	crc64:0A0D16C81F73184D	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 3.4156491018468E-08 ) paralog2 (YGR163W)-prey (YGR163W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:WJ1KpWgG4en4GY88ClJavXtKQDQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:Q00582	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711054|imex:IM-26166-6642	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:55CAE5DACDC6A00B	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 1.22390811255039E-06 ) paralog2 (YML121W)-prey (YHR183W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:p6sW1q4T8aHiXAyynQtb1unrYus	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07170	uniprotkb:P53278	intact:EBI-9447|ensemblfungi:YDR226W|uniprotkb:D6VSK8|uniprotkb:Q6Q539	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:kad2_yeast(display_long)|uniprotkb:AKY(gene name synonym)|uniprotkb:AKY1(gene name synonym)|uniprotkb:AKY2(gene name synonym)|uniprotkb:ADK1(gene name)|psi-mi:ADK1(display_short)|uniprotkb:Adenylate kinase cytosolic and mitochondrial(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)|uniprotkb:YD9934.11(orf name)|uniprotkb:YDR226W(locus name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711042|imex:IM-26166-6560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YDR226W(gene)|ensemblfungi:YDR226W_mRNA(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|rcsb pdb:1AKY|rcsb pdb:1DVR|rcsb pdb:2AKY|reactome:R-SCE-499943|rcsb pdb:3AKY|refseq:NP_010512.1|sgd:S000002634|mint:P07170|dip:DIP-5129N|ensembl:YDR226W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:FE566FD8015907CE	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.00436012259835657 ) paralog2 (YGR130C)-prey (YDR226W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:G7pDmrl28ukuAmoX2EjGIKcQy/M559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:TFrc9X2C0pb6msSUZ8inmFcftig	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61830	uniprotkb:Q06205	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	intact:EBI-6956|uniprotkb:D6VZ83|ensemblfungi:YLR449W	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:fkbp4_yeast(display_long)|uniprotkb:FPR4(gene name)|psi-mi:FPR4(display_short)|uniprotkb:YLR449W(locus name)|uniprotkb:L9324.3(orf name)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Histone proline isomerase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711030|imex:IM-26166-6442	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G|ensembl:YNL031C(identity)	sgd:S000004441|refseq:NP_013554.3|dip:DIP-909N|mint:Q06205|ensemblfungi:YLR449W(gene)|ensemblfungi:YLR449W_mRNA(transcript)|go:"GO:0000412"(histone peptidyl-prolyl isomerization)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|rcsb pdb:4BF8|ensembl:YLR449W(identity)	-	crc64:A6115FEB480AC67A	crc64:CF90C6714F04572E	comment:"paralog1 (YML074C) depletion signifcantly decreases (FDR-corrected p-value: 1.02543292173803E-06 ) paralog2 (YLR449W)-prey (YNL031C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	rogid:rDmDSGEgRbtgkLBoJTzmzxxY7B4559292	rigid:x7sPhVoxnpfH0Qin0g7fquP7tA0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87284	uniprotkb:P53290	intact:EBI-13555|uniprotkb:D6VSQ7|ensemblfungi:YDR276C	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:pmp3_yeast(display_long)|uniprotkb:PMP3(gene name)|psi-mi:PMP3(display_short)|uniprotkb:SNA1(gene name synonym)|uniprotkb:YDR276C(locus name)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711150|imex:IM-26166-6944	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010562.1|sgd:S000002684|ensemblfungi:YDR276C(gene)|ensemblfungi:YDR276C_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000612(Protein of unknown function UPF0057)|dip:DIP-7280N|ensembl:YDR276C(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	-	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 1.43137326673812E-13 ) paralog2 (YGR163W)-prey (YDR276C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6uTuY0fyQfxrzyVqcLiNdDF5oRs559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:C3N6gqGlZGQmGjPxQ0OPMkskxaM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12116	uniprotkb:P38929	intact:EBI-19306|uniprotkb:D6VS91|ensemblfungi:YDR105C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:tms1_yeast(display_long)|uniprotkb:YDR105C(locus name)|uniprotkb:TMS1(gene name)|psi-mi:TMS1(display_short)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711138|imex:IM-26166-6646	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002512|ensemblfungi:YDR105C(gene)|ensemblfungi:YDR105C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR005016(TMS membrane protein/tumour differentially expressed protein)|interpro:IPR029559|reactome:R-SCE-977347|refseq:NP_010390.3|dip:DIP-5198N|mint:Q12116|ensembl:YDR105C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:DFA9011F9D56EEDE	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.00106784132564896 ) paralog2 (YGL006W)-prey (YDR105C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:2r+KaCny/GXJUQ87u+f97/LLn+k559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:v12dr1gUPlzOP2ioS0T6iHd8RcQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53337	uniprotkb:Q04651	intact:EBI-23662|uniprotkb:E9P8T4|uniprotkb:D6VV61|ensemblfungi:YGR284C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:erv29_yeast(display_long)|uniprotkb:ERV29(gene name)|psi-mi:ERV29(display_short)|uniprotkb:YGR284C(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711162|imex:IM-26166-6784	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011800.3|sgd:S000003516|dip:DIP-8110N|mint:P53337|ensemblfungi:YGR284C(gene)|ensemblfungi:YGR284C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0097020"(COPII receptor activity)|interpro:IPR002995(Surfeit locus 4)|reactome:R-SCE-6798695|reactome:R-SCE-6811434|ensembl:YGR284C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.00019545489621003 ) paralog2 (YML067C)-prey (YGR284C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:vlRDf0B9mDUXU6M2tLAiWqX4wN8559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:Y4ZfZ9RlXg0JXbnn1RypklykYPE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11076	uniprotkb:Q04651	intact:EBI-2816|uniprotkb:D6VRG1|ensemblfungi:YDL192W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:arf1_yeast(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)|uniprotkb:D1244(orf name)|uniprotkb:YDL192W(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711174|imex:IM-26166-6502	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010089.1|sgd:S000002351|dip:DIP-2213N|mint:P11076|ensemblfungi:YDL192W(gene)|ensemblfungi:YDL192W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:2K5U|rcsb pdb:2KSQ|rcsb pdb:3TJZ|rcsb pdb:4Q66|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL192W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	crc64:796859026AC63CC0	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 1.27149063233531E-05 ) paralog2 (YML067C)-prey (YDL192W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IX/zwfWagjieSKB1ShJ9P0kq1ZE559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:EkMN7LUoX3781+Lt8YOH3GqVj1o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04046	uniprotkb:P53278	intact:EBI-14238|ensemblfungi:YMR300C|uniprotkb:D6W0C7	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:pur1_yeast(display_long)|uniprotkb:Glutamine phosphoribosylpyrophosphate amidotransferase(gene name synonym)|uniprotkb:ADE4(gene name)|psi-mi:ADE4(display_short)|uniprotkb:YMR300C(locus name)|uniprotkb:YM9952.02C(orf name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711186|imex:IM-26166-6880	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014029.1|sgd:S000004915|ensemblfungi:YMR300C(gene)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005854(Amidophosphoribosyl transferase)|ensemblfungi:YMR300C_mRNA(transcript)|go:"GO:0004044"(amidophosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|interpro:IPR017932|interpro:IPR029055|interpro:IPR029057|interpro:IPR035584|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|mint:P04046|dip:DIP-6727N|ensembl:YMR300C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:1FE7A6F5B7C96710	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.00521348452470398 ) paralog2 (YGR130C)-prey (YMR300C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:v3Q2NjIC4OuMxGAFnC+1r4y70mw559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:dPoGY38FKD4sNug07CDZLoZiiVI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12100	uniprotkb:P53278	intact:EBI-36072|uniprotkb:D6VRW6|ensemblfungi:YDL025C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:rtk1_yeast(display_long)|uniprotkb:YDL025C(locus name)|uniprotkb:D2810(orf name)|uniprotkb:RTK1(gene name)|psi-mi:RTK1(display_short)|uniprotkb:Ribosome biogenesis and tRNA synthetase-associated kinase 1(gene name synonym)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711198|imex:IM-26166-6882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010259.1|sgd:S000002183|dip:DIP-6483N|ensemblfungi:YDL025C(gene)|ensemblfungi:YDL025C_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071944"(cell periphery)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:YDL025C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:AD6160F19F3B75CF	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.00625847346892976 ) paralog2 (YGR130C)-prey (YDL025C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:XBcHXpXSRZDscEoj+hGRn4NJORE559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:/jnQgNDA7DhyVbOgKZMvqfDbYvg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13586	uniprotkb:Q04651	intact:EBI-3091|uniprotkb:D6VTY5|ensemblfungi:YGL167C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:atc1_yeast(display_long)|uniprotkb:PMR1(gene name)|psi-mi:PMR1(display_short)|uniprotkb:BSD1(gene name synonym)|uniprotkb:SCC1(gene name synonym)|uniprotkb:YGL167C(locus name)|uniprotkb:G1666(orf name)|uniprotkb:Bypass SOD defects protein 1(gene name synonym)|uniprotkb:"Golgi Ca(2+)-ATPase"(gene name synonym)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711210|imex:IM-26166-6722	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011348.1|sgd:S000003135|dip:DIP-7899N|mint:P13586|ensemblfungi:YGL167C(gene)|ensemblfungi:YGL167C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030026"(cellular manganese ion homeostasis)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-936837|ensembl:YGL167C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.0002687210540695 ) paralog2 (YML067C)-prey (YGL167C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:FUAnYBfq0rUKxq1wSTgwAx7W6yA559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:wozd8Be2MLnLFo0mPV2eLwxb23Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40474	uniprotkb:P53278	intact:EBI-25203|uniprotkb:D6VVG6|ensemblfungi:YIL121W	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:qdr2_yeast(display_long)|uniprotkb:YIL121W(locus name)|uniprotkb:QDR2(gene name)|psi-mi:QDR2(display_short)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711222|imex:IM-26166-6446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012145.1|sgd:S000001383|mint:P40474|dip:DIP-5661N|ensemblfungi:YIL121W(gene)|ensemblfungi:YIL121W_mRNA(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060003"(copper ion export)|go:"GO:0071944"(cell periphery)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|ensembl:YIL121W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000926834630450322 ) paralog2 (YGR130C)-prey (YIL121W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:5vIWIjaHjbqDqaeGri7sbxOt2XQ559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:Z+Njzutj+HCnrYTpFWB3xC2htI4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35844	uniprotkb:P38929	intact:EBI-9648|ensemblfungi:YPL145C|uniprotkb:D6W3M4|uniprotkb:E9P8U8	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:kes1_yeast(display_long)|uniprotkb:KES1(gene name)|psi-mi:KES1(display_short)|uniprotkb:OSH4(gene name synonym)|uniprotkb:Protein KES1(gene name synonym)|uniprotkb:LPI3C(orf name)|uniprotkb:P2614(orf name)|uniprotkb:YPL145C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711234|imex:IM-26166-6562	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL145C(gene)|ensemblfungi:YPL145C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0008142"(oxysterol binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0120015"(sterol transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:1ZHT|rcsb pdb:1ZHW|rcsb pdb:1ZHX|rcsb pdb:1ZHY|rcsb pdb:1ZHZ|rcsb pdb:1ZI7|rcsb pdb:3SPW|rcsb pdb:4F4B|rcsb pdb:4FES|rcsb pdb:4JCH|reactome:R-SCE-1482801|reactome:R-SCE-192105|refseq:NP_015180.1|sgd:S000006066|dip:DIP-2867N|mint:P35844|ensembl:YPL145C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.00113292904823521 ) paralog2 (YGL006W)-prey (YPL145C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6vsHrA4RScGr2+xmii0wiuvK1OM559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:CgB/Otm3MiFlinFWxo0Gh3MZ6AQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:P53290	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711258|imex:IM-26166-6564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	-	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 4.66048746415366E-05 ) paralog2 (YGR163W)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:71bq1TQPgYfN/RuXJLMQ/RfFrB0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04651	uniprotkb:Q04651	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711270|imex:IM-26166-6800	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 2.53610310834757E-06 ) paralog2 (YML067C)-prey (YML067C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:asEMriC0Q7TwsJO370qWf+LLicA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12057	uniprotkb:P53278	intact:EBI-29838|uniprotkb:D6W2G4|ensemblfungi:YOR104W	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:pin2_yeast(display_long)|uniprotkb:PIN2(gene name)|psi-mi:PIN2(display_short)|uniprotkb:YOR3214W(orf name)|uniprotkb:YOR104W(locus name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711282|imex:IM-26166-6648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005630|refseq:NP_014747.1|dip:DIP-4459N|mint:Q12057|ensemblfungi:YOR104W(gene)|ensemblfungi:YOR104W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037504|ensembl:YOR104W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 1.35096150970854E-06 ) paralog2 (YGR130C)-prey (YOR104W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Zk6iUcpP++MEXuhKZ79TMOYQYqM559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:rn0gzPQoPkeB3ampcHU8UNwFqhE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06815	uniprotkb:P38929	intact:EBI-33784|uniprotkb:D6W481|ensemblfungi:YPR079W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:mrl1_yeast(display_long)|uniprotkb:YPR079W(locus name)|uniprotkb:MRL1(gene name)|psi-mi:MRL1(display_short)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711294|imex:IM-26166-6504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015404.1|sgd:S000006283|mint:Q06815|dip:DIP-2873N|ensemblfungi:YPR079W(gene)|ensemblfungi:YPR079W_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007034"(vacuolar transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR036607|interpro:IPR044865|reactome:R-SCE-6798695|reactome:R-SCE-8856825|reactome:R-SCE-8856828|ensembl:YPR079W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.00356428796604581 ) paralog2 (YGL006W)-prey (YPR079W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:PFMxRfVBupoO0p3pb+BB5H2fidg559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:e24F8qLig1F0lV64PMHR8GoK+tM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:P38929	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711306|imex:IM-26166-6506	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:8ABA71761B512242	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.0020876431181247 ) paralog2 (YGL006W)-prey (YMR120C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:fRAwu6K7xe9drvdY1DZqAYXb/bQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33760	uniprotkb:P33760	intact:EBI-13178|uniprotkb:D6W0L8|ensemblfungi:YNL329C	intact:EBI-13178|uniprotkb:D6W0L8|ensemblfungi:YNL329C	psi-mi:pex6_yeast(display_long)|uniprotkb:PEX6(gene name)|psi-mi:PEX6(display_short)|uniprotkb:PAS8(gene name synonym)|uniprotkb:YNL329C(locus name)|uniprotkb:N0310(orf name)|uniprotkb:Peroxin-6(gene name synonym)|uniprotkb:Peroxisome biosynthesis protein PAS8(gene name synonym)|uniprotkb:Peroxisomal assembly protein 8(gene name synonym)	psi-mi:pex6_yeast(display_long)|uniprotkb:PEX6(gene name)|psi-mi:PEX6(display_short)|uniprotkb:PAS8(gene name synonym)|uniprotkb:YNL329C(locus name)|uniprotkb:N0310(orf name)|uniprotkb:Peroxin-6(gene name synonym)|uniprotkb:Peroxisome biosynthesis protein PAS8(gene name synonym)|uniprotkb:Peroxisomal assembly protein 8(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711318|imex:IM-26166-6566	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014070.1|sgd:S000005273|mint:P33760|dip:DIP-2621N|ensemblfungi:YNL329C(gene)|ensemblfungi:YNL329C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|ensembl:YNL329C(identity)	refseq:NP_014070.1|sgd:S000005273|mint:P33760|dip:DIP-2621N|ensemblfungi:YNL329C(gene)|ensemblfungi:YNL329C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|ensembl:YNL329C(identity)	-	crc64:736FECB57BBFF8F8	crc64:736FECB57BBFF8F8	comment:"paralog1 (YKL197C) depletion signifcantly decreases (FDR-corrected p-value: 1.42592767139088E-07 ) paralog2 (YNL329C)-prey (YNL329C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:vonluDQS+We5JMYERfce8BzCIVk559292	rogid:vonluDQS+We5JMYERfce8BzCIVk559292	rigid:MZdMVs0sQqofI8cMUfC3q18BjD4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43621	uniprotkb:Q04651	intact:EBI-4876|uniprotkb:D6VTT4|ensemblfungi:YFR051C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:copd_yeast(display_long)|uniprotkb:RET2(gene name)|psi-mi:RET2(display_short)|uniprotkb:YFR051C(locus name)|uniprotkb:Delta-coat protein(gene name synonym)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711330|imex:IM-26166-6650	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001947|refseq:NP_116709.3|dip:DIP-5255N|mint:P43621|ensemblfungi:YFR051C(gene)|ensemblfungi:YFR051C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|rcsb pdb:5FJW|rcsb pdb:5FJX|rcsb pdb:5FJZ|rcsb pdb:5FK0|reactome:R-SCE-6807878|reactome:R-SCE-6811434|ensembl:YFR051C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	crc64:AA730F046655EE5A	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 3.30327214115461E-07 ) paralog2 (YML067C)-prey (YFR051C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:auvjuT8ffm1R4P3mRKEIWAsynW0559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:xyqOJdqy8ZwlJq5idNBwbJYwziQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:P38929	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711342|imex:IM-26166-6508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:245575E65D3C2193	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 5.36259301920285E-05 ) paralog2 (YGL006W)-prey (YDR233C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:spCYxurubr9uUxLbJxtA2BZ9Z9w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35844	uniprotkb:Q00582	intact:EBI-9648|ensemblfungi:YPL145C|uniprotkb:D6W3M4|uniprotkb:E9P8U8	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:kes1_yeast(display_long)|uniprotkb:KES1(gene name)|psi-mi:KES1(display_short)|uniprotkb:OSH4(gene name synonym)|uniprotkb:Protein KES1(gene name synonym)|uniprotkb:LPI3C(orf name)|uniprotkb:P2614(orf name)|uniprotkb:YPL145C(locus name)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711354|imex:IM-26166-6946	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL145C(gene)|ensemblfungi:YPL145C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0008142"(oxysterol binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0120015"(sterol transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:1ZHT|rcsb pdb:1ZHW|rcsb pdb:1ZHX|rcsb pdb:1ZHY|rcsb pdb:1ZHZ|rcsb pdb:1ZI7|rcsb pdb:3SPW|rcsb pdb:4F4B|rcsb pdb:4FES|rcsb pdb:4JCH|reactome:R-SCE-1482801|reactome:R-SCE-192105|refseq:NP_015180.1|sgd:S000006066|dip:DIP-2867N|mint:P35844|ensembl:YPL145C(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	-	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 6.62454703960478E-07 ) paralog2 (YML121W)-prey (YPL145C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6vsHrA4RScGr2+xmii0wiuvK1OM559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:M9qRF0a/BjG8UwIAZibUsAKHD8E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24004	uniprotkb:P24004	intact:EBI-13155|uniprotkb:D6VX03|ensemblfungi:YKL197C	intact:EBI-13155|uniprotkb:D6VX03|ensemblfungi:YKL197C	psi-mi:pex1_yeast(display_long)|uniprotkb:YKL197C(locus name)|uniprotkb:PEX1(gene name)|psi-mi:PEX1(display_short)|uniprotkb:PAS1(gene name synonym)|uniprotkb:Peroxin-1(gene name synonym)|uniprotkb:Peroxisome biogenesis protein PAS1(gene name synonym)|uniprotkb:Peroxisomal assembly protein 1(gene name synonym)	psi-mi:pex1_yeast(display_long)|uniprotkb:YKL197C(locus name)|uniprotkb:PEX1(gene name)|psi-mi:PEX1(display_short)|uniprotkb:PAS1(gene name synonym)|uniprotkb:Peroxin-1(gene name synonym)|uniprotkb:Peroxisome biogenesis protein PAS1(gene name synonym)|uniprotkb:Peroxisomal assembly protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711366|imex:IM-26166-6568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012724.1|sgd:S000001680|dip:DIP-4266N|ensemblfungi:YKL197C(gene)|ensemblfungi:YKL197C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR015342(Peroxisome biogenesis factor 1, N-terminal)|interpro:IPR025653|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|ensembl:YKL197C(identity)	refseq:NP_012724.1|sgd:S000001680|dip:DIP-4266N|ensemblfungi:YKL197C(gene)|ensemblfungi:YKL197C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR015342(Peroxisome biogenesis factor 1, N-terminal)|interpro:IPR025653|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|ensembl:YKL197C(identity)	-	-	-	comment:"paralog1 (YNL329C) depletion signifcantly decreases (FDR-corrected p-value: 5.65836361959611E-15 ) paralog2 (YKL197C)-prey (YKL197C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:dk1kX5xmVl+XC0YkOgFnrrx5wG4559292	rogid:dk1kX5xmVl+XC0YkOgFnrrx5wG4559292	rigid:KrN/YxkWcIGD2SypSYu3MK10+Yk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04031	uniprotkb:Q06205	intact:EBI-31091|uniprotkb:D6VT44|ensemblfungi:YDR412W	intact:EBI-6956|uniprotkb:D6VZ83|ensemblfungi:YLR449W	psi-mi:rrp17_yeast(display_long)|uniprotkb:RRP17(gene name)|psi-mi:RRP17(display_short)|uniprotkb:YDR412W(locus name)	psi-mi:fkbp4_yeast(display_long)|uniprotkb:FPR4(gene name)|psi-mi:FPR4(display_short)|uniprotkb:YLR449W(locus name)|uniprotkb:L9324.3(orf name)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Histone proline isomerase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711378|imex:IM-26166-6570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010700.3|sgd:S000002820|dip:DIP-1264N|mint:Q04031|ensemblfungi:YDR412W(gene)|ensemblfungi:YDR412W_mRNA(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|interpro:IPR019186|ensembl:YDR412W(identity)	sgd:S000004441|refseq:NP_013554.3|dip:DIP-909N|mint:Q06205|ensemblfungi:YLR449W(gene)|ensemblfungi:YLR449W_mRNA(transcript)|go:"GO:0000412"(histone peptidyl-prolyl isomerization)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|rcsb pdb:4BF8|ensembl:YLR449W(identity)	-	crc64:A61BB3AE3838CBAF	crc64:CF90C6714F04572E	comment:"paralog1 (YML074C) depletion signifcantly decreases (FDR-corrected p-value: 4.40873767848409E-05 ) paralog2 (YLR449W)-prey (YDR412W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aC8bLzE4Tlvguem648OlXxm5iR0559292	rogid:rDmDSGEgRbtgkLBoJTzmzxxY7B4559292	rigid:Obpf8T7EWqEqkFdL+0LIklDcOTU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P38929	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711390|imex:IM-26166-6510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976|ensembl:YHR007C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.0034707266929351 ) paralog2 (YGL006W)-prey (YHR007C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:ntAQsvKP+0rKHu/beE7B1FrvmsA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41810	uniprotkb:Q04651	intact:EBI-4869|uniprotkb:Q03779|uniprotkb:D6VSL9|ensemblfungi:YDR238C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:copb_yeast(display_long)|uniprotkb:SEC26(gene name)|psi-mi:SEC26(display_short)|uniprotkb:YDR238C(locus name)|uniprotkb:YD8419.05C(orf name)|uniprotkb:Beta-coat protein(gene name synonym)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711246|imex:IM-26166-6786	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002646|refseq:NP_010524.3|dip:DIP-6467N|mint:P41810|ensemblfungi:YDR238C(gene)|ensemblfungi:YDR238C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0030126"(COPI vesicle coat)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|reactome:R-SCE-6798695|reactome:R-SCE-6807878|reactome:R-SCE-6811434|ensembl:YDR238C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	crc64:885420DB026BCFA3	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 3.26906167124617E-06 ) paralog2 (YML067C)-prey (YDR238C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ZfLp1BUmvVuTiXn7/Zbf/3m6VtE559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:fsfHs47WTqnKqLJlwDFj6Kt7A5M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38247	uniprotkb:P53290	intact:EBI-21507|uniprotkb:D6VQ76|ensemblfungi:YBR077C	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:slm4_yeast(display_long)|uniprotkb:YBR077C(locus name)|uniprotkb:YBR0723(orf name)|uniprotkb:GSE complex subunit 1(gene name synonym)|uniprotkb:EGO complex subunit 3(gene name synonym)|uniprotkb:SLM4(gene name)|psi-mi:SLM4(display_short)|uniprotkb:EGO3(gene name synonym)|uniprotkb:GSE1(gene name synonym)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711414|imex:IM-26166-6512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009633.3|sgd:S000000281|mint:P38247|dip:DIP-1763N|ensemblfungi:YBR077C(gene)|ensemblfungi:YBR077C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0071986"(Ragulator complex)|interpro:IPR020233|rcsb pdb:3LGO|rcsb pdb:4FTX|rcsb pdb:4FUW|rcsb pdb:4XPM|rcsb pdb:6JWP|ensembl:YBR077C(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	crc64:D64ABDE1CDF265FD	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 1.33682765870943E-05 ) paralog2 (YGR163W)-prey (YBR077C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:BCEWjA3PQvwm3n08QwY0D//TpbA559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:RuiZnRjeeeoPTYgV/6eU40FALoE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38166	uniprotkb:Q04651	intact:EBI-17046|uniprotkb:D6VPQ1|ensemblfungi:YBL102W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:sft2_yeast(display_long)|uniprotkb:YBL0812(orf name)|uniprotkb:YBL102W(locus name)|uniprotkb:SFT2(gene name)|psi-mi:SFT2(display_short)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711426|imex:IM-26166-6724	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YBL102W(gene)|ensemblfungi:YBL102W_mRNA(transcript)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR007305(Got1-like protein)|interpro:IPR011691(SFT2-like)|refseq:NP_009448.1|sgd:S000000198|dip:DIP-1865N|mint:P38166|ensembl:YBL102W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	crc64:1BF971749814382C	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 7.81669160730068E-06 ) paralog2 (YML067C)-prey (YBL102W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:tGTSgSqEOsu/4dXIp31UzvtkyKs559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:xdi3cz++RtKcWhNrjlU6+rnjMT0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46965	uniprotkb:Q04651	intact:EBI-17823|uniprotkb:D6VWI6|ensemblfungi:YJR010C-A	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:spc1_yeast(display_long)|uniprotkb:SPC1(gene name)|psi-mi:SPC1(display_short)|uniprotkb:YJR010C-A(locus name)|uniprotkb:YJR010BW(orf name)|uniprotkb:Microsomal signal peptidase subunit 1(gene name synonym)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711438|imex:IM-26166-6572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012544.1|sgd:S000003770|ensemblfungi:YJR010C-A(gene)|ensemblfungi:YJR010C-A_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0006465"(signal peptide processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|mint:P46965|dip:DIP-2770N|ensembl:YJR010C-A(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 2.15975025249642E-06 ) paralog2 (YML067C)-prey (YJR010C-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:kchUi3mkadvzweVkrWO3QkbbHew559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:ngWwqJTgDMzjQdtF2zX91bpWw3o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35735	uniprotkb:P19454	intact:EBI-26678|uniprotkb:D6VXN6|ensemblfungi:YKL051W	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:sfk1_yeast(display_long)|uniprotkb:YKL051W(locus name)|uniprotkb:YKL303(orf name)|uniprotkb:SFK1(gene name)|psi-mi:SFK1(display_short)|uniprotkb:Suppressor of four kinase protein 1(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711450|imex:IM-26166-6726	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012873.1|sgd:S000001534|mint:P35735|dip:DIP-5309N|ensemblfungi:YKL051W(gene)|ensemblfungi:YKL051W_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007033"(vacuole organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0061093"(negative regulation of phospholipid translocation)|go:"GO:0071944"(cell periphery)|interpro:IPR019402|ensembl:YKL051W(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 3.92337019334005E-06 ) paralog2 (YOR061W)-prey (YKL051W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:MUFJgCWecmYI5IvVgC3UXQzptcY559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:JxtFSDgYGHCJWn3BtPX2nnJ3WSM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61830	uniprotkb:P38911	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	intact:EBI-6951|uniprotkb:D6W0K9|ensemblfungi:YML074C	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:fkbp3_yeast(display_long)|uniprotkb:YML074C(locus name)|uniprotkb:FPR3(gene name)|psi-mi:FPR3(display_short)|uniprotkb:NPI46(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Proline rotamase(gene name synonym)|uniprotkb:Nucleolar proline isomerase(gene name synonym)|uniprotkb:FKBP-70(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711462|imex:IM-26166-6802	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G|ensembl:YNL031C(identity)	refseq:NP_013637.1|sgd:S000004539|dip:DIP-6578N|ensemblfungi:YML074C(gene)|ensemblfungi:YML074C_mRNA(transcript)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0051598"(meiotic recombination checkpoint signaling)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|ensembl:YML074C(identity)	-	crc64:A6115FEB480AC67A	crc64:A01D24DE0078FE11	comment:"paralog1 (YLR449W) depletion signifcantly decreases (FDR-corrected p-value: 2.51442853021207E-08 ) paralog2 (YML074C)-prey (YNL031C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	rogid:4xZebf94akWQyMgPLbH6ExNGjoY559292	rigid:9ZxkHPq18msDWVDDtvr8XFXTies	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38930	uniprotkb:P19454	intact:EBI-9578|ensemblfungi:YOR039W|uniprotkb:D6W2A6	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:csk2c_yeast(display_long)|uniprotkb:CKB2(gene name)|psi-mi:CKB2(display_short)|uniprotkb:OR26.32(orf name)|uniprotkb:YOR039W(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711402|imex:IM-26166-6652	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR039W(gene)|ensemblfungi:YOR039W_mRNA(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0032545"(CURI complex)|go:"GO:0034456"(UTP-C complex)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-SCE-2514853|reactome:R-SCE-6798695|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014682.1|sgd:S000005565|mint:P38930|dip:DIP-262N|ensembl:YOR039W(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:D6060CB3D70B19A4	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 1.70022523116803E-06 ) paralog2 (YOR061W)-prey (YOR039W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:X+0JSYVQigL0wSbWYCkorc8jqpw559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:qIOUgiWwfVanMOVztJlwK2hpVBA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53551	uniprotkb:Q06205	intact:EBI-8064|uniprotkb:Q6Q5R6|uniprotkb:D6W3P0|ensemblfungi:YPL127C	intact:EBI-6956|uniprotkb:D6VZ83|ensemblfungi:YLR449W	psi-mi:h1_yeast(display_long)|uniprotkb:HHO1(gene name)|psi-mi:HHO1(display_short)|uniprotkb:LPI17C(orf name)|uniprotkb:YPL127C(locus name)	psi-mi:fkbp4_yeast(display_long)|uniprotkb:FPR4(gene name)|psi-mi:FPR4(display_short)|uniprotkb:YLR449W(locus name)|uniprotkb:L9324.3(orf name)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Histone proline isomerase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711486|imex:IM-26166-6514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015198.1|sgd:S000006048|mint:P53551|dip:DIP-6587N|ensemblfungi:YPL127C(gene)|ensemblfungi:YPL127C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:1UHM|rcsb pdb:1USS|rcsb pdb:1UST|rcsb pdb:1YQA|ensembl:YPL127C(identity)	sgd:S000004441|refseq:NP_013554.3|dip:DIP-909N|mint:Q06205|ensemblfungi:YLR449W(gene)|ensemblfungi:YLR449W_mRNA(transcript)|go:"GO:0000412"(histone peptidyl-prolyl isomerization)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|rcsb pdb:4BF8|ensembl:YLR449W(identity)	-	crc64:B0C53AC186E49F96	crc64:CF90C6714F04572E	comment:"paralog1 (YML074C) depletion signifcantly decreases (FDR-corrected p-value: 0.000320823574672734 ) paralog2 (YLR449W)-prey (YPL127C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:dPMYSAq1Cr7pfGGNgb3GDp3LnsQ559292	rogid:rDmDSGEgRbtgkLBoJTzmzxxY7B4559292	rigid:NjNqaHTQNao+H814GLbTtOSr/Dk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26570	uniprotkb:P19454	intact:EBI-13807|uniprotkb:Q00979|ensemblfungi:YML016C|uniprotkb:D6VZF8	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:ppz1_yeast(display_long)|uniprotkb:PPZ1(gene name)|psi-mi:PPZ1(display_short)|uniprotkb:YM9571.02C(orf name)|uniprotkb:YML016C(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711498|imex:IM-26166-6448	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML016C(gene)|ensemblfungi:YML016C_mRNA(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011159(Phosphoprotein phosphatase PPZ)|interpro:IPR029052|interpro:IPR031675|refseq:NP_013696.1|sgd:S000004478|mint:P26570|dip:DIP-557N|ensembl:YML016C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:8B7F009521F72C15	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.000572473204817509 ) paralog2 (YOR061W)-prey (YML016C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aybUrPA5WH/mgdDx6VD8N4F/4x0559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:HO87kLPqDfzABm1kLGzb+++S/wQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03640	uniprotkb:P53278	intact:EBI-27872|uniprotkb:D6VZA1|ensemblfungi:YML072C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:tcb3_yeast(display_long)|uniprotkb:YML072C(locus name)|uniprotkb:TCB3(gene name)|psi-mi:TCB3(display_short)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711510|imex:IM-26166-6520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013639.1|sgd:S000004537|dip:DIP-6589N|mint:Q03640|ensemblfungi:YML072C(gene)|ensemblfungi:YML072C_mRNA(transcript)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0006869"(lipid transport)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0046872"(metal ion binding)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR017147(Tricalbin)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037756|interpro:IPR037761|interpro:IPR037762|interpro:IPR037765|ensembl:YML072C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:77A0AE57F9259784	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 5.36259301920285E-05 ) paralog2 (YGR130C)-prey (YML072C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:miu2Eqlp/xqS/9aOMycLTcERCEU559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:zXZoVktquvHPqRyIYxle4kgZCik	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12462	uniprotkb:P24004	intact:EBI-13198|uniprotkb:D6W1S2|ensemblfungi:YOL147C	intact:EBI-13155|uniprotkb:D6VX03|ensemblfungi:YKL197C	psi-mi:pex11_yeast(display_long)|uniprotkb:PEX11(gene name)|psi-mi:PEX11(display_short)|uniprotkb:PMP24(gene name synonym)|uniprotkb:PMP27(gene name synonym)|uniprotkb:O0454(orf name)|uniprotkb:YOL147C(locus name)|uniprotkb:Peroxin-11(gene name synonym)	psi-mi:pex1_yeast(display_long)|uniprotkb:YKL197C(locus name)|uniprotkb:PEX1(gene name)|psi-mi:PEX1(display_short)|uniprotkb:PAS1(gene name synonym)|uniprotkb:Peroxin-1(gene name synonym)|uniprotkb:Peroxisome biogenesis protein PAS1(gene name synonym)|uniprotkb:Peroxisomal assembly protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711474|imex:IM-26166-6660	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014494.1|sgd:S000005507|mint:Q12462|dip:DIP-3839N|ensemblfungi:YOL147C(gene)|ensemblfungi:YOL147C_mRNA(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0016559"(peroxisome fission)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0044375"(regulation of peroxisome size)|go:"GO:1990429"(peroxisomal importomer complex)|interpro:IPR008733(Peroxisomal biogenesis factor 11)|reactome:R-SCE-9603798|go:"GO:0005783"(endoplasmic reticulum)|ensembl:YOL147C(identity)	refseq:NP_012724.1|sgd:S000001680|dip:DIP-4266N|ensemblfungi:YKL197C(gene)|ensemblfungi:YKL197C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR015342(Peroxisome biogenesis factor 1, N-terminal)|interpro:IPR025653|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|ensembl:YKL197C(identity)	-	-	-	comment:"paralog1 (YNL329C) depletion signifcantly decreases (FDR-corrected p-value: 2.00277278287908E-13 ) paralog2 (YKL197C)-prey (YOL147C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Wgd0xHDx1jc9msL55PpTWFNL7cA559292	rogid:dk1kX5xmVl+XC0YkOgFnrrx5wG4559292	rigid:78bCLKtpdVR+8X95nGlXuMkUqJE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12296	uniprotkb:P38929	intact:EBI-33338|uniprotkb:D6W207|ensemblfungi:YOL060C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:mam3_yeast(display_long)|uniprotkb:YOL060C(locus name)|uniprotkb:MAM3(gene name)|psi-mi:MAM3(display_short)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711534|imex:IM-26166-6948	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014581.1|sgd:S000005421|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR002550(Protein of unknown function DUF21)|interpro:IPR044751|ensemblfungi:YOL060C(gene)|ensemblfungi:YOL060C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030026"(cellular manganese ion homeostasis)|ensembl:YOL060C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.004187092018683 ) paralog2 (YGL006W)-prey (YOL060C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:/WgMB/PmwTY68gSczgTLx3VBdUs559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:GK3YzV+nXt/rc+L/iGBtpeYSAYE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04396	uniprotkb:P17898	intact:EBI-35436|uniprotkb:D6VTC5|ensemblfungi:YDR503C	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:lpp1_yeast(display_long)|uniprotkb:LPP1(gene name)|psi-mi:LPP1(display_short)|uniprotkb:YDR503C(locus name)|uniprotkb:D9719.9(orf name)|uniprotkb:Phosphatidate phosphatase(gene name synonym)|uniprotkb:Lysophosphatidate phosphatase(gene name synonym)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711522|imex:IM-26166-6574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010791.3|sgd:S000002911|mint:Q04396|dip:DIP-1415N|ensemblfungi:YDR503C(gene)|ensemblfungi:YDR503C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000810"(diacylglycerol diphosphate phosphatase activity)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042577"(lipid phosphatase activity)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR036938|interpro:IPR043216|reactome:R-SCE-1660661|reactome:R-SCE-2029485|reactome:R-SCE-419408|ensembl:YDR503C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog1 (YHR123W) depletion signifcantly decreases (FDR-corrected p-value: 1.93382939077013E-05 ) paralog2 (YNL130C)-prey (YDR503C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:WSLmGL9DQuSCqyVf3vQjK753VsI559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:x0dQ9dVjKlk7DqCxKOIqh1vdiSA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:Q04651	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711709|imex:IM-26166-6730	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976|ensembl:YHR007C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.000424176971747481 ) paralog2 (YML067C)-prey (YHR007C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:N/1nMN55oXaTECzWMnSAdHAkkbg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87284	uniprotkb:P38929	intact:EBI-13555|uniprotkb:D6VSQ7|ensemblfungi:YDR276C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:pmp3_yeast(display_long)|uniprotkb:PMP3(gene name)|psi-mi:PMP3(display_short)|uniprotkb:SNA1(gene name synonym)|uniprotkb:YDR276C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711697|imex:IM-26166-6524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010562.1|sgd:S000002684|ensemblfungi:YDR276C(gene)|ensemblfungi:YDR276C_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000612(Protein of unknown function UPF0057)|dip:DIP-7280N|ensembl:YDR276C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.000770483962889062 ) paralog2 (YGL006W)-prey (YDR276C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6uTuY0fyQfxrzyVqcLiNdDF5oRs559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:3CjVLg6GRVDZooHtfVFtnYZNR9c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02785	uniprotkb:P19454	intact:EBI-13065|uniprotkb:D6W3V6|ensemblfungi:YPL058C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:pdr12_yeast(display_long)|uniprotkb:PDR12(gene name)|psi-mi:PDR12(display_short)|uniprotkb:LPE14C(orf name)|uniprotkb:YPL058C(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711685|imex:IM-26166-6950	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015267.1|sgd:S000005979|interpro:IPR013525(ABC-2 type transporter)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010929(CDR ABC transporter)|interpro:IPR027417|interpro:IPR029481|mint:Q02785|interpro:IPR034001|interpro:IPR034003|interpro:IPR043926|ensemblfungi:YPL058C(gene)|ensemblfungi:YPL058C_mRNA(transcript)|go:"GO:0005342"(organic acid transmembrane transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0015849"(organic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|ensembl:YPL058C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 1.57337633778555E-05 ) paralog2 (YOR061W)-prey (YPL058C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ADiU46Ad/dXDE9tXUfGj0rFIO6M559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:+HrE3x6GXExnevuoUJkGlRsXqiY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07800	uniprotkb:P19454	intact:EBI-31129|uniprotkb:D6VXZ2|ensemblfungi:YLL010C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:psr1_yeast(display_long)|uniprotkb:PSR1(gene name)|psi-mi:PSR1(display_short)|uniprotkb:YLL010C(locus name)|uniprotkb:L1341(orf name)|uniprotkb:Plasma membrane sodium response protein 1(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711673|imex:IM-26166-6884	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013091.1|sgd:S000003933|dip:DIP-4182N|mint:Q07800|ensemblfungi:YLL010C(gene)|ensemblfungi:YLL010C_mRNA(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0009651"(response to salt stress)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:1903293"(phosphatase complex)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|ensembl:YLL010C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:402F5C395132A080	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 2.48975946056278E-06 ) paralog2 (YOR061W)-prey (YLL010C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:i6IY+xA5uBhJsxXyYCiE5ol3W4I559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:RGmstyfGGcrAkMx8U9pQpKAreZA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41807	uniprotkb:Q00582	intact:EBI-20281|uniprotkb:D6W446|ensemblfungi:YPR036W	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:vath_yeast(display_long)|uniprotkb:YP3085.02(orf name)|uniprotkb:VMA13(gene name)|psi-mi:VMA13(display_short)|uniprotkb:CLS11(gene name synonym)|uniprotkb:YPR036W(locus name)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 54 kDa subunit(gene name synonym)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711661|imex:IM-26166-6452	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015361.1|sgd:S000006240|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|rcsb pdb:1HO8|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YPR036W(gene)|ensemblfungi:YPR036W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-6640N|mint:P41807|ensembl:YPR036W(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:54131FF9C2C87594	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 0.00047301990007014 ) paralog2 (YML121W)-prey (YPR036W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:kEXWvOsnTk0WdgGOny+mufz4lTo559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:dKK/QkT7MBpber7tB1wGSc0K8h8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53049	uniprotkb:P53278	intact:EBI-29324|uniprotkb:D6VV58|ensemblfungi:YGR281W	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:yor1_yeast(display_long)|uniprotkb:YOR1(gene name)|psi-mi:YOR1(display_short)|uniprotkb:ABC transporter YOR1(gene name synonym)|uniprotkb:"ABC-type Cd(2+) transporter"(gene name synonym)|uniprotkb:ABC-type glutathione-S-conjugate transporter(gene name synonym)|uniprotkb:YRS1(gene name synonym)|uniprotkb:Yeast oligomycin resistance protein 1(gene name synonym)|uniprotkb:YGR281W(locus name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711649|imex:IM-26166-6806	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003513|refseq:NP_011797.3|dip:DIP-6796N|mint:P53049|ensemblfungi:YGR281W(gene)|ensemblfungi:YGR281W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008551"(P-type cadmium transporter activity)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0015434"(ABC-type cadmium transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071944"(cell periphery)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030244|interpro:IPR036640|reactome:R-SCE-2142850|reactome:R-SCE-382556|ensembl:YGR281W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 6.80747349303081E-05 ) paralog2 (YGR130C)-prey (YGR281W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:p71p+cqRzx+Iry0pb2s6q2DdPzA559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:/9K9ow5QSBvr7EjMxDhJNpuvQJ4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15367	uniprotkb:Q04651	intact:EBI-16513|uniprotkb:D6VVV3|ensemblfungi:YIR022W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:sec11_yeast(display_long)|uniprotkb:SEC11(gene name)|psi-mi:SEC11(display_short)|uniprotkb:Signal peptidase I(gene name synonym)|uniprotkb:Secretory protein 11(gene name synonym)|uniprotkb:YIR022W(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711565|imex:IM-26166-6804	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012288.1|sgd:S000001461|go:"GO:0005787"(signal peptidase complex)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR001733(Peptidase S26B, eukaryotic signal peptidase)|interpro:IPR015927(Peptidase S24, S26A, S26B and S26C)|interpro:IPR019756|interpro:IPR019758|interpro:IPR027245|interpro:IPR036286|ensemblfungi:YIR022W(gene)|ensemblfungi:YIR022W_mRNA(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-5667N|mint:P15367|ensembl:YIR022W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.000355116562464717 ) paralog2 (YML067C)-prey (YIR022W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:t+RiGy79Pv7EbHywbjkd4BMyJwk559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:lygQWxJiyNEPTuhnZ3i7FU9Hcz4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35844	uniprotkb:P53290	intact:EBI-9648|ensemblfungi:YPL145C|uniprotkb:D6W3M4|uniprotkb:E9P8U8	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	psi-mi:kes1_yeast(display_long)|uniprotkb:KES1(gene name)|psi-mi:KES1(display_short)|uniprotkb:OSH4(gene name synonym)|uniprotkb:Protein KES1(gene name synonym)|uniprotkb:LPI3C(orf name)|uniprotkb:P2614(orf name)|uniprotkb:YPL145C(locus name)	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711625|imex:IM-26166-6664	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL145C(gene)|ensemblfungi:YPL145C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0008142"(oxysterol binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0120015"(sterol transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:1ZHT|rcsb pdb:1ZHW|rcsb pdb:1ZHX|rcsb pdb:1ZHY|rcsb pdb:1ZHZ|rcsb pdb:1ZI7|rcsb pdb:3SPW|rcsb pdb:4F4B|rcsb pdb:4FES|rcsb pdb:4JCH|reactome:R-SCE-1482801|reactome:R-SCE-192105|refseq:NP_015180.1|sgd:S000006066|dip:DIP-2867N|mint:P35844|ensembl:YPL145C(identity)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	-	-	crc64:0A0D16C81F73184D	comment:"paralog1 (YML121W) depletion signifcantly decreases (FDR-corrected p-value: 6.13564620616151E-05 ) paralog2 (YGR163W)-prey (YPL145C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6vsHrA4RScGr2+xmii0wiuvK1OM559292	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rigid:aNOp6b+sA1mA/LiJqPwrFN56WUQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23542	uniprotkb:P53278	intact:EBI-2002|uniprotkb:D6VY29|ensemblfungi:YLR027C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:aatc_yeast(display_long)|uniprotkb:AAT2(gene name)|psi-mi:AAT2(display_short)|uniprotkb:YLR027C(locus name)|uniprotkb:ASP5(gene name synonym)|uniprotkb:L1746(orf name)|uniprotkb:Transaminase A(gene name synonym)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711613|imex:IM-26166-6450	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013127.2|sgd:S000004017|dip:DIP-2897N|mint:P23542|go:"GO:0019266"(asparagine biosynthetic process from oxaloacetate)|go:"GO:0030170"(pyridoxal phosphate binding)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1YAA|reactome:R-SCE-70263|reactome:R-SCE-8963693|ensemblfungi:YLR027C(gene)|ensemblfungi:YLR027C_mRNA(transcript)|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006536"(glutamate metabolic process)|ensembl:YLR027C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:D25F40F6C6DD2B33	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000266017534815946 ) paralog2 (YGR130C)-prey (YLR027C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:eNypS723YWwMMuWVVoTnidvQuaA559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:r2Eg586ELI1nd2hoyG6wJKYmUgk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12462	uniprotkb:P33760	intact:EBI-13198|uniprotkb:D6W1S2|ensemblfungi:YOL147C	intact:EBI-13178|uniprotkb:D6W0L8|ensemblfungi:YNL329C	psi-mi:pex11_yeast(display_long)|uniprotkb:PEX11(gene name)|psi-mi:PEX11(display_short)|uniprotkb:PMP24(gene name synonym)|uniprotkb:PMP27(gene name synonym)|uniprotkb:O0454(orf name)|uniprotkb:YOL147C(locus name)|uniprotkb:Peroxin-11(gene name synonym)	psi-mi:pex6_yeast(display_long)|uniprotkb:PEX6(gene name)|psi-mi:PEX6(display_short)|uniprotkb:PAS8(gene name synonym)|uniprotkb:YNL329C(locus name)|uniprotkb:N0310(orf name)|uniprotkb:Peroxin-6(gene name synonym)|uniprotkb:Peroxisome biosynthesis protein PAS8(gene name synonym)|uniprotkb:Peroxisomal assembly protein 8(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711601|imex:IM-26166-6576	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014494.1|sgd:S000005507|mint:Q12462|dip:DIP-3839N|ensemblfungi:YOL147C(gene)|ensemblfungi:YOL147C_mRNA(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0016559"(peroxisome fission)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0044375"(regulation of peroxisome size)|go:"GO:1990429"(peroxisomal importomer complex)|interpro:IPR008733(Peroxisomal biogenesis factor 11)|reactome:R-SCE-9603798|go:"GO:0005783"(endoplasmic reticulum)|ensembl:YOL147C(identity)	refseq:NP_014070.1|sgd:S000005273|mint:P33760|dip:DIP-2621N|ensemblfungi:YNL329C(gene)|ensemblfungi:YNL329C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|ensembl:YNL329C(identity)	-	-	crc64:736FECB57BBFF8F8	comment:"paralog1 (YKL197C) depletion signifcantly decreases (FDR-corrected p-value: 6.22554391063627E-12 ) paralog2 (YNL329C)-prey (YOL147C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Wgd0xHDx1jc9msL55PpTWFNL7cA559292	rogid:vonluDQS+We5JMYERfce8BzCIVk559292	rigid:ufuLZ9FJmpoNknpbzY0uO9mchXU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28795	uniprotkb:Q08580	intact:EBI-13164|uniprotkb:D6VSW1|ensemblfungi:YDR329C	intact:EBI-34476|uniprotkb:D6W2Q2|ensemblfungi:YOR193W	psi-mi:pex3_yeast(display_long)|uniprotkb:PEX3(gene name)|psi-mi:PEX3(display_short)|uniprotkb:PAS3(gene name synonym)|uniprotkb:YDR329C(locus name)|uniprotkb:D9798.15(orf name)|uniprotkb:Peroxin-3(gene name synonym)	psi-mi:pex27_yeast(display_long)|uniprotkb:PEX27(gene name)|psi-mi:PEX27(display_short)|uniprotkb:Peroxin-27(gene name synonym)|uniprotkb:YOR193W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711589|imex:IM-26166-6728	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002737|refseq:NP_010616.3|mint:P28795|dip:DIP-2477N|ensemblfungi:YDR329C(gene)|ensemblfungi:YDR329C_mRNA(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0045033"(peroxisome inheritance)|go:"GO:0045046"(protein import into peroxisome membrane)|interpro:IPR006966(Peroxin-3)|reactome:R-SCE-1369062|reactome:R-SCE-9603798|ensembl:YDR329C(identity)	sgd:S000005719|mint:Q08580|refseq:NP_014836.3|ensemblfungi:YOR193W(gene)|ensemblfungi:YOR193W_mRNA(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016559"(peroxisome fission)|go:"GO:0044375"(regulation of peroxisome size)|ensembl:YOR193W(identity)	-	crc64:3CDC1D036DF0D0F9	-	comment:"paralog1 (YPL112C) depletion signifcantly decreases (FDR-corrected p-value: 4.56449058843504E-09 ) paralog2 (YOR193W)-prey (YDR329C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:YcXHJijTXVH0oLXYmqsvIT/OeV4559292	rogid:4KDjn/JFPYAMsOKZxfT5DiKQWyE559292	rigid:92PaY0y+AqbQq/Ce+wbsg512RGM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54837	uniprotkb:Q04651	intact:EBI-6642|uniprotkb:D6VZG2|ensemblfungi:YML012W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:tmeda_yeast(display_long)|uniprotkb:ERV25(gene name)|psi-mi:ERV25(display_short)|uniprotkb:YM9571.06(orf name)|uniprotkb:YML012W(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711577|imex:IM-26166-6662	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013701.1|sgd:S000004473|mint:P54837|dip:DIP-2134N|ensemblfungi:YML012W(gene)|ensemblfungi:YML012W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YML012W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 7.97868696798904E-06 ) paralog2 (YML067C)-prey (YML012W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:H4bQL5k77CB85Hz+8rjJcSAG/98559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:ZXjZszEmT6udfQP1ehL8CMEhXuE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36076	uniprotkb:P19454	intact:EBI-26778|uniprotkb:D6VXK0|ensemblfungi:YKL088W	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:cab3_yeast(display_long)|uniprotkb:YKL088W(locus name)|uniprotkb:CAB3(gene name)|psi-mi:CAB3(display_short)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711637|imex:IM-26166-6522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012835.1|sgd:S000001571|mint:P36076|dip:DIP-4475N|ensemblfungi:YKL088W(gene)|ensemblfungi:YKL088W_mRNA(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|reactome:R-SCE-196783|ensembl:YKL088W(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.000026985369193569 ) paralog2 (YOR061W)-prey (YKL088W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Li7vZOassm4PC5fW111/j5ivgEc559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:awuB1rJ71HZ5GZBqKaYN0trnVFA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05359	uniprotkb:P22140	intact:EBI-6581|uniprotkb:D6VPL7|uniprotkb:E9P8S8|ensemblfungi:YAR002C-A	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:erp1_yeast(display_long)|uniprotkb:ERP1(gene name)|psi-mi:ERP1(display_short)|uniprotkb:YAR002A(orf name)|uniprotkb:YAR002C-A(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711793|imex:IM-26166-6578	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009402.1|sgd:S000002129|mint:Q05359|dip:DIP-5147N|ensemblfungi:YAR002C-A(gene)|ensemblfungi:YAR002C-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YAR002C-A(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 8.48747559057314E-05 ) paralog2 (YHR123W)-prey (YAR002C-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:RX3ynMqEVNp4bRTVb16YoXaQW3U559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:DEEy9ohPLreTMiqMcRzfK+7rj5g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23202	uniprotkb:Q00582	intact:EBI-20138|uniprotkb:D6W0W3|ensemblfungi:YNL229C	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:ure2_yeast(display_long)|uniprotkb:URE2(gene name)|psi-mi:URE2(display_short)|uniprotkb:Disulfide reductase(gene name synonym)|uniprotkb:Glutathione peroxidase(gene name synonym)|uniprotkb:N1165(orf name)|uniprotkb:YNL229C(locus name)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711781|imex:IM-26166-6668	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014170.1|sgd:S000005173|ensemblfungi:YNL229C(gene)|ensemblfungi:YNL229C_mRNA(transcript)|mint:P23202|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0032447"(protein urmylation)|go:"GO:0042128"(nitrate assimilation)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR017298(Prion URE2)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|rcsb pdb:1G6W|rcsb pdb:1G6Y|rcsb pdb:1HQO|rcsb pdb:1JZR|rcsb pdb:1K0A|rcsb pdb:1K0B|rcsb pdb:1K0C|rcsb pdb:1K0D|go:"GO:0003714"(transcription corepressor activity)|dip:DIP-1308N|ensembl:YNL229C(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:2C628976034B0F1C	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 0.00265873244591668 ) paralog2 (YML121W)-prey (YNL229C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:jjsWygBsEp8axNurMa3pxPMQJ2k559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:/zk3Y9s514we2PQXgYaHjbq7J3Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36024	uniprotkb:P19454	intact:EBI-17250|uniprotkb:D6VXD3|ensemblfungi:YKR072C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:sis2_yeast(display_long)|uniprotkb:SIS2(gene name)|psi-mi:SIS2(display_short)|uniprotkb:HAL3(gene name synonym)|uniprotkb:YKR072C(locus name)|uniprotkb:Halotolerance protein HAL3(gene name synonym)|uniprotkb:Sit4 suppressor 2(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711769|imex:IM-26166-6666	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012998.1|sgd:S000001780|ensemblfungi:YKR072C(gene)|ensemblfungi:YKR072C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003824"(catalytic activity)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0009651"(response to salt stress)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|dip:DIP-2521N|mint:P36024|ensembl:YKR072C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 2.6518234140912E-06 ) paralog2 (YOR061W)-prey (YKR072C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:oiDiGYmZy7PE7zchnyTa2x4g9zo559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:qSYpmz2tPbHdASlWdRfVlXAhXcs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53388	uniprotkb:Q04651	intact:EBI-5904|uniprotkb:D6W3A5|ensemblfungi:YPL265W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:dip5_yeast(display_long)|uniprotkb:YPL265W(locus name)|uniprotkb:DIP5(gene name)|psi-mi:DIP5(display_short)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711757|imex:IM-26166-6526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015058.1|sgd:S000006186|dip:DIP-5540N|mint:P53388|ensemblfungi:YPL265W(gene)|ensemblfungi:YPL265W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005310"(dicarboxylic acid transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071944"(cell periphery)|interpro:IPR004762(Amino acid permease, fungi)|interpro:IPR004840(Amino acid permease, conserved site)|interpro:IPR004841(Amino acid permease-associated region)|ensembl:YPL265W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	crc64:488A382656039D0B	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.000808835632063589 ) paralog2 (YML067C)-prey (YPL265W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:TcjS7gtrFXNOhJrNDu8kVkxHs1w559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:aCi8C81Pkr/KbiX7QU4K2LO9i2Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:Q00582	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711745|imex:IM-26166-6886	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	-	crc64:C86AE5ABB508EA03	crc64:B79CE7FE7AD2FDBE	comment:"paralog1 (YGR163W) depletion signifcantly decreases (FDR-corrected p-value: 3.94312401638949E-07 ) paralog2 (YML121W)-prey (YGR086C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rigid:sr3OQuckoogXUPvEF3mMHhyFP4Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39010	uniprotkb:Q04651	intact:EBI-2421|uniprotkb:D6VSP8|ensemblfungi:YDR264C	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:akr1_yeast(display_long)|uniprotkb:AKR1(gene name)|psi-mi:AKR1(display_short)|uniprotkb:YDR264C(locus name)|uniprotkb:D9954.9(orf name)|uniprotkb:YD9230B.03C(orf name)|uniprotkb:Ankyrin repeat-containing protein AKR1(gene name synonym)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711733|imex:IM-26166-6952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010550.1|sgd:S000002672|dip:DIP-1145N|mint:P39010|ensemblfungi:YDR264C(gene)|ensemblfungi:YDR264C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016409"(palmitoyltransferase activity)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0090029"(negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion)|interpro:IPR001594(Zinc finger, DHHC-type)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|ensembl:YDR264C(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.000515778553891404 ) paralog2 (YML067C)-prey (YDR264C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:INuSfspu5JYfFnlcgzVdvDeTerU559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:7DJe0Hv7Z0UrtoxPyQKGofrvkKA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53829	uniprotkb:Q07655	intact:EBI-28306|uniprotkb:D6W0Q5|ensemblfungi:YNL288W	intact:EBI-31312|uniprotkb:D6VRD1|ensemblfungi:YDL224C	psi-mi:caf40_yeast(display_long)|uniprotkb:YNL288W(locus name)|uniprotkb:N0540(orf name)|uniprotkb:40 kDa CCR4-associated factor(gene name synonym)|uniprotkb:CAF40(gene name)|psi-mi:CAF40(display_short)	psi-mi:whi4_yeast(display_long)|uniprotkb:WHI4(gene name)|psi-mi:WHI4(display_short)|uniprotkb:D0839(orf name)|uniprotkb:YDL224C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711721|imex:IM-26166-6808	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014111.1|sgd:S000005232|dip:DIP-1995N|mint:P53829|ensemblfungi:YNL288W(gene)|ensemblfungi:YNL288W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|interpro:IPR007216(Cell differentiation, Rcd1-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:4CV5|ensembl:YNL288W(identity)	refseq:NP_010057.1|sgd:S000002383|dip:DIP-4321N|mint:Q07655|ensemblfungi:YDL224C(gene)|ensemblfungi:YDL224C_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0061157"(mRNA destabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|ensembl:YDL224C(identity)	-	crc64:F3DBABE6AD3C7F3C	-	comment:"paralog1 (YNL197C) depletion signifcantly decreases (FDR-corrected p-value: 0.00895884076193098 ) paralog2 (YDL224C)-prey (YNL288W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:etuSSgFGQOcgxPDexEXUqQg6H5s559292	rogid:zPUzt32TQkMfrkafLvfsgHhZbYA559292	rigid:1g6scDhrJmRhYanKuz0r+bmQ88I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08926	uniprotkb:Q07549	intact:EBI-2044051|uniprotkb:D6W3I3|ensemblfungi:YPL186C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:uip4_yeast(display_long)|uniprotkb:YPL186C(locus name)|uniprotkb:UIP4(gene name)|psi-mi:UIP4(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711805|imex:IM-26166-6954	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000006107|refseq:NP_015138.1|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR013783(Immunoglobulin-like fold)|mint:Q08926|ensemblfungi:YPL186C(gene)|ensemblfungi:YPL186C_mRNA(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:YPL186C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 0.000290279143093134 ) paralog2 (YDL123W)-prey (YPL186C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:jZmXJYN6MQPlKDZXQnkU2tSI7vM559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:Ku+O/8jly5duy9Bp7/muHAPYI9Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34110	uniprotkb:P38929	intact:EBI-20415|uniprotkb:D6VW33|ensemblfungi:YJL154C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:vps35_yeast(display_long)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:Vacuolar protein-targeting protein 7(gene name synonym)|uniprotkb:VPT7(gene name synonym)|uniprotkb:J0580(orf name)|uniprotkb:YJL154C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711865|imex:IM-26166-6734	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012381.1|sgd:S000003690|ensemblfungi:YJL154C(gene)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1904377"(positive regulation of protein localization to cell periphery)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR042491|reactome:R-SCE-3238698|ensemblfungi:YJL154C_mRNA(transcript)|dip:DIP-1743N|mint:P34110|ensembl:YJL154C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:DE1BC57B9DFB606E	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 1.68136286185702E-05 ) paralog2 (YGL006W)-prey (YJL154C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:5KBi/lSF+BsMyg9ulP9eLCp2xCc559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:QjeTkAy1nzpdePVB37H91kV461k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25361	uniprotkb:P17898	intact:EBI-21909|uniprotkb:D6VR52|ensemblfungi:YCR043C	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:yct3_yeast(display_long)|uniprotkb:YCR43C(orf name)|uniprotkb:YCR725(orf name)|uniprotkb:YCR043C(locus name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711877|imex:IM-26166-6956	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000639|refseq:NP_009972.1|mint:P25361|ensemblfungi:YCR043C(gene)|ensemblfungi:YCR043C_mRNA(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0043332"(mating projection tip)|ensembl:YCR043C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog1 (YHR123W) depletion signifcantly decreases (FDR-corrected p-value: 0.00136794624099311 ) paralog2 (YNL130C)-prey (YCR043C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:bEMtsAa5vCsWqGOiXwBK40Pa0xQ559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:cWj1jPbMhWpTOaR+8aV2oimJJGg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26570	uniprotkb:P53278	intact:EBI-13807|uniprotkb:Q00979|ensemblfungi:YML016C|uniprotkb:D6VZF8	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:ppz1_yeast(display_long)|uniprotkb:PPZ1(gene name)|psi-mi:PPZ1(display_short)|uniprotkb:YM9571.02C(orf name)|uniprotkb:YML016C(locus name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711913|imex:IM-26166-6580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML016C(gene)|ensemblfungi:YML016C_mRNA(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011159(Phosphoprotein phosphatase PPZ)|interpro:IPR029052|interpro:IPR031675|refseq:NP_013696.1|sgd:S000004478|mint:P26570|dip:DIP-557N|ensembl:YML016C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:8B7F009521F72C15	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 2.22761193636521E-05 ) paralog2 (YGR130C)-prey (YML016C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aybUrPA5WH/mgdDx6VD8N4F/4x0559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:oaLLNb6U8QHonxBoxlQ0cvmMdck	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06144	uniprotkb:Q04651	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711901|imex:IM-26166-6812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	crc64:2F474503CAB7C195	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 0.000327562382062078 ) paralog2 (YML067C)-prey (YLR350W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:wQFzZmq9MjbrW8OMA10hYRGHqAI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40540	uniprotkb:P14359	intact:EBI-24977|uniprotkb:D6VVQ3|ensemblfungi:YIL027C	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:emc5_yeast(display_long)|uniprotkb:EMC5(gene name)|psi-mi:EMC5(display_short)|uniprotkb:KRE27(gene name synonym)|uniprotkb:Killer toxin-resistance protein 27(gene name synonym)|uniprotkb:YIL027C(locus name)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711817|imex:IM-26166-6810	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012237.1|sgd:S000001289|mint:P40540|dip:DIP-4937N|ensemblfungi:YIL027C(gene)|ensemblfungi:YIL027C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0072546"(EMC complex)|interpro:IPR018937|rcsb pdb:6WB9|rcsb pdb:7KRA|rcsb pdb:7KTX|ensembl:YIL027C(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:6DBEEEE7722203B0	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly decreases (FDR-corrected p-value: 3.10183787074986E-05 ) paralog2 (YJL151C)-prey (YIL027C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Ex5hBMZknjtCElxJOPBOPsjQZik559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:1K5OREYp9TOAKMa5YagN1YtiJJ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02887	uniprotkb:Q07549	intact:EBI-2045775|uniprotkb:D6W3R6|ensemblfungi:YPL100W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:atg21_yeast(display_long)|uniprotkb:HSV1(gene name synonym)|uniprotkb:MAI1(gene name synonym)|uniprotkb:Maturation of proaminopeptidase I protein 1(gene name synonym)|uniprotkb:Homologous with SVP1 protein 1(gene name synonym)|uniprotkb:Cytoplasm to vacuole transport protein 21(gene name synonym)|uniprotkb:YPL100W(locus name)|uniprotkb:CVT21(gene name synonym)|uniprotkb:ATG21(gene name)|psi-mi:ATG21(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711889|imex:IM-26166-6454	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015225.1|sgd:S000006021|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|reactome:R-SCE-1632852|ensemblfungi:YPL100W(gene)|ensemblfungi:YPL100W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0016050"(vesicle organization)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|ensembl:YPL100W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 7.01831680858672E-06 ) paralog2 (YDL123W)-prey (YPL100W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8Yxe4bnF8jejF11JWY90qMkxBak559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:SScaay/GGnqgqjJqxKicPnM6Kk4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:Q04651	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-27850|uniprotkb:E9PAD9|uniprotkb:D6VZA6|ensemblfungi:YML067C	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:erv41_yeast(display_long)|uniprotkb:YML067C(locus name)|uniprotkb:ERV41(gene name)|psi-mi:ERV41(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711841|imex:IM-26166-6528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	refseq:NP_013644.1|sgd:S000004532|dip:DIP-6791N|mint:Q04651|ensemblfungi:YML067C(gene)|ensemblfungi:YML067C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|rcsb pdb:3ZLC|ensembl:YML067C(identity)	-	-	-	comment:"paralog1 (YAL042W) depletion signifcantly decreases (FDR-corrected p-value: 7.96923886451255E-05 ) paralog2 (YML067C)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:IpGpvBxckHz1ExXTnTsKEHU2su8559292	rigid:pfoVxoha9VNHlozB5X3VLVToHgw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38234	uniprotkb:P19454	intact:EBI-21445|uniprotkb:D6VQ51|ensemblfungi:YBR052C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:rfs1_yeast(display_long)|uniprotkb:YBR052C(locus name)|uniprotkb:YBR0505(orf name)|uniprotkb:RFS1(gene name)|psi-mi:RFS1(display_short)|uniprotkb:RAD55 suppressor protein 1(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711853|imex:IM-26166-6670	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009608.1|sgd:S000000256|mint:P38234|dip:DIP-1761N|ensemblfungi:YBR052C(gene)|ensemblfungi:YBR052C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0045121"(membrane raft)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR029039|ensembl:YBR052C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.00105155792357095 ) paralog2 (YOR061W)-prey (YBR052C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:cb04D8hoVh5fvWEd5oT6iDTL2X0559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:51FHGJRlpsfT8/Xx++yhFn3/kME	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32495	uniprotkb:Q06205	intact:EBI-12014|ensemblfungi:YDL208W|uniprotkb:D6VRE6	intact:EBI-6956|uniprotkb:D6VZ83|ensemblfungi:YLR449W	psi-mi:nhp2_yeast(display_long)|uniprotkb:NHP2(gene name)|psi-mi:NHP2(display_short)|uniprotkb:YDL208W(locus name)|uniprotkb:D1045(orf name)|uniprotkb:H/ACA snoRNP protein NHP2(gene name synonym)|uniprotkb:High mobility group-like nuclear protein 2(gene name synonym)	psi-mi:fkbp4_yeast(display_long)|uniprotkb:FPR4(gene name)|psi-mi:FPR4(display_short)|uniprotkb:YLR449W(locus name)|uniprotkb:L9324.3(orf name)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Histone proline isomerase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711829|imex:IM-26166-6732	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YDL208W(gene)|ensemblfungi:YDL208W_mRNA(transcript)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|rcsb pdb:2LBW|rcsb pdb:2LBX|refseq:NP_010073.2|sgd:S000002367|mint:P32495|dip:DIP-5134N|ensembl:YDL208W(identity)	sgd:S000004441|refseq:NP_013554.3|dip:DIP-909N|mint:Q06205|ensemblfungi:YLR449W(gene)|ensemblfungi:YLR449W_mRNA(transcript)|go:"GO:0000412"(histone peptidyl-prolyl isomerization)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|rcsb pdb:4BF8|ensembl:YLR449W(identity)	-	crc64:008188132B494E5D	crc64:CF90C6714F04572E	comment:"paralog1 (YML074C) depletion signifcantly decreases (FDR-corrected p-value: 8.35762822471468E-06 ) paralog2 (YLR449W)-prey (YDL208W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:p5AQTuMF3Vvdu6HWSTYjdjjE1Vs559292	rogid:rDmDSGEgRbtgkLBoJTzmzxxY7B4559292	rigid:qlNXMF1m6vclv+fQM72ajDhyiyA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26570	uniprotkb:P22140	intact:EBI-13807|uniprotkb:Q00979|ensemblfungi:YML016C|uniprotkb:D6VZF8	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:ppz1_yeast(display_long)|uniprotkb:PPZ1(gene name)|psi-mi:PPZ1(display_short)|uniprotkb:YM9571.02C(orf name)|uniprotkb:YML016C(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712045|imex:IM-26166-6736	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML016C(gene)|ensemblfungi:YML016C_mRNA(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011159(Phosphoprotein phosphatase PPZ)|interpro:IPR029052|interpro:IPR031675|refseq:NP_013696.1|sgd:S000004478|mint:P26570|dip:DIP-557N|ensembl:YML016C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	crc64:8B7F009521F72C15	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 0.00017506160204483 ) paralog2 (YHR123W)-prey (YML016C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aybUrPA5WH/mgdDx6VD8N4F/4x0559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:hyU6Yzd8wuW/bAJ2N6beBQrFrSo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41807	uniprotkb:P37296	intact:EBI-20281|uniprotkb:D6W446|ensemblfungi:YPR036W	intact:EBI-18479|uniprotkb:D6VZM9|ensemblfungi:YMR054W	psi-mi:vath_yeast(display_long)|uniprotkb:YP3085.02(orf name)|uniprotkb:VMA13(gene name)|psi-mi:VMA13(display_short)|uniprotkb:CLS11(gene name synonym)|uniprotkb:YPR036W(locus name)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 54 kDa subunit(gene name synonym)	psi-mi:stv1_yeast(display_long)|uniprotkb:STV1(gene name)|psi-mi:STV1(display_short)|uniprotkb:YMR054W(locus name)|uniprotkb:YM9796.07(orf name)|uniprotkb:V-ATPase 101 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit AC115(gene name synonym)|uniprotkb:Similar to VPH1 protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 2(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712057|imex:IM-26166-6888	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015361.1|sgd:S000006240|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|rcsb pdb:1HO8|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YPR036W(gene)|ensemblfungi:YPR036W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-6640N|mint:P41807|ensembl:YPR036W(identity)	refseq:NP_013770.1|sgd:S000004658|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YMR054W(gene)|ensemblfungi:YMR054W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-4450N|mint:P37296|ensembl:YMR054W(identity)	-	crc64:54131FF9C2C87594	-	comment:"paralog1 (YOR270C) depletion signifcantly decreases (FDR-corrected p-value: 0.000439336016738945 ) paralog2 (YMR054W)-prey (YPR036W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:kEXWvOsnTk0WdgGOny+mufz4lTo559292	rogid:gqntHtP6AtAjACy5Az0QpXAfL10559292	rigid:BU9/3f50fTmTbmQ8t8HFUpN8yec	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38930	uniprotkb:P15790	intact:EBI-9578|ensemblfungi:YOR039W|uniprotkb:D6W2A6	intact:EBI-9533|ensemblfungi:YIL035C|uniprotkb:D6VVP7	psi-mi:csk2c_yeast(display_long)|uniprotkb:CKB2(gene name)|psi-mi:CKB2(display_short)|uniprotkb:OR26.32(orf name)|uniprotkb:YOR039W(locus name)	psi-mi:csk21_yeast(display_long)|uniprotkb:YIL035C(locus name)|uniprotkb:CKA1(gene name)|psi-mi:CKA1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712069|imex:IM-26166-6820	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR039W(gene)|ensemblfungi:YOR039W_mRNA(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0032545"(CURI complex)|go:"GO:0034456"(UTP-C complex)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-SCE-2514853|reactome:R-SCE-6798695|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014682.1|sgd:S000005565|mint:P38930|dip:DIP-262N|ensembl:YOR039W(identity)	refseq:NP_012229.1|sgd:S000001297|ensemblfungi:YIL035C(gene)|ensemblfungi:YIL035C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4FI1|rcsb pdb:4JQE|rcsb pdb:4JR7|rcsb pdb:4LFI|rcsb pdb:4MWH|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|mint:P15790|dip:DIP-48N|ensembl:YIL035C(identity)	-	crc64:D6060CB3D70B19A4	crc64:6A1A7F1BF47250C9	comment:"paralog1 (YOR061W) depletion signifcantly decreases (FDR-corrected p-value: 0.000578469016148938 ) paralog2 (YIL035C)-prey (YOR039W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:X+0JSYVQigL0wSbWYCkorc8jqpw559292	rogid:SNrrYvyWdzd6bAyvluPlZqs5WJw559292	rigid:uFP6J1uSEj1gtEoxmZknduNPh8Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53832	uniprotkb:P53278	intact:EBI-2055941|uniprotkb:D6W0R1|ensemblfungi:YNL283C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:wsc2_yeast(display_long)|uniprotkb:YNL283C(locus name)|uniprotkb:N0583(orf name)|uniprotkb:WSC2(gene name)|psi-mi:WSC2(display_short)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712081|imex:IM-26166-6584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014116.1|sgd:S000005227|interpro:IPR002889(Carbohydrate-binding WSC)|mint:P53832|ensemblfungi:YNL283C(gene)|ensemblfungi:YNL283C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009408"(response to heat)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0043332"(mating projection tip)|ensembl:YNL283C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000057125737388874 ) paralog2 (YGR130C)-prey (YNL283C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:5wadvTv6SxcIAb60yfnuGMfa8pY559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:3GjQYUd4WnUeCEHAZX55iSrANfI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:P19454	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712093|imex:IM-26166-6890	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:245575E65D3C2193	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.000439336016738945 ) paralog2 (YOR061W)-prey (YDR233C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:uW4wHvfjrYVd5liPKFKUm7WkQZU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40260	uniprotkb:P53278	intact:EBI-10714|ensemblfungi:YGR121C|uniprotkb:D6VUQ2	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:mep1_yeast(display_long)|uniprotkb:MEP1(gene name)|psi-mi:MEP1(display_short)|uniprotkb:YGR121C(locus name)|uniprotkb:G6331(orf name)|uniprotkb:AMT1(gene name synonym)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712105|imex:IM-26166-6462	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR121C(gene)|ensemblfungi:YGR121C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015696"|go:"GO:0019740"(nitrogen utilization)|interpro:IPR001905(Ammonium transporter)|interpro:IPR018047|interpro:IPR024041|interpro:IPR029020|sgd:S000003353|refseq:NP_011636.3|mint:P40260|dip:DIP-5530N|ensembl:YGR121C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.00442471054945962 ) paralog2 (YGR130C)-prey (YGR121C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:VnoBl5jhQD24N0SbCLv68HCwl1U559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:l7sYTI/I5TOCONZGVl21XwrHVqk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:P33760	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-13178|uniprotkb:D6W0L8|ensemblfungi:YNL329C	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:pex6_yeast(display_long)|uniprotkb:PEX6(gene name)|psi-mi:PEX6(display_short)|uniprotkb:PAS8(gene name synonym)|uniprotkb:YNL329C(locus name)|uniprotkb:N0310(orf name)|uniprotkb:Peroxin-6(gene name synonym)|uniprotkb:Peroxisome biosynthesis protein PAS8(gene name synonym)|uniprotkb:Peroxisomal assembly protein 8(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712117|imex:IM-26166-6464	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	refseq:NP_014070.1|sgd:S000005273|mint:P33760|dip:DIP-2621N|ensemblfungi:YNL329C(gene)|ensemblfungi:YNL329C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|ensembl:YNL329C(identity)	-	crc64:C86AE5ABB508EA03	crc64:736FECB57BBFF8F8	comment:"paralog1 (YKL197C) depletion signifcantly decreases (FDR-corrected p-value: 0.000220050630790862 ) paralog2 (YNL329C)-prey (YGR086C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:vonluDQS+We5JMYERfce8BzCIVk559292	rigid:KjuE+ohlej+3Rnl++BDNaRo+q6w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:P15790	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-9533|ensemblfungi:YIL035C|uniprotkb:D6VVP7	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:csk21_yeast(display_long)|uniprotkb:YIL035C(locus name)|uniprotkb:CKA1(gene name)|psi-mi:CKA1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712129|imex:IM-26166-6466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	refseq:NP_012229.1|sgd:S000001297|ensemblfungi:YIL035C(gene)|ensemblfungi:YIL035C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4FI1|rcsb pdb:4JQE|rcsb pdb:4JR7|rcsb pdb:4LFI|rcsb pdb:4MWH|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|mint:P15790|dip:DIP-48N|ensembl:YIL035C(identity)	-	crc64:8ABA71761B512242	crc64:6A1A7F1BF47250C9	comment:"paralog1 (YOR061W) depletion signifcantly decreases (FDR-corrected p-value: 2.72317607634821E-05 ) paralog2 (YIL035C)-prey (YMR120C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:SNrrYvyWdzd6bAyvluPlZqs5WJw559292	rigid:AfrL+Iav63vTroz4agotZtwpsKI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19807	uniprotkb:P19454	intact:EBI-8409|uniprotkb:D6VU67|ensemblfungi:YGL077C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:hnm1_yeast(display_long)|uniprotkb:YGL077C(locus name)|uniprotkb:HNM1(gene name)|psi-mi:HNM1(display_short)|uniprotkb:CTR(gene name synonym)|uniprotkb:CTR1(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712141|imex:IM-26166-6964	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011438.1|sgd:S000003045|mint:P19807|dip:DIP-7965N|ensemblfungi:YGL077C(gene)|ensemblfungi:YGL077C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006865"(amino acid transport)|go:"GO:0015220"(choline transmembrane transporter activity)|go:"GO:0015871"(choline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0034228"(ethanolamine transmembrane transporter activity)|go:"GO:0034229"(ethanolamine transport)|go:"GO:0071944"(cell periphery)|go:"GO:1900749"("(R)-carnitine transport")|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|interpro:IPR002293(Amino acid/polyamine transporter I)|interpro:IPR004756(Amino acid permease subfamily)|interpro:IPR004840(Amino acid permease, conserved site)|ensembl:YGL077C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 7.26719940354465E-05 ) paralog2 (YOR061W)-prey (YGL077C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:FiBH5o16YuOHdiAMTRZyChHHMos559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:r0JGvp3tIJC+ECb/OH36jCdmfSs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:P22140	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712153|imex:IM-26166-6586	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 0.000824012739121624 ) paralog2 (YHR123W)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:aIo/Z5FFJ3r0IyUgc9IORhV2Rt0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36027	uniprotkb:P15790	intact:EBI-10901|uniprotkb:P41944|ensemblfungi:YLR332W|uniprotkb:D6VYX3	intact:EBI-9533|ensemblfungi:YIL035C|uniprotkb:D6VVP7	psi-mi:mid2_yeast(display_long)|uniprotkb:SMS1(gene name synonym)|uniprotkb:L8543.19(orf name)|uniprotkb:YLR332W(locus name)|uniprotkb:MID2(gene name)|psi-mi:MID2(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:Mating pheromone-induced death protein 2(gene name synonym)|uniprotkb:Serine-rich multicopy suppressor protein 1(gene name synonym)|uniprotkb:Protein kinase A interference protein 1(gene name synonym)	psi-mi:csk21_yeast(display_long)|uniprotkb:YIL035C(locus name)|uniprotkb:CKA1(gene name)|psi-mi:CKA1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712033|imex:IM-26166-6818	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR332W(gene)|ensemblfungi:YLR332W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000767"(cell morphogenesis involved in conjugation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010447"(response to acidic pH)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043332"(mating projection tip)|interpro:IPR007567(Mid2 like cell wall stress sensor)|refseq:NP_013436.1|sgd:S000004324|mint:P36027|dip:DIP-4676N|ensembl:YLR332W(identity)	refseq:NP_012229.1|sgd:S000001297|ensemblfungi:YIL035C(gene)|ensemblfungi:YIL035C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4FI1|rcsb pdb:4JQE|rcsb pdb:4JR7|rcsb pdb:4LFI|rcsb pdb:4MWH|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|mint:P15790|dip:DIP-48N|ensembl:YIL035C(identity)	-	-	crc64:6A1A7F1BF47250C9	comment:"paralog1 (YOR061W) depletion signifcantly decreases (FDR-corrected p-value: 0.000782333022871709 ) paralog2 (YIL035C)-prey (YLR332W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:o4cMDBqIZorgGZ6iEACUFcfgO7I559292	rogid:SNrrYvyWdzd6bAyvluPlZqs5WJw559292	rigid:Km8BzVwSvY2uhlkidETBfRyB8Xo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02046	uniprotkb:P53278	intact:EBI-2045181|uniprotkb:D6VXE0|ensemblfungi:YKR080W	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:mtd1_yeast(display_long)|uniprotkb:YKR400(orf name)|uniprotkb:YKR080W(locus name)|uniprotkb:MTD1(gene name)|psi-mi:MTD1(display_short)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712021|imex:IM-26166-6816	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001788|refseq:NP_013006.3|dip:DIP-730N|mint:Q02046|ensemblfungi:YKR080W(gene)|ensemblfungi:YKR080W_mRNA(transcript)|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009396"(folic acid-containing compound biosynthetic process)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020630|interpro:IPR020631|interpro:IPR035812|interpro:IPR036291|rcsb pdb:1EDZ|rcsb pdb:1EE9|ensembl:YKR080W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000419801812204937 ) paralog2 (YGR130C)-prey (YKR080W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:xAOzw/g5xSBjpNJuVTxsxTeWAEI559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:YWQq0PbMPn4vEKtjBZgwoUaLM9Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23542	uniprotkb:P19454	intact:EBI-2002|uniprotkb:D6VY29|ensemblfungi:YLR027C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:aatc_yeast(display_long)|uniprotkb:AAT2(gene name)|psi-mi:AAT2(display_short)|uniprotkb:YLR027C(locus name)|uniprotkb:ASP5(gene name synonym)|uniprotkb:L1746(orf name)|uniprotkb:Transaminase A(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712009|imex:IM-26166-6530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013127.2|sgd:S000004017|dip:DIP-2897N|mint:P23542|go:"GO:0019266"(asparagine biosynthetic process from oxaloacetate)|go:"GO:0030170"(pyridoxal phosphate binding)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1YAA|reactome:R-SCE-70263|reactome:R-SCE-8963693|ensemblfungi:YLR027C(gene)|ensemblfungi:YLR027C_mRNA(transcript)|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006536"(glutamate metabolic process)|ensembl:YLR027C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:D25F40F6C6DD2B33	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 8.20365847976871E-05 ) paralog2 (YOR061W)-prey (YLR027C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:eNypS723YWwMMuWVVoTnidvQuaA559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:PC3ID6iEn9vqR8kSoe1zDGvunMk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11076	uniprotkb:P17898	intact:EBI-2816|uniprotkb:D6VRG1|ensemblfungi:YDL192W	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:arf1_yeast(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)|uniprotkb:D1244(orf name)|uniprotkb:YDL192W(locus name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711985|imex:IM-26166-6962	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010089.1|sgd:S000002351|dip:DIP-2213N|mint:P11076|ensemblfungi:YDL192W(gene)|ensemblfungi:YDL192W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:2K5U|rcsb pdb:2KSQ|rcsb pdb:3TJZ|rcsb pdb:4Q66|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL192W(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	crc64:796859026AC63CC0	-	comment:"paralog1 (YHR123W) depletion signifcantly decreases (FDR-corrected p-value: 0.00820427554680207 ) paralog2 (YNL130C)-prey (YDL192W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IX/zwfWagjieSKB1ShJ9P0kq1ZE559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:uohPYwqNs66ycF79Mtwby8xEJRM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P33760	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-13178|uniprotkb:D6W0L8|ensemblfungi:YNL329C	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:pex6_yeast(display_long)|uniprotkb:PEX6(gene name)|psi-mi:PEX6(display_short)|uniprotkb:PAS8(gene name synonym)|uniprotkb:YNL329C(locus name)|uniprotkb:N0310(orf name)|uniprotkb:Peroxin-6(gene name synonym)|uniprotkb:Peroxisome biosynthesis protein PAS8(gene name synonym)|uniprotkb:Peroxisomal assembly protein 8(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711973|imex:IM-26166-6458	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_014070.1|sgd:S000005273|mint:P33760|dip:DIP-2621N|ensemblfungi:YNL329C(gene)|ensemblfungi:YNL329C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|ensembl:YNL329C(identity)	-	crc64:55CAE5DACDC6A00B	crc64:736FECB57BBFF8F8	comment:"paralog1 (YKL197C) depletion signifcantly decreases (FDR-corrected p-value: 0.000117670522198242 ) paralog2 (YNL329C)-prey (YHR183W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:vonluDQS+We5JMYERfce8BzCIVk559292	rigid:eBqrgL3FPhHNMbsrEwyAW1LC8+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38234	uniprotkb:P53278	intact:EBI-21445|uniprotkb:D6VQ51|ensemblfungi:YBR052C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:rfs1_yeast(display_long)|uniprotkb:YBR052C(locus name)|uniprotkb:YBR0505(orf name)|uniprotkb:RFS1(gene name)|psi-mi:RFS1(display_short)|uniprotkb:RAD55 suppressor protein 1(gene name synonym)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711961|imex:IM-26166-6582	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009608.1|sgd:S000000256|mint:P38234|dip:DIP-1761N|ensemblfungi:YBR052C(gene)|ensemblfungi:YBR052C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0045121"(membrane raft)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR029039|ensembl:YBR052C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 7.15530681914853E-07 ) paralog2 (YGR130C)-prey (YBR052C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:cb04D8hoVh5fvWEd5oT6iDTL2X0559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:zcH9P2SavBd1X0XDeR04EP+Xe7E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06102	uniprotkb:Q07655	intact:EBI-12165|uniprotkb:D6VVP4|uniprotkb:Q6B233|ensemblfungi:YIL038C	intact:EBI-31312|uniprotkb:D6VRD1|ensemblfungi:YDL224C	psi-mi:not3_yeast(display_long)|uniprotkb:NOT3(gene name)|psi-mi:NOT3(display_short)|uniprotkb:YIL038C(locus name)	psi-mi:whi4_yeast(display_long)|uniprotkb:WHI4(gene name)|psi-mi:WHI4(display_short)|uniprotkb:D0839(orf name)|uniprotkb:YDL224C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711949|imex:IM-26166-6960	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR007207(Not CCR4-Not complex component, N-terminal)|interpro:IPR007282(NOT2/NOT3/NOT5)|interpro:IPR012270(CCR4-NOT complex, subunits 3 and 5)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|interpro:IPR038635|interpro:IPR040168|ensemblfungi:YIL038C(gene)|ensemblfungi:YIL038C_mRNA(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030015"(CCR4-NOT core complex)|refseq:NP_012226.3|sgd:S000001300|dip:DIP-2256N|mint:P06102|ensembl:YIL038C(identity)	refseq:NP_010057.1|sgd:S000002383|dip:DIP-4321N|mint:Q07655|ensemblfungi:YDL224C(gene)|ensemblfungi:YDL224C_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0061157"(mRNA destabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|ensembl:YDL224C(identity)	-	crc64:69B76694FCC6846F	-	comment:"paralog1 (YNL197C) depletion signifcantly decreases (FDR-corrected p-value: 0.00117855002588576 ) paralog2 (YDL224C)-prey (YIL038C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EfakZPDNU3FZeI5+rnu7YV1UsCg559292	rogid:zPUzt32TQkMfrkafLvfsgHhZbYA559292	rigid:sOAVzxSJ8HBHbqpm1Qga8+3UB2s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32582	uniprotkb:P53278	intact:EBI-4167|uniprotkb:Q05177|uniprotkb:Q27JK1|uniprotkb:Q27JK4|uniprotkb:D6VUT5|ensemblfungi:YGR155W	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:cbs_yeast(display_long)|uniprotkb:STR4(gene name synonym)|uniprotkb:CYS4(gene name)|psi-mi:CYS4(display_short)|uniprotkb:YGR155W(locus name)|uniprotkb:G6667(orf name)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym)|uniprotkb:Sulfur transfer protein 4(gene name synonym)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711937|imex:IM-26166-6456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003387|refseq:NP_011671.3|dip:DIP-1282N|mint:P32582|ensemblfungi:YGR155W(gene)|ensemblfungi:YGR155W_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004122"(cystathionine beta-synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019346"(transsulfuration)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|rcsb pdb:6C2H|rcsb pdb:6C2Q|rcsb pdb:6C2Z|rcsb pdb:6C4P|reactome:R-SCE-1614603|ensembl:YGR155W(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:D0C7059B20FD0746	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000137437066002359 ) paralog2 (YGR130C)-prey (YGR155W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:bHamyLQqLgqrPxKcyNSzJJR5n+M559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:wQVxCJgd+9mamGPsc2apwi0Ocb8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36143	uniprotkb:P27472	intact:EBI-2064417|uniprotkb:D6VXB9|ensemblfungi:YKR058W	intact:EBI-8036|uniprotkb:D6VYQ5|ensemblfungi:YLR258W	psi-mi:glg1_yeast(display_long)|uniprotkb:GLG1(gene name)|psi-mi:GLG1(display_short)|uniprotkb:Glycogenin glucosyltransferase 1(gene name synonym)|uniprotkb:Glycogen synthesis initiator protein 1(gene name synonym)|uniprotkb:YKR058W(locus name)	psi-mi:gys2_yeast(display_long)|uniprotkb:L8479.8(orf name)|uniprotkb:YLR258W(locus name)|uniprotkb:GSY2(gene name)|psi-mi:GSY2(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711925|imex:IM-26166-6814	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012984.2|sgd:S000001766|interpro:IPR002495(Glycosyl transferase, family 8)|interpro:IPR029044|mint:P36143|ensemblfungi:YKR058W(gene)|ensemblfungi:YKR058W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008466"(glycogenin glucosyltransferase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0102751"("UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity")|reactome:R-SCE-3322077|reactome:R-SCE-70221|ensembl:YKR058W(identity)	refseq:NP_013359.1|sgd:S000004248|mint:P27472|dip:DIP-1255N|ensemblfungi:YLR258W(gene)|ensemblfungi:YLR258W_mRNA(transcript)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR008631(Glycogen synthase)|rcsb pdb:3NAZ|rcsb pdb:3NB0|rcsb pdb:3NCH|rcsb pdb:3O3C|rcsb pdb:3RSZ|rcsb pdb:3RT1|rcsb pdb:4KQ2|rcsb pdb:4KQM|rcsb pdb:5SUK|rcsb pdb:5SUL|rcsb pdb:5UW0|rcsb pdb:5UW1|rcsb pdb:5UW4|rcsb pdb:5UX7|rcsb pdb:5VNC|rcsb pdb:6U77|reactome:R-SCE-3322077|ensembl:YLR258W(identity)	-	-	crc64:4670D8328CEDB0D2	comment:"paralog1 (YFR015C) depletion signifcantly decreases (FDR-corrected p-value: 0.00047412284173083 ) paralog2 (YLR258W)-prey (YKR058W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:XK7v4e4eSk6bi7JtQcL1HOr9M78559292	rogid:K8l8dzJOtoIWZHpDN8Bq31o6ahA559292	rigid:eL6QGMijOmiVY5OgHYPFtADSUXE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P15790	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-9533|ensemblfungi:YIL035C|uniprotkb:D6VVP7	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:csk21_yeast(display_long)|uniprotkb:YIL035C(locus name)|uniprotkb:CKA1(gene name)|psi-mi:CKA1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16711997|imex:IM-26166-6460	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_012229.1|sgd:S000001297|ensemblfungi:YIL035C(gene)|ensemblfungi:YIL035C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4FI1|rcsb pdb:4JQE|rcsb pdb:4JR7|rcsb pdb:4LFI|rcsb pdb:4MWH|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|mint:P15790|dip:DIP-48N|ensembl:YIL035C(identity)	-	crc64:55CAE5DACDC6A00B	crc64:6A1A7F1BF47250C9	comment:"paralog1 (YOR061W) depletion signifcantly decreases (FDR-corrected p-value: 4.40873767848409E-05 ) paralog2 (YIL035C)-prey (YHR183W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:SNrrYvyWdzd6bAyvluPlZqs5WJw559292	rigid:GUVLCBuH5IfPc/LqtxHCrEs4rrI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02046	uniprotkb:Q07549	intact:EBI-2045181|uniprotkb:D6VXE0|ensemblfungi:YKR080W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:mtd1_yeast(display_long)|uniprotkb:YKR400(orf name)|uniprotkb:YKR080W(locus name)|uniprotkb:MTD1(gene name)|psi-mi:MTD1(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712176|imex:IM-26166-6738	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001788|refseq:NP_013006.3|dip:DIP-730N|mint:Q02046|ensemblfungi:YKR080W(gene)|ensemblfungi:YKR080W_mRNA(transcript)|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009396"(folic acid-containing compound biosynthetic process)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020630|interpro:IPR020631|interpro:IPR035812|interpro:IPR036291|rcsb pdb:1EDZ|rcsb pdb:1EE9|ensembl:YKR080W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 0.00166601102038721 ) paralog2 (YDL123W)-prey (YKR080W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:xAOzw/g5xSBjpNJuVTxsxTeWAEI559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:hjkhhl9VKtFRO9b0PsHGU9sKpCM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38694	uniprotkb:P22140	intact:EBI-24511|uniprotkb:D3DKY6|ensemblfungi:YHR039C	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:msc7_yeast(display_long)|uniprotkb:MSC7(gene name)|psi-mi:MSC7(display_short)|uniprotkb:Meiotic sister-chromatid recombination protein 7(gene name synonym)|uniprotkb:YHR039C(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712188|imex:IM-26166-6966	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011904.1|sgd:S000001081|dip:DIP-1878N|mint:P38694|ensemblfungi:YHR039C(gene)|ensemblfungi:YHR039C_mRNA(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007131"(reciprocal meiotic recombination)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|ensembl:YHR039C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 0.000111511505770279 ) paralog2 (YHR123W)-prey (YHR039C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:p2xtb6/xYI/jfPNtO6JRZs+5t6I559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:AhsmE+6trk1yqGyemHH4BTpCw/g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54837	uniprotkb:P22140	intact:EBI-6642|uniprotkb:D6VZG2|ensemblfungi:YML012W	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:tmeda_yeast(display_long)|uniprotkb:ERV25(gene name)|psi-mi:ERV25(display_short)|uniprotkb:YM9571.06(orf name)|uniprotkb:YML012W(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712212|imex:IM-26166-6822	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013701.1|sgd:S000004473|mint:P54837|dip:DIP-2134N|ensemblfungi:YML012W(gene)|ensemblfungi:YML012W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YML012W(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 4.50276755440785E-05 ) paralog2 (YHR123W)-prey (YML012W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:H4bQL5k77CB85Hz+8rjJcSAG/98559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:HL6ePycsGQkUk8XrOwZh1uzlI00	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53390	uniprotkb:P53278	intact:EBI-10729|uniprotkb:Q6B2F5|ensemblfungi:YPR138C|uniprotkb:D6W4D6	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:mep3_yeast(display_long)|uniprotkb:MEP3(gene name)|psi-mi:MEP3(display_short)|uniprotkb:YPR138C(locus name)|uniprotkb:P9659.14(orf name)|uniprotkb:AMT3(gene name synonym)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712224|imex:IM-26166-6824	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015464.1|sgd:S000006342|ensemblfungi:YPR138C(gene)|ensemblfungi:YPR138C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015696"|go:"GO:0019740"(nitrogen utilization)|interpro:IPR001905(Ammonium transporter)|interpro:IPR018047|interpro:IPR024041|interpro:IPR029020|mint:P53390|dip:DIP-4909N|ensembl:YPR138C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	crc64:2309338F36D96258	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.00030385433269487 ) paralog2 (YGR130C)-prey (YPR138C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:UajvXf1E8FU957+oquLoPeSfTjk559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:2NSl8bVHruH653MdxX58AvJ60bo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53874	uniprotkb:Q06205	intact:EBI-19873|uniprotkb:D6W101|ensemblfungi:YNL186W	intact:EBI-6956|uniprotkb:D6VZ83|ensemblfungi:YLR449W	psi-mi:ubp10_yeast(display_long)|uniprotkb:UBP10(gene name)|psi-mi:UBP10(display_short)|uniprotkb:YNL186W(locus name)|uniprotkb:N1619(orf name)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Disrupter of telomere silencing protein 4(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:DOT4(gene name synonym)	psi-mi:fkbp4_yeast(display_long)|uniprotkb:FPR4(gene name)|psi-mi:FPR4(display_short)|uniprotkb:YLR449W(locus name)|uniprotkb:L9324.3(orf name)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Histone proline isomerase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712236|imex:IM-26166-6672	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014213.2|sgd:S000005130|ensemblfungi:YNL186W(gene)|ensemblfungi:YNL186W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006348"|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0043596"(nuclear replication fork)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:6RR0|dip:DIP-6664N|mint:P53874|ensembl:YNL186W(identity)	sgd:S000004441|refseq:NP_013554.3|dip:DIP-909N|mint:Q06205|ensemblfungi:YLR449W(gene)|ensemblfungi:YLR449W_mRNA(transcript)|go:"GO:0000412"(histone peptidyl-prolyl isomerization)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|rcsb pdb:4BF8|ensembl:YLR449W(identity)	-	-	crc64:CF90C6714F04572E	comment:"paralog1 (YML074C) depletion signifcantly decreases (FDR-corrected p-value: 0.000163185768762412 ) paralog2 (YLR449W)-prey (YNL186W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Z1rRAI9RLgHeGd7QwLbrf51v5LY559292	rogid:rDmDSGEgRbtgkLBoJTzmzxxY7B4559292	rigid:zfnlV/M8wQhkd3pjeveKr8N6aJE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34909	uniprotkb:Q07655	intact:EBI-12174|uniprotkb:D3DLX3|ensemblfungi:YER068W	intact:EBI-31312|uniprotkb:D6VRD1|ensemblfungi:YDL224C	psi-mi:not4_yeast(display_long)|uniprotkb:MOT2(gene name)|psi-mi:MOT2(display_short)|uniprotkb:CCL1(gene name synonym)|uniprotkb:NOT4(gene name synonym)|uniprotkb:SIG1(gene name synonym)|uniprotkb:SSF1(gene name synonym)|uniprotkb:Modulator of transcription 2(gene name synonym)|uniprotkb:YER068W(locus name)	psi-mi:whi4_yeast(display_long)|uniprotkb:WHI4(gene name)|psi-mi:WHI4(display_short)|uniprotkb:D0839(orf name)|uniprotkb:YDL224C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712200|imex:IM-26166-6968	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YER068W(gene)|ensemblfungi:YER068W_mRNA(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034261|interpro:IPR035979|interpro:IPR039515|interpro:IPR039780|rcsb pdb:5AIE|rcsb pdb:5AJD|refseq:NP_010991.3|sgd:S000000870|dip:DIP-2255N|mint:P34909|ensembl:YER068W(identity)	refseq:NP_010057.1|sgd:S000002383|dip:DIP-4321N|mint:Q07655|ensemblfungi:YDL224C(gene)|ensemblfungi:YDL224C_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0061157"(mRNA destabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|ensembl:YDL224C(identity)	-	crc64:8847084BD9BF48B7	-	comment:"paralog1 (YNL197C) depletion signifcantly decreases (FDR-corrected p-value: 0.00211199650623819 ) paralog2 (YDL224C)-prey (YER068W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:TLt8Wu8+ygYk/0dtfXHhnCITKqc559292	rogid:zPUzt32TQkMfrkafLvfsgHhZbYA559292	rigid:nsyHFC437jkGbqXo+81a7v69LcY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38247	uniprotkb:Q07549	intact:EBI-21507|uniprotkb:D6VQ76|ensemblfungi:YBR077C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:slm4_yeast(display_long)|uniprotkb:YBR077C(locus name)|uniprotkb:YBR0723(orf name)|uniprotkb:GSE complex subunit 1(gene name synonym)|uniprotkb:EGO complex subunit 3(gene name synonym)|uniprotkb:SLM4(gene name)|psi-mi:SLM4(display_short)|uniprotkb:EGO3(gene name synonym)|uniprotkb:GSE1(gene name synonym)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712260|imex:IM-26166-6740	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009633.3|sgd:S000000281|mint:P38247|dip:DIP-1763N|ensemblfungi:YBR077C(gene)|ensemblfungi:YBR077C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0071986"(Ragulator complex)|interpro:IPR020233|rcsb pdb:3LGO|rcsb pdb:4FTX|rcsb pdb:4FUW|rcsb pdb:4XPM|rcsb pdb:6JWP|ensembl:YBR077C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	crc64:D64ABDE1CDF265FD	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 0.000277106457983429 ) paralog2 (YDL123W)-prey (YBR077C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:BCEWjA3PQvwm3n08QwY0D//TpbA559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:1uWIZw5tqJEQXY4IjxHffGh2VYc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32610	uniprotkb:P38929	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712248|imex:IM-26166-6588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610|ensembl:YEL051W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:FDE93E1FAF0AEC5B	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 6.89655599416751E-05 ) paralog2 (YGL006W)-prey (YEL051W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:es2wnVOfMwAjunosAyK4SqF5FUI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53290	uniprotkb:P38929	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712284|imex:IM-26166-6742	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:0A0D16C81F73184D	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.000459009430756885 ) paralog2 (YGL006W)-prey (YGR163W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:rdI8Q5dQJpMcRu+OJtI9kRaoFtQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P38929	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712296|imex:IM-26166-6674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:55CAE5DACDC6A00B	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.00103543109716581 ) paralog2 (YGL006W)-prey (YHR183W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:AP+mcZKnIFs8RdnCVfxXHxjjHtk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36027	uniprotkb:P19454	intact:EBI-10901|uniprotkb:P41944|ensemblfungi:YLR332W|uniprotkb:D6VYX3	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:mid2_yeast(display_long)|uniprotkb:SMS1(gene name synonym)|uniprotkb:L8543.19(orf name)|uniprotkb:YLR332W(locus name)|uniprotkb:MID2(gene name)|psi-mi:MID2(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:Mating pheromone-induced death protein 2(gene name synonym)|uniprotkb:Serine-rich multicopy suppressor protein 1(gene name synonym)|uniprotkb:Protein kinase A interference protein 1(gene name synonym)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712308|imex:IM-26166-6826	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR332W(gene)|ensemblfungi:YLR332W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000767"(cell morphogenesis involved in conjugation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010447"(response to acidic pH)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043332"(mating projection tip)|interpro:IPR007567(Mid2 like cell wall stress sensor)|refseq:NP_013436.1|sgd:S000004324|mint:P36027|dip:DIP-4676N|ensembl:YLR332W(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 1.27436988874701E-05 ) paralog2 (YOR061W)-prey (YLR332W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:o4cMDBqIZorgGZ6iEACUFcfgO7I559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:QiaGTNEwFmzVYBdAq4ZNROc5MUI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41807	uniprotkb:P38929	intact:EBI-20281|uniprotkb:D6W446|ensemblfungi:YPR036W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:vath_yeast(display_long)|uniprotkb:YP3085.02(orf name)|uniprotkb:VMA13(gene name)|psi-mi:VMA13(display_short)|uniprotkb:CLS11(gene name synonym)|uniprotkb:YPR036W(locus name)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 54 kDa subunit(gene name synonym)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712320|imex:IM-26166-6970	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015361.1|sgd:S000006240|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|rcsb pdb:1HO8|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YPR036W(gene)|ensemblfungi:YPR036W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-6640N|mint:P41807|ensembl:YPR036W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:54131FF9C2C87594	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.000161693689408398 ) paralog2 (YGL006W)-prey (YPR036W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:kEXWvOsnTk0WdgGOny+mufz4lTo559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:p2UAxGjvX0yNKb70/0qLTSwxa9Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38328	uniprotkb:Q12449	intact:EBI-2777|uniprotkb:D6VQN0|ensemblfungi:YBR234C	intact:EBI-37072|uniprotkb:Q02565|uniprotkb:Q7LIE3|uniprotkb:D6VSJ8|ensemblfungi:YDR214W	psi-mi:arpc1_yeast(display_long)|uniprotkb:ARC40(gene name)|psi-mi:ARC40(display_short)|uniprotkb:YBR234C(locus name)|uniprotkb:YBR1532(orf name)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)	psi-mi:aha1_yeast(display_long)|uniprotkb:AHA1(gene name)|psi-mi:AHA1(display_short)|uniprotkb:YDR214W(locus name)|uniprotkb:YD8142.16(orf name)|uniprotkb:YD8142B.06(orf name)|uniprotkb:Activator of Hsp90 ATPase protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712332|imex:IM-26166-6892	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000438|refseq:NP_009793.1|dip:DIP-2219N|mint:P38328|ensemblfungi:YBR234C(gene)|ensemblfungi:YBR234C_mRNA(transcript)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR036322|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828|ensembl:YBR234C(identity)	sgd:S000002622|refseq:NP_010500.3|mint:Q12449|dip:DIP-1831N|ensemblfungi:YDR214W(gene)|ensemblfungi:YDR214W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|rcsb pdb:1USU|rcsb pdb:1USV|rcsb pdb:6XLB|rcsb pdb:6XLD|rcsb pdb:6XLE|rcsb pdb:6XLF|rcsb pdb:6XLG|rcsb pdb:6XLH|ensembl:YDR214W(identity)	-	crc64:D75C6BB8EC35EEDF	crc64:06DF6B40EB5050BE	comment:"paralog1 (YNL281W) depletion signifcantly decreases (FDR-corrected p-value: 0.000868026250002335 ) paralog2 (YDR214W)-prey (YBR234C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:SDFaDFaJRhwZT02o7w/XmITMZgI559292	rogid:jCVFPwj0+auPVB/BJ/OwlMSBWUM559292	rigid:yCCgz4bFNwYOK9Uy22MJSkX2xlE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43639	uniprotkb:P19454	intact:EBI-9563|uniprotkb:Q9URG5|ensemblfungi:YGL019W|uniprotkb:D6VUB8	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:csk2b_yeast(display_long)|uniprotkb:CKB1(gene name)|psi-mi:CKB1(display_short)|uniprotkb:YGL019W(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712344|imex:IM-26166-6470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGL019W(gene)|ensemblfungi:YGL019W_mRNA(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0034456"(UTP-C complex)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR035991|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|refseq:NP_011496.3|sgd:S000002987|mint:P43639|dip:DIP-282N|ensembl:YGL019W(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:9ACA8D285E6990AF	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 3.28644304016964E-07 ) paralog2 (YOR061W)-prey (YGL019W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:etfQ7p1F805HcUhV/Uiv9TPtejU559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:LTXHUvkEIYJNbSvfGCKF2WAFdEU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00582	uniprotkb:Q07549	intact:EBI-7954|uniprotkb:D6W0G3|ensemblfungi:YML121W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:gtr1_yeast(display_long)|uniprotkb:YM7056.05(orf name)|uniprotkb:YML121W(locus name)|uniprotkb:GTR1(gene name)|psi-mi:GTR1(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712356|imex:IM-26166-6676	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013585.1|sgd:S000004590|mint:Q00582|dip:DIP-1358N|ensemblfungi:YML121W(gene)|ensemblfungi:YML121W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006348"|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YML121W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	crc64:B79CE7FE7AD2FDBE	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 0.000754338622068833 ) paralog2 (YDL123W)-prey (YML121W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:5LJU5zMF4NDDY9Bmndu0Q+JIm54559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:R4Z4NEWbhH+g8pyMewbMW/uITps	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40540	uniprotkb:P22140	intact:EBI-24977|uniprotkb:D6VVQ3|ensemblfungi:YIL027C	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:emc5_yeast(display_long)|uniprotkb:EMC5(gene name)|psi-mi:EMC5(display_short)|uniprotkb:KRE27(gene name synonym)|uniprotkb:Killer toxin-resistance protein 27(gene name synonym)|uniprotkb:YIL027C(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712368|imex:IM-26166-6590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012237.1|sgd:S000001289|mint:P40540|dip:DIP-4937N|ensemblfungi:YIL027C(gene)|ensemblfungi:YIL027C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0072546"(EMC complex)|interpro:IPR018937|rcsb pdb:6WB9|rcsb pdb:7KRA|rcsb pdb:7KTX|ensembl:YIL027C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	crc64:6DBEEEE7722203B0	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 0.00141181463992691 ) paralog2 (YHR123W)-prey (YIL027C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Ex5hBMZknjtCElxJOPBOPsjQZik559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:IwwPEQRhrJgQUKcTC1IHmVeCg94	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:P33760	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-13178|uniprotkb:D6W0L8|ensemblfungi:YNL329C	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:pex6_yeast(display_long)|uniprotkb:PEX6(gene name)|psi-mi:PEX6(display_short)|uniprotkb:PAS8(gene name synonym)|uniprotkb:YNL329C(locus name)|uniprotkb:N0310(orf name)|uniprotkb:Peroxin-6(gene name synonym)|uniprotkb:Peroxisome biosynthesis protein PAS8(gene name synonym)|uniprotkb:Peroxisomal assembly protein 8(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712380|imex:IM-26166-6592	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	refseq:NP_014070.1|sgd:S000005273|mint:P33760|dip:DIP-2621N|ensemblfungi:YNL329C(gene)|ensemblfungi:YNL329C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016562"(protein import into peroxisome matrix, receptor recycling)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0043335"(protein unfolding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|ensembl:YNL329C(identity)	-	crc64:8ABA71761B512242	crc64:736FECB57BBFF8F8	comment:"paralog1 (YKL197C) depletion signifcantly decreases (FDR-corrected p-value: 0.00601439198831215 ) paralog2 (YNL329C)-prey (YMR120C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:vonluDQS+We5JMYERfce8BzCIVk559292	rigid:zDpXt+HO57Gw6cd8jVbnXByZxrc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32386	uniprotkb:P38929	intact:EBI-21511|uniprotkb:Q07882|uniprotkb:D6VXW0|ensemblfungi:YLL048C	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:ybt1_yeast(display_long)|uniprotkb:YBT1(gene name)|psi-mi:YBT1(display_short)|uniprotkb:BAT1(gene name synonym)|uniprotkb:YLL048C(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712392|imex:IM-26166-6472	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013052.1|sgd:S000003971|mint:P32386|dip:DIP-6474N|ensemblfungi:YLL048C(gene)|ensemblfungi:YLL048C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033285"(ATPase-coupled monocarboxylic acid transmembrane transporter activity)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|reactome:R-SCE-2142850|reactome:R-SCE-382556|ensembl:YLL048C(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:E71D3D57A3013C38	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.000100416588076014 ) paralog2 (YGL006W)-prey (YLL048C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:b0Cz526nha/7DJPmG1uADmBnNPA559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:Kr9MZ11FeLg2XwRWevUdTBARBaY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06328	uniprotkb:P38929	intact:EBI-37173|uniprotkb:D6VSY2|ensemblfungi:YDR352W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:ypq2_yeast(display_long)|uniprotkb:YPQ2(gene name)|psi-mi:YPQ2(display_short)|uniprotkb:PQ-loop repeat-containing protein 2(gene name synonym)|uniprotkb:YDR352W(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712404|imex:IM-26166-6744	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010639.1|sgd:S000002760|interpro:IPR006603(Cystinosin/ERS1p repeat)|mint:Q06328|ensemblfungi:YDR352W(gene)|ensemblfungi:YDR352W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0015174"(basic amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034488"(basic amino acid transmembrane export from vacuole)|go:"GO:0071627"(integral component of fungal-type vacuolar membrane)|reactome:R-SCE-5223345|ensembl:YDR352W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.000253835712122148 ) paralog2 (YGL006W)-prey (YDR352W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:tLoew2CtLfiBlJVBfq1TPSEozJk559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:dKVViAHSxnZwsyl6WySF9RcVETQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P22140	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712416|imex:IM-26166-6532	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976|ensembl:YHR007C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 0.00366057691958783 ) paralog2 (YHR123W)-prey (YHR007C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:raUgWBhlheiAmf6PBlJFqXnTJqM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:P22140	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712428|imex:IM-26166-6474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	crc64:245575E65D3C2193	-	comment:"paralog1 (YNL130C) depletion signifcantly decreases (FDR-corrected p-value: 3.57668159198913E-05 ) paralog2 (YHR123W)-prey (YDR233C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:ogj2KItmTOAxnAdp3AUCpiBjzpI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03941	uniprotkb:Q07549	intact:EBI-22174|uniprotkb:D6VSH9|ensemblfungi:YDR196C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:cab5_yeast(display_long)|uniprotkb:YDR196C(locus name)|uniprotkb:YD9346.07C(orf name)|uniprotkb:CAB5(gene name)|psi-mi:CAB5(display_short)|uniprotkb:Dephosphocoenzyme A kinase(gene name synonym)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712440|imex:IM-26166-6594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010482.3|sgd:S000002604|dip:DIP-5705N|ensemblfungi:YDR196C(gene)|ensemblfungi:YDR196C_mRNA(transcript)|go:"GO:0004140"(dephospho-CoA kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR001977(Dephospho-CoA kinase)|interpro:IPR027417|ensembl:YDR196C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 0.00162718525641868 ) paralog2 (YDL123W)-prey (YDR196C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hTDuUy/nwajAM4hXzk5Mr0w+sw0559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:pcz9drTZd7q7Ul8UyjtA4xnsAYE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17064	uniprotkb:P53278	intact:EBI-2047850|uniprotkb:D3DLV9|ensemblfungi:YER056C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:fcy2_yeast(display_long)|uniprotkb:Cytosine/purine transport protein FCY2(gene name synonym)|uniprotkb:Fluorocytosine resistance protein 2(gene name synonym)|uniprotkb:YER056C(locus name)|uniprotkb:FCY2(gene name)|psi-mi:FCY2(display_short)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712452|imex:IM-26166-6828	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010976.1|sgd:S000000858|dip:DIP-7593N|mint:P17064|ensemblfungi:YER056C(gene)|ensemblfungi:YER056C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015212"(cytidine transmembrane transporter activity)|go:"GO:0015856"(cytosine transport)|go:"GO:0015861"(cytidine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|go:"GO:0072530"(purine-containing compound transmembrane transport)|interpro:IPR001248(Permease for cytosine/purines, uracil, thiamine, allantoin)|interpro:IPR012681(Nucleobase cation symporter-1, NCS1)|interpro:IPR026030|ensembl:YER056C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000176158758704664 ) paralog2 (YGR130C)-prey (YER056C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:797s9w2xSSBhW0uTLcFEESToqgg559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:fI/+sSZpWp0IRGYT79y8U1k1AJ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:Q07549	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712464|imex:IM-26166-6534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly decreases (FDR-corrected p-value: 1.41637873884944E-05 ) paralog2 (YDL123W)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:SRR3mtRewMc77UhOgsEZDGtxGB4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P19454	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712476|imex:IM-26166-6678	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:55CAE5DACDC6A00B	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.000417050390519483 ) paralog2 (YOR061W)-prey (YHR183W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:Jb7bxx9RGnt+mmJbpKDiDkTSEIs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32610	uniprotkb:P32798	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	intact:EBI-5006|uniprotkb:D6W314|ensemblfungi:YOR316C	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:cot1_yeast(display_long)|uniprotkb:COT1(gene name)|psi-mi:COT1(display_short)|uniprotkb:O6131(orf name)|uniprotkb:YOR316C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712488|imex:IM-26166-6596	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610|ensembl:YEL051W(identity)	sgd:S000005843|refseq:NP_014961.3|dip:DIP-7554N|mint:P32798|ensemblfungi:YOR316C(gene)|ensemblfungi:YOR316C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006824"(cobalt ion transport)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0015087"(cobalt ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-SCE-425410|ensembl:YOR316C(identity)	-	crc64:FDE93E1FAF0AEC5B	-	comment:"paralog1 (YMR243C) depletion signifcantly decreases (FDR-corrected p-value: 0.00375224705682287 ) paralog2 (YOR316C)-prey (YEL051W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rogid:HEIg6lhS698E9H3BJeESYAipNwA559292	rigid:Hm5KPZTxPEjDVZFU92GoUQI/kQ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3E756	uniprotkb:P53278	intact:EBI-2044812|uniprotkb:D6VPX0|ensemblfungi:YBL029C-A	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:yb029_yeast(display_long)|uniprotkb:YBL029C-A(locus name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712500|imex:IM-26166-6830	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000007591|refseq:NP_076874.1|mint:Q3E756|ensemblfungi:YBL029C-A(gene)|ensemblfungi:YBL029C-A_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|ensembl:YBL029C-A(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000176158758704664 ) paralog2 (YGR130C)-prey (YBL029C-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Y9LDkESr65DK5SLFNTw1dBKeqPc559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:W37FU8kRkwzhU8oi3vmkzvOxkCM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38703	uniprotkb:P19454	intact:EBI-10035|uniprotkb:Q6LD26|uniprotkb:D3DKR1|ensemblfungi:YHL003C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:lag1_yeast(display_long)|uniprotkb:LAG1(gene name)|psi-mi:LAG1(display_short)|uniprotkb:Longevity assurance factor 1(gene name synonym)|uniprotkb:Longevity assurance protein 1(gene name synonym)|uniprotkb:Longevity assurance gene 1 protein(gene name synonym)|uniprotkb:Very-long-chain ceramide synthase LAG1(gene name synonym)|uniprotkb:YHL003C(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712512|imex:IM-26166-6832	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011860.1|sgd:S000000995|ensemblfungi:YHL003C(gene)|ensemblfungi:YHL003C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0050291"(sphingosine N-acyltransferase activity)|go:"GO:0061576"(acyl-CoA ceramide synthase complex)|interpro:IPR006634(TRAM, LAG1 and CLN8 homology)|interpro:IPR013599(TRAM1-like protein)|interpro:IPR016439(Longevity assurance, LAG1/LAC1)|reactome:R-SCE-1660661|dip:DIP-4393N|mint:P38703|ensembl:YHL003C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	-	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.00253042290225212 ) paralog2 (YOR061W)-prey (YHL003C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:KCAjx/gXmy0oGd3aKgasDuFHJzw559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:+oULjleyNblm0kMQbgr1cPxwIlU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:P19454	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712524|imex:IM-26166-6680	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:8ABA71761B512242	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 2.96520689318323E-05 ) paralog2 (YOR061W)-prey (YMR120C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:k+uQqUtuarEnOn8jnAtHeG0cklo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53188	uniprotkb:Q06205	intact:EBI-23731|uniprotkb:D6VUA9|ensemblfungi:YGL029W	intact:EBI-6956|uniprotkb:D6VZ83|ensemblfungi:YLR449W	psi-mi:cgr1_yeast(display_long)|uniprotkb:YGL029W(locus name)|uniprotkb:CGR1(gene name)|psi-mi:CGR1(display_short)|uniprotkb:Coiled-coil growth-regulated protein 1(gene name synonym)	psi-mi:fkbp4_yeast(display_long)|uniprotkb:FPR4(gene name)|psi-mi:FPR4(display_short)|uniprotkb:YLR449W(locus name)|uniprotkb:L9324.3(orf name)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Histone proline isomerase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712536|imex:IM-26166-6598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011486.1|sgd:S000002997|dip:DIP-5450N|mint:P53188|ensemblfungi:YGL029W(gene)|ensemblfungi:YGL029W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR005579(Cgr1)|rcsb pdb:3JCT|rcsb pdb:6FT6|rcsb pdb:6M62|rcsb pdb:6YLG|rcsb pdb:6YLH|ensembl:YGL029W(identity)	sgd:S000004441|refseq:NP_013554.3|dip:DIP-909N|mint:Q06205|ensemblfungi:YLR449W(gene)|ensemblfungi:YLR449W_mRNA(transcript)|go:"GO:0000412"(histone peptidyl-prolyl isomerization)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|rcsb pdb:4BF8|ensembl:YLR449W(identity)	-	-	crc64:CF90C6714F04572E	comment:"paralog1 (YML074C) depletion signifcantly decreases (FDR-corrected p-value: 0.000459009430756885 ) paralog2 (YLR449W)-prey (YGL029W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:G7SUf9/XRWXFaYG1LRPoChi6BVA559292	rogid:rDmDSGEgRbtgkLBoJTzmzxxY7B4559292	rigid:xEhSJGz5NaSLN1aUYCQAlW6lZtg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08235	uniprotkb:P38911	intact:EBI-3775|uniprotkb:D6W1Z1|ensemblfungi:YOL077C	intact:EBI-6951|uniprotkb:D6W0K9|ensemblfungi:YML074C	psi-mi:brx1_yeast(display_long)|uniprotkb:YOL077C(locus name)|uniprotkb:BRX1(gene name)|psi-mi:BRX1(display_short)	psi-mi:fkbp3_yeast(display_long)|uniprotkb:YML074C(locus name)|uniprotkb:FPR3(gene name)|psi-mi:FPR3(display_short)|uniprotkb:NPI46(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Proline rotamase(gene name synonym)|uniprotkb:Nucleolar proline isomerase(gene name synonym)|uniprotkb:FKBP-70(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712548|imex:IM-26166-6536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014565.2|sgd:S000005437|dip:DIP-6317N|mint:Q08235|ensemblfungi:YOL077C(gene)|ensemblfungi:YOL077C_mRNA(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000464"("endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000465"("exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042134"(rRNA primary transcript binding)|interpro:IPR007109(Brix)|interpro:IPR026532|rcsb pdb:5Z1G|rcsb pdb:5Z3G|rcsb pdb:6C0F|rcsb pdb:6CB1|rcsb pdb:6ELZ|rcsb pdb:6EM1|rcsb pdb:6EM3|rcsb pdb:6EM4|rcsb pdb:6EM5|ensembl:YOL077C(identity)	refseq:NP_013637.1|sgd:S000004539|dip:DIP-6578N|ensemblfungi:YML074C(gene)|ensemblfungi:YML074C_mRNA(transcript)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0051598"(meiotic recombination checkpoint signaling)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR023566|interpro:IPR041232|ensembl:YML074C(identity)	-	crc64:31466853EF0E7301	crc64:A01D24DE0078FE11	comment:"paralog1 (YLR449W) depletion signifcantly decreases (FDR-corrected p-value: 0.000333568278995427 ) paralog2 (YML074C)-prey (YOL077C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:mPR6HWKwM6RNCRE/vezsYlCmEGY559292	rogid:4xZebf94akWQyMgPLbH6ExNGjoY559292	rigid:+Z75j2PDCtik2ikTtj3/te/pZnI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53139	uniprotkb:P53278	intact:EBI-23908|uniprotkb:D6VU38|ensemblfungi:YGL108C	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	psi-mi:ygk8_yeast(display_long)|uniprotkb:G3070(orf name)|uniprotkb:YGL108C(locus name)	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712560|imex:IM-26166-6746	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003076|refseq:NP_011407.3|mint:P53139|ensemblfungi:YGL108C(gene)|ensemblfungi:YGL108C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|ensembl:YGL108C(identity)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	-	-	crc64:D482327C9274C026	comment:"paralog1 (YLR200W) depletion signifcantly decreases (FDR-corrected p-value: 0.000124046006171952 ) paralog2 (YGR130C)-prey (YGL108C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6rg2zcMN57peeKKy/RolIDcNaLc559292	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rigid:woXTcMAZP90a/zPvxlYsMyrSCBI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:P19454	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-9548|ensemblfungi:YOR061W|uniprotkb:D6W2C4	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:csk22_yeast(display_long)|uniprotkb:CKA2(gene name)|psi-mi:CKA2(display_short)|uniprotkb:YOR29-12(orf name)|uniprotkb:YOR061W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712572|imex:IM-26166-6972	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	ensemblfungi:YOR061W(gene)|ensemblfungi:YOR061W_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|refseq:NP_014704.1|sgd:S000005587|mint:P19454|dip:DIP-1038N|ensembl:YOR061W(identity)	-	crc64:C86AE5ABB508EA03	crc64:30E214BD852824D0	comment:"paralog1 (YIL035C) depletion signifcantly decreases (FDR-corrected p-value: 0.000161749247505405 ) paralog2 (YOR061W)-prey (YGR086C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:E39eioYivVEqVSUhL99a2iGvisg559292	rigid:qYeMeiMpe2dtjyX15AFucm+GG1Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:P15790	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-9533|ensemblfungi:YIL035C|uniprotkb:D6VVP7	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:csk21_yeast(display_long)|uniprotkb:YIL035C(locus name)|uniprotkb:CKA1(gene name)|psi-mi:CKA1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712272|imex:IM-26166-6468	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	refseq:NP_012229.1|sgd:S000001297|ensemblfungi:YIL035C(gene)|ensemblfungi:YIL035C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007535"(donor selection)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034456"(UTP-C complex)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4FI1|rcsb pdb:4JQE|rcsb pdb:4JR7|rcsb pdb:4LFI|rcsb pdb:4MWH|reactome:R-SCE-2514853|reactome:R-SCE-6804756|reactome:R-SCE-8934903|reactome:R-SCE-8948751|mint:P15790|dip:DIP-48N|ensembl:YIL035C(identity)	-	crc64:C86AE5ABB508EA03	crc64:6A1A7F1BF47250C9	comment:"paralog1 (YOR061W) depletion signifcantly decreases (FDR-corrected p-value: 0.0026133430039154 ) paralog2 (YIL035C)-prey (YGR086C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:SNrrYvyWdzd6bAyvluPlZqs5WJw559292	rigid:i0t2S2EuOVsoo2dJ2sxhLKKjIeM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06144	uniprotkb:Q05031	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712728|imex:IM-26166-6896	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	crc64:2F474503CAB7C195	-	comment:"paralog1 (YKL046C) depletion signifcantly increases (FDR-corrected p-value: 0.00079714186120087 ) paralog2 (YMR238W)-prey (YLR350W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:jK3I/FJNHUi7oVvTG6wzydbcAKs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53278	uniprotkb:Q08967	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712716|imex:IM-26166-6836	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	crc64:D482327C9274C026	-	comment:"paralog1 (YGL139W) depletion signifcantly increases (FDR-corrected p-value: 0.000437880890150039 ) paralog2 (YPL221W)-prey (YGR130C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:/ycM3GJ4TWB5Ez1gZAOW1kX+9O0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36027	uniprotkb:Q12443	intact:EBI-10901|uniprotkb:P41944|ensemblfungi:YLR332W|uniprotkb:D6VYX3	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:mid2_yeast(display_long)|uniprotkb:SMS1(gene name synonym)|uniprotkb:L8543.19(orf name)|uniprotkb:YLR332W(locus name)|uniprotkb:MID2(gene name)|psi-mi:MID2(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:Mating pheromone-induced death protein 2(gene name synonym)|uniprotkb:Serine-rich multicopy suppressor protein 1(gene name synonym)|uniprotkb:Protein kinase A interference protein 1(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712704|imex:IM-26166-6608	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR332W(gene)|ensemblfungi:YLR332W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000767"(cell morphogenesis involved in conjugation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010447"(response to acidic pH)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043332"(mating projection tip)|interpro:IPR007567(Mid2 like cell wall stress sensor)|refseq:NP_013436.1|sgd:S000004324|mint:P36027|dip:DIP-4676N|ensembl:YLR332W(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	-	crc64:E937E2B77759DFF5	comment:"paralog1 (YDR233C) depletion signifcantly increases (FDR-corrected p-value: 0.000396269204458885 ) paralog2 (YDL204W)-prey (YLR332W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:o4cMDBqIZorgGZ6iEACUFcfgO7I559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:kw7hUoSt8/i9AlQFYBmxHPfTnUg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47072	uniprotkb:Q08967	intact:EBI-25803|uniprotkb:D6VWG2|uniprotkb:P47071|uniprotkb:Q86ZR5|ensemblfungi:YJL016W	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:yjb6_yeast(display_long)|uniprotkb:J1320(orf name)|uniprotkb:J1326(orf name)|uniprotkb:YJL017W(orf name)|uniprotkb:YJL016W(locus name)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712692|imex:IM-26166-6606	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003553|refseq:NP_012518.2|mint:P47072|dip:DIP-4907N|ensemblfungi:YJL016W(gene)|ensemblfungi:YJL016W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|ensembl:YJL016W(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	crc64:21D1541BCFEFDFF6	-	comment:"paralog1 (YGL139W) depletion signifcantly increases (FDR-corrected p-value: 0.000797346132850511 ) paralog2 (YPL221W)-prey (YJL016W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:XRf3g3pILUK7J16Tol90s1MoEY4559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:RbNGRwAzhbWjpY1+N78LCSeN48Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25361	uniprotkb:P14359	intact:EBI-21909|uniprotkb:D6VR52|ensemblfungi:YCR043C	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:yct3_yeast(display_long)|uniprotkb:YCR43C(orf name)|uniprotkb:YCR725(orf name)|uniprotkb:YCR043C(locus name)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712680|imex:IM-26166-6476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000639|refseq:NP_009972.1|mint:P25361|ensemblfungi:YCR043C(gene)|ensemblfungi:YCR043C_mRNA(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0043332"(mating projection tip)|ensembl:YCR043C(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	-	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 7.4969692388918E-06 ) paralog2 (YJL151C)-prey (YCR043C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:bEMtsAa5vCsWqGOiXwBK40Pa0xQ559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:X8IpBhTqXl14sDuimGU2zO3WdvY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:P38310	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712668|imex:IM-26166-6538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.00223220754640369 ) paralog2 (YBR207W)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:hyZA7QWbzTatTTvYHMiQv7dq3zU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26570	uniprotkb:Q02896	intact:EBI-13807|uniprotkb:Q00979|ensemblfungi:YML016C|uniprotkb:D6VZF8	intact:EBI-22203|uniprotkb:D6W3T0|ensemblfungi:YPL087W	psi-mi:ppz1_yeast(display_long)|uniprotkb:PPZ1(gene name)|psi-mi:PPZ1(display_short)|uniprotkb:YM9571.02C(orf name)|uniprotkb:YML016C(locus name)	psi-mi:ydc1_yeast(display_long)|uniprotkb:YDC1(gene name)|psi-mi:YDC1(display_short)|uniprotkb:Acyl-CoA-independent ceramide synthase(gene name synonym)|uniprotkb:LPG21W(orf name)|uniprotkb:YPL087W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712656|imex:IM-26166-6604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML016C(gene)|ensemblfungi:YML016C_mRNA(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011159(Phosphoprotein phosphatase PPZ)|interpro:IPR029052|interpro:IPR031675|refseq:NP_013696.1|sgd:S000004478|mint:P26570|dip:DIP-557N|ensembl:YML016C(identity)	refseq:NP_015238.1|sgd:S000006008|dip:DIP-7600N|mint:Q02896|ensemblfungi:YPL087W(gene)|ensemblfungi:YPL087W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046514"(ceramide catabolic process)|go:"GO:0070774"(phytoceramidase activity)|go:"GO:0071633"(dihydroceramidase activity)|interpro:IPR008901(Alkaline phytoceramidase)|reactome:R-SCE-1660661|ensembl:YPL087W(identity)	-	crc64:8B7F009521F72C15	-	comment:"paralog1 (YBR183W) depletion signifcantly increases (FDR-corrected p-value: 0.00309521262522818 ) paralog2 (YPL087W)-prey (YML016C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aybUrPA5WH/mgdDx6VD8N4F/4x0559292	rogid:UjLo2FMUWJPaHBDIYPjWZbqpk98559292	rigid:bgo5i83IQpqPh6xiY4YIVRDSvZA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35735	uniprotkb:Q02201	intact:EBI-26678|uniprotkb:D6VXN6|ensemblfungi:YKL051W	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:sfk1_yeast(display_long)|uniprotkb:YKL051W(locus name)|uniprotkb:YKL303(orf name)|uniprotkb:SFK1(gene name)|psi-mi:SFK1(display_short)|uniprotkb:Suppressor of four kinase protein 1(gene name synonym)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712644|imex:IM-26166-6602	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012873.1|sgd:S000001534|mint:P35735|dip:DIP-5309N|ensemblfungi:YKL051W(gene)|ensemblfungi:YKL051W_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007033"(vacuole organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0061093"(negative regulation of phospholipid translocation)|go:"GO:0071944"(cell periphery)|interpro:IPR019402|ensembl:YKL051W(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00747633715771539 ) paralog2 (YKR003W)-prey (YKL051W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:MUFJgCWecmYI5IvVgC3UXQzptcY559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:eH1l9aO/GfGd6YH7y2QRdFk09zU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53283	uniprotkb:Q08967	intact:EBI-2044753|uniprotkb:D6VUR9|ensemblfungi:YGR138C	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:tpo2_yeast(display_long)|uniprotkb:G6417(orf name)|uniprotkb:YGR138C(locus name)|uniprotkb:TPO2(gene name)|psi-mi:TPO2(display_short)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712632|imex:IM-26166-6974	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011654.1|sgd:S000003370|dip:DIP-7902N|mint:P53283|ensemblfungi:YGR138C(gene)|ensemblfungi:YGR138C_mRNA(transcript)|go:"GO:0000296"(spermine transport)|go:"GO:0000297"(spermine transmembrane transporter activity)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015297"(antiporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|ensembl:YGR138C(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	-	-	comment:"paralog1 (YGL139W) depletion signifcantly increases (FDR-corrected p-value: 1.64358165354595E-05 ) paralog2 (YPL221W)-prey (YGR138C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:UuyY7fJHoszA44v9O9c6T54xslg559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:ungUS4vPYp0lrfk1x/HgVt5JhEE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13134	uniprotkb:P38310	intact:EBI-9658|ensemblfungi:YNL238W|uniprotkb:D6W0V5	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:kex2_yeast(display_long)|uniprotkb:KEX2(gene name)|psi-mi:KEX2(display_short)|uniprotkb:QDS1(gene name synonym)|uniprotkb:YNL238W(locus name)|uniprotkb:N1122(orf name)|uniprotkb:Protease KEX2(gene name synonym)|uniprotkb:Proteinase YSCF(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712620|imex:IM-26166-6600	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002884(Proprotein convertase, P)|interpro:IPR008979(Galactose-binding like)|ensemblfungi:YNL238W(gene)|ensemblfungi:YNL238W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007323"(peptide pheromone maturation)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023827|interpro:IPR023828|interpro:IPR034182|interpro:IPR036852|rcsb pdb:1OT5|rcsb pdb:1R64|rcsb pdb:2ID4|refseq:NP_014161.1|sgd:S000005182|dip:DIP-6287N|mint:P13134|ensembl:YNL238W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:5DCEEDADCF439C78	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.00296398863866364 ) paralog2 (YBR207W)-prey (YNL238W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:DI29wdB9fSIOhlHVEuVoRiDbzl8559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:caaPH1O1ywp2rievR0tI/XlSH8o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:P23287	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-12771|uniprotkb:D6VZ68|ensemblfungi:YLR433C	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:pp2b1_yeast(display_long)|uniprotkb:CNA1(gene name)|psi-mi:CNA1(display_short)|uniprotkb:Calcineurin A1(gene name synonym)|uniprotkb:Calmodulin-binding protein 1(gene name synonym)|uniprotkb:CMP1(gene name synonym)|uniprotkb:L9753.6(orf name)|uniprotkb:YLR433C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712608|imex:IM-26166-6834	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	ensemblfungi:YLR433C(gene)|ensemblfungi:YLR433C_mRNA(transcript)|go:"GO:0000754"(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0106306"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0106307"|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|rcsb pdb:2LHI|reactome:R-SCE-2871809|reactome:R-SCE-4086398|reactome:R-SCE-5607763|refseq:NP_013537.1|sgd:S000004425|mint:P23287|dip:DIP-662N|ensembl:YLR433C(identity)	-	crc64:C86AE5ABB508EA03	crc64:D5D6F91CC0BD277B	comment:"paralog1 (YML057W) depletion signifcantly decreases (FDR-corrected p-value: 0.00731665831763993 ) paralog2 (YLR433C)-prey (YGR086C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:zRq8yuSMapTQXHWOyZDsdD4W9Ds559292	rigid:cLb2b5We1RAfESLopUlufIaOomc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38310	uniprotkb:P38929	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712596|imex:IM-26166-6682	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	crc64:7B4E620ABC39A053	crc64:5BD9ECFF8508F396	comment:"paralog1 (YGL167C) depletion signifcantly decreases (FDR-corrected p-value: 0.000565356333694445 ) paralog2 (YGL006W)-prey (YBR207W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:Xv02bus7//Y0+bfDswvdZMDkf0o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17898	uniprotkb:P53224	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	intact:EBI-12592|uniprotkb:D6VUH5|ensemblfungi:YGR038W	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:orm1_yeast(display_long)|uniprotkb:YGR038W(locus name)|uniprotkb:ORM1(gene name)|psi-mi:ORM1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712584|imex:IM-26166-6894	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	ensemblfungi:YGR038W(gene)|ensemblfungi:YGR038W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|refseq:NP_011552.1|sgd:S000003270|reactome:R-SCE-6798695|dip:DIP-8124N|ensembl:YGR038W(identity)	-	-	crc64:4387D00ACE4F3A1D	comment:"paralog1 (YLR350W) depletion signifcantly decreases (FDR-corrected p-value: 0.00244020754391539 ) paralog2 (YGR038W)-prey (YNL130C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rogid:HsbGN/V/sSXpez8xOIDmVo6oiSk559292	rigid:K54KvFRpBVof39rACHzLoqQQD3M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36076	uniprotkb:P17898	intact:EBI-26778|uniprotkb:D6VXK0|ensemblfungi:YKL088W	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:cab3_yeast(display_long)|uniprotkb:YKL088W(locus name)|uniprotkb:CAB3(gene name)|psi-mi:CAB3(display_short)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712740|imex:IM-26166-6478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012835.1|sgd:S000001571|mint:P36076|dip:DIP-4475N|ensemblfungi:YKL088W(gene)|ensemblfungi:YKL088W_mRNA(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|reactome:R-SCE-196783|ensembl:YKL088W(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog1 (YHR123W) depletion signifcantly increases (FDR-corrected p-value: 0.000476131127660093 ) paralog2 (YNL130C)-prey (YKL088W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Li7vZOassm4PC5fW111/j5ivgEc559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:5m/rABYRVKmrqPAPaGiQnMJnQXo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16603	uniprotkb:Q03529	intact:EBI-11940|ensemblfungi:YHR042W|uniprotkb:D3DKZ0	intact:EBI-16747|ensemblfungi:YMR272C|uniprotkb:D6W098	psi-mi:ncpr_yeast(display_long)|uniprotkb:NCP1(gene name)|psi-mi:NCP1(display_short)|uniprotkb:NCPR1(gene name synonym)|uniprotkb:PRD1(gene name synonym)|uniprotkb:CPR1(gene name synonym)|uniprotkb:YHR042W(locus name)	psi-mi:scs7_yeast(display_long)|uniprotkb:SCS7(gene name)|psi-mi:SCS7(display_short)|uniprotkb:FAH1(gene name synonym)|uniprotkb:YMR272C(locus name)|uniprotkb:YM8156.14C(orf name)|uniprotkb:Suppressor of calcium sensitivity 7(gene name synonym)|uniprotkb:4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase SCS7(gene name synonym)|uniprotkb:Dihydroceramide fatty acyl 2-hydroxylase SCS7(gene name synonym)|uniprotkb:Sphingolipid alpha-hydroxylase(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712752|imex:IM-26166-6976	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YHR042W(gene)|ensemblfungi:YHR042W_mRNA(transcript)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0003959"(NADPH dehydrogenase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010181"(FMN binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR039261|rcsb pdb:2BF4|rcsb pdb:2BN4|rcsb pdb:2BPO|rcsb pdb:3FJO|reactome:R-SCE-1222556|reactome:R-SCE-1474151|reactome:R-SCE-203615|reactome:R-SCE-392154|reactome:R-SCE-5218920|reactome:R-SCE-5578775|reactome:R-SCE-9009391|reactome:R-SCE-9033241|interpro:IPR029039|refseq:NP_011908.1|sgd:S000001084|mint:P16603|dip:DIP-8294N|ensembl:YHR042W(identity)	ensemblfungi:YMR272C(gene)|ensemblfungi:YMR272C_mRNA(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006673"(inositol phosphoceramide metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0080132"(fatty acid alpha-hydroxylase activity)|go:"GO:0102771"(sphingolipid very long chain fatty acid alpha-hydroxylase activity)|rcsb pdb:4ZR0|rcsb pdb:4ZR1|reactome:R-SCE-1660661|refseq:NP_013999.1|sgd:S000004885|interpro:IPR001199(Cytochrome b5)|interpro:IPR018506|interpro:IPR006694(Fatty acid hydroxylase)|interpro:IPR014430(Inositolphosphorylceramide-B hydroxylase)|mint:Q03529|interpro:IPR036400|ensembl:YMR272C(identity)	-	-	-	comment:"paralog1 (YNL111C) depletion signifcantly increases (FDR-corrected p-value: 0.0066500584318331 ) paralog2 (YMR272C)-prey (YHR042W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:l8faixht4sd0KQhbt2DadH/8BPw559292	rogid:M34W8LH4q+H1EOi7khg+f/TKtgQ559292	rigid:xttUVjdlFR7CiqES73UOXs3hzog	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38623	uniprotkb:P14359	intact:EBI-14885|uniprotkb:Q02532|uniprotkb:Q06557|uniprotkb:D6VYP6|ensemblfungi:YLR248W	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:rck2_yeast(display_long)|uniprotkb:RCK2(gene name)|psi-mi:RCK2(display_short)|uniprotkb:CLK1(gene name synonym)|uniprotkb:CMK3(gene name synonym)|uniprotkb:YLR248W(locus name)|uniprotkb:L9672.6(orf name)|uniprotkb:CAM kinase-like protein kinase CLK1(gene name synonym)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712764|imex:IM-26166-6898	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013349.1|sgd:S000004238|ensemblfungi:YLR248W(gene)|ensemblfungi:YLR248W_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-9619229|dip:DIP-5079N|mint:P38623|ensembl:YLR248W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:00DDC674F6723E6A	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 0.0013924151772176 ) paralog2 (YJL151C)-prey (YLR248W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:4VUkn/0mqnutY8hSJdNTA3ZyPeY559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:JSm48Z0ZF0c33YDzI+R3sTsONKc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36076	uniprotkb:Q07549	intact:EBI-26778|uniprotkb:D6VXK0|ensemblfungi:YKL088W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:cab3_yeast(display_long)|uniprotkb:YKL088W(locus name)|uniprotkb:CAB3(gene name)|psi-mi:CAB3(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712823|imex:IM-26166-6980	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012835.1|sgd:S000001571|mint:P36076|dip:DIP-4475N|ensemblfungi:YKL088W(gene)|ensemblfungi:YKL088W_mRNA(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|reactome:R-SCE-196783|ensembl:YKL088W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 1.73055453345994E-05 ) paralog2 (YDL123W)-prey (YKL088W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Li7vZOassm4PC5fW111/j5ivgEc559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:ra+RlEheCgkoVWkbyHrCQGXz2Mk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53315	uniprotkb:Q07549	intact:EBI-17690|uniprotkb:D6VV28|ensemblfungi:YGR248W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:sol4_yeast(display_long)|uniprotkb:YGR248W(locus name)|uniprotkb:SOL4(gene name)|psi-mi:SOL4(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712835|imex:IM-26166-6610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR248W(gene)|ensemblfungi:YGR248W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0017057"(6-phosphogluconolactonase activity)|sgd:S000003480|interpro:IPR005900(6-phosphogluconolactonase)|interpro:IPR006148(Glucosamine/galactosamine-6-phosphate isomerase)|refseq:NP_011764.3|interpro:IPR037171|mint:P53315|interpro:IPR039104|ensembl:YGR248W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.00155605167711191 ) paralog2 (YDL123W)-prey (YGR248W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ZHNdo8cf1CZ6iFBekhKKEC34bXs559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:rHDinuN7wJObe05LZE+AwDCcWOQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87284	uniprotkb:Q02201	intact:EBI-13555|uniprotkb:D6VSQ7|ensemblfungi:YDR276C	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:pmp3_yeast(display_long)|uniprotkb:PMP3(gene name)|psi-mi:PMP3(display_short)|uniprotkb:SNA1(gene name synonym)|uniprotkb:YDR276C(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712859|imex:IM-26166-6982	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010562.1|sgd:S000002684|ensemblfungi:YDR276C(gene)|ensemblfungi:YDR276C_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000612(Protein of unknown function UPF0057)|dip:DIP-7280N|ensembl:YDR276C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00176245576444665 ) paralog2 (YKR003W)-prey (YDR276C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6uTuY0fyQfxrzyVqcLiNdDF5oRs559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:NbXwU9H8RjrKLHXH5fZTQfMjU2g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12329	uniprotkb:Q12443	intact:EBI-8571|uniprotkb:D6VSF3|ensemblfungi:YDR171W	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:hsp42_yeast(display_long)|uniprotkb:HSP42(gene name)|psi-mi:HSP42(display_short)|uniprotkb:YDR171W(locus name)|uniprotkb:YD9395.04(orf name)|uniprotkb:42 kDa heat shock protein(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712871|imex:IM-26166-6612	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010456.1|sgd:S000002578|mint:Q12329|dip:DIP-2515N|ensemblfungi:YDR171W(gene)|ensemblfungi:YDR171W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0009408"(response to heat)|go:"GO:0009651"(response to salt stress)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043621"(protein self-association)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR031107|ensembl:YDR171W(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:DF353A76493E3CE6	crc64:E937E2B77759DFF5	comment:"paralog1 (YDR233C) depletion signifcantly increases (FDR-corrected p-value: 0.000612167860532622 ) paralog2 (YDL204W)-prey (YDR171W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:izvrv04fA3zcBqTeUeHD/erKGf4559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:AwZN25Ru11c8W0p6I3ZLPLV9qiA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41807	uniprotkb:P14359	intact:EBI-20281|uniprotkb:D6W446|ensemblfungi:YPR036W	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:vath_yeast(display_long)|uniprotkb:YP3085.02(orf name)|uniprotkb:VMA13(gene name)|psi-mi:VMA13(display_short)|uniprotkb:CLS11(gene name synonym)|uniprotkb:YPR036W(locus name)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 54 kDa subunit(gene name synonym)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712883|imex:IM-26166-6480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015361.1|sgd:S000006240|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|rcsb pdb:1HO8|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YPR036W(gene)|ensemblfungi:YPR036W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-6640N|mint:P41807|ensembl:YPR036W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:54131FF9C2C87594	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 0.000023823781853295 ) paralog2 (YJL151C)-prey (YPR036W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:kEXWvOsnTk0WdgGOny+mufz4lTo559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:mpfZXkxjevxsPo7Sre6fG1AT+G8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22140	uniprotkb:P22140	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712895|imex:IM-26166-6614	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly increases (FDR-corrected p-value: 0.000125129190612789 ) paralog2 (YHR123W)-prey (YHR123W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:F0R4HnIToGEaUTj9Sr8Wfe3Bgn0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P39729	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-20651|uniprotkb:D6VPI1|ensemblfungi:YAL036C	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:rbg1_yeast(display_long)|uniprotkb:GTP-binding protein RBG1(gene name synonym)|uniprotkb:YAL036C(locus name)|uniprotkb:RBG1(gene name)|psi-mi:RBG1(display_short)|uniprotkb:FUN11(gene name synonym)|uniprotkb:Genetically interacts with ribosomal genes protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712907|imex:IM-26166-6482	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_009364.1|sgd:S000000034|ensemblfungi:YAL036C_mRNA(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:1903833"(positive regulation of cellular response to amino acid starvation)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:4A9A|ensemblfungi:YAL036C(gene)|dip:DIP-1750N|mint:P39729|ensembl:YAL036C(identity)	-	crc64:55CAE5DACDC6A00B	crc64:D25C6C732B462A6B	comment:"paralog1 (YGR173W) depletion signifcantly increases (FDR-corrected p-value: 6.95807287575175E-08 ) paralog2 (YAL036C)-prey (YHR183W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:PYUgCeuX5pWutVTDI01InMby/OE559292	rigid://lEZlnjdI3acpcoaq1oxfxPFtY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69771	uniprotkb:P53843	intact:EBI-2053489|uniprotkb:D6VX98|ensemblfungi:YKR035W-A	intact:EBI-28245|uniprotkb:D6W0S8|ensemblfungi:YNL265C	psi-mi:did2_yeast(display_long)|uniprotkb:CHM1(gene name synonym)|uniprotkb:FTI1(gene name synonym)|uniprotkb:Fifty two inhibitor 1(gene name synonym)|uniprotkb:YKR035W-A(locus name)|uniprotkb:VPS46(gene name synonym)|uniprotkb:Charged multivesicular body protein 1(gene name synonym)|uniprotkb:DOA4-independent degradation protein 2(gene name synonym)|uniprotkb:DID2(gene name)|psi-mi:DID2(display_short)	psi-mi:ist1_yeast(display_long)|uniprotkb:YNL265C(locus name)|uniprotkb:N0809(orf name)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Increased sodium tolerance protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712919|imex:IM-26166-6984	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000006435|refseq:NP_012961.3|dip:DIP-52223N|mint:P69771|ensemblfungi:YKR035W-A(gene)|ensemblfungi:YKR035W-A_mRNA(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015031"(protein transport)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:1904902"(ESCRT III complex assembly)|interpro:IPR005024(Snf7)|rcsb pdb:3GGZ|rcsb pdb:5H7P|ensembl:YKR035W-A(identity)	refseq:NP_014134.1|sgd:S000005209|dip:DIP-6713N|mint:P53843|ensemblfungi:YNL265C(gene)|ensemblfungi:YNL265C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3GGY|rcsb pdb:3GGZ|reactome:R-SCE-6798695|reactome:R-SCE-9668328|ensembl:YNL265C(identity)	-	crc64:70D1CF4588A8C6E6	-	comment:"paralog1 (YLR181C) depletion signifcantly increases (FDR-corrected p-value: 0.00416785882493347 ) paralog2 (YNL265C)-prey (YKR035W-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:SVI1+8lRI6qwD0CSLY11Xq0LG0o559292	rogid:c8ngH6tobftaOGIxLH8qXiOpi28559292	rigid:B99gmwNEnTICzDD4Ci/ZeLVO5gg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36027	uniprotkb:P14359	intact:EBI-10901|uniprotkb:P41944|ensemblfungi:YLR332W|uniprotkb:D6VYX3	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:mid2_yeast(display_long)|uniprotkb:SMS1(gene name synonym)|uniprotkb:L8543.19(orf name)|uniprotkb:YLR332W(locus name)|uniprotkb:MID2(gene name)|psi-mi:MID2(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:Mating pheromone-induced death protein 2(gene name synonym)|uniprotkb:Serine-rich multicopy suppressor protein 1(gene name synonym)|uniprotkb:Protein kinase A interference protein 1(gene name synonym)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712811|imex:IM-26166-6838	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR332W(gene)|ensemblfungi:YLR332W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000767"(cell morphogenesis involved in conjugation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010447"(response to acidic pH)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043332"(mating projection tip)|interpro:IPR007567(Mid2 like cell wall stress sensor)|refseq:NP_013436.1|sgd:S000004324|mint:P36027|dip:DIP-4676N|ensembl:YLR332W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	-	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 2.70079449237527E-05 ) paralog2 (YJL151C)-prey (YLR332W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:o4cMDBqIZorgGZ6iEACUFcfgO7I559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:Z//1cX1ur0Nvt6lVIUyOJtzpleY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38344	uniprotkb:P38344	intact:EBI-21136|uniprotkb:D6VQR3|ensemblfungi:YBR267W	intact:EBI-21136|uniprotkb:D6VQR3|ensemblfungi:YBR267W	psi-mi:rei1_yeast(display_long)|uniprotkb:REI1(gene name)|psi-mi:REI1(display_short)|uniprotkb:Required for isotropic bud growth protein 1(gene name synonym)|uniprotkb:pre-60S factor REI1(gene name synonym)|uniprotkb:YBR1736(orf name)|uniprotkb:YBR267W(locus name)	psi-mi:rei1_yeast(display_long)|uniprotkb:REI1(gene name)|psi-mi:REI1(display_short)|uniprotkb:Required for isotropic bud growth protein 1(gene name synonym)|uniprotkb:pre-60S factor REI1(gene name synonym)|uniprotkb:YBR1736(orf name)|uniprotkb:YBR267W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712799|imex:IM-26166-6900	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009825.4|sgd:S000000471|mint:P38344|dip:DIP-6347N|rcsb pdb:6RZZ|rcsb pdb:5APN|ensemblfungi:YBR267W(gene)|ensemblfungi:YBR267W_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR040025|interpro:IPR041661|ensembl:YBR267W(identity)	refseq:NP_009825.4|sgd:S000000471|mint:P38344|dip:DIP-6347N|rcsb pdb:6RZZ|rcsb pdb:5APN|ensemblfungi:YBR267W(gene)|ensemblfungi:YBR267W_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR040025|interpro:IPR041661|ensembl:YBR267W(identity)	-	crc64:D01AA8FFDF4A0BAC	crc64:D01AA8FFDF4A0BAC	comment:"paralog1 (YLR387C) depletion signifcantly increases (FDR-corrected p-value: 0.000104193311000762 ) paralog2 (YBR267W)-prey (YBR267W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:YxMyWWxJUH2Pk41X+98x8jcnqhc559292	rogid:YxMyWWxJUH2Pk41X+98x8jcnqhc559292	rigid:fDSzBJs/iTLxhFFZ+Pz7qMddeD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47155	uniprotkb:Q04201	intact:EBI-2051644|uniprotkb:D6VWT7|ensemblfungi:YJR118C	intact:EBI-27928|uniprotkb:D6W0I3|ensemblfungi:YML101C	psi-mi:ilm1_yeast(display_long)|uniprotkb:Increased loss of mitochondrial DNA protein 1(gene name synonym)|uniprotkb:J2033(orf name)|uniprotkb:ILM1(gene name)|psi-mi:ILM1(display_short)|uniprotkb:YJR118C(locus name)	psi-mi:cue4_yeast(display_long)|uniprotkb:YML101C(locus name)|uniprotkb:Coupling of ubiquitin conjugation to ER degradation protein 4(gene name synonym)|uniprotkb:CUE4(gene name)|psi-mi:CUE4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712787|imex:IM-26166-6978	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003879|interpro:IPR018815|refseq:NP_012652.3|mint:P47155|ensemblfungi:YJR118C(gene)|ensemblfungi:YJR118C_mRNA(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|ensembl:YJR118C(identity)	refseq:NP_013607.1|sgd:S000004568|dip:DIP-4525N|mint:Q04201|ensemblfungi:YML101C(gene)|ensemblfungi:YML101C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR003892(Ubiquitin system component Cue)|ensembl:YML101C(identity)	-	-	-	comment:"paralog1 (YMR264W) depletion signifcantly increases (FDR-corrected p-value: 0.00030873193151892 ) paralog2 (YML101C)-prey (YJR118C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:BrQhbXGvUjNG6Bt5c0J7T8qzMeI559292	rogid:NMBJHZbX4/gU01fk4evPDXm/M6w559292	rigid:sXNt0o1mKPjrW45LOIb1HxjZg08	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36018	uniprotkb:Q07549	intact:EBI-29407|uniprotkb:D6VX79|ensemblfungi:YKR014C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:ypt52_yeast(display_long)|uniprotkb:YPT52(gene name)|psi-mi:YPT52(display_short)|uniprotkb:YK112(orf name)|uniprotkb:YKR014C(locus name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712847|imex:IM-26166-6684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012939.1|sgd:S000001722|dip:DIP-2121N|mint:P36018|ensemblfungi:YKR014C(gene)|ensemblfungi:YKR014C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0036258"(multivesicular body assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-SCE-6798695|reactome:R-SCE-8856828|reactome:R-SCE-8873719|reactome:R-SCE-8876198|reactome:R-SCE-983231|ensembl:YKR014C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	crc64:34AB2FFE38697261	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.000131228427419569 ) paralog2 (YDL123W)-prey (YKR014C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:KZ9/F9Ilto2oDHiPHffIM2gcVnY559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:/Pmsd4GuvzKmmVU03cr2W5ZsQUM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32660	uniprotkb:Q07549	intact:EBI-3121|uniprotkb:D3DM74|ensemblfungi:YER166W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:atc5_yeast(display_long)|uniprotkb:DNF1(gene name)|psi-mi:DNF1(display_short)|uniprotkb:YER166W(locus name)|uniprotkb:SYGP-ORF7(orf name)|uniprotkb:Flippase DNF1(gene name synonym)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713003|imex:IM-26166-6988	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000968|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070867"(mating projection tip membrane)|go:"GO:0071944"(cell periphery)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR026871|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:7KY6|rcsb pdb:7KYB|rcsb pdb:7KYC|refseq:NP_011093.3|dip:DIP-7949N|mint:P32660|ensemblfungi:YER166W(gene)|ensemblfungi:YER166W_mRNA(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000749"(response to pheromone triggering conjugation with cellular fusion)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|ensembl:YER166W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	crc64:3CC3FBA8ADDE8960	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 5.75638679796661E-05 ) paralog2 (YDL123W)-prey (YER166W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:4ciEaV0aGjDqtpexkFJ0l737SpA559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:qk/Se8FPK2wd1Pb1hqdOFTUL9hE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53262	uniprotkb:P38310	intact:EBI-2061527|uniprotkb:D6VUN8|ensemblfungi:YGR106C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:voa1_yeast(display_long)|uniprotkb:YGR106C(locus name)|uniprotkb:VOA1(gene name)|psi-mi:VOA1(display_short)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712991|imex:IM-26166-6986	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003338|refseq:NP_011620.1|mint:P53262|ensemblfungi:YGR106C(gene)|ensemblfungi:YGR106C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|ensembl:YGR106C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 1.72723136028032E-05 ) paralog2 (YBR207W)-prey (YGR106C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:lKLIonttSEX36IQaIKlzxS/Cdxg559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:RLeMPdK83XqUL0ZYpjkL9nIc9GA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12028	uniprotkb:P38310	intact:EBI-33025|uniprotkb:D6W439|ensemblfungi:YPR029C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:ap1g1_yeast(display_long)|uniprotkb:APL4(gene name)|psi-mi:APL4(display_short)|uniprotkb:Clathrin assembly protein complex 1 gamma large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large gamma chain(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:YPR029C(locus name)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712979|imex:IM-26166-6750	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015354.1|sgd:S000006233|mint:Q12028|dip:DIP-3913N|ensemblfungi:YPR029C(gene)|ensemblfungi:YPR029C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|reactome:R-SCE-432720|ensembl:YPR029C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:ABB619E9DC4F565C	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.00167131164649516 ) paralog2 (YBR207W)-prey (YPR029C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:nzjklmQlRHNY/Wqmrg6GbLG17e8559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:ldZiYPpbNMo4HWgoTr+37XTYxUc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38845	uniprotkb:Q05031	intact:EBI-24770|uniprotkb:D3DL95|ensemblfungi:YHR146W	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:crp1_yeast(display_long)|uniprotkb:YHR146W(locus name)|uniprotkb:CRP1(gene name)|psi-mi:CRP1(display_short)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712967|imex:IM-26166-6616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014756(Immunoglobulin E-set)|refseq:NP_012016.1|sgd:S000001189|interpro:IPR032640|interpro:IPR013783(Immunoglobulin-like fold)|mint:P38845|ensemblfungi:YHR146W(gene)|ensemblfungi:YHR146W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0080090"(regulation of primary metabolic process)|reactome:R-SCE-1632852|reactome:R-SCE-380972|ensembl:YHR146W(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	-	-	comment:"paralog1 (YKL046C) depletion signifcantly increases (FDR-corrected p-value: 1.72723136028032E-05 ) paralog2 (YMR238W)-prey (YHR146W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:hXYeMer3Mt7Lypa5GEsbmTXs9I0559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:RfLFY96SMBJexgWsyGqd06se2gI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03640	uniprotkb:Q02201	intact:EBI-27872|uniprotkb:D6VZA1|ensemblfungi:YML072C	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:tcb3_yeast(display_long)|uniprotkb:YML072C(locus name)|uniprotkb:TCB3(gene name)|psi-mi:TCB3(display_short)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712955|imex:IM-26166-6748	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013639.1|sgd:S000004537|dip:DIP-6589N|mint:Q03640|ensemblfungi:YML072C(gene)|ensemblfungi:YML072C_mRNA(transcript)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0006869"(lipid transport)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0046872"(metal ion binding)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR017147(Tricalbin)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037756|interpro:IPR037761|interpro:IPR037762|interpro:IPR037765|ensembl:YML072C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	crc64:77A0AE57F9259784	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.000210629866889469 ) paralog2 (YKR003W)-prey (YML072C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:miu2Eqlp/xqS/9aOMycLTcERCEU559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:NF2BLIqIPfC8w9+DzEZl4BEUMXI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12057	uniprotkb:P38310	intact:EBI-29838|uniprotkb:D6W2G4|ensemblfungi:YOR104W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:pin2_yeast(display_long)|uniprotkb:PIN2(gene name)|psi-mi:PIN2(display_short)|uniprotkb:YOR3214W(orf name)|uniprotkb:YOR104W(locus name)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712943|imex:IM-26166-6902	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005630|refseq:NP_014747.1|dip:DIP-4459N|mint:Q12057|ensemblfungi:YOR104W(gene)|ensemblfungi:YOR104W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037504|ensembl:YOR104W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 2.27897668805951E-05 ) paralog2 (YBR207W)-prey (YOR104W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Zk6iUcpP++MEXuhKZ79TMOYQYqM559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:OJbKey6GJbcokOjMKW5SDNGE/Dg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38756	uniprotkb:P32582	intact:EBI-24431|uniprotkb:D3DKU6|ensemblfungi:YHR003C	intact:EBI-4167|uniprotkb:Q05177|uniprotkb:Q27JK1|uniprotkb:Q27JK4|uniprotkb:D6VUT5|ensemblfungi:YGR155W	psi-mi:tcd1_yeast(display_long)|uniprotkb:TCD1(gene name)|psi-mi:TCD1(display_short)|uniprotkb:"t(6)A37 dehydratase 1"(gene name synonym)|uniprotkb:YHR003C(locus name)	psi-mi:cbs_yeast(display_long)|uniprotkb:STR4(gene name synonym)|uniprotkb:CYS4(gene name)|psi-mi:CYS4(display_short)|uniprotkb:YGR155W(locus name)|uniprotkb:G6667(orf name)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym)|uniprotkb:Sulfur transfer protein 4(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16712931|imex:IM-26166-6840	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011866.1|sgd:S000001045|dip:DIP-4417N|mint:P38756|ensemblfungi:YHR003C(gene)|ensemblfungi:YHR003C_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008641"(ubiquitin-like modifier activating enzyme activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0061503"(tRNA threonylcarbamoyladenosine dehydratase)|go:"GO:0061504"(cyclic threonylcarbamoyladenosine biosynthetic process)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR035985|ensembl:YHR003C(identity)	sgd:S000003387|refseq:NP_011671.3|dip:DIP-1282N|mint:P32582|ensemblfungi:YGR155W(gene)|ensemblfungi:YGR155W_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004122"(cystathionine beta-synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019346"(transsulfuration)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|rcsb pdb:6C2H|rcsb pdb:6C2Q|rcsb pdb:6C2Z|rcsb pdb:6C4P|reactome:R-SCE-1614603|ensembl:YGR155W(identity)	-	-	crc64:D0C7059B20FD0746	comment:"paralog1 (YGR012W) depletion signifcantly increases (FDR-corrected p-value: 1.07684361509615E-09 ) paralog2 (YGR155W)-prey (YHR003C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Mce7jBtBDJ9bSrw+cQDCbhK8DvY559292	rogid:bHamyLQqLgqrPxKcyNSzJJR5n+M559292	rigid:gVJShM0rrcjf8yrOxIBwHkbSe3c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3E756	uniprotkb:Q02201	intact:EBI-2044812|uniprotkb:D6VPX0|ensemblfungi:YBL029C-A	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:yb029_yeast(display_long)|uniprotkb:YBL029C-A(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713015|imex:IM-26166-6686	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000007591|refseq:NP_076874.1|mint:Q3E756|ensemblfungi:YBL029C-A(gene)|ensemblfungi:YBL029C-A_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|ensembl:YBL029C-A(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00122631555313723 ) paralog2 (YKR003W)-prey (YBL029C-A) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Y9LDkESr65DK5SLFNTw1dBKeqPc559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:g0KTEQYamT+CVt6+FMDsrc8mbIA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26570	uniprotkb:Q02201	intact:EBI-13807|uniprotkb:Q00979|ensemblfungi:YML016C|uniprotkb:D6VZF8	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:ppz1_yeast(display_long)|uniprotkb:PPZ1(gene name)|psi-mi:PPZ1(display_short)|uniprotkb:YM9571.02C(orf name)|uniprotkb:YML016C(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713027|imex:IM-26166-6688	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML016C(gene)|ensemblfungi:YML016C_mRNA(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011159(Phosphoprotein phosphatase PPZ)|interpro:IPR029052|interpro:IPR031675|refseq:NP_013696.1|sgd:S000004478|mint:P26570|dip:DIP-557N|ensembl:YML016C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	crc64:8B7F009521F72C15	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00116556382675964 ) paralog2 (YKR003W)-prey (YML016C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aybUrPA5WH/mgdDx6VD8N4F/4x0559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:Pu5huY3B8VUF+xyw2vP0L2PEXKQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54858	uniprotkb:P14359	intact:EBI-6042|uniprotkb:D6VS54|ensemblfungi:YDR068W	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:dos2_yeast(display_long)|uniprotkb:D4267(orf name)|uniprotkb:YD8554.01(orf name)|uniprotkb:YD9609.22(orf name)|uniprotkb:DOS2(gene name)|psi-mi:DOS2(display_short)|uniprotkb:YDR068W(locus name)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713039|imex:IM-26166-6752	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002475|refseq:NP_010353.3|dip:DIP-4785N|mint:P54858|ensemblfungi:YDR068W(gene)|ensemblfungi:YDR068W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR005607(BSD)|interpro:IPR035925|ensembl:YDR068W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	-	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 0.000487890905430082 ) paralog2 (YJL151C)-prey (YDR068W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:/4fnAAPmC12DMUbUB8MVS9yjjeg559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:HXonZs1ajwEt+gUIMHNSlOWqBX0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26570	uniprotkb:Q12443	intact:EBI-13807|uniprotkb:Q00979|ensemblfungi:YML016C|uniprotkb:D6VZF8	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:ppz1_yeast(display_long)|uniprotkb:PPZ1(gene name)|psi-mi:PPZ1(display_short)|uniprotkb:YM9571.02C(orf name)|uniprotkb:YML016C(locus name)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713051|imex:IM-26166-6484	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML016C(gene)|ensemblfungi:YML016C_mRNA(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011159(Phosphoprotein phosphatase PPZ)|interpro:IPR029052|interpro:IPR031675|refseq:NP_013696.1|sgd:S000004478|mint:P26570|dip:DIP-557N|ensembl:YML016C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:8B7F009521F72C15	crc64:E937E2B77759DFF5	comment:"paralog1 (YDR233C) depletion signifcantly increases (FDR-corrected p-value: 0.00104600327760329 ) paralog2 (YDL204W)-prey (YML016C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aybUrPA5WH/mgdDx6VD8N4F/4x0559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:B+b6aKae8JbIO0i4o+vs53AXy9o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02785	uniprotkb:Q07549	intact:EBI-13065|uniprotkb:D6W3V6|ensemblfungi:YPL058C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:pdr12_yeast(display_long)|uniprotkb:PDR12(gene name)|psi-mi:PDR12(display_short)|uniprotkb:LPE14C(orf name)|uniprotkb:YPL058C(locus name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713063|imex:IM-26166-6618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015267.1|sgd:S000005979|interpro:IPR013525(ABC-2 type transporter)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010929(CDR ABC transporter)|interpro:IPR027417|interpro:IPR029481|mint:Q02785|interpro:IPR034001|interpro:IPR034003|interpro:IPR043926|ensemblfungi:YPL058C(gene)|ensemblfungi:YPL058C_mRNA(transcript)|go:"GO:0005342"(organic acid transmembrane transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0015849"(organic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|ensembl:YPL058C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.000302585549162811 ) paralog2 (YDL123W)-prey (YPL058C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ADiU46Ad/dXDE9tXUfGj0rFIO6M559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:/4ymFRH0TAj9gOty9Jv0vr9JMkQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54837	uniprotkb:Q05031	intact:EBI-6642|uniprotkb:D6VZG2|ensemblfungi:YML012W	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:tmeda_yeast(display_long)|uniprotkb:ERV25(gene name)|psi-mi:ERV25(display_short)|uniprotkb:YM9571.06(orf name)|uniprotkb:YML012W(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713075|imex:IM-26166-6690	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013701.1|sgd:S000004473|mint:P54837|dip:DIP-2134N|ensemblfungi:YML012W(gene)|ensemblfungi:YML012W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YML012W(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	-	-	comment:"paralog1 (YKL046C) depletion signifcantly increases (FDR-corrected p-value: 0.000222288369588475 ) paralog2 (YMR238W)-prey (YML012W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:H4bQL5k77CB85Hz+8rjJcSAG/98559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:Tmtw27MsVrkOT402djPlM2O4ajg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:Q06144	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713087|imex:IM-26166-6692	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062|ensembl:YLR056W(identity)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	-	-	crc64:2F474503CAB7C195	comment:"paralog1 (YGR038W) depletion signifcantly increases (FDR-corrected p-value: 0.00120029604785728 ) paralog2 (YLR350W)-prey (YLR056W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rigid:Du52l6UGIvzL+IcvPkhJD4wNgHE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12434	uniprotkb:Q07549	intact:EBI-7525|uniprotkb:D6VRL3|ensemblfungi:YDL135C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:gdir_yeast(display_long)|uniprotkb:D2175(orf name)|uniprotkb:YDL135C(locus name)|uniprotkb:RDI1(gene name)|psi-mi:RDI1(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713099|imex:IM-26166-6754	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010146.1|sgd:S000002294|mint:Q12434|dip:DIP-1231N|ensemblfungi:YDL135C(gene)|ensemblfungi:YDL135C_mRNA(transcript)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007015"(actin filament organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|reactome:R-SCE-8980692|reactome:R-SCE-9013026|reactome:R-SCE-9013148|reactome:R-SCE-9013423|ensembl:YDL135C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.000177008787807793 ) paralog2 (YDL123W)-prey (YDL135C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:c6hedxvS0nm7P/LTsqjdfAoC49k559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:W/VWrTX1qi8B8ZQ2bZyyw3hd39g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53049	uniprotkb:Q02201	intact:EBI-29324|uniprotkb:D6VV58|ensemblfungi:YGR281W	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:yor1_yeast(display_long)|uniprotkb:YOR1(gene name)|psi-mi:YOR1(display_short)|uniprotkb:ABC transporter YOR1(gene name synonym)|uniprotkb:"ABC-type Cd(2+) transporter"(gene name synonym)|uniprotkb:ABC-type glutathione-S-conjugate transporter(gene name synonym)|uniprotkb:YRS1(gene name synonym)|uniprotkb:Yeast oligomycin resistance protein 1(gene name synonym)|uniprotkb:YGR281W(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713111|imex:IM-26166-6620	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003513|refseq:NP_011797.3|dip:DIP-6796N|mint:P53049|ensemblfungi:YGR281W(gene)|ensemblfungi:YGR281W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008551"(P-type cadmium transporter activity)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0015434"(ABC-type cadmium transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071944"(cell periphery)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030244|interpro:IPR036640|reactome:R-SCE-2142850|reactome:R-SCE-382556|ensembl:YGR281W(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00299794716986317 ) paralog2 (YKR003W)-prey (YGR281W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:p71p+cqRzx+Iry0pb2s6q2DdPzA559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:tM4PvFielPXEvWxuWSnAm2fi7s4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12256	uniprotkb:Q02201	intact:EBI-37213|uniprotkb:D6W2X3|ensemblfungi:YOR273C	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:tpo4_yeast(display_long)|uniprotkb:TPO4(gene name)|psi-mi:TPO4(display_short)|uniprotkb:O5440(orf name)|uniprotkb:YOR273C(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713123|imex:IM-26166-6842	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014916.1|sgd:S000005799|mint:Q12256|dip:DIP-4096N|ensemblfungi:YOR273C(gene)|ensemblfungi:YOR273C_mRNA(transcript)|go:"GO:0000296"(spermine transport)|go:"GO:0000297"(spermine transmembrane transporter activity)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015297"(antiporter activity)|go:"GO:0015606"(spermidine transmembrane transporter activity)|go:"GO:0015848"(spermidine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR036259|ensembl:YOR273C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.000891378759779404 ) paralog2 (YKR003W)-prey (YOR273C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:0b5bKjS3gQ/O9NkoLugh6okqwOs559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:2ZumC9Z8119zxO9FmcL36fm9OM0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38795	uniprotkb:Q07549	intact:EBI-11799|ensemblfungi:YHR074W|uniprotkb:D3DL24	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:nade_yeast(display_long)|uniprotkb:QNS1(gene name)|psi-mi:QNS1(display_short)|uniprotkb:"NAD(+) synthase [glutamine-hydrolyzing]"(gene name synonym)|uniprotkb:YHR074W(locus name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713135|imex:IM-26166-6540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003694(NAD+ synthase)|interpro:IPR014445("Glutamine-dependent NAD(+) synthetase, GAT region")|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR022310|interpro:IPR036526|reactome:R-SCE-196807|ensemblfungi:YHR074W(gene)|ensemblfungi:YHR074W_mRNA(transcript)|go:"GO:0003952"("NAD+ synthase (glutamine-hydrolyzing) activity")|go:"GO:0004359"(glutaminase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009435"(NAD biosynthetic process)|interpro:IPR003010(Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase)|refseq:NP_011941.1|sgd:S000001116|dip:DIP-5592N|mint:P38795|ensembl:YHR074W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	crc64:ED8C723550F9E8A9	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.00669609852898685 ) paralog2 (YDL123W)-prey (YHR074W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Vlj8G6/f0t/V+e1SPoDI/YhrnIM559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:bhP4AN6Q8O4mjTf/bey3i6WMe6E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39719	uniprotkb:Q07549	intact:EBI-20703|uniprotkb:Q05165|uniprotkb:D6VPG5|ensemblfungi:YAL053W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:flc2_yeast(display_long)|uniprotkb:YAL053W(locus name)|uniprotkb:FLC2(gene name)|psi-mi:FLC2(display_short)|uniprotkb:FAD transporter 2(gene name synonym)|uniprotkb:TRP-like ion channel FLC2(gene name synonym)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713147|imex:IM-26166-6756	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009348.2|sgd:S000000049|ensemblfungi:YAL053W(gene)|ensemblfungi:YAL053W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|go:"GO:0055085"(transmembrane transport)|dip:DIP-6708N|mint:P39719|ensembl:YAL053W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.00239218899710561 ) paralog2 (YDL123W)-prey (YAL053W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:NOmMW54DNa0o7vM945DlZgVUy44559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:AmCmeJLLdXkLdkVKTFD1+JjCFvY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53324	uniprotkb:P14359	intact:EBI-23602|uniprotkb:D6VV42|ensemblfungi:YGR263C	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:say1_yeast(display_long)|uniprotkb:SAY1(gene name)|psi-mi:SAY1(display_short)|uniprotkb:YGR263C(locus name)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713159|imex:IM-26166-6694	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011779.3|sgd:S000003495|dip:DIP-5103N|mint:P53324|ensemblfungi:YGR263C(gene)|ensemblfungi:YGR263C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0034084"(steryl deacetylase activity)|go:"GO:0034210"(sterol deacetylation)|go:"GO:0071944"(cell periphery)|interpro:IPR019436|interpro:IPR029058|ensembl:YGR263C(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:EB0D1D6078CD6516	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 0.000381614045846027 ) paralog2 (YJL151C)-prey (YGR263C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:+fIQb4Lo1yoaik8zQSwSFS01qXA559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:lfnXeXOA1BEIjZzLtsumyFUXjg0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02201	uniprotkb:Q07549	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713171|imex:IM-26166-6990	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.000267821213146336 ) paralog2 (YDL123W)-prey (YKR003W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:l3GjJnyMYefT2t3swpC3Zs7ICOU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04410	uniprotkb:P14359	intact:EBI-32083|uniprotkb:D6VTD8|ensemblfungi:YDR517W	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:grh1_yeast(display_long)|uniprotkb:GRH1(gene name)|psi-mi:GRH1(display_short)|uniprotkb:YDR517W(locus name)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713195|imex:IM-26166-6542	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010805.1|sgd:S000002925|dip:DIP-6613N|mint:Q04410|ensemblfungi:YDR517W(gene)|ensemblfungi:YDR517W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0009306"(protein secretion)|go:"GO:0031090"(organelle membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR007583(GRASP55/65)|interpro:IPR024958|interpro:IPR036034|rcsb pdb:6G8Y|reactome:R-SCE-162658|reactome:R-SCE-204005|ensembl:YDR517W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:A7CE62DFE4631214	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 0.000100610709892147 ) paralog2 (YJL151C)-prey (YDR517W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Tj4Jf1BeT57ROzFoNoi+g9GLuYk559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:vgJ/PRXdCLgoac2ZNswAQmX0My0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36027	uniprotkb:P38310	intact:EBI-10901|uniprotkb:P41944|ensemblfungi:YLR332W|uniprotkb:D6VYX3	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:mid2_yeast(display_long)|uniprotkb:SMS1(gene name synonym)|uniprotkb:L8543.19(orf name)|uniprotkb:YLR332W(locus name)|uniprotkb:MID2(gene name)|psi-mi:MID2(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:Mating pheromone-induced death protein 2(gene name synonym)|uniprotkb:Serine-rich multicopy suppressor protein 1(gene name synonym)|uniprotkb:Protein kinase A interference protein 1(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713183|imex:IM-26166-6622	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR332W(gene)|ensemblfungi:YLR332W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000767"(cell morphogenesis involved in conjugation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010447"(response to acidic pH)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043332"(mating projection tip)|interpro:IPR007567(Mid2 like cell wall stress sensor)|refseq:NP_013436.1|sgd:S000004324|mint:P36027|dip:DIP-4676N|ensembl:YLR332W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.000104547265070041 ) paralog2 (YBR207W)-prey (YLR332W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:o4cMDBqIZorgGZ6iEACUFcfgO7I559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:MYaaBa3DTREt9HJnOq9rIWukOgE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19146	uniprotkb:Q07549	intact:EBI-2820|uniprotkb:A2TBP3|uniprotkb:D6VRL1|ensemblfungi:YDL137W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:arf2_yeast(display_long)|uniprotkb:ARF2(gene name)|psi-mi:ARF2(display_short)|uniprotkb:D2165(orf name)|uniprotkb:YDL137W(locus name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713219|imex:IM-26166-6696	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010144.1|sgd:S000002296|dip:DIP-2215N|mint:P19146|ensemblfungi:YDL137W(gene)|ensemblfungi:YDL137W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:1MR3|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL137W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	crc64:7E43FF792E8D64E8	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.000629302013308903 ) paralog2 (YDL123W)-prey (YDL137W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:I4V9cXleaZ2sAE2DXGKt8zpAPzw559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:nlt/6iuUxOGOC0zmE+TfuiRoQig	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40368	uniprotkb:Q12443	intact:EBI-12331|ensemblfungi:YJL061W|uniprotkb:D6VWC1	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:nup82_yeast(display_long)|uniprotkb:NUP82(gene name)|psi-mi:NUP82(display_short)|uniprotkb:YJL061W(locus name)|uniprotkb:J1135(orf name)|uniprotkb:HRB187(orf name)|uniprotkb:Nuclear pore protein NUP82(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713207|imex:IM-26166-6904	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012474.1|sgd:S000003597|ensemblfungi:YJL061W(gene)|ensemblfungi:YJL061W_mRNA(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0005634"(nucleus)|interpro:IPR037700|rcsb pdb:3PBP|rcsb pdb:3TKN|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0044612"(nuclear pore linkers)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|mint:P40368|dip:DIP-913N|ensembl:YJL061W(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:C379B5E111E26B50	crc64:E937E2B77759DFF5	comment:"paralog1 (YDR233C) depletion signifcantly increases (FDR-corrected p-value: 5.48693793571315E-05 ) paralog2 (YDL204W)-prey (YJL061W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:g1+jqOMmde8phrNI9H7nFlXwjH0559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:+qq4aSJ/5Iol3Eoj4b5eyd5taPY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53924	uniprotkb:P53924	intact:EBI-28867|uniprotkb:B0KZS8|uniprotkb:B0KZU6|uniprotkb:B0KZW4|uniprotkb:B0L009|uniprotkb:Q66GT0|uniprotkb:D6W166|ensemblfungi:YNL116W	intact:EBI-28867|uniprotkb:B0KZS8|uniprotkb:B0KZU6|uniprotkb:B0KZW4|uniprotkb:B0L009|uniprotkb:Q66GT0|uniprotkb:D6W166|ensemblfungi:YNL116W	psi-mi:dma2_yeast(display_long)|uniprotkb:CHF2(gene name synonym)|uniprotkb:DMA2(gene name)|psi-mi:DMA2(display_short)|uniprotkb:Defective in mitotic arrest protein 2(gene name synonym)|uniprotkb:Checkpoint forkhead associated with RING domains-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DMA2(gene name synonym)|uniprotkb:N1925(orf name)|uniprotkb:YNL116W(locus name)	psi-mi:dma2_yeast(display_long)|uniprotkb:CHF2(gene name synonym)|uniprotkb:DMA2(gene name)|psi-mi:DMA2(display_short)|uniprotkb:Defective in mitotic arrest protein 2(gene name synonym)|uniprotkb:Checkpoint forkhead associated with RING domains-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DMA2(gene name synonym)|uniprotkb:N1925(orf name)|uniprotkb:YNL116W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713243|imex:IM-26166-6992	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005060|refseq:NP_014283.3|dip:DIP-1774N|mint:P53924|ensemblfungi:YNL116W(gene)|ensemblfungi:YNL116W_mRNA(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000921"(septin ring assembly)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005934"(cellular bud tip)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031030"(negative regulation of septation initiation signaling)|go:"GO:0031578"(mitotic spindle orientation checkpoint signaling)|go:"GO:0032153"(cell division site)|go:"GO:0032177"(cellular bud neck split septin rings)|go:"GO:0032186"(cellular bud neck septin ring organization)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090337"(regulation of formin-nucleated actin cable assembly)|go:"GO:0097271"(protein localization to bud neck)|go:"GO:1902364"(negative regulation of protein localization to spindle pole body)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042823|reactome:R-SCE-532668|ensembl:YNL116W(identity)	sgd:S000005060|refseq:NP_014283.3|dip:DIP-1774N|mint:P53924|ensemblfungi:YNL116W(gene)|ensemblfungi:YNL116W_mRNA(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000921"(septin ring assembly)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005934"(cellular bud tip)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031030"(negative regulation of septation initiation signaling)|go:"GO:0031578"(mitotic spindle orientation checkpoint signaling)|go:"GO:0032153"(cell division site)|go:"GO:0032177"(cellular bud neck split septin rings)|go:"GO:0032186"(cellular bud neck septin ring organization)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090337"(regulation of formin-nucleated actin cable assembly)|go:"GO:0097271"(protein localization to bud neck)|go:"GO:1902364"(negative regulation of protein localization to spindle pole body)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042823|reactome:R-SCE-532668|ensembl:YNL116W(identity)	-	crc64:AE1BD2D617221607	crc64:AE1BD2D617221607	comment:"paralog1 (YHR115C) depletion signifcantly increases (FDR-corrected p-value: 1.73055453345994E-05 ) paralog2 (YNL116W)-prey (YNL116W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Yiml+05RR3OVAkhB8G0Pudpw6HI559292	rogid:Yiml+05RR3OVAkhB8G0Pudpw6HI559292	rigid:Vjh6vJnGPms6jHZq1bDvkksFKjc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32500	uniprotkb:Q05166	intact:EBI-11950|ensemblfungi:YML031W|uniprotkb:D6VZE3	intact:EBI-3035|uniprotkb:Q12456|uniprotkb:E9P903|uniprotkb:D6VRR0|ensemblfungi:YDL088C	psi-mi:ndc1_yeast(display_long)|uniprotkb:YML031W(locus name)|uniprotkb:NDC1(gene name)|psi-mi:NDC1(display_short)|uniprotkb:Nuclear pore protein NDC1(gene name synonym)|uniprotkb:Nuclear division cycle protein 1(gene name synonym)	psi-mi:nup59_yeast(display_long)|uniprotkb:ASM4(gene name)|psi-mi:ASM4(display_short)|uniprotkb:Nuclear pore protein NUP59(gene name synonym)|uniprotkb:NUP59(gene name synonym)|uniprotkb:D2420(orf name)|uniprotkb:YDL088C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713255|imex:IM-26166-6844	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML031W(gene)|ensemblfungi:YML031W_mRNA(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030474"(spindle pole body duplication)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|go:"GO:0070631"(spindle pole body localization)|go:"GO:0070762"(nuclear pore transmembrane ring)|go:"GO:0106166"(spindle pole body-nuclear membrane anchor activity)|interpro:IPR019049|go:"GO:0017056"(structural constituent of nuclear pore)|refseq:NP_013681.1|sgd:S000004493|mint:P32500|dip:DIP-1465N|ensembl:YML031W(identity)	refseq:NP_010195.1|sgd:S000002246|dip:DIP-1466N|mint:Q05166|ensemblfungi:YDL088C(gene)|ensemblfungi:YDL088C_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051301"(cell division)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|ensembl:YDL088C(identity)	-	-	-	comment:"paralog1 (YMR153W) depletion signifcantly increases (FDR-corrected p-value: 0.000487890905430082 ) paralog2 (YDL088C)-prey (YML031W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:CJawnqL6UYhpSqsKMbif8ifzgUY559292	rogid:t8/JWDKB0Spe2P8qdZnKs/RB3SY559292	rigid:ISJRySoF8A4QH55nfl6aOvr1q4E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32798	uniprotkb:P38310	intact:EBI-5006|uniprotkb:D6W314|ensemblfungi:YOR316C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:cot1_yeast(display_long)|uniprotkb:COT1(gene name)|psi-mi:COT1(display_short)|uniprotkb:O6131(orf name)|uniprotkb:YOR316C(locus name)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713267|imex:IM-26166-6906	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005843|refseq:NP_014961.3|dip:DIP-7554N|mint:P32798|ensemblfungi:YOR316C(gene)|ensemblfungi:YOR316C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006824"(cobalt ion transport)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0015087"(cobalt ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-SCE-425410|ensembl:YOR316C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.000489608159001173 ) paralog2 (YBR207W)-prey (YOR316C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:HEIg6lhS698E9H3BJeESYAipNwA559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:K1zSCFzWWm7XbjHjjZtmjtnbct8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12127	uniprotkb:Q06144	intact:EBI-5303|uniprotkb:D6VYB0|ensemblfungi:YLR110C	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	psi-mi:ccw12_yeast(display_long)|uniprotkb:CCW12(gene name)|psi-mi:CCW12(display_short)|uniprotkb:YLR110C(locus name)|uniprotkb:L9354.7(orf name)|uniprotkb:Protein Alpha0.6(gene name synonym)	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713279|imex:IM-26166-6994	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004100|refseq:NP_013211.1|dip:DIP-4570N|mint:Q12127|ensemblfungi:YLR110C(gene)|ensemblfungi:YLR110C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000752"(agglutination involved in conjugation with cellular fusion)|go:"GO:0005199"(structural constituent of cell wall)|go:"GO:0005576"(extracellular region)|go:"GO:0005934"(cellular bud tip)|go:"GO:0009277"(fungal-type cell wall)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0043332"(mating projection tip)|go:"GO:0071944"(cell periphery)|interpro:IPR025928|ensembl:YLR110C(identity)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	-	-	crc64:2F474503CAB7C195	comment:"paralog1 (YGR038W) depletion signifcantly increases (FDR-corrected p-value: 0.000312415244545345 ) paralog2 (YLR350W)-prey (YLR110C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:a43bKccHJ97vpmespaaZH0ADZ8U559292	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rigid:Udk+YOOfsChS5rPHgnFeDBY8cso	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19807	uniprotkb:P38310	intact:EBI-8409|uniprotkb:D6VU67|ensemblfungi:YGL077C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:hnm1_yeast(display_long)|uniprotkb:YGL077C(locus name)|uniprotkb:HNM1(gene name)|psi-mi:HNM1(display_short)|uniprotkb:CTR(gene name synonym)|uniprotkb:CTR1(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713291|imex:IM-26166-6846	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011438.1|sgd:S000003045|mint:P19807|dip:DIP-7965N|ensemblfungi:YGL077C(gene)|ensemblfungi:YGL077C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006865"(amino acid transport)|go:"GO:0015220"(choline transmembrane transporter activity)|go:"GO:0015871"(choline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0034228"(ethanolamine transmembrane transporter activity)|go:"GO:0034229"(ethanolamine transport)|go:"GO:0071944"(cell periphery)|go:"GO:1900749"("(R)-carnitine transport")|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|interpro:IPR002293(Amino acid/polyamine transporter I)|interpro:IPR004756(Amino acid permease subfamily)|interpro:IPR004840(Amino acid permease, conserved site)|ensembl:YGL077C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.000304321397912985 ) paralog2 (YBR207W)-prey (YGL077C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:FiBH5o16YuOHdiAMTRZyChHHMos559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:lnUZ4LsAKHmHrD4CtRwMqsvvbTk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11076	uniprotkb:P22140	intact:EBI-2816|uniprotkb:D6VRG1|ensemblfungi:YDL192W	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:arf1_yeast(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)|uniprotkb:D1244(orf name)|uniprotkb:YDL192W(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713303|imex:IM-26166-6758	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010089.1|sgd:S000002351|dip:DIP-2213N|mint:P11076|ensemblfungi:YDL192W(gene)|ensemblfungi:YDL192W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:2K5U|rcsb pdb:2KSQ|rcsb pdb:3TJZ|rcsb pdb:4Q66|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL192W(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	crc64:796859026AC63CC0	-	comment:"paralog1 (YNL130C) depletion signifcantly increases (FDR-corrected p-value: 0.000176158758704664 ) paralog2 (YHR123W)-prey (YDL192W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IX/zwfWagjieSKB1ShJ9P0kq1ZE559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:iHmlBJxJZ81egMc3oHb3JIYR+Ts	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07804	uniprotkb:Q07549	intact:EBI-36254|uniprotkb:D6VXZ0|ensemblfungi:YLL012W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:yeh1_yeast(display_long)|uniprotkb:Steryl ester hydrolase 1(gene name synonym)|uniprotkb:YEH1(gene name)|psi-mi:YEH1(display_short)|uniprotkb:YLL012W(locus name)|uniprotkb:L1329(orf name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713315|imex:IM-26166-6908	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013089.1|sgd:S000003935|mint:Q07804|dip:DIP-4156N|ensemblfungi:YLL012W(gene)|ensemblfungi:YLL012W_mRNA(transcript)|go:"GO:0004771"(sterol esterase activity)|go:"GO:0005811"(lipid droplet)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016125"(sterol metabolic process)|interpro:IPR006693(AB-hydrolase associated lipase region)|interpro:IPR029058|reactome:R-SCE-192456|reactome:R-SCE-6809371|ensembl:YLL012W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog1 (YDR276C) depletion signifcantly increases (FDR-corrected p-value: 0.000180086281359232 ) paralog2 (YDL123W)-prey (YLL012W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Fv+RBBi6c7i++sW0AISZDXDrlrI559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:Og3UPRy0OgVFrF3lTUxCOMCl6aE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53290	uniprotkb:P14359	intact:EBI-7962|uniprotkb:D6VUU7|ensemblfungi:YGR163W	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:gtr2_yeast(display_long)|uniprotkb:YGR163W(locus name)|uniprotkb:GTR2(gene name)|psi-mi:GTR2(display_short)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713327|imex:IM-26166-6624	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003395|refseq:NP_011679.3|mint:P53290|dip:DIP-4521N|ensemblfungi:YGR163W(gene)|ensemblfungi:YGR163W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000785"(chromatin)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3R7W|rcsb pdb:4ARZ|rcsb pdb:6JWP|reactome:R-SCE-165159|reactome:R-SCE-9639288|ensembl:YGR163W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:0A0D16C81F73184D	crc64:DBA26AF5B769C02A	comment:"paralog1 (YDR525W-A) depletion signifcantly increases (FDR-corrected p-value: 1.73055453345994E-05 ) paralog2 (YJL151C)-prey (YGR163W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:+b9bPvzin/YUc5fOZZVCcFu/GEM559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:PelU0/5GfQMgBkhG2yMt/fLOc78	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43603	uniprotkb:P53309	intact:EBI-22980|uniprotkb:D6VTQ4|ensemblfungi:YFR024C-A	intact:EBI-23557|uniprotkb:D6VV22|ensemblfungi:YGR241C	psi-mi:lsb3_yeast(display_long)|uniprotkb:LSB3(gene name)|psi-mi:LSB3(display_short)|uniprotkb:YFR024C(orf name)|uniprotkb:YFR024C-A(locus name)	psi-mi:ap18b_yeast(display_long)|uniprotkb:G8610(orf name)|uniprotkb:YGR241C(locus name)|uniprotkb:YAP1802(gene name)|psi-mi:YAP1802(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713339|imex:IM-26166-6910	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002968|refseq:NP_219497.4|dip:DIP-6259N|mint:P43603|ensemblfungi:YFR024C-A(gene)|ensemblfungi:YFR024C-A_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005935"(cellular bud neck)|go:"GO:0030479"(actin cortical patch)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051666"(actin cortical patch localization)|interpro:IPR001452(Src homology-3)|interpro:IPR007461(Protein of unknown function DUF500)|interpro:IPR033643|interpro:IPR036028|rcsb pdb:1OOT|rcsb pdb:1SSH|ensembl:YFR024C-A(identity)	refseq:NP_011757.3|sgd:S000003473|dip:DIP-2751N|mint:P53309|ensemblfungi:YGR241C(gene)|ensemblfungi:YGR241C_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|ensembl:YGR241C(identity)	-	crc64:F486C787B5771AAC	-	comment:"paralog1 (YHR161C) depletion signifcantly increases (FDR-corrected p-value: 0.000895509036030704 ) paralog2 (YGR241C)-prey (YFR024C-A) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:zKMZQRpG4d/at/NecQDyEi/kVKg559292	rogid:fbC/HO6axa7TLPJAvYbKc1jlQjQ559292	rigid:BLDND8LIk0Epdx4cyE5KvFs1lVw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13586	uniprotkb:Q05031	intact:EBI-3091|uniprotkb:D6VTY5|ensemblfungi:YGL167C	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:atc1_yeast(display_long)|uniprotkb:PMR1(gene name)|psi-mi:PMR1(display_short)|uniprotkb:BSD1(gene name synonym)|uniprotkb:SCC1(gene name synonym)|uniprotkb:YGL167C(locus name)|uniprotkb:G1666(orf name)|uniprotkb:Bypass SOD defects protein 1(gene name synonym)|uniprotkb:"Golgi Ca(2+)-ATPase"(gene name synonym)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713351|imex:IM-26166-6996	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011348.1|sgd:S000003135|dip:DIP-7899N|mint:P13586|ensemblfungi:YGL167C(gene)|ensemblfungi:YGL167C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030026"(cellular manganese ion homeostasis)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-936837|ensembl:YGL167C(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	-	-	comment:"paralog1 (YKL046C) depletion signifcantly increases (FDR-corrected p-value: 6.13980104953924E-05 ) paralog2 (YMR238W)-prey (YGL167C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:FUAnYBfq0rUKxq1wSTgwAx7W6yA559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:fxtjoyTAjeZ47z9KKr3hc5D2l3k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40260	uniprotkb:Q02201	intact:EBI-10714|ensemblfungi:YGR121C|uniprotkb:D6VUQ2	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:mep1_yeast(display_long)|uniprotkb:MEP1(gene name)|psi-mi:MEP1(display_short)|uniprotkb:YGR121C(locus name)|uniprotkb:G6331(orf name)|uniprotkb:AMT1(gene name synonym)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713363|imex:IM-26166-6626	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR121C(gene)|ensemblfungi:YGR121C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015696"|go:"GO:0019740"(nitrogen utilization)|interpro:IPR001905(Ammonium transporter)|interpro:IPR018047|interpro:IPR024041|interpro:IPR029020|sgd:S000003353|refseq:NP_011636.3|mint:P40260|dip:DIP-5530N|ensembl:YGR121C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00176245576444665 ) paralog2 (YKR003W)-prey (YGR121C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:VnoBl5jhQD24N0SbCLv68HCwl1U559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:a4Z2no2CH44ZmA0RWwvNoEEaOr0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36024	uniprotkb:P17898	intact:EBI-17250|uniprotkb:D6VXD3|ensemblfungi:YKR072C	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:sis2_yeast(display_long)|uniprotkb:SIS2(gene name)|psi-mi:SIS2(display_short)|uniprotkb:HAL3(gene name synonym)|uniprotkb:YKR072C(locus name)|uniprotkb:Halotolerance protein HAL3(gene name synonym)|uniprotkb:Sit4 suppressor 2(gene name synonym)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713375|imex:IM-26166-6698	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012998.1|sgd:S000001780|ensemblfungi:YKR072C(gene)|ensemblfungi:YKR072C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003824"(catalytic activity)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0009651"(response to salt stress)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|dip:DIP-2521N|mint:P36024|ensembl:YKR072C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog1 (YHR123W) depletion signifcantly increases (FDR-corrected p-value: 0.00402643625978852 ) paralog2 (YNL130C)-prey (YKR072C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:oiDiGYmZy7PE7zchnyTa2x4g9zo559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:6/YjqC4EB4pKzwrEOJbTZLx36no	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11076	uniprotkb:P38310	intact:EBI-2816|uniprotkb:D6VRG1|ensemblfungi:YDL192W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:arf1_yeast(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)|uniprotkb:D1244(orf name)|uniprotkb:YDL192W(locus name)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713231|imex:IM-26166-6544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010089.1|sgd:S000002351|dip:DIP-2213N|mint:P11076|ensemblfungi:YDL192W(gene)|ensemblfungi:YDL192W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:2K5U|rcsb pdb:2KSQ|rcsb pdb:3TJZ|rcsb pdb:4Q66|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL192W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:796859026AC63CC0	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 1.72723136028032E-05 ) paralog2 (YBR207W)-prey (YDL192W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IX/zwfWagjieSKB1ShJ9P0kq1ZE559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:lbRCRYXI3UqgpgTZE97AKiM2iC0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38084	uniprotkb:Q06144	intact:EBI-3414|uniprotkb:D6VQ67|ensemblfungi:YBR068C	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	psi-mi:bap2_yeast(display_long)|uniprotkb:Branched-chain amino-acid permease 2(gene name synonym)|uniprotkb:BAP2(gene name)|psi-mi:BAP2(display_short)|uniprotkb:YBR068C(locus name)|uniprotkb:YBR0629(orf name)	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713410|imex:IM-26166-6848	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000272|refseq:NP_009624.4|dip:DIP-4910N|mint:P38084|ensemblfungi:YBR068C(gene)|ensemblfungi:YBR068C_mRNA(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015192"(L-phenylalanine transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0098713"(leucine import across plasma membrane)|interpro:IPR004762(Amino acid permease, fungi)|interpro:IPR004840(Amino acid permease, conserved site)|interpro:IPR004841(Amino acid permease-associated region)|ensembl:YBR068C(identity)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	-	crc64:B87FD6A7464E07F5	crc64:2F474503CAB7C195	comment:"paralog1 (YGR038W) depletion signifcantly increases (FDR-corrected p-value: 0.00185288280505575 ) paralog2 (YLR350W)-prey (YBR068C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:7Fw7+M5mBikZBztHE2tSDpvBi/M559292	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rigid:DkTfBERKTQm4I4idRdWPo09OuH8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:P32784	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-2086016|uniprotkb:D6VPY8|uniprotkb:Q07062|uniprotkb:Q96TV1|ensemblfungi:YBL011W	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:gpt1_yeast(display_long)|uniprotkb:SCT1(gene name)|psi-mi:SCT1(display_short)|uniprotkb:GAT2(gene name synonym)|uniprotkb:Dihydroxyacetone phosphate acyltransferase 1(gene name synonym)|uniprotkb:Glycerol-3-phosphate / dihydroxyacetone phosphate acyltransferase 1(gene name synonym)|uniprotkb:YBL0315(orf name)|uniprotkb:YBL0309(orf name)|uniprotkb:YBL011W(locus name)|uniprotkb:Suppressor of choline-transport mutants 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713398|imex:IM-26166-6998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	refseq:NP_009542.1|sgd:S000000107|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|mint:P32784|ensemblfungi:YBL011W(gene)|ensemblfungi:YBL011W_mRNA(transcript)|go:"GO:0004366"(glycerol-3-phosphate O-acyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|go:"GO:0016287"(glycerone-phosphate O-acyltransferase activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0102420"("sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity")|ensembl:YBL011W(identity)	-	crc64:245575E65D3C2193	-	comment:"paralog1 (YKR067W) depletion signifcantly increases (FDR-corrected p-value: 0.000465428380495026 ) paralog2 (YBL011W)-prey (YDR233C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:hP001xiUKC8ioTODiwrYiPAwhVU559292	rigid:UYNH7eyo25sBHnwsusiw5/oMhXg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39010	uniprotkb:P22140	intact:EBI-2421|uniprotkb:D6VSP8|ensemblfungi:YDR264C	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:akr1_yeast(display_long)|uniprotkb:AKR1(gene name)|psi-mi:AKR1(display_short)|uniprotkb:YDR264C(locus name)|uniprotkb:D9954.9(orf name)|uniprotkb:YD9230B.03C(orf name)|uniprotkb:Ankyrin repeat-containing protein AKR1(gene name synonym)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713458|imex:IM-26166-6628	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010550.1|sgd:S000002672|dip:DIP-1145N|mint:P39010|ensemblfungi:YDR264C(gene)|ensemblfungi:YDR264C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016409"(palmitoyltransferase activity)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0090029"(negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion)|interpro:IPR001594(Zinc finger, DHHC-type)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|ensembl:YDR264C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog1 (YNL130C) depletion signifcantly increases (FDR-corrected p-value: 1.82334012732756E-05 ) paralog2 (YHR123W)-prey (YDR264C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:INuSfspu5JYfFnlcgzVdvDeTerU559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:bffOzwHEh0zet/MiUKvXgMWz7ug	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33327	uniprotkb:Q12443	intact:EBI-5815|ensemblfungi:YDL215C|uniprotkb:D6VRD9	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:dhe2_yeast(display_long)|uniprotkb:YDL215C(locus name)|uniprotkb:GDH2(gene name)|psi-mi:GDH2(display_short)|uniprotkb:D0892(orf name)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713446|imex:IM-26166-7000	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YDL215C(gene)|ensemblfungi:YDL215C_mRNA(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0019551"(glutamate catabolic process to 2-oxoglutarate)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR016210(Glutamate dehydrogenase, NAD-dependent)|interpro:IPR033524|interpro:IPR036291|refseq:NP_010066.1|sgd:S000002374|dip:DIP-1689N|mint:P33327|ensembl:YDL215C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:DF8358D831E4545F	crc64:E937E2B77759DFF5	comment:"paralog1 (YDR233C) depletion signifcantly increases (FDR-corrected p-value: 1.41637873884944E-05 ) paralog2 (YDL204W)-prey (YDL215C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:bjvKAO4gyrNUq2Wwq3Y+FvEv7RM559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:wvwjgMS8SCHzvE0R1Gr5rYEmOEE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33413	uniprotkb:Q02201	intact:EBI-2060312|uniprotkb:D3DKP5|ensemblfungi:YHL016C	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:dur3_yeast(display_long)|uniprotkb:DUR3(gene name)|psi-mi:DUR3(display_short)|uniprotkb:YHL016C(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713434|imex:IM-26166-6760	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031155|refseq:NP_011847.1|sgd:S000001008|interpro:IPR001734(Na+/solute symporter)|interpro:IPR038377|mint:P33413|ensemblfungi:YHL016C(gene)|ensemblfungi:YHL016C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015489"(putrescine transmembrane transporter activity)|go:"GO:0015606"(spermidine transmembrane transporter activity)|go:"GO:0015840"(urea transport)|go:"GO:0015847"(putrescine transport)|go:"GO:0015848"(spermidine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071944"(cell periphery)|ensembl:YHL016C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog1 (YHR001W) depletion signifcantly increases (FDR-corrected p-value: 0.00278933058121141 ) paralog2 (YKR003W)-prey (YHL016C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:oTFsdtOngA3q5wCbhK/fpVlIsz0559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:j/gEjqGdUXY8GyHB2Ko2EQzf8Mw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32366	uniprotkb:P37296	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-18479|uniprotkb:D6VZM9|ensemblfungi:YMR054W	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:stv1_yeast(display_long)|uniprotkb:STV1(gene name)|psi-mi:STV1(display_short)|uniprotkb:YMR054W(locus name)|uniprotkb:YM9796.07(orf name)|uniprotkb:V-ATPase 101 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit AC115(gene name synonym)|uniprotkb:Similar to VPH1 protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 2(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713422|imex:IM-26166-6486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N|ensembl:YLR447C(identity)	refseq:NP_013770.1|sgd:S000004658|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YMR054W(gene)|ensemblfungi:YMR054W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-4450N|mint:P37296|ensembl:YMR054W(identity)	-	crc64:53A19450CAF35632	-	comment:"paralog1 (YOR270C) depletion signifcantly increases (FDR-corrected p-value: 0.00131979940563079 ) paralog2 (YMR054W)-prey (YLR447C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:gqntHtP6AtAjACy5Az0QpXAfL10559292	rigid:KUwFK+Os4BlyyG/lPKIX7TdTMcA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53262	uniprotkb:P38856	intact:EBI-2061527|uniprotkb:D6VUN8|ensemblfungi:YGR106C	intact:EBI-24811|uniprotkb:D3DLB0|ensemblfungi:YHR161C	psi-mi:voa1_yeast(display_long)|uniprotkb:YGR106C(locus name)|uniprotkb:VOA1(gene name)|psi-mi:VOA1(display_short)	psi-mi:ap18a_yeast(display_long)|uniprotkb:YAP1801(gene name)|psi-mi:YAP1801(display_short)|uniprotkb:YHR161C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713470|imex:IM-26166-7002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003338|refseq:NP_011620.1|mint:P53262|ensemblfungi:YGR106C(gene)|ensemblfungi:YGR106C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|ensembl:YGR106C(identity)	refseq:NP_012031.1|sgd:S000001204|mint:P38856|dip:DIP-2278N|ensemblfungi:YHR161C(gene)|ensemblfungi:YHR161C_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|ensembl:YHR161C(identity)	-	-	-	comment:"paralog1 (YGR241C) depletion signifcantly increases (FDR-corrected p-value: 0.00328567379303328 ) paralog2 (YHR161C)-prey (YGR106C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:lKLIonttSEX36IQaIKlzxS/Cdxg559292	rogid:SusWB53Amzh3hgiCoQ6zx6Y1Yx8559292	rigid:HzLaKMRvrKJ+QIau/Tc6VXU8xYc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39719	uniprotkb:P38310	intact:EBI-20703|uniprotkb:Q05165|uniprotkb:D6VPG5|ensemblfungi:YAL053W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:flc2_yeast(display_long)|uniprotkb:YAL053W(locus name)|uniprotkb:FLC2(gene name)|psi-mi:FLC2(display_short)|uniprotkb:FAD transporter 2(gene name synonym)|uniprotkb:TRP-like ion channel FLC2(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713482|imex:IM-26166-6912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009348.2|sgd:S000000049|ensemblfungi:YAL053W(gene)|ensemblfungi:YAL053W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|go:"GO:0055085"(transmembrane transport)|dip:DIP-6708N|mint:P39719|ensembl:YAL053W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 0.000219108455092326 ) paralog2 (YBR207W)-prey (YAL053W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:NOmMW54DNa0o7vM945DlZgVUy44559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:2uqlmb7ItVfXhPKkyNOVNEQaXSo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32915	uniprotkb:Q06144	intact:EBI-16400|ensemblfungi:YLR378C|uniprotkb:D6VZ14	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	psi-mi:sc61a_yeast(display_long)|uniprotkb:Sec61 complex subunit SEC61(gene name synonym)|uniprotkb:L3502.5(orf name)|uniprotkb:YLR378C(locus name)|uniprotkb:SEC61(gene name)|psi-mi:SEC61(display_short)|uniprotkb:Sec61 complex subunit alpha(gene name synonym)	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713494|imex:IM-26166-6546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070843"(misfolded protein transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:6N3Q|rcsb pdb:6ND1|rcsb pdb:7AFT|rcsb pdb:7KAH|rcsb pdb:7KAI|rcsb pdb:7KAJ|rcsb pdb:7KAO|rcsb pdb:7KAP|rcsb pdb:7KAQ|rcsb pdb:7KAR|rcsb pdb:7KAS|rcsb pdb:7KAT|rcsb pdb:7KAU|rcsb pdb:7KB5|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|ensemblfungi:YLR378C(gene)|ensemblfungi:YLR378C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|refseq:NP_013482.1|sgd:S000004370|dip:DIP-2433N|mint:P32915|ensembl:YLR378C(identity)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	-	-	crc64:2F474503CAB7C195	comment:"paralog1 (YGR038W) depletion signifcantly increases (FDR-corrected p-value: 0.000489608159001173 ) paralog2 (YLR350W)-prey (YLR378C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Gi0aAi/lO9gi5h6LMgke4advNsM559292	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rigid:WtsEtJmUO5PFBVmBTUcIkNkua7Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30605	uniprotkb:P38310	intact:EBI-2050956|uniprotkb:D6VTB9|ensemblfungi:YDR497C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:itr1_yeast(display_long)|uniprotkb:D9719.3(orf name)|uniprotkb:YDR497C(locus name)|uniprotkb:ITR1(gene name)|psi-mi:ITR1(display_short)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713506|imex:IM-26166-7004	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010785.1|sgd:S000002905|dip:DIP-7406N|mint:P30605|ensemblfungi:YDR497C(gene)|ensemblfungi:YDR497C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005365"(myo-inositol transmembrane transporter activity)|go:"GO:0005366"("myo-inositol:proton symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0015798"(myo-inositol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071944"(cell periphery)|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|ensembl:YDR497C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 2.98411633935779E-05 ) paralog2 (YBR207W)-prey (YDR497C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:GgtK4YFe7ZCZcmVpV5q1KY2F0Ds559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:uh7rbgk3jVmXdHyyXqxrZuNHj7A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69771	uniprotkb:Q06263	intact:EBI-2053489|uniprotkb:D6VX98|ensemblfungi:YKR035W-A	intact:EBI-37098|uniprotkb:Q07057|uniprotkb:D6VYI5|ensemblfungi:YLR181C	psi-mi:did2_yeast(display_long)|uniprotkb:CHM1(gene name synonym)|uniprotkb:FTI1(gene name synonym)|uniprotkb:Fifty two inhibitor 1(gene name synonym)|uniprotkb:YKR035W-A(locus name)|uniprotkb:VPS46(gene name synonym)|uniprotkb:Charged multivesicular body protein 1(gene name synonym)|uniprotkb:DOA4-independent degradation protein 2(gene name synonym)|uniprotkb:DID2(gene name)|psi-mi:DID2(display_short)	psi-mi:vta1_yeast(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:YLR181C(locus name)|uniprotkb:VPS20-associated protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713518|imex:IM-26166-6704	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000006435|refseq:NP_012961.3|dip:DIP-52223N|mint:P69771|ensemblfungi:YKR035W-A(gene)|ensemblfungi:YKR035W-A_mRNA(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015031"(protein transport)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:1904902"(ESCRT III complex assembly)|interpro:IPR005024(Snf7)|rcsb pdb:3GGZ|rcsb pdb:5H7P|ensembl:YKR035W-A(identity)	refseq:NP_013282.1|sgd:S000004171|mint:Q06263|dip:DIP-4802N|ensemblfungi:YLR181C(gene)|ensemblfungi:YLR181C_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0006869"(lipid transport)|go:"GO:0015031"(protein transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:1990621"(ESCRT IV complex)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LUH|rcsb pdb:2RKK|rcsb pdb:2RKL|rcsb pdb:3MHV|rcsb pdb:5H7P|rcsb pdb:5UIE|rcsb pdb:5XMK|rcsb pdb:6AP1|rcsb pdb:6OO2|reactome:R-SCE-917729|ensembl:YLR181C(identity)	-	crc64:70D1CF4588A8C6E6	crc64:BB6E6975596C1674	comment:"paralog1 (YNL265C) depletion signifcantly increases (FDR-corrected p-value: 2.22761193636521E-05 ) paralog2 (YLR181C)-prey (YKR035W-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:SVI1+8lRI6qwD0CSLY11Xq0LG0o559292	rogid:X9sRQb1nZECFkdjvDUTjxEgokRM559292	rigid:k2GqIufem/gaOsVQsfcoo4PWeQA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53145	uniprotkb:Q06709	intact:EBI-23885|uniprotkb:D6VU46|ensemblfungi:YGL099W	intact:EBI-35391|uniprotkb:Q7LIF0|uniprotkb:D6VZ22|ensemblfungi:YLR387C	psi-mi:lsg1_yeast(display_long)|uniprotkb:LSG1(gene name)|psi-mi:LSG1(display_short)|uniprotkb:YGL099W(locus name)	psi-mi:reh1_yeast(display_long)|uniprotkb:REH1(gene name)|psi-mi:REH1(display_short)|uniprotkb:REI1-homolog 1(gene name synonym)|uniprotkb:pre-60S factor REH1(gene name synonym)|uniprotkb:YLR387C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713530|imex:IM-26166-6630	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003067|refseq:NP_011416.3|dip:DIP-6659N|mint:P53145|ensemblfungi:YGL099W(gene)|ensemblfungi:YGL099W_mRNA(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0043332"(mating projection tip)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|rcsb pdb:5T62|rcsb pdb:6N8N|rcsb pdb:6N8O|rcsb pdb:6QIK|rcsb pdb:6QTZ|rcsb pdb:6RI5|rcsb pdb:6RZZ|rcsb pdb:6S05|ensembl:YGL099W(identity)	refseq:NP_013491.1|sgd:S000004379|mint:Q06709|dip:DIP-4235N|ensemblfungi:YLR387C(gene)|ensemblfungi:YLR387C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR040025|interpro:IPR041661|rcsb pdb:5H4P|rcsb pdb:6QIK|rcsb pdb:6QT0|rcsb pdb:6QTZ|rcsb pdb:6RI5|rcsb pdb:6S05|ensembl:YLR387C(identity)	-	crc64:15FD76541A2E8410	-	comment:"paralog1 (YBR267W) depletion signifcantly increases (FDR-corrected p-value: 0.00680193781791112 ) paralog2 (YLR387C)-prey (YGL099W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:9mANWO3rTsE/zCUr9GL6WxIexMU559292	rogid:bzQ5GpJXM3JCyK2Tk4soKDnRAg8559292	rigid:l96axlbGsEu9Av+OzU7zmPZ8PH8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32660	uniprotkb:P38856	intact:EBI-3121|uniprotkb:D3DM74|ensemblfungi:YER166W	intact:EBI-24811|uniprotkb:D3DLB0|ensemblfungi:YHR161C	psi-mi:atc5_yeast(display_long)|uniprotkb:DNF1(gene name)|psi-mi:DNF1(display_short)|uniprotkb:YER166W(locus name)|uniprotkb:SYGP-ORF7(orf name)|uniprotkb:Flippase DNF1(gene name synonym)	psi-mi:ap18a_yeast(display_long)|uniprotkb:YAP1801(gene name)|psi-mi:YAP1801(display_short)|uniprotkb:YHR161C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713542|imex:IM-26166-6850	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000968|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070867"(mating projection tip membrane)|go:"GO:0071944"(cell periphery)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR026871|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:7KY6|rcsb pdb:7KYB|rcsb pdb:7KYC|refseq:NP_011093.3|dip:DIP-7949N|mint:P32660|ensemblfungi:YER166W(gene)|ensemblfungi:YER166W_mRNA(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000749"(response to pheromone triggering conjugation with cellular fusion)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|ensembl:YER166W(identity)	refseq:NP_012031.1|sgd:S000001204|mint:P38856|dip:DIP-2278N|ensemblfungi:YHR161C(gene)|ensemblfungi:YHR161C_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|ensembl:YHR161C(identity)	-	crc64:3CC3FBA8ADDE8960	-	comment:"paralog1 (YGR241C) depletion signifcantly increases (FDR-corrected p-value: 6.84489648684459E-05 ) paralog2 (YHR161C)-prey (YER166W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:4ciEaV0aGjDqtpexkFJ0l737SpA559292	rogid:SusWB53Amzh3hgiCoQ6zx6Y1Yx8559292	rigid:tG48inoysZA/592NdOHJwtDal4A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43621	uniprotkb:P38310	intact:EBI-4876|uniprotkb:D6VTT4|ensemblfungi:YFR051C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:copd_yeast(display_long)|uniprotkb:RET2(gene name)|psi-mi:RET2(display_short)|uniprotkb:YFR051C(locus name)|uniprotkb:Delta-coat protein(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713554|imex:IM-26166-7006	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001947|refseq:NP_116709.3|dip:DIP-5255N|mint:P43621|ensemblfungi:YFR051C(gene)|ensemblfungi:YFR051C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|rcsb pdb:5FJW|rcsb pdb:5FJX|rcsb pdb:5FJZ|rcsb pdb:5FK0|reactome:R-SCE-6807878|reactome:R-SCE-6811434|ensembl:YFR051C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:AA730F046655EE5A	crc64:7B4E620ABC39A053	comment:"paralog1 (YER145C) depletion signifcantly increases (FDR-corrected p-value: 2.92919292701531E-05 ) paralog2 (YBR207W)-prey (YFR051C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:auvjuT8ffm1R4P3mRKEIWAsynW0559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:BTMa9Q54pogr4q2yL22xhXXsXPw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53278	uniprotkb:Q12443	intact:EBI-23314|uniprotkb:D6VUR2|ensemblfungi:YGR130C	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:yg3a_yeast(display_long)|uniprotkb:YGR130C(locus name)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713566|imex:IM-26166-6762	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011646.1|sgd:S000003362|dip:DIP-3006N|mint:P53278|ensemblfungi:YGR130C(gene)|ensemblfungi:YGR130C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0032126"(eisosome)|ensembl:YGR130C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:D482327C9274C026	crc64:E937E2B77759DFF5	comment:"paralog1 (YDR233C) depletion signifcantly increases (FDR-corrected p-value: 1.48455912034593E-06 ) paralog2 (YDL204W)-prey (YGR130C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:iTa1C3VXvI8QteEEgkfjQDp9gvY559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:q/dWC5/VKSFv/GKc8+aYjgYVhEE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23337	uniprotkb:P23337	intact:EBI-8031|uniprotkb:D6VTP6|ensemblfungi:YFR015C	intact:EBI-8031|uniprotkb:D6VTP6|ensemblfungi:YFR015C	psi-mi:gys1_yeast(display_long)|uniprotkb:YFR015C(locus name)|uniprotkb:GSY1(gene name)|psi-mi:GSY1(display_short)	psi-mi:gys1_yeast(display_long)|uniprotkb:YFR015C(locus name)|uniprotkb:GSY1(gene name)|psi-mi:GSY1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713578|imex:IM-26166-7008	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116670.1|sgd:S000001911|mint:P23337|dip:DIP-5354N|ensemblfungi:YFR015C(gene)|ensemblfungi:YFR015C_mRNA(transcript)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005978"(glycogen biosynthetic process)|interpro:IPR008631(Glycogen synthase)|reactome:R-SCE-3322077|ensembl:YFR015C(identity)	refseq:NP_116670.1|sgd:S000001911|mint:P23337|dip:DIP-5354N|ensemblfungi:YFR015C(gene)|ensemblfungi:YFR015C_mRNA(transcript)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005978"(glycogen biosynthetic process)|interpro:IPR008631(Glycogen synthase)|reactome:R-SCE-3322077|ensembl:YFR015C(identity)	-	crc64:9EF2D3858529E68A	crc64:9EF2D3858529E68A	comment:"paralog1 (YLR258W) depletion signifcantly increases (FDR-corrected p-value: 0.00018625522804944 ) paralog2 (YFR015C)-prey (YFR015C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:YDyqS1ELi4nkwAfLsPv+FNzh87k559292	rogid:YDyqS1ELi4nkwAfLsPv+FNzh87k559292	rigid:M6/6bKGtnj8aGzWG8ch9cBTFqAE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05359	uniprotkb:Q03790	intact:EBI-6581|uniprotkb:D6VPL7|uniprotkb:E9P8S8|ensemblfungi:YAR002C-A	intact:EBI-27321|uniprotkb:D6VZX4|ensemblfungi:YMR153W	psi-mi:erp1_yeast(display_long)|uniprotkb:ERP1(gene name)|psi-mi:ERP1(display_short)|uniprotkb:YAR002A(orf name)|uniprotkb:YAR002C-A(locus name)	psi-mi:nup53_yeast(display_long)|uniprotkb:Nuclear pore protein NUP53(gene name synonym)|uniprotkb:NUP53(gene name)|psi-mi:NUP53(display_short)|uniprotkb:YMR153W(locus name)|uniprotkb:YM8520.02(orf name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713590|imex:IM-26166-6852	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009402.1|sgd:S000002129|mint:Q05359|dip:DIP-5147N|ensemblfungi:YAR002C-A(gene)|ensemblfungi:YAR002C-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YAR002C-A(identity)	refseq:NP_013873.1|sgd:S000004762|dip:DIP-1467N|ensemblfungi:YMR153W(gene)|ensemblfungi:YMR153W_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0060188"(regulation of protein desumoylation)|go:"GO:0072417"(response to spindle checkpoint signaling)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|rcsb pdb:3W3Y|rcsb pdb:5UAZ|ensembl:YMR153W(identity)	-	-	crc64:2ECE0C561D27E523	comment:"paralog1 (YDL088C) depletion signifcantly increases (FDR-corrected p-value: 2.30374011581597E-05 ) paralog2 (YMR153W)-prey (YAR002C-A) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:RX3ynMqEVNp4bRTVb16YoXaQW3U559292	rogid:csq2oRFswkgY2JkT+dmz/L7Zpfk559292	rigid:dVVeB5+OJ71wB4ywnWhx2IYCNto	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43621	uniprotkb:P22140	intact:EBI-4876|uniprotkb:D6VTT4|ensemblfungi:YFR051C	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:copd_yeast(display_long)|uniprotkb:RET2(gene name)|psi-mi:RET2(display_short)|uniprotkb:YFR051C(locus name)|uniprotkb:Delta-coat protein(gene name synonym)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713602|imex:IM-26166-6914	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001947|refseq:NP_116709.3|dip:DIP-5255N|mint:P43621|ensemblfungi:YFR051C(gene)|ensemblfungi:YFR051C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|rcsb pdb:5FJW|rcsb pdb:5FJX|rcsb pdb:5FJZ|rcsb pdb:5FK0|reactome:R-SCE-6807878|reactome:R-SCE-6811434|ensembl:YFR051C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	crc64:AA730F046655EE5A	-	comment:"paralog1 (YNL130C) depletion signifcantly increases (FDR-corrected p-value: 0.00330890211957409 ) paralog2 (YHR123W)-prey (YFR051C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:auvjuT8ffm1R4P3mRKEIWAsynW0559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:iwRGVW4BSGA2uHfuHuEv4bqa4Ig	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06144	uniprotkb:Q06144	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713614|imex:IM-26166-6854	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	-	crc64:2F474503CAB7C195	crc64:2F474503CAB7C195	comment:"paralog1 (YGR038W) depletion signifcantly increases (FDR-corrected p-value: 0.000658527647779177 ) paralog2 (YLR350W)-prey (YLR350W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rigid:TrsCOBBW3CWFbdwa/CyW1usBCCU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:P53843	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-28245|uniprotkb:D6W0S8|ensemblfungi:YNL265C	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:ist1_yeast(display_long)|uniprotkb:YNL265C(locus name)|uniprotkb:N0809(orf name)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Increased sodium tolerance protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713626|imex:IM-26166-6632	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	refseq:NP_014134.1|sgd:S000005209|dip:DIP-6713N|mint:P53843|ensemblfungi:YNL265C(gene)|ensemblfungi:YNL265C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3GGY|rcsb pdb:3GGZ|reactome:R-SCE-6798695|reactome:R-SCE-9668328|ensembl:YNL265C(identity)	-	crc64:C86AE5ABB508EA03	-	comment:"paralog1 (YLR181C) depletion signifcantly increases (FDR-corrected p-value: 0.00468014615565185 ) paralog2 (YNL265C)-prey (YGR086C) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:c8ngH6tobftaOGIxLH8qXiOpi28559292	rigid:RDhaP5C2ntnJKEB0eWNk/juqFSk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03790	uniprotkb:Q03790	intact:EBI-27321|uniprotkb:D6VZX4|ensemblfungi:YMR153W	intact:EBI-27321|uniprotkb:D6VZX4|ensemblfungi:YMR153W	psi-mi:nup53_yeast(display_long)|uniprotkb:Nuclear pore protein NUP53(gene name synonym)|uniprotkb:NUP53(gene name)|psi-mi:NUP53(display_short)|uniprotkb:YMR153W(locus name)|uniprotkb:YM8520.02(orf name)	psi-mi:nup53_yeast(display_long)|uniprotkb:Nuclear pore protein NUP53(gene name synonym)|uniprotkb:NUP53(gene name)|psi-mi:NUP53(display_short)|uniprotkb:YMR153W(locus name)|uniprotkb:YM8520.02(orf name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713638|imex:IM-26166-6548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013873.1|sgd:S000004762|dip:DIP-1467N|ensemblfungi:YMR153W(gene)|ensemblfungi:YMR153W_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0060188"(regulation of protein desumoylation)|go:"GO:0072417"(response to spindle checkpoint signaling)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|rcsb pdb:3W3Y|rcsb pdb:5UAZ|ensembl:YMR153W(identity)	refseq:NP_013873.1|sgd:S000004762|dip:DIP-1467N|ensemblfungi:YMR153W(gene)|ensemblfungi:YMR153W_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0060188"(regulation of protein desumoylation)|go:"GO:0072417"(response to spindle checkpoint signaling)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|rcsb pdb:3W3Y|rcsb pdb:5UAZ|ensembl:YMR153W(identity)	-	crc64:2ECE0C561D27E523	crc64:2ECE0C561D27E523	comment:"paralog1 (YDL088C) depletion signifcantly increases (FDR-corrected p-value: 1.72723136028032E-05 ) paralog2 (YMR153W)-prey (YMR153W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:csq2oRFswkgY2JkT+dmz/L7Zpfk559292	rogid:csq2oRFswkgY2JkT+dmz/L7Zpfk559292	rigid:nlLjVD79aNOqvp6SDjMD0NilAJc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:P47137	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713650|imex:IM-26166-6706	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	crc64:8ABA71761B512242	-	comment:"paralog1 (YHR104W) depletion signifcantly increases (FDR-corrected p-value: 2.30341980781039E-13 ) paralog2 (YJR096W)-prey (YMR120C) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:oV2f2R8jrzYVdN7IpGW6mkmzpz0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36108	uniprotkb:P53843	intact:EBI-26574|uniprotkb:D6VXT5|ensemblfungi:YKL002W	intact:EBI-28245|uniprotkb:D6W0S8|ensemblfungi:YNL265C	psi-mi:did4_yeast(display_long)|uniprotkb:VPL2(gene name synonym)|uniprotkb:VPS2(gene name synonym)|uniprotkb:VPT14(gene name synonym)|uniprotkb:YKL002W(locus name)|uniprotkb:DID4(gene name)|psi-mi:DID4(display_short)|uniprotkb:CHM2(gene name synonym)|uniprotkb:GRD7(gene name synonym)|uniprotkb:REN1(gene name synonym)|uniprotkb:Vacuolar protein-sorting-associated protein 2(gene name synonym)|uniprotkb:Vacuolar protein-targeting protein 14(gene name synonym)|uniprotkb:ESCRT-III complex subunit VPS2(gene name synonym)	psi-mi:ist1_yeast(display_long)|uniprotkb:YNL265C(locus name)|uniprotkb:N0809(orf name)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Increased sodium tolerance protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713674|imex:IM-26166-6764	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012924.2|sgd:S000001485|mint:P36108|dip:DIP-1916N|ensemblfungi:YKL002W(gene)|ensemblfungi:YKL002W_mRNA(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0015031"(protein transport)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:1904669"(ATP export)|interpro:IPR005024(Snf7)|rcsb pdb:2V6X|rcsb pdb:6AP1|rcsb pdb:6BMF|reactome:R-SCE-1632852|reactome:R-SCE-917729|reactome:R-SCE-9668328|ensembl:YKL002W(identity)	refseq:NP_014134.1|sgd:S000005209|dip:DIP-6713N|mint:P53843|ensemblfungi:YNL265C(gene)|ensemblfungi:YNL265C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3GGY|rcsb pdb:3GGZ|reactome:R-SCE-6798695|reactome:R-SCE-9668328|ensembl:YNL265C(identity)	-	crc64:200D07DB4C45DCBC	-	comment:"paralog1 (YLR181C) depletion signifcantly increases (FDR-corrected p-value: 0.000902868364629872 ) paralog2 (YNL265C)-prey (YKL002W) interaction"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:iQ8lcGhal3Pt46dwcOkIW2fp/G0559292	rogid:c8ngH6tobftaOGIxLH8qXiOpi28559292	rigid:7PdSimwFb49WJQUBeM4Xih1GZdI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33892	uniprotkb:P39729	intact:EBI-7442|uniprotkb:D6VTV8|ensemblfungi:YGL195W	intact:EBI-20651|uniprotkb:D6VPI1|ensemblfungi:YAL036C	psi-mi:gcn1_yeast(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:General control non-derepressible protein 1(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)|uniprotkb:G1318(orf name)|uniprotkb:YGL195W(locus name)	psi-mi:rbg1_yeast(display_long)|uniprotkb:GTP-binding protein RBG1(gene name synonym)|uniprotkb:YAL036C(locus name)|uniprotkb:RBG1(gene name)|psi-mi:RBG1(display_short)|uniprotkb:FUN11(gene name synonym)|uniprotkb:Genetically interacts with ribosomal genes protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713662|imex:IM-26166-6856	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003163|refseq:NP_011320.3|mint:P33892|dip:DIP-2344N|ensemblfungi:YGL195W(gene)|ensemblfungi:YGL195W_mRNA(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR022716|interpro:IPR033173|interpro:IPR034085|ensembl:YGL195W(identity)	refseq:NP_009364.1|sgd:S000000034|ensemblfungi:YAL036C_mRNA(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:1903833"(positive regulation of cellular response to amino acid starvation)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:4A9A|ensemblfungi:YAL036C(gene)|dip:DIP-1750N|mint:P39729|ensembl:YAL036C(identity)	-	crc64:980FDD03753E9D1C	crc64:D25C6C732B462A6B	comment:"paralog1 (YGR173W) depletion signifcantly increases (FDR-corrected p-value: 2.15906494858998E-07 ) paralog2 (YAL036C)-prey (YGL195W) interaction"|figure legend:Table S3, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:WPYtEB/xjy4g2cJFwhe+2teVYVk559292	rogid:PYUgCeuX5pWutVTDI01InMby/OE559292	rigid:1qDyOYYfYw/RDfl7RhIfs5J64gU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:Q08967	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713986|imex:IM-26166-6714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	crc64:55CAE5DACDC6A00B	-	comment:"paralog2 (YPL221W)-prey (YHR183W) interaction occurs only under paralog1 (YGL139W) depletion condition (FDR-corrected p-value: 0.00116556382675964)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:ZzmB0V0wkGv+QwAgLo7pKQzTn5E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17064	uniprotkb:Q08967	intact:EBI-2047850|uniprotkb:D3DLV9|ensemblfungi:YER056C	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:fcy2_yeast(display_long)|uniprotkb:Cytosine/purine transport protein FCY2(gene name synonym)|uniprotkb:Fluorocytosine resistance protein 2(gene name synonym)|uniprotkb:YER056C(locus name)|uniprotkb:FCY2(gene name)|psi-mi:FCY2(display_short)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713974|imex:IM-26166-6864	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010976.1|sgd:S000000858|dip:DIP-7593N|mint:P17064|ensemblfungi:YER056C(gene)|ensemblfungi:YER056C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015212"(cytidine transmembrane transporter activity)|go:"GO:0015856"(cytosine transport)|go:"GO:0015861"(cytidine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|go:"GO:0072530"(purine-containing compound transmembrane transport)|interpro:IPR001248(Permease for cytosine/purines, uracil, thiamine, allantoin)|interpro:IPR012681(Nucleobase cation symporter-1, NCS1)|interpro:IPR026030|ensembl:YER056C(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	-	-	comment:"paralog2 (YPL221W)-prey (YER056C) interaction occurs only under paralog1 (YGL139W) depletion condition (FDR-corrected p-value: 0.0012681895570648)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:797s9w2xSSBhW0uTLcFEESToqgg559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:Npzu67iNvIbZIo7PYPdE1D2vj6M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87284	uniprotkb:Q08967	intact:EBI-13555|uniprotkb:D6VSQ7|ensemblfungi:YDR276C	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:pmp3_yeast(display_long)|uniprotkb:PMP3(gene name)|psi-mi:PMP3(display_short)|uniprotkb:SNA1(gene name synonym)|uniprotkb:YDR276C(locus name)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713962|imex:IM-26166-6774	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010562.1|sgd:S000002684|ensemblfungi:YDR276C(gene)|ensemblfungi:YDR276C_mRNA(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000612(Protein of unknown function UPF0057)|dip:DIP-7280N|ensembl:YDR276C(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	-	-	comment:"paralog2 (YPL221W)-prey (YDR276C) interaction occurs only under paralog1 (YGL139W) depletion condition (FDR-corrected p-value: 0.00336749487750805)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:6uTuY0fyQfxrzyVqcLiNdDF5oRs559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:rfOqmNB1xjKLIaq7g4brpYtySpY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08967	uniprotkb:P38310	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713950|imex:IM-26166-6862	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YPL221W) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 2.90672261068048E-05)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:SmcJW0Rwl8Va7D+qNx0NlSWXoOA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38993	uniprotkb:P38310	intact:EBI-6876|uniprotkb:D6VZN2|ensemblfungi:YMR058W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:fet3_yeast(display_long)|uniprotkb:YM9796.11(orf name)|uniprotkb:YMR058W(locus name)|uniprotkb:FET3(gene name)|psi-mi:FET3(display_short)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713938|imex:IM-26166-6858	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013774.1|sgd:S000004662|mint:P38993|dip:DIP-5314N|ensemblfungi:YMR058W(gene)|ensemblfungi:YMR058W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0010106"(cellular response to iron ion starvation)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0033215"(reductive iron assimilation)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0046688"(response to copper ion)|go:"GO:1901684"(arsenate ion transmembrane transport)|interpro:IPR001117(Multicopper oxidase, type 1)|interpro:IPR002355(Multicopper oxidase, copper-binding site)|interpro:IPR008972(Cupredoxin)|interpro:IPR011706(Multicopper oxidase, type 2)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR033138|interpro:IPR044130|rcsb pdb:1ZPU|ensembl:YMR058W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:71CB4352B87746E6	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YMR058W) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 0.000396269204458885)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:yagULld2pZWL/KMb7zOTq7s2emM559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:0Bf8NuhbA3coKYrqO/odfHL53Ek	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12114	uniprotkb:P38310	intact:EBI-4640|uniprotkb:D6VYX2|ensemblfungi:YLR330W	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:chs5_yeast(display_long)|uniprotkb:CHS5(gene name)|psi-mi:CHS5(display_short)|uniprotkb:CAL3(gene name synonym)|uniprotkb:YLR330W(locus name)|uniprotkb:L8543.18(orf name)|uniprotkb:Protein CAL3(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713926|imex:IM-26166-6490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013434.1|sgd:S000004322|dip:DIP-8073N|mint:Q12114|ensemblfungi:YLR330W(gene)|ensemblfungi:YLR330W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006039"(cell wall chitin catabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030476"(ascospore wall assembly)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034044"(exomer complex)|go:"GO:0043332"(mating projection tip)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001357(BRCT)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031669|interpro:IPR031673|interpro:IPR036116|interpro:IPR036420|rcsb pdb:4IN3|rcsb pdb:4WJW|rcsb pdb:4YG8|ensembl:YLR330W(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:FA92741B862814C2	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YLR330W) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 0.00468014615565185)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:iHvfW3fNLv3HLj4Ihya1Vyt0X7I559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:Gf2ZUFPqSi3X32kz1WtBI4PZztY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39010	uniprotkb:P38310	intact:EBI-2421|uniprotkb:D6VSP8|ensemblfungi:YDR264C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:akr1_yeast(display_long)|uniprotkb:AKR1(gene name)|psi-mi:AKR1(display_short)|uniprotkb:YDR264C(locus name)|uniprotkb:D9954.9(orf name)|uniprotkb:YD9230B.03C(orf name)|uniprotkb:Ankyrin repeat-containing protein AKR1(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713914|imex:IM-26166-6712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010550.1|sgd:S000002672|dip:DIP-1145N|mint:P39010|ensemblfungi:YDR264C(gene)|ensemblfungi:YDR264C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016409"(palmitoyltransferase activity)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0090029"(negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion)|interpro:IPR001594(Zinc finger, DHHC-type)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|ensembl:YDR264C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YDR264C) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 3.26906167124617E-06)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:INuSfspu5JYfFnlcgzVdvDeTerU559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:k/rFBFVQ0JcTpeeGAkHovKSpz9U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41810	uniprotkb:P38310	intact:EBI-4869|uniprotkb:Q03779|uniprotkb:D6VSL9|ensemblfungi:YDR238C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:copb_yeast(display_long)|uniprotkb:SEC26(gene name)|psi-mi:SEC26(display_short)|uniprotkb:YDR238C(locus name)|uniprotkb:YD8419.05C(orf name)|uniprotkb:Beta-coat protein(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713902|imex:IM-26166-6710	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002646|refseq:NP_010524.3|dip:DIP-6467N|mint:P41810|ensemblfungi:YDR238C(gene)|ensemblfungi:YDR238C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0030126"(COPI vesicle coat)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|reactome:R-SCE-6798695|reactome:R-SCE-6807878|reactome:R-SCE-6811434|ensembl:YDR238C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:885420DB026BCFA3	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YDR238C) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 3.48673857609906E-07)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ZfLp1BUmvVuTiXn7/Zbf/3m6VtE559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:CblibR6PmLai91aYnqLBVxTQwuA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:P38310	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713890|imex:IM-26166-6658	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	crc64:245575E65D3C2193	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YDR233C) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 0.0016839312803738)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:Wh783w5iSWfNnMt5RQr1oMTQ7CE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29465	uniprotkb:P38310	intact:EBI-4632|uniprotkb:D6VQ25|ensemblfungi:YBR023C	intact:EBI-20959|uniprotkb:Q9URQ1|uniprotkb:D6VQK4|ensemblfungi:YBR207W	psi-mi:chs3_yeast(display_long)|uniprotkb:CHS3(gene name)|psi-mi:CHS3(display_short)|uniprotkb:CAL1(gene name synonym)|uniprotkb:DIT101(gene name synonym)|uniprotkb:KIT2(gene name synonym)|uniprotkb:YBR023C(locus name)|uniprotkb:CSD2(gene name synonym)|uniprotkb:YBR0305(orf name)|uniprotkb:Chitin-UDP acetyl-glucosaminyl transferase 3(gene name synonym)|uniprotkb:Class-IV chitin synthase 3(gene name synonym)	psi-mi:fth1_yeast(display_long)|uniprotkb:YBR1446(orf name)|uniprotkb:YBR207W(locus name)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713878|imex:IM-26166-6656	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009579.1|sgd:S000000227|dip:DIP-2482N|mint:P29465|ensemblfungi:YBR023C(gene)|ensemblfungi:YBR023C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0004100"(chitin synthase activity)|go:"GO:0005628"(prospore membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030428"(cell septum)|go:"GO:0030476"(ascospore wall assembly)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034221"(fungal-type cell wall chitin biosynthetic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0045009"(chitosome)|go:"GO:0071944"(cell periphery)|go:"GO:0097271"(protein localization to bud neck)|interpro:IPR004835(Fungal chitin synthase)|interpro:IPR029044|rcsb pdb:4WJW|ensembl:YBR023C(identity)	refseq:NP_009766.4|sgd:S000000411|mint:P38310|dip:DIP-4165N|ensemblfungi:YBR207W(gene)|ensemblfungi:YBR207W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0033573"(high-affinity iron permease complex)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR004923(Iron permease FTR1)|ensembl:YBR207W(identity)	-	-	crc64:7B4E620ABC39A053	comment:"paralog2 (YBR207W)-prey (YBR023C) interaction occurs only under paralog1 (YER145C) depletion condition (FDR-corrected p-value: 0.000253835712122148)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8Ik0u35UXSJVtqfgNdo49J+nzFk559292	rogid:I8IlcdwivLRr6CY2IflcYTCdIAc559292	rigid:ldZ0mXnEDo86iJl5fs+EY7KjnCQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32660	uniprotkb:P14359	intact:EBI-3121|uniprotkb:D3DM74|ensemblfungi:YER166W	intact:EBI-26122|uniprotkb:D6VW35|uniprotkb:Q6B236|ensemblfungi:YJL151C	psi-mi:atc5_yeast(display_long)|uniprotkb:DNF1(gene name)|psi-mi:DNF1(display_short)|uniprotkb:YER166W(locus name)|uniprotkb:SYGP-ORF7(orf name)|uniprotkb:Flippase DNF1(gene name synonym)	psi-mi:sna3_yeast(display_long)|uniprotkb:J0630(orf name)|uniprotkb:YJL151C(locus name)|uniprotkb:SNA3(gene name)|psi-mi:SNA3(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713866|imex:IM-26166-6922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000968|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070867"(mating projection tip membrane)|go:"GO:0071944"(cell periphery)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR026871|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:7KY6|rcsb pdb:7KYB|rcsb pdb:7KYC|refseq:NP_011093.3|dip:DIP-7949N|mint:P32660|ensemblfungi:YER166W(gene)|ensemblfungi:YER166W_mRNA(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000749"(response to pheromone triggering conjugation with cellular fusion)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|ensembl:YER166W(identity)	refseq:NP_012384.1|sgd:S000003687|mint:P14359|dip:DIP-1730N|ensemblfungi:YJL151C(gene)|ensemblfungi:YJL151C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0044257"(cellular protein catabolic process)|interpro:IPR000612(Protein of unknown function UPF0057)|rcsb pdb:4LCD|ensembl:YJL151C(identity)	-	crc64:3CC3FBA8ADDE8960	crc64:DBA26AF5B769C02A	comment:"paralog2 (YJL151C)-prey (YER166W) interaction occurs only under paralog1 (YDR525W-A) depletion condition (FDR-corrected p-value: 4.79019228813751E-06)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:4ciEaV0aGjDqtpexkFJ0l737SpA559292	rogid:0sViFfDsVtQHk/Stc+aK423Mhmo559292	rigid:zzr5QLughcyaRkTsvcQSMO2xmU0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21825	uniprotkb:Q07549	intact:EBI-16632|ensemblfungi:YPL094C|uniprotkb:D6W3S3	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:sec62_yeast(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short)|uniprotkb:YPL094C(locus name)|uniprotkb:LPG14C(orf name)|uniprotkb:Sec62/63 complex 30 kDa subunit(gene name synonym)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713854|imex:IM-26166-6920	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL094C(gene)|ensemblfungi:YPL094C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031207"(Sec62/Sec63 complex)|interpro:IPR004728(Translocation protein Sec62)|interpro:IPR011553(Translocation protein Sec62, ascomycota)|rcsb pdb:6ZZZ|rcsb pdb:7AFT|refseq:NP_015231.2|sgd:S000006015|dip:DIP-3827N|mint:P21825|ensembl:YPL094C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog2 (YDL123W)-prey (YPL094C) interaction occurs only under paralog1 (YDR276C) depletion condition (FDR-corrected p-value: 0.0030799517270901)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ntcNjurhtyRtHO3uJOOcJXb2Meg559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:RVXP72bodQj44rt6JyQ9fiJ1Kiw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39101	uniprotkb:Q07549	intact:EBI-3949|uniprotkb:D3DLU9|ensemblfungi:YER048C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:caj1_yeast(display_long)|uniprotkb:CAJ1(gene name)|psi-mi:CAJ1(display_short)|uniprotkb:YER048C(locus name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713842|imex:IM-26166-7010	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000850|refseq:NP_010967.3|dip:DIP-5333N|mint:P39101|ensemblfungi:YER048C(gene)|ensemblfungi:YER048C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0016558"(protein import into peroxisome matrix)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR026894|interpro:IPR036869|ensembl:YER048C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog2 (YDL123W)-prey (YER048C) interaction occurs only under paralog1 (YDR276C) depletion condition (FDR-corrected p-value: 0.00289467439734698)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:D2heK4ehSLlxAyWgrexJme418ns559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:UXO6iCh/qnLFA6/OwkyV0V/erYk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38143	uniprotkb:Q07549	intact:EBI-7863|uniprotkb:D6VQP0|ensemblfungi:YBR244W	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:gpx2_yeast(display_long)|uniprotkb:GPX2(gene name)|psi-mi:GPX2(display_short)|uniprotkb:Glutathione peroxidase homolog 2(gene name synonym)|uniprotkb:YBR1632(orf name)|uniprotkb:YBR244W(locus name)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713830|imex:IM-26166-6708	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000448|refseq:NP_009803.3|mint:P38143|dip:DIP-8180N|ensemblfungi:YBR244W(gene)|ensemblfungi:YBR244W_mRNA(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0051920"(peroxiredoxin activity)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|reactome:R-SCE-2142712|reactome:R-SCE-9018676|reactome:R-SCE-9018896|reactome:R-SCE-9020265|reactome:R-SCE-9023661|ensembl:YBR244W(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog2 (YDL123W)-prey (YBR244W) interaction occurs only under paralog1 (YDR276C) depletion condition (FDR-corrected p-value: 0.00122423086961409)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:cL8rm6IttRi0QYzWVEooubWkZN8559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:H7af3aoY5PrR+BBHfCwIoQu+hoY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38234	uniprotkb:Q07549	intact:EBI-21445|uniprotkb:D6VQ51|ensemblfungi:YBR052C	intact:EBI-22078|uniprotkb:D6VRM7|ensemblfungi:YDL123W	psi-mi:rfs1_yeast(display_long)|uniprotkb:YBR052C(locus name)|uniprotkb:YBR0505(orf name)|uniprotkb:RFS1(gene name)|psi-mi:RFS1(display_short)|uniprotkb:RAD55 suppressor protein 1(gene name synonym)	psi-mi:sna4_yeast(display_long)|uniprotkb:YDL123W(locus name)|uniprotkb:SNA4(gene name)|psi-mi:SNA4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713818|imex:IM-26166-6772	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009608.1|sgd:S000000256|mint:P38234|dip:DIP-1761N|ensemblfungi:YBR052C(gene)|ensemblfungi:YBR052C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010181"(FMN binding)|go:"GO:0045121"(membrane raft)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR029039|ensembl:YBR052C(identity)	refseq:NP_010160.1|sgd:S000002281|dip:DIP-2816N|ensemblfungi:YDL123W(gene)|ensemblfungi:YDL123W_mRNA(transcript)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000612(Protein of unknown function UPF0057)|mint:Q07549|ensembl:YDL123W(identity)	-	-	crc64:3B9378FD5EDDFA5A	comment:"paralog2 (YDL123W)-prey (YBR052C) interaction occurs only under paralog1 (YDR276C) depletion condition (FDR-corrected p-value: 0.0091939549021276)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:cb04D8hoVh5fvWEd5oT6iDTL2X0559292	rogid:FYmk+8JkkE8m9CdHoTlaoPRxZtU559292	rigid:oeyIjbQsMS2StgA9XC2GQK8eF80	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99287	uniprotkb:Q12443	intact:EBI-37523|uniprotkb:D6W2M3|ensemblfungi:YOR165W	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:sey1_yeast(display_long)|uniprotkb:SEY1(gene name)|psi-mi:SEY1(display_short)|uniprotkb:YOR165W(locus name)|uniprotkb:Synthetic enhancer of YOP1 protein(gene name synonym)|uniprotkb:O3590(orf name)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713806|imex:IM-26166-6770	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014808.1|sgd:S000005691|dip:DIP-49373N|mint:Q99287|ensemblfungi:YOR165W(gene)|ensemblfungi:YOR165W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|interpro:IPR008803(Root hair defective 3 GTP-binding)|interpro:IPR027417|interpro:IPR030386|ensembl:YOR165W(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:DEC0C9EC3AB172DF	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YOR165W) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 0.000115263555089685)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:zFsgalfyUvAuuV51vChJjraiQmI559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:+CpzsRCc5CjraJNuXpNlCMn6wus	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12462	uniprotkb:Q12443	intact:EBI-13198|uniprotkb:D6W1S2|ensemblfungi:YOL147C	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:pex11_yeast(display_long)|uniprotkb:PEX11(gene name)|psi-mi:PEX11(display_short)|uniprotkb:PMP24(gene name synonym)|uniprotkb:PMP27(gene name synonym)|uniprotkb:O0454(orf name)|uniprotkb:YOL147C(locus name)|uniprotkb:Peroxin-11(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713794|imex:IM-26166-6918	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014494.1|sgd:S000005507|mint:Q12462|dip:DIP-3839N|ensemblfungi:YOL147C(gene)|ensemblfungi:YOL147C_mRNA(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0016559"(peroxisome fission)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0044375"(regulation of peroxisome size)|go:"GO:1990429"(peroxisomal importomer complex)|interpro:IPR008733(Peroxisomal biogenesis factor 11)|reactome:R-SCE-9603798|go:"GO:0005783"(endoplasmic reticulum)|ensembl:YOL147C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	-	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YOL147C) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 9.62180936987784E-07)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Wgd0xHDx1jc9msL55PpTWFNL7cA559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:zllB0jmpo2//6CWWz9FvPdAdwck	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04046	uniprotkb:Q12443	intact:EBI-14238|ensemblfungi:YMR300C|uniprotkb:D6W0C7	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:pur1_yeast(display_long)|uniprotkb:Glutamine phosphoribosylpyrophosphate amidotransferase(gene name synonym)|uniprotkb:ADE4(gene name)|psi-mi:ADE4(display_short)|uniprotkb:YMR300C(locus name)|uniprotkb:YM9952.02C(orf name)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713782|imex:IM-26166-6488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014029.1|sgd:S000004915|ensemblfungi:YMR300C(gene)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005854(Amidophosphoribosyl transferase)|ensemblfungi:YMR300C_mRNA(transcript)|go:"GO:0004044"(amidophosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|interpro:IPR017932|interpro:IPR029055|interpro:IPR029057|interpro:IPR035584|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|mint:P04046|dip:DIP-6727N|ensembl:YMR300C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:1FE7A6F5B7C96710	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YMR300C) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 0.000519176392870626)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:v3Q2NjIC4OuMxGAFnC+1r4y70mw559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:XHNa4q3CrcjHYXpoIOhx+Yi1zd4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02630	uniprotkb:Q12443	intact:EBI-11703|ensemblfungi:YMR047C|uniprotkb:D6VZM2	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:nu116_yeast(display_long)|uniprotkb:NUP116(gene name)|psi-mi:NUP116(display_short)|uniprotkb:NSP116(gene name synonym)|uniprotkb:YMR047C(locus name)|uniprotkb:YM9532.12C(orf name)|uniprotkb:Nuclear pore protein NUP116/NSP116(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713770|imex:IM-26166-6550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YMR047C(gene)|ensemblfungi:YMR047C_mRNA(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000973"(posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005643"(nuclear pore)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0051117"(ATPase binding)|interpro:IPR007230(Peptidase S59, nucleoporin)|interpro:IPR025574|interpro:IPR036903|interpro:IPR037637|interpro:IPR037665|rcsb pdb:1O6P|rcsb pdb:2AIV|rcsb pdb:3PBP|go:"GO:0017056"(structural constituent of nuclear pore)|refseq:NP_013762.1|sgd:S000004650|mint:Q02630|dip:DIP-2389N|ensembl:YMR047C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:FBAB0B9AEA958213	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YMR047C) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 2.99893220554749E-06)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ZuiHiCdDSP9OqFdd1+fJ07WNe7Y559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:Tn5S7e5sgBXve5/hLMkMjKtg64w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03640	uniprotkb:Q12443	intact:EBI-27872|uniprotkb:D6VZA1|ensemblfungi:YML072C	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:tcb3_yeast(display_long)|uniprotkb:YML072C(locus name)|uniprotkb:TCB3(gene name)|psi-mi:TCB3(display_short)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713758|imex:IM-26166-6768	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013639.1|sgd:S000004537|dip:DIP-6589N|mint:Q03640|ensemblfungi:YML072C(gene)|ensemblfungi:YML072C_mRNA(transcript)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0006869"(lipid transport)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0046872"(metal ion binding)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR017147(Tricalbin)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037756|interpro:IPR037761|interpro:IPR037762|interpro:IPR037765|ensembl:YML072C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:77A0AE57F9259784	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YML072C) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 1.1026555289668E-06)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:miu2Eqlp/xqS/9aOMycLTcERCEU559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:yqZLGNuitLviTdFNGhtHog9NT8A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54861	uniprotkb:Q12443	intact:EBI-6002|uniprotkb:D6VY02|ensemblfungi:YLL001W	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:dnm1_yeast(display_long)|uniprotkb:L1381(orf name)|uniprotkb:YLL001W(locus name)|uniprotkb:DNM1(gene name)|psi-mi:DNM1(display_short)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713746|imex:IM-26166-6654	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013100.1|sgd:S000003924|dip:DIP-1908N|mint:P54861|ensemblfungi:YLL001W(gene)|ensemblfungi:YLL001W_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016236"(macroautophagy)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|reactome:R-SCE-169911|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-75153|reactome:R-SCE-8856828|ensembl:YLL001W(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:EBEF8793C5951770	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YLL001W) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 0.00444471757742009)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:1MUFRBj6HOLvJRrwVSYe7afG/1s559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:zmo+pv0e1Mee9SanftdDNSzmYs4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36024	uniprotkb:Q12443	intact:EBI-17250|uniprotkb:D6VXD3|ensemblfungi:YKR072C	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:sis2_yeast(display_long)|uniprotkb:SIS2(gene name)|psi-mi:SIS2(display_short)|uniprotkb:HAL3(gene name synonym)|uniprotkb:YKR072C(locus name)|uniprotkb:Halotolerance protein HAL3(gene name synonym)|uniprotkb:Sit4 suppressor 2(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713734|imex:IM-26166-6638	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012998.1|sgd:S000001780|ensemblfungi:YKR072C(gene)|ensemblfungi:YKR072C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003824"(catalytic activity)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0009651"(response to salt stress)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|dip:DIP-2521N|mint:P36024|ensembl:YKR072C(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	-	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YKR072C) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 0.000176158758704664)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:oiDiGYmZy7PE7zchnyTa2x4g9zo559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:fcAIRBWg5bZ5TNI2M/vtIFlGGAk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32582	uniprotkb:Q12443	intact:EBI-4167|uniprotkb:Q05177|uniprotkb:Q27JK1|uniprotkb:Q27JK4|uniprotkb:D6VUT5|ensemblfungi:YGR155W	intact:EBI-32591|uniprotkb:D6VRF0|ensemblfungi:YDL204W	psi-mi:cbs_yeast(display_long)|uniprotkb:STR4(gene name synonym)|uniprotkb:CYS4(gene name)|psi-mi:CYS4(display_short)|uniprotkb:YGR155W(locus name)|uniprotkb:G6667(orf name)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym)|uniprotkb:Sulfur transfer protein 4(gene name synonym)	psi-mi:rtn2_yeast(display_long)|uniprotkb:RTN2(gene name)|psi-mi:RTN2(display_short)|uniprotkb:D1062(orf name)|uniprotkb:YDL204W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713722|imex:IM-26166-6636	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003387|refseq:NP_011671.3|dip:DIP-1282N|mint:P32582|ensemblfungi:YGR155W(gene)|ensemblfungi:YGR155W_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004122"(cystathionine beta-synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019346"(transsulfuration)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|rcsb pdb:6C2H|rcsb pdb:6C2Q|rcsb pdb:6C2Z|rcsb pdb:6C4P|reactome:R-SCE-1614603|ensembl:YGR155W(identity)	refseq:NP_010077.1|sgd:S000002363|dip:DIP-4231N|mint:Q12443|ensemblfungi:YDL204W(gene)|ensemblfungi:YDL204W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDL204W(identity)	-	crc64:D0C7059B20FD0746	crc64:E937E2B77759DFF5	comment:"paralog2 (YDL204W)-prey (YGR155W) interaction occurs only under paralog1 (YDR233C) depletion condition (FDR-corrected p-value: 0.000124290421971034)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:bHamyLQqLgqrPxKcyNSzJJR5n+M559292	rogid:jF49AeaM5t7a5TBw3/+tJ7H251g559292	rigid:M80oa5zxzjV9gsLqYItJAT0S+Pc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32500	uniprotkb:Q03790	intact:EBI-11950|ensemblfungi:YML031W|uniprotkb:D6VZE3	intact:EBI-27321|uniprotkb:D6VZX4|ensemblfungi:YMR153W	psi-mi:ndc1_yeast(display_long)|uniprotkb:YML031W(locus name)|uniprotkb:NDC1(gene name)|psi-mi:NDC1(display_short)|uniprotkb:Nuclear pore protein NDC1(gene name synonym)|uniprotkb:Nuclear division cycle protein 1(gene name synonym)	psi-mi:nup53_yeast(display_long)|uniprotkb:Nuclear pore protein NUP53(gene name synonym)|uniprotkb:NUP53(gene name)|psi-mi:NUP53(display_short)|uniprotkb:YMR153W(locus name)|uniprotkb:YM8520.02(orf name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713710|imex:IM-26166-6766	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YML031W(gene)|ensemblfungi:YML031W_mRNA(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030474"(spindle pole body duplication)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|go:"GO:0070631"(spindle pole body localization)|go:"GO:0070762"(nuclear pore transmembrane ring)|go:"GO:0106166"(spindle pole body-nuclear membrane anchor activity)|interpro:IPR019049|go:"GO:0017056"(structural constituent of nuclear pore)|refseq:NP_013681.1|sgd:S000004493|mint:P32500|dip:DIP-1465N|ensembl:YML031W(identity)	refseq:NP_013873.1|sgd:S000004762|dip:DIP-1467N|ensemblfungi:YMR153W(gene)|ensemblfungi:YMR153W_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0060188"(regulation of protein desumoylation)|go:"GO:0072417"(response to spindle checkpoint signaling)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|rcsb pdb:3W3Y|rcsb pdb:5UAZ|ensembl:YMR153W(identity)	-	-	crc64:2ECE0C561D27E523	comment:"paralog2 (YMR153W)-prey (YML031W) interaction occurs only under paralog1 (YDL088C) depletion condition (FDR-corrected p-value: 0.000629302013308903)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:CJawnqL6UYhpSqsKMbif8ifzgUY559292	rogid:csq2oRFswkgY2JkT+dmz/L7Zpfk559292	rigid:SV+VHDb0iqHaelXXFSlHP2DfdZ0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36024	uniprotkb:Q02896	intact:EBI-17250|uniprotkb:D6VXD3|ensemblfungi:YKR072C	intact:EBI-22203|uniprotkb:D6W3T0|ensemblfungi:YPL087W	psi-mi:sis2_yeast(display_long)|uniprotkb:SIS2(gene name)|psi-mi:SIS2(display_short)|uniprotkb:HAL3(gene name synonym)|uniprotkb:YKR072C(locus name)|uniprotkb:Halotolerance protein HAL3(gene name synonym)|uniprotkb:Sit4 suppressor 2(gene name synonym)	psi-mi:ydc1_yeast(display_long)|uniprotkb:YDC1(gene name)|psi-mi:YDC1(display_short)|uniprotkb:Acyl-CoA-independent ceramide synthase(gene name synonym)|uniprotkb:LPG21W(orf name)|uniprotkb:YPL087W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713698|imex:IM-26166-6916	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012998.1|sgd:S000001780|ensemblfungi:YKR072C(gene)|ensemblfungi:YKR072C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003824"(catalytic activity)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0009651"(response to salt stress)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|dip:DIP-2521N|mint:P36024|ensembl:YKR072C(identity)	refseq:NP_015238.1|sgd:S000006008|dip:DIP-7600N|mint:Q02896|ensemblfungi:YPL087W(gene)|ensemblfungi:YPL087W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046514"(ceramide catabolic process)|go:"GO:0070774"(phytoceramidase activity)|go:"GO:0071633"(dihydroceramidase activity)|interpro:IPR008901(Alkaline phytoceramidase)|reactome:R-SCE-1660661|ensembl:YPL087W(identity)	-	-	-	comment:"paralog2 (YPL087W)-prey (YKR072C) interaction occurs only under paralog1 (YBR183W) depletion condition (FDR-corrected p-value: 0.00194664741931793)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:oiDiGYmZy7PE7zchnyTa2x4g9zo559292	rogid:UjLo2FMUWJPaHBDIYPjWZbqpk98559292	rigid:fyyn+FL3sPN5IE7YFv7fqJeD8zw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04046	uniprotkb:P53295	intact:EBI-14238|ensemblfungi:YMR300C|uniprotkb:D6W0C7	intact:EBI-23421|uniprotkb:D6VUV7|ensemblfungi:YGR173W	psi-mi:pur1_yeast(display_long)|uniprotkb:Glutamine phosphoribosylpyrophosphate amidotransferase(gene name synonym)|uniprotkb:ADE4(gene name)|psi-mi:ADE4(display_short)|uniprotkb:YMR300C(locus name)|uniprotkb:YM9952.02C(orf name)	psi-mi:rbg2_yeast(display_long)|uniprotkb:YGR173W(locus name)|uniprotkb:RBG2(gene name)|psi-mi:RBG2(display_short)|uniprotkb:GIR1(gene name synonym)|uniprotkb:GTP-binding protein RBG2(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16713686|imex:IM-26166-6634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014029.1|sgd:S000004915|ensemblfungi:YMR300C(gene)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005854(Amidophosphoribosyl transferase)|ensemblfungi:YMR300C_mRNA(transcript)|go:"GO:0004044"(amidophosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|interpro:IPR017932|interpro:IPR029055|interpro:IPR029057|interpro:IPR035584|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|mint:P04046|dip:DIP-6727N|ensembl:YMR300C(identity)	refseq:NP_011689.1|sgd:S000003405|dip:DIP-2827N|mint:P53295|ensemblfungi:YGR173W(gene)|ensemblfungi:YGR173W_mRNA(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:1903833"(positive regulation of cellular response to amino acid starvation)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:7NRC|ensembl:YGR173W(identity)	-	crc64:1FE7A6F5B7C96710	crc64:D144569C9C5D777C	comment:"paralog2 (YGR173W)-prey (YMR300C) interaction occurs only under paralog1 (YAL036C) depletion condition (FDR-corrected p-value: 0.000369612306347983)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:v3Q2NjIC4OuMxGAFnC+1r4y70mw559292	rogid:mj9ToMhAbXBIJJx7qdX+Vi5qs9g559292	rigid:yBkPMRP/tk5CqofyV0gB0Z/VrAM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05359	uniprotkb:P38929	intact:EBI-6581|uniprotkb:D6VPL7|uniprotkb:E9P8S8|ensemblfungi:YAR002C-A	intact:EBI-3097|uniprotkb:D6VUD2|ensemblfungi:YGL006W	psi-mi:erp1_yeast(display_long)|uniprotkb:ERP1(gene name)|psi-mi:ERP1(display_short)|uniprotkb:YAR002A(orf name)|uniprotkb:YAR002C-A(locus name)	psi-mi:atc2_yeast(display_long)|uniprotkb:PMC1(gene name)|psi-mi:PMC1(display_short)|uniprotkb:"Vacuolar Ca(2+)-ATPase"(gene name synonym)|uniprotkb:YGL006W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714033|imex:IM-26166-6552	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009402.1|sgd:S000002129|mint:Q05359|dip:DIP-5147N|ensemblfungi:YAR002C-A(gene)|ensemblfungi:YAR002C-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YAR002C-A(identity)	refseq:NP_011509.1|sgd:S000002974|dip:DIP-5901N|mint:P38929|ensemblfungi:YGL006W(gene)|ensemblfungi:YGL006W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-SCE-418359|reactome:R-SCE-5578775|reactome:R-SCE-936837|ensembl:YGL006W(identity)	-	-	crc64:5BD9ECFF8508F396	comment:"paralog2 (YGL006W)-prey (YAR002C-A) interaction occurs only under paralog1 (YGL167C) depletion condition (FDR-corrected p-value: 0.000177008787807793)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:RX3ynMqEVNp4bRTVb16YoXaQW3U559292	rogid:pvI8E79lFI1hRPK/jgugzIH5LI0559292	rigid:dciZn7K1B4U1kYJyo5RNFwbX4X4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06689	uniprotkb:Q08967	intact:EBI-38659|uniprotkb:D6VZ50|ensemblfungi:YLR413W	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:yl413_yeast(display_long)|uniprotkb:YLR413W(locus name)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714009|imex:IM-26166-6776	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013517.1|sgd:S000004405|mint:Q06689|dip:DIP-5075N|ensemblfungi:YLR413W(gene)|ensemblfungi:YLR413W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0051285"(cell cortex of cell tip)|go:"GO:0071944"(cell periphery)|interpro:IPR009571(SUR7)|ensembl:YLR413W(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	crc64:92E23436DC857E95	-	comment:"paralog2 (YPL221W)-prey (YLR413W) interaction occurs only under paralog1 (YGL139W) depletion condition (FDR-corrected p-value: 0.00271747266199906)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:AoTGKjLhw0NECrtuftZqLANonds559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:r3jv2nboicsIcly+qWnEwlVknHo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53316	uniprotkb:Q12449	intact:EBI-23586|uniprotkb:D6VV30|ensemblfungi:YGR250C	intact:EBI-37072|uniprotkb:Q02565|uniprotkb:Q7LIE3|uniprotkb:D6VSJ8|ensemblfungi:YDR214W	psi-mi:yg5b_yeast(display_long)|uniprotkb:YGR250C(locus name)	psi-mi:aha1_yeast(display_long)|uniprotkb:AHA1(gene name)|psi-mi:AHA1(display_short)|uniprotkb:YDR214W(locus name)|uniprotkb:YD8142.16(orf name)|uniprotkb:YD8142B.06(orf name)|uniprotkb:Activator of Hsp90 ATPase protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714477|imex:IM-26166-6798	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011766.3|sgd:S000003482|dip:DIP-5559N|mint:P53316|ensemblfungi:YGR250C(gene)|ensemblfungi:YGR250C_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010494"(cytoplasmic stress granule)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|ensembl:YGR250C(identity)	sgd:S000002622|refseq:NP_010500.3|mint:Q12449|dip:DIP-1831N|ensemblfungi:YDR214W(gene)|ensemblfungi:YDR214W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|rcsb pdb:1USU|rcsb pdb:1USV|rcsb pdb:6XLB|rcsb pdb:6XLD|rcsb pdb:6XLE|rcsb pdb:6XLF|rcsb pdb:6XLG|rcsb pdb:6XLH|ensembl:YDR214W(identity)	-	crc64:C2CA1CBF5F6D395B	crc64:06DF6B40EB5050BE	comment:"paralog2 (YDR214W)-prey (YGR250C) interaction occurs only under paralog1 (YNL281W) depletion condition (FDR-corrected p-value: 1.71290998723924E-05)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:PMluELxwVWyCMyMnmOBp0HyI604559292	rogid:jCVFPwj0+auPVB/BJ/OwlMSBWUM559292	rigid:3ybTLGQ6ZtK1w0ZfZ6zEZCCOFuQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36095	uniprotkb:Q06263	intact:EBI-26653|uniprotkb:D6VXP5|ensemblfungi:YKL041W	intact:EBI-37098|uniprotkb:Q07057|uniprotkb:D6VYI5|ensemblfungi:YLR181C	psi-mi:vps24_yeast(display_long)|uniprotkb:YKL041W(locus name)|uniprotkb:YKL254(orf name)|uniprotkb:VPS24(gene name)|psi-mi:VPS24(display_short)|uniprotkb:DID3(gene name synonym)|uniprotkb:DOA4-independent degradation protein 3(gene name synonym)|uniprotkb:ESCRT-III complex subunit VPS24(gene name synonym)	psi-mi:vta1_yeast(display_long)|uniprotkb:VTA1(gene name)|psi-mi:VTA1(display_short)|uniprotkb:YLR181C(locus name)|uniprotkb:VPS20-associated protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714465|imex:IM-26166-6958	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012883.1|sgd:S000001524|mint:P36095|dip:DIP-7295N|ensemblfungi:YKL041W(gene)|ensemblfungi:YKL041W_mRNA(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:1904669"(ATP export)|interpro:IPR005024(Snf7)|rcsb pdb:6ZH3|reactome:R-SCE-1632852|reactome:R-SCE-917729|reactome:R-SCE-9668328|ensembl:YKL041W(identity)	refseq:NP_013282.1|sgd:S000004171|mint:Q06263|dip:DIP-4802N|ensemblfungi:YLR181C(gene)|ensemblfungi:YLR181C_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0006869"(lipid transport)|go:"GO:0015031"(protein transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:1990621"(ESCRT IV complex)|interpro:IPR023175|interpro:IPR039431|interpro:IPR041212|interpro:IPR044538|rcsb pdb:2LUH|rcsb pdb:2RKK|rcsb pdb:2RKL|rcsb pdb:3MHV|rcsb pdb:5H7P|rcsb pdb:5UIE|rcsb pdb:5XMK|rcsb pdb:6AP1|rcsb pdb:6OO2|reactome:R-SCE-917729|ensembl:YLR181C(identity)	-	crc64:6073C1B680D58E98	crc64:BB6E6975596C1674	comment:"paralog2 (YLR181C)-prey (YKL041W) interaction occurs only under paralog1 (YNL265C) depletion condition (FDR-corrected p-value: 0.000819424775770787)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:mA7XIOAPTcq8iFqDtd5Uk4cdhD0559292	rogid:X9sRQb1nZECFkdjvDUTjxEgokRM559292	rigid:rfF8aG4BFoLonw5jcaguq9tp6Uk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09620	uniprotkb:P22140	intact:EBI-9653|ensemblfungi:YGL203C|uniprotkb:D6VTV1	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:kex1_yeast(display_long)|uniprotkb:KEX1(gene name)|psi-mi:KEX1(display_short)|uniprotkb:Carboxypeptidase D(gene name synonym)|uniprotkb:Killer expression defective protein 1(gene name synonym)|uniprotkb:YGL203C(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714453|imex:IM-26166-6938	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGL203C(gene)|ensemblfungi:YGL203C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:1AC5|refseq:NP_011312.1|sgd:S000003171|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR018202|interpro:IPR033124|interpro:IPR029058|mint:P09620|ensembl:YGL203C(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	-	-	comment:"paralog2 (YHR123W)-prey (YGL203C) interaction occurs only under paralog1 (YNL130C) depletion condition (FDR-corrected p-value: 0.00743456964181197)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:R6uP/9o38goNzIvIX0SQKjONH/8559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:5NLBDwx/EB516Ri5e5hSacvdnRg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19146	uniprotkb:P22140	intact:EBI-2820|uniprotkb:A2TBP3|uniprotkb:D6VRL1|ensemblfungi:YDL137W	intact:EBI-6494|uniprotkb:D3DL73|ensemblfungi:YHR123W	psi-mi:arf2_yeast(display_long)|uniprotkb:ARF2(gene name)|psi-mi:ARF2(display_short)|uniprotkb:D2165(orf name)|uniprotkb:YDL137W(locus name)	psi-mi:ept1_yeast(display_long)|uniprotkb:EPT1(gene name)|psi-mi:EPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase EPT1(gene name synonym)|uniprotkb:YHR123W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714441|imex:IM-26166-6878	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010144.1|sgd:S000002296|dip:DIP-2215N|mint:P19146|ensemblfungi:YDL137W(gene)|ensemblfungi:YDL137W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:1MR3|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL137W(identity)	refseq:NP_011991.1|sgd:S000001165|mint:P22140|dip:DIP-5619N|ensemblfungi:YHR123W(gene)|ensemblfungi:YHR123W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|ensembl:YHR123W(identity)	-	crc64:7E43FF792E8D64E8	-	comment:"paralog2 (YHR123W)-prey (YDL137W) interaction occurs only under paralog1 (YNL130C) depletion condition (FDR-corrected p-value: 2.71335476320549E-05)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:I4V9cXleaZ2sAE2DXGKt8zpAPzw559292	rogid:CWeN5fKw1tHLle/Vgn+jmL/zrQk559292	rigid:NVem4W1fc5PnrfMj5Zh/5o9vg6E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:Q04201	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-27928|uniprotkb:D6W0I3|ensemblfungi:YML101C	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:cue4_yeast(display_long)|uniprotkb:YML101C(locus name)|uniprotkb:Coupling of ubiquitin conjugation to ER degradation protein 4(gene name synonym)|uniprotkb:CUE4(gene name)|psi-mi:CUE4(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714429|imex:IM-26166-6936	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	refseq:NP_013607.1|sgd:S000004568|dip:DIP-4525N|mint:Q04201|ensemblfungi:YML101C(gene)|ensemblfungi:YML101C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR003892(Ubiquitin system component Cue)|ensembl:YML101C(identity)	-	crc64:245575E65D3C2193	-	comment:"paralog2 (YML101C)-prey (YDR233C) interaction occurs only under paralog1 (YMR264W) depletion condition (FDR-corrected p-value: 0.000373992661255099)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:NMBJHZbX4/gU01fk4evPDXm/M6w559292	rigid:zZn8euQTj3TQ0Hc6vlZFit3Yb18	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04947	uniprotkb:Q05166	intact:EBI-38020|uniprotkb:D6VSL4|ensemblfungi:YDR233C	intact:EBI-3035|uniprotkb:Q12456|uniprotkb:E9P903|uniprotkb:D6VRR0|ensemblfungi:YDL088C	psi-mi:rtn1_yeast(display_long)|uniprotkb:RTN1(gene name)|psi-mi:RTN1(display_short)|uniprotkb:YDR233C(locus name)	psi-mi:nup59_yeast(display_long)|uniprotkb:ASM4(gene name)|psi-mi:ASM4(display_short)|uniprotkb:Nuclear pore protein NUP59(gene name synonym)|uniprotkb:NUP59(gene name synonym)|uniprotkb:D2420(orf name)|uniprotkb:YDL088C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714417|imex:IM-26166-7018	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002641|refseq:NP_010519.3|dip:DIP-4090N|mint:Q04947|ensemblfungi:YDR233C(gene)|ensemblfungi:YDR233C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032581"(ER-dependent peroxisome organization)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0048309"(endoplasmic reticulum inheritance)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071788"(endoplasmic reticulum tubular network maintenance)|go:"GO:0071944"(cell periphery)|interpro:IPR003388(Reticulon)|ensembl:YDR233C(identity)	refseq:NP_010195.1|sgd:S000002246|dip:DIP-1466N|mint:Q05166|ensemblfungi:YDL088C(gene)|ensemblfungi:YDL088C_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051301"(cell division)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|ensembl:YDL088C(identity)	-	crc64:245575E65D3C2193	-	comment:"paralog2 (YDL088C)-prey (YDR233C) interaction occurs only under paralog1 (YMR153W) depletion condition (FDR-corrected p-value: 0.000563168754979032)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:EEXsl6gyB0GVuwAEwN1AAOF8h1E559292	rogid:t8/JWDKB0Spe2P8qdZnKs/RB3SY559292	rigid:5gAFCk0gsPaO34qfy0TH0a/PlB8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05166	uniprotkb:Q05166	intact:EBI-3035|uniprotkb:Q12456|uniprotkb:E9P903|uniprotkb:D6VRR0|ensemblfungi:YDL088C	intact:EBI-3035|uniprotkb:Q12456|uniprotkb:E9P903|uniprotkb:D6VRR0|ensemblfungi:YDL088C	psi-mi:nup59_yeast(display_long)|uniprotkb:ASM4(gene name)|psi-mi:ASM4(display_short)|uniprotkb:Nuclear pore protein NUP59(gene name synonym)|uniprotkb:NUP59(gene name synonym)|uniprotkb:D2420(orf name)|uniprotkb:YDL088C(locus name)	psi-mi:nup59_yeast(display_long)|uniprotkb:ASM4(gene name)|psi-mi:ASM4(display_short)|uniprotkb:Nuclear pore protein NUP59(gene name synonym)|uniprotkb:NUP59(gene name synonym)|uniprotkb:D2420(orf name)|uniprotkb:YDL088C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714405|imex:IM-26166-6876	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010195.1|sgd:S000002246|dip:DIP-1466N|mint:Q05166|ensemblfungi:YDL088C(gene)|ensemblfungi:YDL088C_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051301"(cell division)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|ensembl:YDL088C(identity)	refseq:NP_010195.1|sgd:S000002246|dip:DIP-1466N|mint:Q05166|ensemblfungi:YDL088C(gene)|ensemblfungi:YDL088C_mRNA(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007049"(cell cycle)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051301"(cell division)|interpro:IPR007846(MPPN)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017389(Nucleoporin, NUP53)|interpro:IPR035979|ensembl:YDL088C(identity)	-	-	-	comment:"paralog2 (YDL088C)-prey (YDL088C) interaction occurs only under paralog1 (YMR153W) depletion condition (FDR-corrected p-value: 5.65836361959611E-15)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:t8/JWDKB0Spe2P8qdZnKs/RB3SY559292	rogid:t8/JWDKB0Spe2P8qdZnKs/RB3SY559292	rigid:C5VZlUQpA4bCHksWLfej4AaArgc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36095	uniprotkb:P53843	intact:EBI-26653|uniprotkb:D6VXP5|ensemblfungi:YKL041W	intact:EBI-28245|uniprotkb:D6W0S8|ensemblfungi:YNL265C	psi-mi:vps24_yeast(display_long)|uniprotkb:YKL041W(locus name)|uniprotkb:YKL254(orf name)|uniprotkb:VPS24(gene name)|psi-mi:VPS24(display_short)|uniprotkb:DID3(gene name synonym)|uniprotkb:DOA4-independent degradation protein 3(gene name synonym)|uniprotkb:ESCRT-III complex subunit VPS24(gene name synonym)	psi-mi:ist1_yeast(display_long)|uniprotkb:YNL265C(locus name)|uniprotkb:N0809(orf name)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Increased sodium tolerance protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714393|imex:IM-26166-7016	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012883.1|sgd:S000001524|mint:P36095|dip:DIP-7295N|ensemblfungi:YKL041W(gene)|ensemblfungi:YKL041W_mRNA(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:1904669"(ATP export)|interpro:IPR005024(Snf7)|rcsb pdb:6ZH3|reactome:R-SCE-1632852|reactome:R-SCE-917729|reactome:R-SCE-9668328|ensembl:YKL041W(identity)	refseq:NP_014134.1|sgd:S000005209|dip:DIP-6713N|mint:P53843|ensemblfungi:YNL265C(gene)|ensemblfungi:YNL265C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3GGY|rcsb pdb:3GGZ|reactome:R-SCE-6798695|reactome:R-SCE-9668328|ensembl:YNL265C(identity)	-	crc64:6073C1B680D58E98	-	comment:"paralog2 (YNL265C)-prey (YKL041W) interaction occurs only under paralog1 (YLR181C) depletion condition (FDR-corrected p-value: 0.000578469016148938)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:mA7XIOAPTcq8iFqDtd5Uk4cdhD0559292	rogid:c8ngH6tobftaOGIxLH8qXiOpi28559292	rigid:mo/iYPfarWuyUutwI9F2TaaB3Sw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P53843	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-28245|uniprotkb:D6W0S8|ensemblfungi:YNL265C	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:ist1_yeast(display_long)|uniprotkb:YNL265C(locus name)|uniprotkb:N0809(orf name)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Increased sodium tolerance protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714381|imex:IM-26166-6518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_014134.1|sgd:S000005209|dip:DIP-6713N|mint:P53843|ensemblfungi:YNL265C(gene)|ensemblfungi:YNL265C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3GGY|rcsb pdb:3GGZ|reactome:R-SCE-6798695|reactome:R-SCE-9668328|ensembl:YNL265C(identity)	-	crc64:55CAE5DACDC6A00B	-	comment:"paralog2 (YNL265C)-prey (YHR183W) interaction occurs only under paralog1 (YLR181C) depletion condition (FDR-corrected p-value: 0.000612167860532622)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:c8ngH6tobftaOGIxLH8qXiOpi28559292	rigid:kYRuK6ZMRN5wAyc5XpPFrgrZ1xM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32610	uniprotkb:P53843	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	intact:EBI-28245|uniprotkb:D6W0S8|ensemblfungi:YNL265C	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:ist1_yeast(display_long)|uniprotkb:YNL265C(locus name)|uniprotkb:N0809(orf name)|uniprotkb:IST1(gene name)|psi-mi:IST1(display_short)|uniprotkb:Increased sodium tolerance protein 1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714369|imex:IM-26166-6516	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610|ensembl:YEL051W(identity)	refseq:NP_014134.1|sgd:S000005209|dip:DIP-6713N|mint:P53843|ensemblfungi:YNL265C(gene)|ensemblfungi:YNL265C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|interpro:IPR005061(Protein of unknown function DUF292, eukaryotic)|interpro:IPR042277|rcsb pdb:3GGY|rcsb pdb:3GGZ|reactome:R-SCE-6798695|reactome:R-SCE-9668328|ensembl:YNL265C(identity)	-	crc64:FDE93E1FAF0AEC5B	-	comment:"paralog2 (YNL265C)-prey (YEL051W) interaction occurs only under paralog1 (YLR181C) depletion condition (FDR-corrected p-value: 0.00109317194370184)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rogid:c8ngH6tobftaOGIxLH8qXiOpi28559292	rigid:ieW4mJM7cSkPaA5DzpfdETmq9OI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21825	uniprotkb:P38755	intact:EBI-16632|ensemblfungi:YPL094C|uniprotkb:D6W3S3	intact:EBI-12641|uniprotkb:D3DKR7|ensemblfungi:YHR001W	psi-mi:sec62_yeast(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short)|uniprotkb:YPL094C(locus name)|uniprotkb:LPG14C(orf name)|uniprotkb:Sec62/63 complex 30 kDa subunit(gene name synonym)	psi-mi:osh7_yeast(display_long)|uniprotkb:YHR001W(locus name)|uniprotkb:OSH7(gene name)|psi-mi:OSH7(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714357|imex:IM-26166-6934	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL094C(gene)|ensemblfungi:YPL094C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031207"(Sec62/Sec63 complex)|interpro:IPR004728(Translocation protein Sec62)|interpro:IPR011553(Translocation protein Sec62, ascomycota)|rcsb pdb:6ZZZ|rcsb pdb:7AFT|refseq:NP_015231.2|sgd:S000006015|dip:DIP-3827N|mint:P21825|ensembl:YPL094C(identity)	ensemblfungi:YHR001W(gene)|ensemblfungi:YHR001W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0120015"(sterol transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|reactome:R-SCE-1482801|reactome:R-SCE-192105|refseq:NP_011863.1|sgd:S000001043|mint:P38755|dip:DIP-6363N|ensembl:YHR001W(identity)	-	-	crc64:1C972ED6517D529B	comment:"paralog2 (YHR001W)-prey (YPL094C) interaction occurs only under paralog1 (YKR003W) depletion condition (FDR-corrected p-value: 0.00857445941816262)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:ntcNjurhtyRtHO3uJOOcJXb2Meg559292	rogid:CnsyJOWY7SpdJZ6GeUshxYiBNJk559292	rigid:h8753vMzhjfv4GoXUNFVfxyMgRg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15367	uniprotkb:Q05031	intact:EBI-16513|uniprotkb:D6VVV3|ensemblfungi:YIR022W	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:sec11_yeast(display_long)|uniprotkb:SEC11(gene name)|psi-mi:SEC11(display_short)|uniprotkb:Signal peptidase I(gene name synonym)|uniprotkb:Secretory protein 11(gene name synonym)|uniprotkb:YIR022W(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714345|imex:IM-26166-6796	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012288.1|sgd:S000001461|go:"GO:0005787"(signal peptidase complex)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR001733(Peptidase S26B, eukaryotic signal peptidase)|interpro:IPR015927(Peptidase S24, S26A, S26B and S26C)|interpro:IPR019756|interpro:IPR019758|interpro:IPR027245|interpro:IPR036286|ensemblfungi:YIR022W(gene)|ensemblfungi:YIR022W_mRNA(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-5667N|mint:P15367|ensembl:YIR022W(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	-	-	comment:"paralog2 (YMR238W)-prey (YIR022W) interaction occurs only under paralog1 (YKL046C) depletion condition (FDR-corrected p-value: 0.000333439873566532)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:t+RiGy79Pv7EbHywbjkd4BMyJwk559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:s5w+e0kHivDG3O2qCtnqFvSzkN8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53337	uniprotkb:Q05031	intact:EBI-23662|uniprotkb:E9P8T4|uniprotkb:D6VV61|ensemblfungi:YGR284C	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:erv29_yeast(display_long)|uniprotkb:ERV29(gene name)|psi-mi:ERV29(display_short)|uniprotkb:YGR284C(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714333|imex:IM-26166-6794	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011800.3|sgd:S000003516|dip:DIP-8110N|mint:P53337|ensemblfungi:YGR284C(gene)|ensemblfungi:YGR284C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0097020"(COPII receptor activity)|interpro:IPR002995(Surfeit locus 4)|reactome:R-SCE-6798695|reactome:R-SCE-6811434|ensembl:YGR284C(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	-	-	comment:"paralog2 (YMR238W)-prey (YGR284C) interaction occurs only under paralog1 (YKL046C) depletion condition (FDR-corrected p-value: 0.000358236209420618)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:vlRDf0B9mDUXU6M2tLAiWqX4wN8559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:jQLsIlaHPe6BBqgFvUwZZ8OPvo8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11076	uniprotkb:Q05031	intact:EBI-2816|uniprotkb:D6VRG1|ensemblfungi:YDL192W	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:arf1_yeast(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)|uniprotkb:D1244(orf name)|uniprotkb:YDL192W(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714321|imex:IM-26166-6558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010089.1|sgd:S000002351|dip:DIP-2213N|mint:P11076|ensemblfungi:YDL192W(gene)|ensemblfungi:YDL192W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:2K5U|rcsb pdb:2KSQ|rcsb pdb:3TJZ|rcsb pdb:4Q66|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-SCE-1660514|reactome:R-SCE-199992|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-6811438|ensembl:YDL192W(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	crc64:796859026AC63CC0	-	comment:"paralog2 (YMR238W)-prey (YDL192W) interaction occurs only under paralog1 (YKL046C) depletion condition (FDR-corrected p-value: 0.00014979185062296)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IX/zwfWagjieSKB1ShJ9P0kq1ZE559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:Kd1djr6fxvcrdXvXSUu0pysfgfM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38353	uniprotkb:Q05031	intact:EBI-18175|uniprotkb:D6VQS8|ensemblfungi:YBR283C	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:ssh1_yeast(display_long)|uniprotkb:SSH1(gene name)|psi-mi:SSH1(display_short)|uniprotkb:Ssh1 complex subunit alpha(gene name synonym)|uniprotkb:Ssh1 complex subunit SSH1(gene name synonym)|uniprotkb:YBR2020(orf name)|uniprotkb:YBR283C(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714309|imex:IM-26166-6792	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009842.1|sgd:S000000487|ensemblfungi:YBR283C(gene)|ensemblfungi:YBR283C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|go:"GO:0071261"(Ssh1 translocon complex)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:2WW9|rcsb pdb:2WWA|dip:DIP-4962N|mint:P38353|ensembl:YBR283C(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	crc64:48267EEA3E0191BD	-	comment:"paralog2 (YMR238W)-prey (YBR283C) interaction occurs only under paralog1 (YKL046C) depletion condition (FDR-corrected p-value: 1.73055453345994E-05)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:76wvZIdv7W5BQn6wI+sHOGQAyuc559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:Fg9vHWli9ngx6p4tS86rQqXXWQo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05359	uniprotkb:Q05031	intact:EBI-6581|uniprotkb:D6VPL7|uniprotkb:E9P8S8|ensemblfungi:YAR002C-A	intact:EBI-27512|uniprotkb:D6W064|ensemblfungi:YMR238W	psi-mi:erp1_yeast(display_long)|uniprotkb:ERP1(gene name)|psi-mi:ERP1(display_short)|uniprotkb:YAR002A(orf name)|uniprotkb:YAR002C-A(locus name)	psi-mi:dfg5_yeast(display_long)|uniprotkb:DFG5(gene name)|psi-mi:DFG5(display_short)|uniprotkb:YMR238W(locus name)|uniprotkb:YM9959.20(orf name)|uniprotkb:Endo-alpha-1->6-D-mannanase DFG5(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714297|imex:IM-26166-6718	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009402.1|sgd:S000002129|mint:Q05359|dip:DIP-5147N|ensemblfungi:YAR002C-A(gene)|ensemblfungi:YAR002C-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YAR002C-A(identity)	mint:Q05031|refseq:NP_013965.1|sgd:S000004851|dip:DIP-2739N|ensemblfungi:YMR238W(gene)|ensemblfungi:YMR238W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007117"(budding cell bud growth)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008496"(mannan endo-1,6-alpha-mannosidase activity)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0071555"(cell wall organization)|interpro:IPR005198(Glycoside hydrolase, family 76)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR014480(Mannan endo-1,6-alpha-mannosidase)|ensembl:YMR238W(identity)	-	-	-	comment:"paralog2 (YMR238W)-prey (YAR002C-A) interaction occurs only under paralog1 (YKL046C) depletion condition (FDR-corrected p-value: 4.64625809391106E-05)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:RX3ynMqEVNp4bRTVb16YoXaQW3U559292	rogid:nnHGptBCE3g8JbHRaiJvIbe4Nw8559292	rigid:bK/SxoYylJ52yIZfnpXmHTRnK9k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:P32047	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-2611643|uniprotkb:D6W1A5|ensemblfungi:YNL074C	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:mlf3_yeast(display_long)|uniprotkb:MLF3(gene name)|psi-mi:MLF3(display_short)|uniprotkb:YMK1(gene name synonym)|uniprotkb:Multicopy suppressor of leflunomide sensitivity 3(gene name synonym)|uniprotkb:N2359(orf name)|uniprotkb:YNL074C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714285|imex:IM-26166-7014	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	sgd:S000005018|ensemblfungi:YNL074C(gene)|ensemblfungi:YNL074C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|refseq:NP_014325.3|mint:P32047|ensembl:YNL074C(identity)	-	crc64:8ABA71761B512242	-	comment:"paralog2 (YNL074C)-prey (YMR120C) interaction occurs only under paralog1 (YIL135C) depletion condition (FDR-corrected p-value: 0.00605713531149883)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:xGy7VtcGBDB0vMhYki3uhH0w0Sc559292	rigid:/pBPOuK/NO+Tft07BZ2s3x55reI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53262	uniprotkb:P53309	intact:EBI-2061527|uniprotkb:D6VUN8|ensemblfungi:YGR106C	intact:EBI-23557|uniprotkb:D6VV22|ensemblfungi:YGR241C	psi-mi:voa1_yeast(display_long)|uniprotkb:YGR106C(locus name)|uniprotkb:VOA1(gene name)|psi-mi:VOA1(display_short)	psi-mi:ap18b_yeast(display_long)|uniprotkb:G8610(orf name)|uniprotkb:YGR241C(locus name)|uniprotkb:YAP1802(gene name)|psi-mi:YAP1802(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714273|imex:IM-26166-6498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003338|refseq:NP_011620.1|mint:P53262|ensemblfungi:YGR106C(gene)|ensemblfungi:YGR106C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|ensembl:YGR106C(identity)	refseq:NP_011757.3|sgd:S000003473|dip:DIP-2751N|mint:P53309|ensemblfungi:YGR241C(gene)|ensemblfungi:YGR241C_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|ensembl:YGR241C(identity)	-	-	-	comment:"paralog2 (YGR241C)-prey (YGR106C) interaction occurs only under paralog1 (YHR161C) depletion condition (FDR-corrected p-value: 0.00116556382675964)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:lKLIonttSEX36IQaIKlzxS/Cdxg559292	rogid:fbC/HO6axa7TLPJAvYbKc1jlQjQ559292	rigid:aw9WKw5unBLQd1uJdw4TmKOvShw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36027	uniprotkb:P17898	intact:EBI-10901|uniprotkb:P41944|ensemblfungi:YLR332W|uniprotkb:D6VYX3	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:mid2_yeast(display_long)|uniprotkb:SMS1(gene name synonym)|uniprotkb:L8543.19(orf name)|uniprotkb:YLR332W(locus name)|uniprotkb:MID2(gene name)|psi-mi:MID2(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:Mating pheromone-induced death protein 2(gene name synonym)|uniprotkb:Serine-rich multicopy suppressor protein 1(gene name synonym)|uniprotkb:Protein kinase A interference protein 1(gene name synonym)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714261|imex:IM-26166-6496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR332W(gene)|ensemblfungi:YLR332W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000767"(cell morphogenesis involved in conjugation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010447"(response to acidic pH)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043332"(mating projection tip)|interpro:IPR007567(Mid2 like cell wall stress sensor)|refseq:NP_013436.1|sgd:S000004324|mint:P36027|dip:DIP-4676N|ensembl:YLR332W(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog2 (YNL130C)-prey (YLR332W) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.00665602828047867)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:o4cMDBqIZorgGZ6iEACUFcfgO7I559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:1BVB8WEqf3RtDtfWwff327Wvrbs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15365	uniprotkb:P17898	intact:EBI-5527|uniprotkb:D6VWX1|ensemblfungi:YJR152W	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:dal5_yeast(display_long)|uniprotkb:DAL5(gene name)|psi-mi:DAL5(display_short)|uniprotkb:UREP1(gene name synonym)|uniprotkb:YJR152W(locus name)|uniprotkb:J2230(orf name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714249|imex:IM-26166-6790	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003913|refseq:NP_012686.3|dip:DIP-7873N|mint:P15365|ensemblfungi:YJR152W(gene)|ensemblfungi:YJR152W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0015124"(allantoate transmembrane transporter activity)|go:"GO:0015719"(allantoate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0042938"(dipeptide transport)|go:"GO:0042939"(tripeptide transport)|go:"GO:0071916"(dipeptide transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR036259|ensembl:YJR152W(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog2 (YNL130C)-prey (YJR152W) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.00511152355602847)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Y2kCv3dK4Hjn9hJpK+WK5rp6VKU559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:5pW4uePRfM2TZ9poHMmZrk2HP68	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47155	uniprotkb:P17898	intact:EBI-2051644|uniprotkb:D6VWT7|ensemblfungi:YJR118C	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:ilm1_yeast(display_long)|uniprotkb:Increased loss of mitochondrial DNA protein 1(gene name synonym)|uniprotkb:J2033(orf name)|uniprotkb:ILM1(gene name)|psi-mi:ILM1(display_short)|uniprotkb:YJR118C(locus name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714237|imex:IM-26166-6788	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003879|interpro:IPR018815|refseq:NP_012652.3|mint:P47155|ensemblfungi:YJR118C(gene)|ensemblfungi:YJR118C_mRNA(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|ensembl:YJR118C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog2 (YNL130C)-prey (YJR118C) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.00939959718662511)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:BrQhbXGvUjNG6Bt5c0J7T8qzMeI559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:Git1JB5hqXpIi1VoBnSgmkgBN0w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11986	uniprotkb:P17898	intact:EBI-9257|ensemblfungi:YJL153C|uniprotkb:D6VW34	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:ino1_yeast(display_long)|uniprotkb:INO1(gene name)|psi-mi:INO1(display_short)|uniprotkb:Myo-inositol 1-phosphate synthase(gene name synonym)|uniprotkb:J0610(orf name)|uniprotkb:YJL153C(locus name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714225|imex:IM-26166-6932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1P1K|ensemblfungi:YJL153C(gene)|ensemblfungi:YJL153C_mRNA(transcript)|go:"GO:0004512"(inositol-3-phosphate synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006021"(inositol biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|interpro:IPR002587(Myo-inositol-1-phosphate synthase)|interpro:IPR013021(Myo-inositol-1-phosphate synthase, GAPDH-like)|interpro:IPR036291|rcsb pdb:1JKF|rcsb pdb:1JKI|rcsb pdb:1LA2|rcsb pdb:1P1F|rcsb pdb:1P1H|rcsb pdb:1P1I|rcsb pdb:1P1J|rcsb pdb:1RM0|reactome:R-SCE-1855183|refseq:NP_012382.2|sgd:S000003689|dip:DIP-5687N|mint:P11986|ensembl:YJL153C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	crc64:282E2AE5D156289D	-	comment:"paralog2 (YNL130C)-prey (YJL153C) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.000871850256527116)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:3OB3q28fOVxXSBMwMpLe2c1g8p8559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:oTxlX4IgsvdNEahVue2FZuF80kw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38875	uniprotkb:P17898	intact:EBI-24869|uniprotkb:D3DLD6|ensemblfungi:YHR188C	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:gpi16_yeast(display_long)|uniprotkb:GPI16(gene name)|psi-mi:GPI16(display_short)|uniprotkb:YHR188C(locus name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714213|imex:IM-26166-6874	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012058.1|sgd:S000001231|mint:P38875|dip:DIP-1888N|ensemblfungi:YHR188C(gene)|ensemblfungi:YHR188C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016255"(attachment of GPI anchor to protein)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042765"(GPI-anchor transamidase complex)|interpro:IPR007245(Gpi16 subunit, GPI transamidase component)|ensembl:YHR188C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	crc64:E9613CE0EA99F963	-	comment:"paralog2 (YNL130C)-prey (YHR188C) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.00236065390186572)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:qvK2gNcnfXW5KU81xOCtdz54jgI559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:rzCHRhy7gHebzOpjkt9LRDHLVuk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02774	uniprotkb:P17898	intact:EBI-17099|uniprotkb:Q12413|ensemblfungi:YDL212W|uniprotkb:D6VRE2	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:shr3_yeast(display_long)|uniprotkb:D1022(orf name)|uniprotkb:YDL212W(locus name)|uniprotkb:SHR3(gene name)|psi-mi:SHR3(display_short)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714201|imex:IM-26166-6930	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010069.1|sgd:S000002371|ensemblfungi:YDL212W(gene)|ensemblfungi:YDL212W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0006865"(amino acid transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0043332"(mating projection tip)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR013248(Shr3 amino acid permease chaperone)|dip:DIP-1615N|mint:Q02774|ensembl:YDL212W(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	-	-	comment:"paralog2 (YNL130C)-prey (YDL212W) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.00191394303033012)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:IGYbkr6cAVoYYx9LhZxB/B9Onnc559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:z9xcnrsAMfnBfim/Ei+on+1kJDE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38353	uniprotkb:P17898	intact:EBI-18175|uniprotkb:D6VQS8|ensemblfungi:YBR283C	intact:EBI-2050738|uniprotkb:D6W152|ensemblfungi:YNL130C	psi-mi:ssh1_yeast(display_long)|uniprotkb:SSH1(gene name)|psi-mi:SSH1(display_short)|uniprotkb:Ssh1 complex subunit alpha(gene name synonym)|uniprotkb:Ssh1 complex subunit SSH1(gene name synonym)|uniprotkb:YBR2020(orf name)|uniprotkb:YBR283C(locus name)	psi-mi:cpt1_yeast(display_long)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:Sn-1,2-diacylglycerol cholinephosphotransferase(gene name synonym)|uniprotkb:N1218(orf name)|uniprotkb:N1867(orf name)|uniprotkb:YNL130C(locus name)|uniprotkb:CPT1(gene name)|psi-mi:CPT1(display_short)|uniprotkb:Aminoalcohol phosphotransferase CPT1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714189|imex:IM-26166-6872	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009842.1|sgd:S000000487|ensemblfungi:YBR283C(gene)|ensemblfungi:YBR283C_mRNA(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|go:"GO:0071261"(Ssh1 translocon complex)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|rcsb pdb:2WW9|rcsb pdb:2WWA|dip:DIP-4962N|mint:P38353|ensembl:YBR283C(identity)	sgd:S000005074|refseq:NP_014269.4|dip:DIP-7848N|mint:P17898|ensemblfungi:YNL130C(gene)|ensemblfungi:YNL130C_mRNA(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-SCE-1483191|reactome:R-SCE-1483213|ensembl:YNL130C(identity)	-	crc64:48267EEA3E0191BD	-	comment:"paralog2 (YNL130C)-prey (YBR283C) interaction occurs only under paralog1 (YHR123W) depletion condition (FDR-corrected p-value: 0.00050301602491447)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:76wvZIdv7W5BQn6wI+sHOGQAyuc559292	rogid:PsU8UELFPsbtbzOS6oBnXJAuk/A559292	rigid:WKUwIQm36qqecPHOHBcLGDi94CU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06146	uniprotkb:P47137	intact:EBI-36149|uniprotkb:D6VYQ4|ensemblfungi:YLR257W	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:yl257_yeast(display_long)|uniprotkb:YLR257W(locus name)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714177|imex:IM-26166-6928	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004247|refseq:NP_013358.1|mint:Q06146|dip:DIP-4779N|ensemblfungi:YLR257W(gene)|ensemblfungi:YLR257W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|ensembl:YLR257W(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	-	-	comment:"paralog2 (YJR096W)-prey (YLR257W) interaction occurs only under paralog1 (YHR104W) depletion condition (FDR-corrected p-value: 0.00143281483764195)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:SB7mpLFMvR1CbPIXfELPS7rdYiw559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:SnFqPvDYs7dVYsbtQP9jGSrq+CQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02046	uniprotkb:P47137	intact:EBI-2045181|uniprotkb:D6VXE0|ensemblfungi:YKR080W	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:mtd1_yeast(display_long)|uniprotkb:YKR400(orf name)|uniprotkb:YKR080W(locus name)|uniprotkb:MTD1(gene name)|psi-mi:MTD1(display_short)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714165|imex:IM-26166-6926	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001788|refseq:NP_013006.3|dip:DIP-730N|mint:Q02046|ensemblfungi:YKR080W(gene)|ensemblfungi:YKR080W_mRNA(transcript)|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009396"(folic acid-containing compound biosynthetic process)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020630|interpro:IPR020631|interpro:IPR035812|interpro:IPR036291|rcsb pdb:1EDZ|rcsb pdb:1EE9|ensembl:YKR080W(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	-	-	comment:"paralog2 (YJR096W)-prey (YKR080W) interaction occurs only under paralog1 (YHR104W) depletion condition (FDR-corrected p-value: 0.0065458164351464)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:xAOzw/g5xSBjpNJuVTxsxTeWAEI559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:RtAwEve4zvwXh+s3HydRuvgjh9A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40518	uniprotkb:P47137	intact:EBI-2750|uniprotkb:D6VVM2|ensemblfungi:YIL062C	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:arpc5_yeast(display_long)|uniprotkb:ARC15(gene name)|psi-mi:ARC15(display_short)|uniprotkb:Arp2/3 complex 16 kDa subunit(gene name synonym)|uniprotkb:YIL062C(locus name)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714153|imex:IM-26166-7012	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012202.1|sgd:S000001324|dip:DIP-2101N|mint:P40518|ensemblfungi:YIL062C(gene)|ensemblfungi:YIL062C_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|interpro:IPR006789("ARP2/3 complex 16 kDa subunit (p16-Arc)")|interpro:IPR036743|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-6798695|reactome:R-SCE-8856828|ensembl:YIL062C(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	crc64:10E4DAF0F0801B02	-	comment:"paralog2 (YJR096W)-prey (YIL062C) interaction occurs only under paralog1 (YHR104W) depletion condition (FDR-corrected p-value: 0.000320823574672734)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:iQ0mLisINMjXPulrRyDmrLcdpzU559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:KUSlxDEpwv8nrFN4zIQMzNv9d/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38720	uniprotkb:P47137	intact:EBI-1965|uniprotkb:D3DLD1|ensemblfungi:YHR183W	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:6pgd1_yeast(display_long)|uniprotkb:GND1(gene name)|psi-mi:GND1(display_short)|uniprotkb:YHR183W(locus name)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714141|imex:IM-26166-6556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000001226|refseq:NP_012053.3|dip:DIP-6604N|mint:P38720|ensemblfungi:YHR183W(gene)|ensemblfungi:YHR183W_mRNA(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2P4Q|reactome:R-SCE-71336|ensembl:YHR183W(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	crc64:55CAE5DACDC6A00B	-	comment:"paralog2 (YJR096W)-prey (YHR183W) interaction occurs only under paralog1 (YHR104W) depletion condition (FDR-corrected p-value: 1.43137326673812E-13)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:8nBsN83LnQMIoQOqo1H+uOiTFsU559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:5oQmfPXge9AS4n46UZCxdT1CgKc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53252	uniprotkb:P47137	intact:EBI-23225|uniprotkb:D6VUL8|ensemblfungi:YGR086C	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:pil1_yeast(display_long)|uniprotkb:YGR086C(locus name)|uniprotkb:PIL1(gene name)|psi-mi:PIL1(display_short)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714129|imex:IM-26166-6870	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003318|refseq:NP_011600.3|dip:DIP-4618N|mint:P53252|ensemblfungi:YGR086C(gene)|ensemblfungi:YGR086C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008289"(lipid binding)|go:"GO:0009408"(response to heat)|go:"GO:0032126"(eisosome)|go:"GO:0036286"(eisosome filament)|go:"GO:0070941"(eisosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0097446"(protein localization to eisosome filament)|interpro:IPR027267|interpro:IPR028245|ensembl:YGR086C(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	crc64:C86AE5ABB508EA03	-	comment:"paralog2 (YJR096W)-prey (YGR086C) interaction occurs only under paralog1 (YHR104W) depletion condition (FDR-corrected p-value: 1.43134648638095E-08)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:OtBCHiFwxzPwPX5y1oMTFqlc1Po559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:FgmfpgFtYE+1LJHxGsqkXMnPPw4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32610	uniprotkb:P47137	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	intact:EBI-25572|uniprotkb:D6VWR5|ensemblfungi:YJR096W	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:yj66_yeast(display_long)|uniprotkb:J1926(orf name)|uniprotkb:YJR096W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714117|imex:IM-26166-6494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610|ensembl:YEL051W(identity)	refseq:NP_012630.1|sgd:S000003857|interpro:IPR018170|interpro:IPR020471|interpro:IPR023210|mint:P47137|interpro:IPR036812|ensemblfungi:YJR096W(gene)|ensemblfungi:YJR096W_mRNA(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019568"(arabinose catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042843"(D-xylose catabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|ensembl:YJR096W(identity)	-	crc64:FDE93E1FAF0AEC5B	-	comment:"paralog2 (YJR096W)-prey (YEL051W) interaction occurs only under paralog1 (YHR104W) depletion condition (FDR-corrected p-value: 9.38415716877643E-07)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rogid:fXbNw7U43+Xc9l2zHWzbbRjx8Zs559292	rigid:OXZKLFXKm1baht0CAd/p6d4h87c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53390	uniprotkb:Q02201	intact:EBI-10729|uniprotkb:Q6B2F5|ensemblfungi:YPR138C|uniprotkb:D6W4D6	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:mep3_yeast(display_long)|uniprotkb:MEP3(gene name)|psi-mi:MEP3(display_short)|uniprotkb:YPR138C(locus name)|uniprotkb:P9659.14(orf name)|uniprotkb:AMT3(gene name synonym)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714105|imex:IM-26166-6554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015464.1|sgd:S000006342|ensemblfungi:YPR138C(gene)|ensemblfungi:YPR138C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015696"|go:"GO:0019740"(nitrogen utilization)|interpro:IPR001905(Ammonium transporter)|interpro:IPR018047|interpro:IPR024041|interpro:IPR029020|mint:P53390|dip:DIP-4909N|ensembl:YPR138C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	crc64:2309338F36D96258	-	comment:"paralog2 (YKR003W)-prey (YPR138C) interaction occurs only under paralog1 (YHR001W) depletion condition (FDR-corrected p-value: 0.000415265125674184)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:UajvXf1E8FU957+oquLoPeSfTjk559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:/B3W+HuLSF6GCHeojzfMMrCXNvs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36024	uniprotkb:Q02201	intact:EBI-17250|uniprotkb:D6VXD3|ensemblfungi:YKR072C	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:sis2_yeast(display_long)|uniprotkb:SIS2(gene name)|psi-mi:SIS2(display_short)|uniprotkb:HAL3(gene name synonym)|uniprotkb:YKR072C(locus name)|uniprotkb:Halotolerance protein HAL3(gene name synonym)|uniprotkb:Sit4 suppressor 2(gene name synonym)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714093|imex:IM-26166-6924	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012998.1|sgd:S000001780|ensemblfungi:YKR072C(gene)|ensemblfungi:YKR072C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003824"(catalytic activity)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0009651"(response to salt stress)|go:"GO:0010181"(FMN binding)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0071513"(phosphopantothenoylcysteine decarboxylase complex)|go:"GO:1990143"(CoA-synthesizing protein complex)|interpro:IPR003382(Flavoprotein)|interpro:IPR036551|dip:DIP-2521N|mint:P36024|ensembl:YKR072C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog2 (YKR003W)-prey (YKR072C) interaction occurs only under paralog1 (YHR001W) depletion condition (FDR-corrected p-value: 0.002395099141192)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:oiDiGYmZy7PE7zchnyTa2x4g9zo559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:XWe2bxbvGEW9iGw+1/P9L/ncJCo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53283	uniprotkb:Q02201	intact:EBI-2044753|uniprotkb:D6VUR9|ensemblfungi:YGR138C	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:tpo2_yeast(display_long)|uniprotkb:G6417(orf name)|uniprotkb:YGR138C(locus name)|uniprotkb:TPO2(gene name)|psi-mi:TPO2(display_short)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714081|imex:IM-26166-6868	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011654.1|sgd:S000003370|dip:DIP-7902N|mint:P53283|ensemblfungi:YGR138C(gene)|ensemblfungi:YGR138C_mRNA(transcript)|go:"GO:0000296"(spermine transport)|go:"GO:0000297"(spermine transmembrane transporter activity)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015297"(antiporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0071944"(cell periphery)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|ensembl:YGR138C(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog2 (YKR003W)-prey (YGR138C) interaction occurs only under paralog1 (YHR001W) depletion condition (FDR-corrected p-value: 3.1474417726892E-07)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:UuyY7fJHoszA44v9O9c6T54xslg559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:16TzRYcjj8asmqtxeEhSyDAMxts	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05359	uniprotkb:Q02201	intact:EBI-6581|uniprotkb:D6VPL7|uniprotkb:E9P8S8|ensemblfungi:YAR002C-A	intact:EBI-12636|uniprotkb:D6VXT9|ensemblfungi:YKR003W	psi-mi:erp1_yeast(display_long)|uniprotkb:ERP1(gene name)|psi-mi:ERP1(display_short)|uniprotkb:YAR002A(orf name)|uniprotkb:YAR002C-A(locus name)	psi-mi:osh6_yeast(display_long)|uniprotkb:YK102(orf name)|uniprotkb:YKR003W(locus name)|uniprotkb:OSH6(gene name)|psi-mi:OSH6(display_short)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714069|imex:IM-26166-6492	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009402.1|sgd:S000002129|mint:Q05359|dip:DIP-5147N|ensemblfungi:YAR002C-A(gene)|ensemblfungi:YAR002C-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-SCE-6811434|ensembl:YAR002C-A(identity)	go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0015914"(phospholipid transport)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0120015"(sterol transfer activity)|rcsb pdb:4B2Z|rcsb pdb:4PH7|reactome:R-SCE-1482801|reactome:R-SCE-192105|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensemblfungi:YKR003W(gene)|ensemblfungi:YKR003W_mRNA(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|refseq:NP_012928.1|sgd:S000001711|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|mint:Q02201|ensembl:YKR003W(identity)	-	-	-	comment:"paralog2 (YKR003W)-prey (YAR002C-A) interaction occurs only under paralog1 (YHR001W) depletion condition (FDR-corrected p-value: 0.00095432220718886)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:RX3ynMqEVNp4bRTVb16YoXaQW3U559292	rogid:aOZdSdLn96ns0C9w9E3r62iNyYo559292	rigid:O9hag8HYsCwWqJWwMBDpWH1Vx/A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43603	uniprotkb:P38856	intact:EBI-22980|uniprotkb:D6VTQ4|ensemblfungi:YFR024C-A	intact:EBI-24811|uniprotkb:D3DLB0|ensemblfungi:YHR161C	psi-mi:lsb3_yeast(display_long)|uniprotkb:LSB3(gene name)|psi-mi:LSB3(display_short)|uniprotkb:YFR024C(orf name)|uniprotkb:YFR024C-A(locus name)	psi-mi:ap18a_yeast(display_long)|uniprotkb:YAP1801(gene name)|psi-mi:YAP1801(display_short)|uniprotkb:YHR161C(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714057|imex:IM-26166-6716	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002968|refseq:NP_219497.4|dip:DIP-6259N|mint:P43603|ensemblfungi:YFR024C-A(gene)|ensemblfungi:YFR024C-A_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005935"(cellular bud neck)|go:"GO:0030479"(actin cortical patch)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051666"(actin cortical patch localization)|interpro:IPR001452(Src homology-3)|interpro:IPR007461(Protein of unknown function DUF500)|interpro:IPR033643|interpro:IPR036028|rcsb pdb:1OOT|rcsb pdb:1SSH|ensembl:YFR024C-A(identity)	refseq:NP_012031.1|sgd:S000001204|mint:P38856|dip:DIP-2278N|ensemblfungi:YHR161C(gene)|ensemblfungi:YHR161C_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|ensembl:YHR161C(identity)	-	crc64:F486C787B5771AAC	-	comment:"paralog2 (YHR161C)-prey (YFR024C-A) interaction occurs only under paralog1 (YGR241C) depletion condition (FDR-corrected p-value: 0.00156881732110601)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:zKMZQRpG4d/at/NecQDyEi/kVKg559292	rogid:SusWB53Amzh3hgiCoQ6zx6Y1Yx8559292	rigid:cLED5ON/Ycl1sSQm7cmZz81NX+c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03554	uniprotkb:Q06144	intact:EBI-2057821|uniprotkb:D6W0B9|ensemblfungi:YMR292W	intact:EBI-34916|uniprotkb:D6VYY8|ensemblfungi:YLR350W	psi-mi:got1_yeast(display_long)|uniprotkb:GOT1(gene name)|psi-mi:GOT1(display_short)|uniprotkb:Golgi transport protein 1(gene name synonym)|uniprotkb:YMR292W(locus name)	psi-mi:orm2_yeast(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:YLR350W(locus name)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714045|imex:IM-26166-6866	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014020.1|sgd:S000004906|dip:DIP-8271N|mint:Q03554|ensemblfungi:YMR292W(gene)|ensemblfungi:YMR292W_mRNA(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR007305(Got1-like protein)|ensembl:YMR292W(identity)	refseq:NP_013454.1|sgd:S000004342|mint:Q06144|dip:DIP-5579N|ensemblfungi:YLR350W(gene)|ensemblfungi:YLR350W_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|interpro:IPR007203(ORMDL)|reactome:R-SCE-6798695|ensembl:YLR350W(identity)	-	-	crc64:2F474503CAB7C195	comment:"paralog2 (YLR350W)-prey (YMR292W) interaction occurs only under paralog1 (YGR038W) depletion condition (FDR-corrected p-value: 0.00275386830175063)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:wO79x4uMwWaL6v00y28srGL561E559292	rogid:sY9Jt1Ogpw+lL+9cnBqUeXBiBdE559292	rigid:M69534zIJjKwd7mZ6ohDPnrZuyU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38009	uniprotkb:Q08967	intact:EBI-14223|ensemblfungi:YMR120C|uniprotkb:D6VZU3	intact:EBI-36673|uniprotkb:D6W3E9|ensemblfungi:YPL221W	psi-mi:pur92_yeast(display_long)|uniprotkb:ADE17(gene name)|psi-mi:ADE17(display_short)|uniprotkb:YM8564.02C(orf name)|uniprotkb:YMR120C(locus name)	psi-mi:flc1_yeast(display_long)|uniprotkb:FAD transporter 1(gene name synonym)|uniprotkb:FLC1(gene name)|psi-mi:FLC1(display_short)|uniprotkb:TRP-like ion channel protein FLC1(gene name synonym)|uniprotkb:Heme utilization factor 1(gene name synonym)|uniprotkb:Bypass of PAM1 protein 1(gene name synonym)|uniprotkb:HUF1(gene name synonym)|uniprotkb:YPL221W(locus name)|uniprotkb:BOP1(gene name synonym)	psi-mi:"MI:0111"(dihydrofolate reductase reconstruction)	Diss et al. (2017)	pubmed:28183979|imex:IM-26166|doi:10.1126/science.aai7685	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16714021|imex:IM-26166-6778	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013839.1|sgd:S000004727|ensemblfungi:YMR120C(gene)|ensemblfungi:YMR120C_mRNA(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|reactome:R-SCE-73817|interpro:IPR036914|mint:P38009|dip:DIP-6288N|ensembl:YMR120C(identity)	refseq:NP_015103.1|sgd:S000006142|mint:Q08967|dip:DIP-3965N|ensemblfungi:YPL221W(gene)|ensemblfungi:YPL221W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006457"(protein folding)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0015230"(FAD transmembrane transporter activity)|go:"GO:0015883"(FAD transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0055085"(transmembrane transport)|interpro:IPR010308(Protein of unknown function DUF907, fungi)|interpro:IPR032800|interpro:IPR040241|ensembl:YPL221W(identity)	-	crc64:8ABA71761B512242	-	comment:"paralog2 (YPL221W)-prey (YMR120C) interaction occurs only under paralog1 (YGL139W) depletion condition (FDR-corrected p-value: 2.30374011581597E-05)"|figure legend:Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2017/02/13	2018/01/16	rogid:Bwp78WXy91CpBBXEqmM7MQV7XJk559292	rogid:r6CcZGEjxHUk2w0iBUBvnAPaFd4559292	rigid:HonJ8xevYAnxjQ3ZUNMCQLKO1l8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)