#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03018	uniprotkb:P40316	intact:EBI-6657|uniprotkb:D6VUN0|ensemblfungi:YGR098C	intact:EBI-16908|uniprotkb:D6VS98|ensemblfungi:YDR113C	psi-mi:esp1_yeast(display_long)|uniprotkb:ESP1(gene name)|psi-mi:ESP1(display_short)|uniprotkb:YGR098C(locus name)|uniprotkb:Separase(gene name synonym)	psi-mi:secu_yeast(display_long)|uniprotkb:PDS1(gene name)|psi-mi:PDS1(display_short)|uniprotkb:YD9727.08C(orf name)|uniprotkb:YDR113C(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Luo et al. (2017)	pubmed:28146474|imex:IM-26223	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16427697|wwpdb:5u1s|wwpdb:5U1T|imex:IM-26223-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003330|refseq:NP_011612.3|dip:DIP-2933N|mint:Q03018|ensemblfungi:YGR098C(gene)|ensemblfungi:YGR098C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0006915"(apoptotic process)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032888"(regulation of mitotic spindle elongation)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|interpro:IPR005314(Peptidase C50, separase)|interpro:IPR030397|rcsb pdb:5U1S|rcsb pdb:5U1T|reactome:R-SCE-2467813	refseq:NP_010398.3|sgd:S000002520|ensemblfungi:YDR113C(gene)|ensemblfungi:YDR113C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000725"(recombinational repair)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007127"(meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019899"(enzyme binding)|go:"GO:0051301"(cell division)|interpro:IPR006940(Securin sister-chromatid separation inhibitor)|rcsb pdb:5U1S|rcsb pdb:5U1T|dip:DIP-2798N|mint:P40316	-	-	crc64:7B31777C539433F4	3d-r-factors:5U1S Rworking 0.19 Rfree 0.25, 5U1T Rworking 0.221 Rfree 0.264|figure legend:Extended Data Table 1|3d-resolution:5U1S -3.0A  5U1T -2.6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/17	2017/10/17	rogid:UMTGDO9alhQOMP7ZXNTEDs/ZB68559292	rogid:bmRdMpzyYPMwAfMORsk6yJRBCf4559292	rigid:VrnkUuLDIKPILjqSYV5iOh15DMQ	false	sufficient binding region:51-1630	sufficient binding region:257-373	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)