#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q14627 uniprotkb:P36222 intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004 intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7 psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym) psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym) psi-mi:"MI:0096"(pull down) Chen et al. (2017) pubmed:28143526|imex:IM-26200 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15187745|imex:IM-26200-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2 - - - figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/16 2017/06/26 rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606 rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606 rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q14627 uniprotkb:P36222-PRO_0000011965 intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004 intact:EBI-15187802 psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym) psi-mi:p36222-pro_0000011965(display_long)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chen et al. (2017) pubmed:28143526|imex:IM-26200 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15187795|imex:IM-26200-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N intact:EBI-6917454(chain-parent) - - chain-seq-start:22|chain-seq-end:383 figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/16 2017/06/26 rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606 rogid:eHqLnIQu7kfYBbTud2ix0agXLwQ9606 rigid:moxG5t6i+gU8cO+BGXfbf8yduR4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14627 uniprotkb:P36222-PRO_0000011965 intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004 intact:EBI-15187802 psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym) psi-mi:p36222-pro_0000011965(display_long)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short) psi-mi:"MI:0663"(confocal microscopy) Chen et al. (2017) pubmed:28143526|imex:IM-26200 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-15187830|imex:IM-26200-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N intact:EBI-6917454(chain-parent) go:"GO:0005886"(plasma membrane) - chain-seq-start:22|chain-seq-end:383 figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/16 2017/06/26 rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606 rogid:eHqLnIQu7kfYBbTud2ix0agXLwQ9606 rigid:moxG5t6i+gU8cO+BGXfbf8yduR4 false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)