#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y2G2-1	uniprotkb:Q9Y2G2-1	intact:EBI-14034258	intact:EBI-14034258	psi-mi:q9y2g2-1(display_long)|uniprotkb:CARD8(gene name)|psi-mi:CARD8(display_short)|uniprotkb:KIAA0955(gene name synonym)|uniprotkb:NDPP1(gene name synonym)|uniprotkb:CARD-inhibitor of NF-kappa-B-activating ligand(gene name synonym)|uniprotkb:DACAR(gene name synonym)|uniprotkb:Tumor up-regulated CARD-containing antagonist of CASP9(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:T48(isoform synonym)	psi-mi:q9y2g2-1(display_long)|uniprotkb:CARD8(gene name)|psi-mi:CARD8(display_short)|uniprotkb:KIAA0955(gene name synonym)|uniprotkb:NDPP1(gene name synonym)|uniprotkb:CARD-inhibitor of NF-kappa-B-activating ligand(gene name synonym)|uniprotkb:DACAR(gene name synonym)|uniprotkb:Tumor up-regulated CARD-containing antagonist of CASP9(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:T48(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheung et al. (2017)	pubmed:28137891|imex:IM-25728	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034246|imex:IM-25728-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2808370(isoform-parent)	intact:EBI-2808370(isoform-parent)	-	-	-	figure legend:2|comment:"The VSV tagged CARD8-FS variant, which has a truncated C terminal region, does not bind. (rs140826611)  The variant  V148K mutation corresponds to residue 42 in CARD8 Isoform 1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/24	2017/04/26	rogid:Y7/YRy7wSoSYrKtrfaFeyU9mCHQ9606	rogid:Y7/YRy7wSoSYrKtrfaFeyU9mCHQ9606	rigid:fc44va1HxChYhTVgQgWJ00onfQk	false	flag tag:?-?	vsv tag:?-?|necessary binding region:41-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96P20	uniprotkb:Q9Y2G2-1	intact:EBI-6253230|uniprotkb:B2RC97|uniprotkb:B7ZKS9|uniprotkb:A0A024R5Q0|uniprotkb:B7ZKT2|uniprotkb:B7ZKT3|uniprotkb:O75434|uniprotkb:Q17RS2|uniprotkb:Q59H68|uniprotkb:Q5JQS8|uniprotkb:Q5JQS9|uniprotkb:Q6TG35|uniprotkb:Q8TCW0|uniprotkb:Q8TEU9|uniprotkb:Q8WXH9	intact:EBI-14034258	psi-mi:nlrp3_human(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)	psi-mi:q9y2g2-1(display_long)|uniprotkb:CARD8(gene name)|psi-mi:CARD8(display_short)|uniprotkb:KIAA0955(gene name synonym)|uniprotkb:NDPP1(gene name synonym)|uniprotkb:CARD-inhibitor of NF-kappa-B-activating ligand(gene name synonym)|uniprotkb:DACAR(gene name synonym)|uniprotkb:Tumor up-regulated CARD-containing antagonist of CASP9(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:T48(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheung et al. (2017)	pubmed:28137891|imex:IM-25728	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034282|imex:IM-25728-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000139"(Golgi membrane)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|go:"GO:0042834"(peptidoglycan binding)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2NAQ|rcsb pdb:3QF2|rcsb pdb:6NPY|refseq:XP_011542350.1|reactome:R-HSA-9707564|reactome:R-HSA-844456|refseq:NP_001073289.1|refseq:NP_001120933.1|refseq:NP_001120934.1|refseq:NP_001230062.1|refseq:NP_004886.3|refseq:NP_899632.1|reactome:R-HSA-5689901|refseq:XP_016855670.1|refseq:XP_016855671.1|refseq:XP_016855672.1|refseq:XP_016855673.1|dip:DIP-41153N|reactome:R-HSA-9660826	intact:EBI-2808370(isoform-parent)	-	-	-	figure legend:2-2|comment:"The VSV tagged CARD8-FS variant, which has a truncated C terminal region, does not bind. (rs140826611)  The variant  V148K mutation corresponds to residue 42 in CARD8 Isoform 1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/24	2017/04/26	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:Y7/YRy7wSoSYrKtrfaFeyU9mCHQ9606	rigid:BUuL/Sf4T4WVo/6XmwedXyExrj4	false	flag tag:?-?	vsv tag:?-?|necessary binding region:41-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)