#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00468	uniprotkb:P05067-PRO_0000000092	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	intact:EBI-821758	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482196|imex:IM-25796-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2018/09/18	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:VnGxCk1JHlOYsAiLcuF4ReRBQUU	false	his tag:n-n|sufficient binding region:1260-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02769	uniprotkb:P05067-PRO_0000000092	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-821758	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482205|imex:IM-25796-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:uOs4domYrfL27YntEKSfEIBGr1o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BY76	uniprotkb:P05067-PRO_0000000092	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	intact:EBI-821758	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482216|imex:IM-25796-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:HQiUCtc6Sd7clEBPOeBk0TdOwIM	false	his tag:c-c|mutation:163-163,164-164	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6X2-2	uniprotkb:P05067-PRO_0000000092	intact:EBI-905659|ensembl:ENSP00000386494	intact:EBI-821758	psi-mi:q9h6x2-2(display_long)|uniprotkb:ANTXR1(gene name)|psi-mi:ANTXR1(display_short)|uniprotkb:ATR(gene name synonym)|uniprotkb:TEM8(gene name synonym)|uniprotkb:Tumor endothelial marker 8(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482226|imex:IM-25796-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-905643(antr1_human)|ensembl:ENSG00000169604(gene)|ensembl:ENST00000409349(transcript)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:Zf4W6+r4NcIRwEQGEnaj5oENeak9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:hcAxLb30JYrww6GS7Dhn5fyq3/Y	false	glutathione s tranferase tag:n-n|sufficient binding region:1-368	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GW7	uniprotkb:P05067-PRO_0000000092	intact:EBI-2690445|uniprotkb:Q5SZ10|uniprotkb:Q9HBK4|uniprotkb:Q8TBB9|uniprotkb:Q5T3I5|uniprotkb:Q9HBK1|uniprotkb:D3DVC2|ensembl:ENSP00000331210	intact:EBI-821758	psi-mi:pgcb_human(display_long)|uniprotkb:BEHAB(gene name synonym)|uniprotkb:CSPG7(gene name synonym)|uniprotkb:Brain-enriched hyaluronan-binding protein(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 7(gene name synonym)|uniprotkb:UNQ2525/PRO6018(orf name)|uniprotkb:BCAN(gene name)|psi-mi:BCAN(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482235|imex:IM-25796-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011508168.1|refseq:NP_068767.3|refseq:NP_940819.1|ensembl:ENSG00000132692(gene)|ensembl:ENST00000329117(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0060074"(synapse maturation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR035976|interpro:IPR036179|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:tQpgHyHCK7CoB3KDqkJ59qRa+049606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:r+jnEv6PurRINKLi1zOc+8fK8YY	false	his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27797	uniprotkb:P05067-PRO_0000000092	intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037	intact:EBI-821758	psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482242|imex:IM-25796-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:fJsCBteQBUzto+qvbhsb8NCUFCA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00432	uniprotkb:P05067-PRO_0000000092	intact:EBI-15482262|ensembl:ENSBTAP00000027941|uniprotkb:Q3SZ80	intact:EBI-821758	psi-mi:cata_bovin(display_long)|uniprotkb:CAT(gene name)|psi-mi:CAT(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482257|imex:IM-25796-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000020980(gene)|ensembl:ENSBTAT00000027941(transcript)|go:"GO:0004096"(catalase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0020037"(heme binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051781"(positive regulation of cell division)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|rcsb pdb:1TGU|rcsb pdb:1TH2|rcsb pdb:1TH3|rcsb pdb:1TH4|rcsb pdb:3J7B|rcsb pdb:3NWL|rcsb pdb:3RE8|rcsb pdb:3RGP|rcsb pdb:3RGS|rcsb pdb:4BLC|rcsb pdb:5GKN|go:"GO:0019899"(enzyme binding)|rcsb pdb:6JNT|rcsb pdb:6JNU|rcsb pdb:6PM7|rcsb pdb:7CAT|rcsb pdb:7DI8|rcsb pdb:8CAT|rcsb pdb:6PO0|refseq:NP_001030463.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:D/N8O++eAy7TyEM545AJK4YfOAQ9913	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:s/GFH2+XtV1gZtzPeGlJwtq9tU4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00743	uniprotkb:P05067-PRO_0000000092	intact:EBI-15482327	intact:EBI-821758	psi-mi:fa10_bovin(display_long)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)|uniprotkb:Stuart factor(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482322|imex:IM-25796-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007596"(blood coagulation)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|refseq:NP_001073682.1|rcsb pdb:1APO|rcsb pdb:1CCF|rcsb pdb:1IOD|rcsb pdb:1KIG|rcsb pdb:1WHE|rcsb pdb:1WHF|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	rogid:QEqFlYKk7+ZuI43yL+l88s9gUHg9913	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:CjJ8oMkCmCcPlaFQBITpXP1pDzw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-2089970	uniprotkb:P05067-PRO_0000000092	intact:EBI-2325312|matrixdb:MULT_3_human|reactome:R-HSA-2467139|reactome:R-HSA-2396132|reactome:R-HSA-2396423|reactome:R-HSA-2396135|reactome:R-HSA-2396296|reactome:R-HSA-2396322|reactome:R-HSA-2428941|reactome:R-HSA-2396033|reactome:R-HSA-2396048	intact:EBI-821758	psi-mi:collagen_i_human(display_short)|psi-mi:R-HSA-2089970(display_long)|intact:Collagen type I trimer(complex recommended name)|intact:Type I collagen(complex synonym)|intact:"2xCOL1A1:COL1A2"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482366|imex:IM-25796-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|complex portal:CPX-1650(complex-primary)|intact:EBI-25750246(exp-evidence)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030199"(collagen fibril organization)|evidence ontology:"ECO:0000353"	intact:EBI-77613(chain-parent)	-	curated-complex:Forms the fibrils of tendon, ligaments and bones, also present in skin. In bones the fibrils are mineralized with calcium hydroxyapatite.|assembly:Heterotrimer|complex-properties:"Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the center of the superhelix. Propeptides (telopeptides) at both ends of the molecular precursor undergo highly complex fibrillogenesis."	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs with Abeta42 peptide, oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_9_bovine	uniprotkb:P05067-PRO_0000000092	intact:EBI-9551452	intact:EBI-821758	psi-mi:collagen_ii_bovin(display_short)|psi-mi:MULT_9_bovine(display_long)|intact:Collagen type II trimer(complex recommended name)|intact:Type II collagen(complex synonym)|intact:COL1A2 trimer(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482372|imex:IM-25796-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005544"|go:"GO:0005585"(collagen type II trimer)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|pubmed:1916105(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|pubmed:17876790(see-also)|go:"GO:0030199"(collagen fibril organization)|complex portal:CPX-2957(inferred-from)|complex portal:CPX-3105(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:The major component of cartilage.|complex-assembly:Homotrimer|complex-properties:"Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the center of the superhelix. The hydroxylysyl  residues are highly 0-glycosylated. Propeptides (telopeptides) at both ends of the molecular precursor undergo highly complex fibrillogenesis."	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs with Abeta42 peptide, oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-2127436	uniprotkb:P05067-PRO_0000000092	intact:EBI-2431547|matrixdb:MULT_10_human|wwpdb:3dmw|reactome:R-HSA-2468091	intact:EBI-821758	psi-mi:collagen_iii_human(display_short)|psi-mi:R-HSA-2127436(display_long)|intact:Collagen type III trimer(complex recommended name)|intact:Type III collagen(complex synonym)|intact:COL3A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482378|imex:IM-25796-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005586"(collagen type III trimer)|pubmed:1916105(see-also)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0005201"(extracellular matrix structural constituent)|pubmed:17876790(see-also)|evidence ontology:"ECO:0000353"|complex portal:CPX-1714(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:"Occurs in most soft connective tissues. Bonded to type I collagen (CPX-1650) by covalent lysine-derived cross-links."|complex-assembly:Homotrimer|complex-properties:"Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the center of the superhelix. Propeptides (telopeptides) at both ends of the molecular precursor undergo highly complex fibrillogenesis."	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-215992	uniprotkb:P05067-PRO_0000000092	intact:EBI-2461395|matrixdb:MULT_4_VAR1_human|wwpdb:1li1|reactome:R-HSA-2127348|reactome:R-HSA-2468115	intact:EBI-821758	psi-mi:collagen_iv_human-1(display_short)|psi-mi:R-HSA-215992(display_long)|intact:Collagen type IV trimer variant 1(complex recommended name)|intact:Type IV collagen variant I(complex synonym)|intact:"2xCOL4A1:COL4A2"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482384|imex:IM-25796-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005587"(collagen type IV trimer)|pubmed:1916105(see-also)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0005201"(extracellular matrix structural constituent)|pubmed:17876790(see-also)|intact:EBI-2535681(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1723(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Basement membranes are formed by a fine network of collagen IV fibres that are laced together and entrap large associated molecules.|complex-assembly:Heterotrimer|complex-properties:"This assembly process requires lateral interactions between triple helices at two levels. In the short N-terminal triple-helical 7S domain, four  triple helical domains from four different molecules assemble head to tail to form the structure known as a spider whose legs are made of a long triple helical region made of several triple helical domains interrupted by short nontriple helical sequences. In the tissue the molecules interact laterally by this region in a staggered fashion. Finally, interactions of nontriple helical COOH-terminal NC1 domains (IPR001442) to form dimers are responsible for tail-to-tail binding of type IV  molecules."	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-2127308	uniprotkb:P05067-PRO_0000000092	intact:EBI-2464572|matrixdb:MULT_5_VAR1_human|wwpdb:1a9a	intact:EBI-821758	psi-mi:collagen_v_human-1(display_short)|psi-mi:R-HSA-2127308(display_long)|intact:Collagen type V trimer variant 1(complex recommended name)|intact:Type V collagen variant 1(complex synonym)|intact:"2xCOL5A1:COL5A2"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482390|imex:IM-25796-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0000353"|go:"GO:0005588"(collagen type V trimer)|pubmed:1916105(see-also)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0005201"(extracellular matrix structural constituent)|pubmed:17876790(see-also)|complex portal:CPX-1727(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Form the fibrils of tendon, ligaments and bones, also present in skin. In bones the fibrils are mineralized with calcium hydroxyapatite.|complex-assembly:Heterotrimer|complex-properties:"Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix. Propeptides (telopeptides) at both ends of the molecular precursor undergo highly complex fibrillogenesis but a significant globular region remains uncleaved. Type V collagens are located within heterotypic fibrils and might actually constitute the core of fibrils."	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_8_human	uniprotkb:P05067-PRO_0000000092	intact:EBI-2465980|reactome:R-HSA-381923	intact:EBI-821758	psi-mi:collagen_vi_human(display_short)|psi-mi:MULT_8_human(display_long)|intact:Collagen type VI trimer(complex recommended name)|intact:Type VI collagen(complex synonym)|intact:"COL6A1:COL6A2:COL6A3"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482396|imex:IM-25796-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005547"|pubmed:17876790(see-also)|pubmed:1916105(see-also)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005201"(extracellular matrix structural constituent)|complex portal:CPX-1736(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:May play a role as an interface between the main collagen fibril network and the cells.|complex-assembly:Heterotrimer.|complex-properties:Forms a short triple helical domain, containing a single cysteine/chain, with prominent globular ends. It dimerises by antiparallel association and tetramerises by lateral association of dimers. The association of tetramers is via their extremities which forms beaded filaments.	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_45_human	uniprotkb:P05067-PRO_0000000092	intact:EBI-2528731	intact:EBI-821758	psi-mi:collagen_xvii_human(display_short)|psi-mi:MULT_45_human(display_long)|intact:Collagen type XVII trimer(complex recommended name)|intact:Type XVII collagen(complex synonym)|intact:COL17A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482402|imex:IM-25796-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005198"(structural molecule activity)|evidence ontology:"ECO:0005547"|go:"GO:0030937"(collagen type XVII trimer)|complex portal:CPX-1758(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Nonfibrillar collagen that is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane.|complex-assembly:Homotrimer.|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/11	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	sufficient binding region:489-1497|his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_12_human	uniprotkb:P05067-PRO_0000000092	intact:EBI-2528478	intact:EBI-821758	psi-mi:collagen_xiii_human(display_short)|psi-mi:MULT_12_human(display_long)|intact:Collagen type XIII trimer(complex recommended name)|intact:Type XIII collagen(complex synonym)|intact:COL13A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482423|imex:IM-25796-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0008201"(heparin binding)|go:"GO:0005600"(collagen type XIII trimer)|go:"GO:0005201"(extracellular matrix structural constituent)|evidence ontology:"ECO:0005547"|complex portal:CPX-1754(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Nonfibrillar collagen that has been detected at low levels in all connective tissue-producing cells so may serve a general function in connective tissues. Collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. Binds heparin.|complex-assembly:Homotrimer.|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	flag tag:c-c|sufficient binding region:62-717	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12109	uniprotkb:P05067-PRO_0000000092	intact:EBI-2465913|ensembl:ENSP00000355180|uniprotkb:O00117|uniprotkb:O00118|uniprotkb:Q14040|uniprotkb:Q14041|uniprotkb:Q16258|uniprotkb:Q7Z645|uniprotkb:Q9BSA8	intact:EBI-821758	psi-mi:co6a1_human(display_long)|uniprotkb:COL6A1(gene name)|psi-mi:COL6A1(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482431|imex:IM-25796-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142156(gene)|ensembl:ENST00000361866(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005518"(collagen binding)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042383"(sarcolemma)|go:"GO:0005576"(extracellular region)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR036465|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|refseq:NP_001839.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:ziEV+a4Xb+C4ioMe8uoISJitR6E9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:fXdYhJXQZ72/5PZzUsvmo2F3IVM	false	flag tag:c-c|sufficient binding region:37-235	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07585	uniprotkb:P05067-PRO_0000000092	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	intact:EBI-821758	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482443|imex:IM-25796-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:v/mmenbnIwWQwqx6SX60f1IKVCc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07507	uniprotkb:P05067-PRO_0000000092	intact:EBI-719535|uniprotkb:Q8N4R2|uniprotkb:Q9UIX8|uniprotkb:A8K981|ensembl:ENSP00000356791	intact:EBI-821758	psi-mi:derm_human(display_long)|uniprotkb:Tyrosine-rich acidic matrix protein(gene name synonym)|uniprotkb:DPT(gene name)|psi-mi:DPT(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482449|imex:IM-25796-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001928.2|ensembl:ENSG00000143196(gene)|ensembl:ENST00000367817(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR026645	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:Su6FIKMifD6sS+iYZTzwJqrLvg09606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:z8Ib9gFH+fX25Y8v7Yuy/FcExFw	false	tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16832	uniprotkb:P05067-PRO_0000000092	intact:EBI-1381484|uniprotkb:Q7Z730|ensembl:ENSP00000356898|ensembl:ENSP00000356899|ensembl:ENSP00000400309	intact:EBI-821758	psi-mi:ddr2_human(display_long)|uniprotkb:Discoidin domain-containing receptor tyrosine kinase 2(gene name synonym)|uniprotkb:DDR2(gene name)|psi-mi:DDR2(display_short)|uniprotkb:NTRKR3(gene name synonym)|uniprotkb:TKT(gene name synonym)|uniprotkb:TYRO10(gene name synonym)|uniprotkb:Receptor protein-tyrosine kinase TKT(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO10(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 3(gene name synonym)|uniprotkb:CD167 antigen-like family member B(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482457|imex:IM-25796-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006711407.1|refseq:NP_001014796.1|refseq:NP_006173.2|refseq:XP_011507889.1|refseq:XP_011507888.1|dip:DIP-39699N|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR034299|mint:Q16832|rcsb pdb:2WUH|rcsb pdb:2Z4F|rcsb pdb:6FER|rcsb pdb:7AZB|reactome:R-HSA-3000171|ensembl:ENSG00000162733(gene)|ensembl:ENST00000367921(transcript)|ensembl:ENST00000367922(transcript)|ensembl:ENST00000446985(transcript)|go:"GO:0001503"(ossification)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:aWup/fmqKPNU6Zg5aMeU8wKGUPU9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:04Y3RjVTFqO3Ut0/F6HhwnndLcc	false	his tag:c-c|sufficient binding region:24-399	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01133	uniprotkb:P05067-PRO_0000000092	intact:EBI-640857|uniprotkb:B4DRK7|uniprotkb:E9PBF0|uniprotkb:Q52LZ6|uniprotkb:E7EVD2|ensembl:ENSP00000265171	intact:EBI-821758	psi-mi:egf_human(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482477|imex:IM-25796-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171602.1|refseq:NP_001954.2|refseq:NP_001171601.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01133|rcsb pdb:1IVO|rcsb pdb:1JL9|rcsb pdb:1NQL|rcsb pdb:1P9J|rcsb pdb:2KV4|rcsb pdb:3NJP|reactome:R-HSA-114608|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|ensembl:ENSG00000138798(gene)|ensembl:ENST00000265171(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|dip:DIP-5767N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:H2Ewl436sfCPTMfgz7YGsLKq4Nk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:UR87n5g8g5JG9cHCUFkudBrs23I	false	sufficient binding region:971-1023	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UW88	uniprotkb:P05067-PRO_0000000092	intact:EBI-15482510|ensembl:ENSP00000411898|uniprotkb:A1BMM3|uniprotkb:A1BMM4|uniprotkb:A1BMM5|uniprotkb:A1BMM6|uniprotkb:A1BMM7|uniprotkb:A1BMM8|uniprotkb:A8K090	intact:EBI-821758	psi-mi:epgn_human(display_long)|uniprotkb:EPGN(gene name)|psi-mi:EPGN(display_short)|uniprotkb:Epithelial mitogen(gene name synonym)|uniprotkb:UNQ3072/PRO9904(orf name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482505|imex:IM-25796-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182585(gene)|ensembl:ENST00000413830(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|rcsb pdb:5WB8|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001257918.1|refseq:NP_001257919.1|refseq:NP_001257920.1|refseq:NP_001257921.1|refseq:NP_001257922.1|refseq:XP_005265723.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:vmMwhYDlPfTAfgYlar/mhqg/CBQ9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:HzESTHluSGJ301hiNZBRRbAL000	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:Q16610	intact:EBI-821758	intact:EBI-947964|ensembl:ENSP00000358043|uniprotkb:A8K8S0|uniprotkb:B4DW49|uniprotkb:B4DY60|uniprotkb:O43266|uniprotkb:Q5T5G4|uniprotkb:Q5T5G5|uniprotkb:Q5T5G6|uniprotkb:Q8IZ60	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:ecm1_human(display_long)|uniprotkb:Secretory component p85(gene name synonym)|uniprotkb:ECM1(gene name)|psi-mi:ECM1(display_short)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482560|imex:IM-25796-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	ensembl:ENSG00000143369(gene)|ensembl:ENST00000369047(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|refseq:NP_001189787.1|refseq:NP_004416.2|refseq:NP_073155.2|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043236"(laminin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR008605(Extracellular matrix 1)|interpro:IPR020858|mint:Q16610|reactome:R-HSA-114608|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002828"(regulation of type 2 immune response)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	-	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:Dgo43cKlqBAYL6tWVb9B63CuY+Q9606	rigid:m99fDskkJg/atwUqD7KiqGTrj3M	false	-	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09038	uniprotkb:P05067-PRO_0000000092	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-821758	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482568|imex:IM-25796-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:0T3l19dt8RLTUP3qTG3Tj2evgEY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13605	uniprotkb:P05067-PRO_0000000092	intact:EBI-5281124|uniprotkb:A7E3X1|uniprotkb:Q3SWX6|ensembl:ENSBTAP00000019854	intact:EBI-821758	psi-mi:fmod_bovin(display_long)|uniprotkb:FMOD(gene name)|psi-mi:FMOD(display_short)|uniprotkb:Collagen-binding 59 kDa protein(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan fibromodulin(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482574|imex:IM-25796-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776483.1|ensembl:ENSBTAG00000014912(gene)|ensembl:ENSBTAT00000019854(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027215|interpro:IPR032675|reactome:R-BTA-2022854|reactome:R-BTA-2022857	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:S52O/y3SsP4GnuqitcE1ro9C7q89913	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:s0dvPNpqnrr2MiCXr9DOeQ5shiM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02751	uniprotkb:P05067-PRO_0000000092	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	intact:EBI-821758	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482580|imex:IM-25796-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2019/10/18	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cJOlIal2VX4CN9fReKN3WxY0Eiw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07589	uniprotkb:P05067-PRO_0000000092	intact:EBI-11147184	intact:EBI-821758	psi-mi:finc_bovin(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482586|imex:IM-25796-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000083(Fibronectin, type I)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR036116|interpro:IPR036943	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:4pt20MEf9GMmrbrp/Yxv1UJIaBs9913	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:3pyhHyNJaDIW92oxu8hfiIV+jiY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02751-PRO_0000390479	uniprotkb:P05067-PRO_0000000092	intact:EBI-15482592	intact:EBI-821758	psi-mi:p02751-pro_0000390479(display_long)|uniprotkb:Cold-insoluble globulin(gene name synonym)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482602|imex:IM-25796-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1220319(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:627|chain-seq-end:702	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:gW2sIQCKhD7/tgkQMo1YOQ1a9NM9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:pHifw/aBuMVg3qmJRnyYFI+VKIc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35052	uniprotkb:P05067-PRO_0000000092	intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1	intact:EBI-821758	psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482608|imex:IM-25796-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2	intact:EBI-77613(chain-parent)	-	function:Cell surface proteoglycan that bears heparan sulfate|comment:mint	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:K07dVgLIg8hOXlZcpEVUDLekXFw	false	his tag:c-c|sufficient binding region:24-530	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51654	uniprotkb:P05067-PRO_0000000092	intact:EBI-5654198|uniprotkb:C9JLE3|uniprotkb:Q2L880|uniprotkb:G3V1R0|uniprotkb:Q2L882|ensembl:ENSP00000359854	intact:EBI-821758	psi-mi:gpc3_human(display_long)|uniprotkb:GTR2-2(gene name synonym)|uniprotkb:Intestinal protein OCI-5(gene name synonym)|uniprotkb:MXR7(gene name synonym)|uniprotkb:OCI5(gene name synonym)|uniprotkb:GPC3(gene name)|psi-mi:GPC3(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482618|imex:IM-25796-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158091.1|dip:DIP-61509N|refseq:NP_004475.1|refseq:NP_001158089.1|ensembl:ENSG00000147257(gene)|ensembl:ENST00000370818(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009617"(response to bacterium)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010171"(body morphogenesis)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0016477"(cell migration)|go:"GO:0030282"(bone mineralization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060422"(peptidyl-dipeptidase inhibitor activity)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072111"(cell proliferation involved in kidney development)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072180"(mesonephric duct morphogenesis)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001863(Glypican)|interpro:IPR015501(Glypican 3)|interpro:IPR019803|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|reactome:R-HSA-975634	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:+H2PtA0Y61S+2l56UPxwxBpCosc9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:tSkudTjSFG5RFXZCRLhcPT3uZDg	false	his tag:c-c|sufficient binding region:1-559	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78333	uniprotkb:P05067-PRO_0000000092	intact:EBI-2558325|uniprotkb:Q9BX27|uniprotkb:B2R726|uniprotkb:O60436|ensembl:ENSP00000366267	intact:EBI-821758	psi-mi:gpc5_human(display_long)|uniprotkb:GPC5(gene name)|psi-mi:GPC5(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482628|imex:IM-25796-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004457.1|ensembl:ENSG00000179399(gene)|ensembl:ENST00000377067(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031188|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-5362798|reactome:R-HSA-975634	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:Gcy9S91rADjM2ixSpPD0nLDlKz89606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:1Xxu7NIdtei5h45vH/ThzNp74Og	false	his tag:c-c|sufficient binding region:25-554	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y625	uniprotkb:P05067-PRO_0000000092	intact:EBI-3046690|ensembl:ENSP00000366246|uniprotkb:Q9H1P4|uniprotkb:A8K279|uniprotkb:Q96SG8|uniprotkb:Q96SG5	intact:EBI-821758	psi-mi:gpc6_human(display_long)|uniprotkb:GPC6(gene name)|psi-mi:GPC6(display_short)|uniprotkb:UNQ369/PRO705(orf name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15482638|imex:IM-25796-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000377047(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031183|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|ensembl:ENSG00000183098(gene)|refseq:NP_005699.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/12	rogid:j/F2dtbmfhijHXT5t7FR3CpIyfo9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:6a39sdlhX80cI/xCSTtVfH/QVZI	false	his tag:c-c|sufficient binding region:24-354|sufficient binding region:255-527	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28815"	uniprotkb:P05067-PRO_0000000092	intact:EBI-2566501	intact:EBI-821758	psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483841|imex:IM-25796-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_2(source reference)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28815"	uniprotkb:P05067-PRO_0000000092	intact:EBI-2566501	intact:EBI-821758	psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483847|imex:IM-25796-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_2(source reference)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28304"	uniprotkb:P05067-PRO_0000000092	intact:EBI-1379423	intact:EBI-821758	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483853|imex:IM-25796-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51884	uniprotkb:P05067-PRO_0000000092	intact:EBI-725780|uniprotkb:Q96QM7|uniprotkb:B2R6R5|ensembl:ENSP00000266718	intact:EBI-821758	psi-mi:lum_human(display_long)|uniprotkb:SLRR2D(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan lumican(gene name synonym)|uniprotkb:LUM(gene name)|psi-mi:LUM(display_short)|uniprotkb:LDC(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483859|imex:IM-25796-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002336.1|ensembl:ENSG00000139329(gene)|ensembl:ENST00000266718(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005583"(fibrillar collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007601"(visual perception)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070848"(response to growth factor)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027219|interpro:IPR032675|reactome:R-HSA-2022854|reactome:R-HSA-2022857|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-3656225|reactome:R-HSA-3656243|reactome:R-HSA-3656244	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	rogid:+NFnJYYdpuAtRDyyW3CZE3mKEto9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:HH4S45UJ/DDQhSewfbJCIBJPvRY	false	his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chembl target:CHEMBL1907599	uniprotkb:P05067-PRO_0000000092	intact:EBI-2565117|reactome:R-HSA-198201|matrixdb:MULT_26_human|signor:SIGNOR-C162	intact:EBI-821758	psi-mi:intg_a4_b1_human(display_short)|psi-mi:CHEMBL1907599(display_long)|intact:alpha4-beta1 integrin complex(complex synonym)|intact:Integrin alpha4-beta1 complex(complex recommended name)|intact:alpha-4/beta-1 integrin complex(complex synonym)|intact:VLA-4(complex synonym)|intact:very late antigen 4(complex synonym)|intact:"ITGA4:ITGB1"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483867|imex:IM-25796-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	intact:EBI-703300(exp-evidence)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|complex portal:CPX-1802(complex-primary)|evidence ontology:"ECO:0000353"	intact:EBI-77613(chain-parent)	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin, in which it recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions, and VCAM-1, in which it recognizes the sequence Q-I-D-S. On activated endothelial cells  triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer|comment:"Ectodomain of integrin: sufficient to bind  P13612 Sufficient to bind (34-970) + mutation Arg591Leu + acidic tail + C-terminal 6 His tag  P05556 sufficient to bind (21-728) + basic tail"	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chembl target:CHEMBL2095226	uniprotkb:P05067-PRO_0000000092	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	intact:EBI-821758	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483874|imex:IM-25796-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	intact:EBI-77613(chain-parent)	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer|comment:"Ectodomain: sufficient to bind  P08648 sufficient to bind (42-995) + acidic tail  P05556 sufficient to bind (21-728) + basic tail"	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chembl target:CHEMBL1907598	uniprotkb:P05067-PRO_0000000092	intact:EBI-2550735|reactome:R-HSA-210216|matrixdb:MULT_16_human|wwpdb:3ije|wwpdb:4g1e|wwpdb:1U8C|wwpdb:1jv2|wwpdb:1m1x|wwpdb:4g1m|signor:SIGNOR-C177	intact:EBI-821758	psi-mi:intg_av_b3_human(display_short)|psi-mi:CHEMBL1907598(display_long)|intact:alphav-beta3 integrin complex(complex synonym)|intact:alpha-v/beta-3 integrin complex(complex synonym)|intact:Integrin alphav-beta3 complex(complex recommended name)|intact:"ITGAV:ITGB3"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483881|imex:IM-25796-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0034683"(integrin alphav-beta3 complex)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|intact:EBI-1039821(exp-evidence)|complex portal:CPX-1795(complex-primary)|evidence ontology:"ECO:0000353"	intact:EBI-77613(chain-parent)	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor which its binds via the sequence R-G-D in the ligand.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer|comment:"Ectodomain: sufficient to bind  P06756 sufficient to bind (31-992) + HPGGGSGGGS + acidic tail  P05106 sufficient to bind (27-718) + HPGGGSGGGS + basic tail"	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chembl target:CHEMBL2096675	uniprotkb:P05067-PRO_0000000092	intact:EBI-2550754|reactome:R-HSA-1299497|matrixdb:MULT_17_human|signor:SIGNOR-C178|reactome:R-HSA-1236906	intact:EBI-821758	psi-mi:intg_av_b5_human(display_short)|psi-mi:CHEMBL2096675(display_long)|intact:alpha-v/beta-5 integrin complex(complex synonym)|intact:alphav-beta5 integrin complex(complex synonym)|intact:"ITGAV:ITGB5"(complex systematic name)|intact:Integrin alphav-beta5 complex(complex recommended name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483888|imex:IM-25796-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0034684"(integrin alphav-beta5 complex)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|evidence ontology:"ECO:0005547"|complex portal:CPX-1796(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrands Factor which it binds via the sequence R-G-D in the ligand.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer|comment:"P06756 sufficient to bind (31_992) + HPGGGSGGGS + acidic tail + C-terminal 6 His tag  P18084 sufficient to bind (24-719)  + HPGGGSGGGS + basic tail"	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_1_mouse	uniprotkb:P05067-PRO_0000000092	intact:EBI-9249158	intact:EBI-821758	psi-mi:lm-111_mouse(display_short)|psi-mi:MULT_1_mouse(display_long)|intact:Laminin-111 complex(complex recommended name)|intact:LM-111(complex synonym)|intact:Laminin-1 complex(complex synonym)|intact:EHS laminin(complex synonym)|intact:"LAMA1:LAMB1:LAMC1"(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483895|imex:IM-25796-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:17453709(see-also)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0030155"(regulation of cell adhesion)|complex portal:CPX-3008(complex-primary)|evidence ontology:"ECO:0005547"	intact:EBI-77613(chain-parent)	-	complex-properties:"Complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end."|curated-complex:Major component of basment membranes which binds to cells via a high affinity, cell-surface receptor.  Role in the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Found in the subendothelium of vascular vessels and mediates platelet adhesion under static and shear conditions.|complex-assembly:Heterotrimer.	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P58215	uniprotkb:P05067-PRO_0000000092	intact:EBI-723960|ensembl:ENSP00000264094|uniprotkb:Q96RS1|uniprotkb:D6W5J1|uniprotkb:Q2EHP2|uniprotkb:Q6IPL7	intact:EBI-821758	psi-mi:loxl3_human(display_long)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:LOXL3(gene name)|psi-mi:LOXL3(display_short)|uniprotkb:LOXL(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15483901|imex:IM-25796-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115992.1|ensembl:ENSG00000115318(gene)|ensembl:ENST00000264094(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|reactome:R-HSA-1566948|go:"GO:0001837"(epithelial to mesenchymal transition)|reactome:R-HSA-2243919|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|refseq:XP_011531436.1|refseq:NP_001276094.1|refseq:NP_001276093.1|refseq:XP_016860601.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/17	rogid:ZemGKB4zxFQQW1MbA4fiP/NX7ow9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:RPr0jTvO/GCxpxHX9yTDNz2rGD8	false	his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UEW3	uniprotkb:P05067-PRO_0000000092	intact:EBI-2622414|uniprotkb:B4DW79|uniprotkb:Q9Y5S3|ensembl:ENSP00000318916	intact:EBI-821758	psi-mi:marco_human(display_long)|uniprotkb:SCARA2(gene name synonym)|uniprotkb:Macrophage receptor with collagenous structure(gene name synonym)|uniprotkb:Scavenger receptor class A member 2(gene name synonym)|uniprotkb:MARCO(gene name)|psi-mi:MARCO(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484199|imex:IM-25796-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510384.1|refseq:NP_006761.1|ensembl:ENSG00000019169(gene)|ensembl:ENST00000327097(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045087"(innate immune response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|interpro:IPR001190(Speract/scavenger receptor)|go:"GO:0001934"(positive regulation of protein phosphorylation)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR036772|reactome:R-HSA-3000480	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/18	rogid:iGEW9ztEEgd6+cFFGZsHAsyBo0E9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:7GoMd2H2phJCo0q2XYt5HppvOgc	false	sufficient binding region:29-520|his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08253	uniprotkb:P05067-PRO_0000000092	intact:EBI-1033518|uniprotkb:B2R6U1|uniprotkb:Q9UCJ8|ensembl:ENSP00000219070|uniprotkb:E9PE45|uniprotkb:B4DWH3	intact:EBI-821758	psi-mi:mmp2_human(display_long)|uniprotkb:MMP2(gene name)|psi-mi:MMP2(display_short)|uniprotkb:CLG4A(gene name synonym)|uniprotkb:72 kDa gelatinase(gene name synonym)|uniprotkb:Matrix metalloproteinase-2(gene name synonym)|uniprotkb:Gelatinase A(gene name synonym)|uniprotkb:TBE-1(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484209|imex:IM-25796-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289437.1|refseq:NP_001289438.1|refseq:NP_001289439.1|ensembl:ENSG00000087245(gene)|ensembl:ENST00000219070(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030017"(sarcomere)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028708|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|rcsb pdb:1CK7|rcsb pdb:1CXW|rcsb pdb:1EAK|rcsb pdb:1GEN|rcsb pdb:1GXD|rcsb pdb:1HOV|rcsb pdb:1J7M|rcsb pdb:1KS0|rcsb pdb:1QIB|rcsb pdb:1RTG|rcsb pdb:3AYU|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-9009391|refseq:NP_001121363.1|refseq:NP_004521.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/18	rogid:s0IHoSkzT9GNfkkLZsVsV7cIf1g9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:CtjIjk/I1CkIgqpmBfey15qNCT0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P55066	intact:EBI-821758	intact:EBI-774845|uniprotkb:Q6P1E3|uniprotkb:Q8C4F8	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:ncan_mouse(display_long)|uniprotkb:Chondroitin sulfate proteoglycan 3(gene name synonym)|uniprotkb:Ncan(gene name)|psi-mi:Ncan(display_short)|uniprotkb:Cspg3(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484217|imex:IM-25796-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:NP_031815.2|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR036179|mint:P55066|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045202"(synapse)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0072534"(perineuronal net)|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	-	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:FbEuo7LHWAZLqfPi0o0JVHNX4Y410090	rigid:K8qbUh2PN3hMDGFYwFI1iF4KcAI	false	-	his tag:c-c|sufficient binding region:23-637	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95196	uniprotkb:P05067-PRO_0000000092	intact:EBI-296349|uniprotkb:Q71M39|uniprotkb:Q71M40|ensembl:ENSP00000373244	intact:EBI-821758	psi-mi:cspg5_human(display_long)|uniprotkb:CSPG5(gene name)|psi-mi:CSPG5(display_short)|uniprotkb:Neuroglycan C(gene name synonym)|uniprotkb:Acidic leucine-rich EGF-like domain-containing brain protein(gene name synonym)|uniprotkb:CALEB(gene name synonym)|uniprotkb:NGC(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484227|imex:IM-25796-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193872.1|refseq:NP_001193873.1|refseq:NP_006565.2|ensembl:ENSG00000114646(gene)|ensembl:ENST00000383738(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0040008"(regulation of growth)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045202"(synapse)|go:"GO:0046907"(intracellular transport)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099550"(trans-synaptic signaling, modulating synaptic transmission)|go:"GO:0106091"(glial cell projection elongation)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR009505(Neural chondroitin sulphate proteoglycan cytoplasmic)|interpro:IPR010555(Chondroitin sulphate attachment)|interpro:IPR042382|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:jCdEXy/jGbO8eJWNMbup5sBCf5E9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:aU7XNPY9iNq2OmV5e9Vg4Iwg21Y	false	his tag:c-c|sufficient binding region:31-420	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14786	uniprotkb:P05067-PRO_0000000092	intact:EBI-1187100|uniprotkb:O60461|uniprotkb:Q96IH5|uniprotkb:Q5T7F2|uniprotkb:Q5T7F3|uniprotkb:B0LPG9|uniprotkb:Q86T59|uniprotkb:Q5T7F1|uniprotkb:Q96I90|ensembl:ENSP00000265371|ensembl:ENSP00000364001	intact:EBI-821758	psi-mi:nrp1_human(display_long)|uniprotkb:Vascular endothelial cell growth factor 165 receptor(gene name synonym)|uniprotkb:NRP1(gene name)|psi-mi:NRP1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:VEGF165R(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484252|imex:IM-25796-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019800.1|refseq:NP_001019799.1|refseq:NP_003864.4|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:O14786|rcsb pdb:1KEX|rcsb pdb:2QQI|rcsb pdb:2QQM|rcsb pdb:2QQN|rcsb pdb:3I97|rcsb pdb:4DEQ|rcsb pdb:4RN5|rcsb pdb:5C7G|rcsb pdb:5IJR|rcsb pdb:5IYY|rcsb pdb:5J1X|rcsb pdb:5JGI|rcsb pdb:5JGQ|rcsb pdb:5JHK|rcsb pdb:5L73|rcsb pdb:6FMC|rcsb pdb:6FMF|rcsb pdb:6TKK|rcsb pdb:7JJC|reactome:R-HSA-194306|reactome:R-HSA-376176|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-445144|reactome:R-HSA-447041|refseq:NP_001316997.1|ensembl:ENSG00000099250(gene)|ensembl:ENST00000265371(transcript)|ensembl:ENST00000374867(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060301"(positive regulation of cytokine activity)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|dip:DIP-5743N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:q8i8R/AetWNGkscqBWAJPHhmF+E9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:62gyTfp0zLc0+yN6W0t44In1TsQ	false	sufficient binding region:23-815|flag tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00747	uniprotkb:P05067-PRO_0000000092	intact:EBI-999394|uniprotkb:Q15146|uniprotkb:Q5TEH4|uniprotkb:Q6PA00|ensembl:ENSP00000308938	intact:EBI-821758	psi-mi:plmn_human(display_long)|uniprotkb:PLG(gene name)|psi-mi:PLG(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484262|imex:IM-25796-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000292.1|ensembl:ENSG00000122194(gene)|ensembl:ENST00000308192(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1990405"(protein antigen binding)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P00747|rcsb pdb:1B2I|rcsb pdb:1BML|rcsb pdb:1BUI|rcsb pdb:1CEA|rcsb pdb:1CEB|rcsb pdb:1DDJ|rcsb pdb:1HPJ|rcsb pdb:1HPK|rcsb pdb:1I5K|rcsb pdb:1KI0|rcsb pdb:1KRN|rcsb pdb:1L4D|rcsb pdb:1L4Z|rcsb pdb:1PK4|rcsb pdb:1PKR|rcsb pdb:1PMK|rcsb pdb:1QRZ|rcsb pdb:1RJX|rcsb pdb:2DOH|rcsb pdb:2DOI|rcsb pdb:2KNF|rcsb pdb:2L0S|rcsb pdb:2PK4|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:3UIR|rcsb pdb:4A5T|rcsb pdb:4CIK|rcsb pdb:4DCB|rcsb pdb:4DUR|rcsb pdb:4DUU|rcsb pdb:5HPG|rcsb pdb:5UGD|rcsb pdb:5UGG|rcsb pdb:6D3X|rcsb pdb:6D3Y|rcsb pdb:6D3Z|rcsb pdb:6D40|rcsb pdb:6OG4|rcsb pdb:6OQJ|rcsb pdb:6OQK|rcsb pdb:6Q1U|rcsb pdb:6UZ4|rcsb pdb:6UZ5|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-186797|reactome:R-HSA-381426|reactome:R-HSA-75205	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:f9Y+uCcA1jrDN1AD/clsKtkZWEQ9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:CAM4hezlQU3i2R8YwYFdTApSv7A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P05067-PRO_0000000092	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-821758	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484268|imex:IM-25796-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:+6epkRBBWpXm3EUtWU6AFYZTxlw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60841	uniprotkb:P05067-PRO_0000000092	intact:EBI-9248666|uniprotkb:E9PZ78|uniprotkb:Q9CUA6|ensembl:ENSMUSP00000124052	intact:EBI-821758	psi-mi:reln_mouse(display_long)|uniprotkb:Reln(gene name)|psi-mi:Reln(display_short)|uniprotkb:Rl(gene name synonym)|uniprotkb:Reeler protein(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484276|imex:IM-25796-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035391.2|refseq:NP_001297393.1|dip:DIP-40924N|ensembl:ENSMUSG00000042453(gene)|ensembl:ENSMUST00000161356(transcript)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008306"(associative learning)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021511"(spinal cord patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070325"(lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0097477"(lateral motor column neuron migration)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902078"(positive regulation of lateral motor column neuron migration)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002861(Reeler region)|interpro:IPR034968|interpro:IPR036278|interpro:IPR041161|interpro:IPR042307|rcsb pdb:2DDU|rcsb pdb:2E26|rcsb pdb:3A7Q|rcsb pdb:5B4X|rcsb pdb:6A48|reactome:R-MMU-8866376	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:oh9CRa5hVZ2xTcmgcDNSLYX8etU10090	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:IxiOkJozRqhs6D3IP9Rrht8RheQ	false	his tag:c-c|sufficient binding region:1221-2661	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09486	uniprotkb:P05067-PRO_0000000092	intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061	intact:EBI-821758	psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484286|imex:IM-25796-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:UJUZmJHeqfNcHPsJZXvPeYZCgNQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31431	uniprotkb:P05067-PRO_0000000092	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	intact:EBI-821758	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484292|imex:IM-25796-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:ZyyWuTkRr7BjdRvbATM7hOtF/JY	false	his tag:c-c|sufficient binding region:19-145	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35968	uniprotkb:P05067-PRO_0000000092	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-821758	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484303|imex:IM-25796-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	intact:EBI-77613(chain-parent)	-	comment:Extrasequence IEGRMDbetween the ectodomain of syndecan-4 and the Fc IgG1	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:7cZhCIEK6uFswCAtkDTx+1GPLgo	false	his tag:c-c|fc-igg1:c-c|sufficient binding region:20-764	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_21_bovine	uniprotkb:P05067-PRO_0000000092	intact:EBI-13646219	intact:EBI-821758	psi-mi:tenascin-x_bovin(display_short)|psi-mi:MULT_21_bovine(display_long)|intact:Tenascin-X complex(complex recommended name)|intact:TNXB trimer(complex systematic name)|intact:Tenascin X complex(complex synonym)|intact:TNX complex(complex synonym)|intact:TN-X complex(complex synonym)|intact:Flexilin complex(complex synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484326|imex:IM-25796-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005547"|pubmed:10469149(see-also)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|pubmed:24821840(see-also)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|pubmed:25793578(see-also)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090733"(tenascin complex)|pubmed:11278641(see-also)|go:"GO:0008201"(heparin binding)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901390"(positive regulation of transforming growth factor beta activation)|pubmed:17078949(see-also)|go:"GO:1904028"(positive regulation of collagen fibril organization)|pubmed:25793574(see-also)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:1905935"(positive regulation of cell fate determination)|complex portal:CPX-1035(complex-primary)|go:"GO:0005201"(extracellular matrix structural constituent)	intact:EBI-77613(chain-parent)	-	curated-complex:"A matricellular glycoprotein complex of the extracellular matrix (ECM) constitutively expressed in collagen-rich connective tissues and peripheral nerves. Present in particularly highly levels in developing heart, skeletal muscles, tendons, ligaments and limbs. Plays an important role in ECM architecture, tissue integrity and in the biomechanical properties of connective tissues. Binds to and bridges collagen fibrils and regulates collagen deposition. Binds heparin but, unlike other members of the Tenascin family, does not bind fibronectin.  May also interact with heparin-sulfate proteoglycan receptors. Involved in the regulation of many cellular processes such as cell adhesion, cell migration, cell fate determination or cell differentiation, epithelial cell plasticity (e.g. epithelial to mesenchymal transition or vice versa), cell proliferation and the vascular endothelial growth factor (VEGF) signaling pathway. Regulates transforming growth factor beta activation via cell adhesion by binding of the FBG-like domain (Fibrinogen-like globular domain, IPR002181) of Tenascin-X to alpha11beta1 integrin (CPX-3125). May act as a tumour suppressor.     An alternative promoter and transcription start site is activated by hypoxia in the adrenal gland resulting in a transcript encoding a truncated short TNXB protein with cytoplasmic localization."|complex-assembly:Homotrimer|complex-properties:"Subunits are disulphide-linked to each other within their N-terminal domains. However, Tenascin-X lacks the amino-terminal cysteine found in Tenascin-C (CPX-471) and Tenascin-W (CPX-1013) that allow two trimers to assemble into a hexameric structure.     The number of FNIII repeats encoded by TNXB genes varies among mammalian species and between murine splice variants."|curation request:Sylvie Ricard-Blum, MatrixDB	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs with Abeta42 peptide, oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22105-1	uniprotkb:P05067-PRO_0000000092	intact:EBI-20753895	intact:EBI-821758	psi-mi:p22105-1(display_long)|uniprotkb:TNXB(gene name)|psi-mi:TNXB(display_short)|uniprotkb:HXBL(gene name synonym)|uniprotkb:Hexabrachion-like protein(gene name synonym)|uniprotkb:TNX(gene name synonym)|uniprotkb:TNXB1(gene name synonym)|uniprotkb:TNXB2(gene name synonym)|uniprotkb:XB(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484336|imex:IM-25796-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P22105-1(isoform-parent)|intact:EBI-2821024(isoform-parent)	intact:EBI-77613(chain-parent)	-	isoform-comment:No experimental confirmation available.	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2018/09/18	rogid:mw0rcIzQn2hqz11i9MGTBKmbFaI9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:qdukphIKIN2IRNm61PRJhVDooEA	false	sufficient binding region:745-4135	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21980	uniprotkb:P05067-PRO_0000000092	intact:EBI-727668|uniprotkb:Q16436|uniprotkb:Q9BTN7|uniprotkb:Q9UH35|uniprotkb:Q6B838|uniprotkb:E1P5V9|ensembl:ENSP00000355330|uniprotkb:Q9H035	intact:EBI-821758	psi-mi:tgm2_human(display_long)|uniprotkb:TGM2(gene name)|psi-mi:TGM2(display_short)|uniprotkb:Tissue transglutaminase(gene name synonym)|uniprotkb:Transglutaminase C(gene name synonym)|uniprotkb:Transglutaminase-2(gene name synonym)|uniprotkb:Transglutaminase H(gene name synonym)|uniprotkb:Erythrocyte transglutaminase(gene name synonym)|uniprotkb:"Heart G alpha(h)"(gene name synonym)|uniprotkb:Isopeptidase TGM2(gene name synonym)|uniprotkb:"Protein G alpha(h)"(gene name synonym)|uniprotkb:Protein-glutamine deamidase TGM2(gene name synonym)|uniprotkb:Protein-glutamine dopaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine histaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine noradrenalinyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine serotonyltransferase TGM2(gene name synonym)|uniprotkb:Transglutaminase II(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484369|imex:IM-25796-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004604.2|refseq:NP_945189.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0018153"("isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine")|go:"GO:0018277"(protein deamination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|ensembl:ENSG00000198959(gene)|ensembl:ENST00000361475(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050568"(protein-glutamine glutaminase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0120295"(histone serotonyltransferase activity)|go:"GO:0120297"(histone dopaminyltransferase activity)|go:"GO:0120298"(peptide noradrenalinyltransferase activity)|go:"GO:0120299"(peptide histaminyltransferase activity)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904015"(cellular response to serotonin)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P21980|rcsb pdb:1FAU|rcsb pdb:1KV3|rcsb pdb:2Q3Z|rcsb pdb:3LY6|rcsb pdb:3S3J|rcsb pdb:3S3P|rcsb pdb:3S3S|rcsb pdb:4PYG|rcsb pdb:6A8P|rcsb pdb:6KZB|go:"GO:2000425"(regulation of apoptotic cell clearance)|refseq:XP_011527330.1|refseq:NP_001310245.1|dip:DIP-33557N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:S61on+x/CwI9G/k/0UhS6pFO+wE9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:456o4Rcxox9/IWDUaqUDBNQGcIU	false	his tag:n-n|mutation with no effect:580-580|sufficient binding region:2-687	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15502	uniprotkb:P05067-PRO_0000000092	intact:EBI-1222108|uniprotkb:O15336|uniprotkb:O15337|uniprotkb:Q14233|uniprotkb:Q14234|uniprotkb:Q14235|uniprotkb:Q14238|uniprotkb:Q6P0L4|uniprotkb:Q6ZWJ6|uniprotkb:Q75MU5|uniprotkb:Q7Z316|uniprotkb:Q7Z3F5|uniprotkb:Q9UMF5|uniprotkb:B3KTS6	intact:EBI-821758	psi-mi:eln_human(display_long)|uniprotkb:ELN(gene name)|psi-mi:ELN(display_short)|uniprotkb:Tropoelastin(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484382|imex:IM-25796-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000492.2|refseq:NP_001075221.1|refseq:NP_001075222.1|refseq:NP_001075223.1|refseq:NP_001075224.1|interpro:IPR003979(Tropoelastin)|refseq:NP_001265868.1|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|refseq:NP_001265844.1|refseq:NP_001265845.1|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008015"(blood circulation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071953"(elastic fiber)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs with Abeta42 peptide, oligomers, fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2018/07/23	rogid:rcemQpnE9Kkpsfth+H0n1QU0YZ09606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:tSIWnhJj5zeptq+gQwllurNxhsI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060	uniprotkb:P05067-PRO_0000000092	intact:EBI-981314|uniprotkb:Q58EX6|uniprotkb:Q6RZ39|uniprotkb:Q6RZ40|uniprotkb:Q6RZ41|uniprotkb:Q8N4S4|uniprotkb:Q8WXI5|uniprotkb:Q96T70|uniprotkb:Q9UK38|uniprotkb:Q9Y6Q7|uniprotkb:A8MVI4|ensembl:ENSP00000352798|uniprotkb:Q9Y6Q8	intact:EBI-821758	psi-mi:coia1_human(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2016)	pubmed:28106549|imex:IM-25796	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15484392|imex:IM-25796-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085059.2|refseq:NP_569712.2|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR020067|interpro:IPR035523|interpro:IPR036790|rcsb pdb:1BNL|rcsb pdb:3HON|rcsb pdb:3HSH|reactome:R-HSA-1442490|reactome:R-HSA-1592389|reactome:R-HSA-1650814|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-8948216|ensembl:ENSG00000182871(gene)|ensembl:ENST00000359759(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR010363(Protein of unknown function DUF959, collagen XVIII, N-terminal)|interpro:IPR010515(Collagenase NC10 and endostatin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|refseq:NP_569711.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713|comment:Binding occurs only with Abeta42 fibrils and fibrillar aggregates	figure legend:Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/07/11	2017/07/19	rogid:wLRIpnIxV06w/L+TD0ZldrjEsVs9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:ldtbO7vk/0btkOUi2z/td0aJY5A	false	flag tag:c-c|sufficient binding region:1443-1754	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)