#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02745 uniprotkb:Q07021-PRO_0000018590 intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564 intact:EBI-14032968 psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14032976|imex:IM-26119-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606 intact:EBI-347528(chain-parent) - - chain-seq-start:74|chain-seq-end:282 figure legend:3B-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/09/13 rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:9XnvKWSaSgyIi7HRljQCUsDC6+4 false maltose binding protein tag:?-?|sufficient binding region:88-223 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02746 uniprotkb:Q07021-PRO_0000018590 intact:EBI-2813376|uniprotkb:Q96H17|uniprotkb:Q5T959 intact:EBI-14032968 psi-mi:c1qb_human(display_long)|uniprotkb:C1QB(gene name)|psi-mi:C1QB(display_short) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14032984|imex:IM-26119-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000482.3|rcsb pdb:6FCZ|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|refseq:XP_011540361.1|interpro:IPR037573|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|rcsb pdb:5HKJ|rcsb pdb:5HZF|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:6Z6V intact:EBI-347528(chain-parent) - - chain-seq-start:74|chain-seq-end:282 figure legend:3B-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/09/13 rogid:K8MXRS5Vqyts/FhcmJMJce4t/109606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:3bhTqMSQCsjxg6dM7BjDl1gnZRg false maltose binding protein tag:?-?|sufficient binding region:90-226 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02747 uniprotkb:Q07021-PRO_0000018590 intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771 intact:EBI-14032968 psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14032992|imex:IM-26119-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU intact:EBI-347528(chain-parent) - - chain-seq-start:74|chain-seq-end:282 figure legend:3B-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/09/13 rogid:J70D18e5i22Id/KdUGyA/dcTeME9606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:CstfLi90qkrhc5/z7OayrKd8YAc false maltose binding protein tag:?-?|sufficient binding region:87-217 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) matrixdb:MULT_82_human uniprotkb:Q07021-PRO_0000018590 intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588 intact:EBI-14032968 psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14033034|imex:IM-26119-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1302"(stable complex) psi-mi:"MI:0326"(protein) go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also) intact:EBI-347528(chain-parent) - disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand. Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer chain-seq-start:74|chain-seq-end:282 figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/20 - rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q07021-PRO_0000018590 uniprotkb:P02745 intact:EBI-14032968 intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564 psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033063|imex:IM-26119-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-347528(chain-parent) refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606 - chain-seq-start:74|chain-seq-end:282 - figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/09/13 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606 rigid:9XnvKWSaSgyIi7HRljQCUsDC6+4 false - sufficient binding region:88-223|maltose binding protein tag:?-?|mutation disrupting interaction strength:185-185|mutation disrupting interaction strength:185-185 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q07021-PRO_0000018590 uniprotkb:P02746 intact:EBI-14032968 intact:EBI-2813376|uniprotkb:Q96H17|uniprotkb:Q5T959 psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:c1qb_human(display_long)|uniprotkb:C1QB(gene name)|psi-mi:C1QB(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033095|imex:IM-26119-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-347528(chain-parent) refseq:NP_000482.3|rcsb pdb:6FCZ|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|refseq:XP_011540361.1|interpro:IPR037573|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|rcsb pdb:5HKJ|rcsb pdb:5HZF|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:6Z6V - chain-seq-start:74|chain-seq-end:282 - figure legend:4B|caution:"The mutation T175L has been entered as T204L as there is no \"T\" at position 175/202."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/09/13 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rogid:K8MXRS5Vqyts/FhcmJMJce4t/109606 rigid:3bhTqMSQCsjxg6dM7BjDl1gnZRg false - sufficient binding region:90-226|maltose binding protein tag:?-?|mutation increasing interaction strength:141-141|mutation decreasing interaction strength:141-141|mutation disrupting interaction strength:144-144|mutation disrupting interaction strength:156-156|mutation disrupting interaction strength:156-156|mutation disrupting interaction strength:190-190|mutation decreasing interaction strength:204-204 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q07021-PRO_0000018590 uniprotkb:P02747 intact:EBI-14032968 intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771 psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033131|imex:IM-26119-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-347528(chain-parent) refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU - chain-seq-start:74|chain-seq-end:282 - figure legend:4C|caution:"The L170E mutation has been entered as K170E as there is no \"L\" at residue 170/198."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/09/13 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rogid:J70D18e5i22Id/KdUGyA/dcTeME9606 rigid:CstfLi90qkrhc5/z7OayrKd8YAc false - sufficient binding region:87-217|maltose binding protein tag:?-?|mutation decreasing interaction strength:184-184|mutation decreasing interaction strength:129-129|mutation decreasing interaction strength:198-198 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02745 uniprotkb:Q07021-PRO_0000018590 intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564 intact:EBI-14032968 psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0047"(far western blotting) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033038|imex:IM-26119-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606 intact:EBI-347528(chain-parent) - - chain-seq-start:74|chain-seq-end:282 figure legend:3C-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/20 rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:9XnvKWSaSgyIi7HRljQCUsDC6+4 false maltose binding protein tag:?-?|sufficient binding region:88-223 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02746 uniprotkb:Q07021-PRO_0000018590 intact:EBI-2813376|uniprotkb:Q96H17|uniprotkb:Q5T959 intact:EBI-14032968 psi-mi:c1qb_human(display_long)|uniprotkb:C1QB(gene name)|psi-mi:C1QB(display_short) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0047"(far western blotting) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033046|imex:IM-26119-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000482.3|rcsb pdb:6FCZ|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|refseq:XP_011540361.1|interpro:IPR037573|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|rcsb pdb:5HKJ|rcsb pdb:5HZF|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:6Z6V intact:EBI-347528(chain-parent) - - chain-seq-start:74|chain-seq-end:282 figure legend:3C-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/20 rogid:K8MXRS5Vqyts/FhcmJMJce4t/109606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:3bhTqMSQCsjxg6dM7BjDl1gnZRg false maltose binding protein tag:?-?|sufficient binding region:90-226 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02747 uniprotkb:Q07021-PRO_0000018590 intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771 intact:EBI-14032968 psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0047"(far western blotting) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033054|imex:IM-26119-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU intact:EBI-347528(chain-parent) - - chain-seq-start:74|chain-seq-end:282 figure legend:3C-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/20 rogid:J70D18e5i22Id/KdUGyA/dcTeME9606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:CstfLi90qkrhc5/z7OayrKd8YAc false maltose binding protein tag:?-?|sufficient binding region:87-217 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q07021-PRO_0000018590 uniprotkb:P02745 intact:EBI-14032968 intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564 psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short) psi-mi:"MI:0047"(far western blotting) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14033303|imex:IM-26119-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-347528(chain-parent) refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606 - chain-seq-start:74|chain-seq-end:282 - figure legend:4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/20 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606 rigid:9XnvKWSaSgyIi7HRljQCUsDC6+4 false - sufficient binding region:88-223|maltose binding protein tag:?-?|mutation decreasing interaction strength:185-185|mutation disrupting interaction strength:185-185 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02745 uniprotkb:Q07021-PRO_0000018590 intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564 intact:EBI-14032968 psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-14033324|imex:IM-26119-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606 intact:EBI-347528(chain-parent) go:"GO:0009986"(cell surface) - chain-seq-start:74|chain-seq-end:282 figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2017/03/20 2017/04/20 rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:9XnvKWSaSgyIi7HRljQCUsDC6+4 false maltose binding protein tag:?-?|sufficient binding region:88-223 - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P02746 uniprotkb:Q07021-PRO_0000018590 intact:EBI-2813376|uniprotkb:Q96H17|uniprotkb:Q5T959 intact:EBI-14032968 psi-mi:c1qb_human(display_long)|uniprotkb:C1QB(gene name)|psi-mi:C1QB(display_short) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-14033332|imex:IM-26119-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000482.3|rcsb pdb:6FCZ|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|refseq:XP_011540361.1|interpro:IPR037573|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|rcsb pdb:5HKJ|rcsb pdb:5HZF|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:6Z6V intact:EBI-347528(chain-parent) go:"GO:0009986"(cell surface) - chain-seq-start:74|chain-seq-end:282 figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2017/03/20 2017/04/20 rogid:K8MXRS5Vqyts/FhcmJMJce4t/109606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:3bhTqMSQCsjxg6dM7BjDl1gnZRg false maltose binding protein tag:?-?|sufficient binding region:90-226 - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P02747 uniprotkb:Q07021-PRO_0000018590 intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771 intact:EBI-14032968 psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym) psi-mi:q07021-pro_0000018590(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Pednekar et al. (2015) pubmed:28018340|imex:IM-26119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-14033340|imex:IM-26119-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU intact:EBI-347528(chain-parent) go:"GO:0009986"(cell surface) - chain-seq-start:74|chain-seq-end:282 figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2017/03/20 2017/04/20 rogid:J70D18e5i22Id/KdUGyA/dcTeME9606 rogid:x5jDiBugV1bij8uMlhgeC9xBTbA9606 rigid:CstfLi90qkrhc5/z7OayrKd8YAc false maltose binding protein tag:?-?|sufficient binding region:87-217 - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)