#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q495A1	uniprotkb:Q495A1	intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085	intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085	psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym)	psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Samanta et al. (2017)	pubmed:27978489|imex:IM-26176	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16412846|wwpdb:3rq3|imex:IM-26176-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52	refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52	-	-	-	figure legend:Table 1|3d-resolution:2.7A|3d-r-factors:R Work =0.206  R Free = 0.253|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/22	2017/10/04	rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606	rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606	rigid:TNcP+EdpBBPkqwZ6jtz4IcYy3t4	false	sufficient binding region:22-137(IPR007110)	sufficient binding region:22-137(IPR007110)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q495A1	uniprotkb:Q495A1	intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085	intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085	psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym)	psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Samanta et al. (2017)	pubmed:27978489|imex:IM-26176	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16412865|imex:IM-26176-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52	refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52	-	-	-	figure legend:Fig 1C|comment:the IgV domain of human TIGIT is predominantly a monomer at low concentrations in solution, with the propensity to form a dimer at higher concentration.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2017/06/22	2017/09/06	rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606	rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606	rigid:TNcP+EdpBBPkqwZ6jtz4IcYy3t4	false	sufficient binding region:22-137(IPR007110)	sufficient binding region:22-137(IPR007110)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92692	uniprotkb:Q495A1	intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483	intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085	psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym)	psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Samanta et al. (2017)	pubmed:27978489|imex:IM-26176	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16412882|imex:IM-26176-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N	refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52	-	-	-	figure legend:Fig 4A, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:11.5x10^-6(molar)	2017/06/22	2017/09/06	rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606	rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606	rigid:Wuu5gGFOG58uNfn3nysHP/VZshc	false	sufficient binding region:32-158(IPR003599)	sufficient binding region:22-137(IPR007110)|mutation decreasing interaction strength:112-112|mutation decreasing interaction strength:113-113|mutation decreasing interaction strength:114-114	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15151-1	uniprotkb:Q495A1	intact:EBI-16412926	intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085	psi-mi:p15151-1(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)	psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Samanta et al. (2017)	pubmed:27978489|imex:IM-26176	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16412905|imex:IM-26176-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P15151(isoform-parent)	refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52	-	-	-	figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.36x10^-6(molar)	2017/06/22	2017/09/06	rogid:PsTFmeD+9vG6ieNef6MupXts60g9606	rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606	rigid:HESoHVPaMFFSxeBqFQYcjZEHCwU	false	sufficient binding region:27-343(IPR003599)|his tag:c-c	sufficient binding region:22-137(IPR007110)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)