#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01552	uniprotkb:P42081-1	intact:EBI-1027464	intact:EBI-16182989|ensembl:ENSP00000332049	psi-mi:etxb_staau(display_long)|uniprotkb:entB(gene name)|psi-mi:entB(display_short)|uniprotkb:SEB(gene name synonym)	psi-mi:p42081-1(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16182758|imex:IM-26134-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006177(Toxin, bacterial)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1GOZ|rcsb pdb:1SBB|rcsb pdb:1SE3|rcsb pdb:1SE4|rcsb pdb:1SEB|rcsb pdb:2SEB|rcsb pdb:3GP7|rcsb pdb:3R8B|rcsb pdb:3SEB|rcsb pdb:3W2D|rcsb pdb:4C56|rcsb pdb:4RGM|rcsb pdb:4RGN|rcsb pdb:4RGO|refseq:WP_000278085.1|dip:DIP-35541N	ensembl:ENSG00000114013(gene)|ensembl:ENST00000330540(transcript)|intact:EBI-1030956(isoform-parent)	go:"GO:0009986"(cell surface)	-	-	figure legend:2A|comment:Colocalization of SEB with cell-surface B7-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/13	2017/08/08	rogid:G84qGHuyDP7GpWBh5Jvkzra5PsA1280	rogid:VMDr9AcMwoSX2JyeGy7C0IcHXnY9606	rigid:YxK4X6iwaLhi91XLI2rgO2xGjSY	false	sufficient binding region:177-188|alexa label:?-?	green fluorescent protein tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P01552	uniprotkb:P42081-3	intact:EBI-1027464	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:etxb_staau(display_long)|uniprotkb:entB(gene name)|psi-mi:entB(display_short)|uniprotkb:SEB(gene name synonym)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16190131|imex:IM-26134-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006177(Toxin, bacterial)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1GOZ|rcsb pdb:1SBB|rcsb pdb:1SE3|rcsb pdb:1SE4|rcsb pdb:1SEB|rcsb pdb:2SEB|rcsb pdb:3GP7|rcsb pdb:3R8B|rcsb pdb:3SEB|rcsb pdb:3W2D|rcsb pdb:4C56|rcsb pdb:4RGM|rcsb pdb:4RGN|rcsb pdb:4RGO|refseq:WP_000278085.1|dip:DIP-35541N	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/13	2017/08/08	rogid:G84qGHuyDP7GpWBh5Jvkzra5PsA1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:mqAb7AnGLjjEqm0YiMMlaFHmXxM	false	sufficient binding region:177-188	fc-igg tag:c-c|sufficient binding region:20-239|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01552	uniprotkb:P42081-3	intact:EBI-1027464	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:etxb_staau(display_long)|uniprotkb:entB(gene name)|psi-mi:entB(display_short)|uniprotkb:SEB(gene name synonym)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16192515|imex:IM-26134-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006177(Toxin, bacterial)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1GOZ|rcsb pdb:1SBB|rcsb pdb:1SE3|rcsb pdb:1SE4|rcsb pdb:1SEB|rcsb pdb:2SEB|rcsb pdb:3GP7|rcsb pdb:3R8B|rcsb pdb:3SEB|rcsb pdb:3W2D|rcsb pdb:4C56|rcsb pdb:4RGM|rcsb pdb:4RGN|rcsb pdb:4RGO|refseq:WP_000278085.1|dip:DIP-35541N	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.4x10^-6(molar)	2017/06/13	2017/08/08	rogid:G84qGHuyDP7GpWBh5Jvkzra5PsA1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:mqAb7AnGLjjEqm0YiMMlaFHmXxM	false	sufficient binding region:177-188	fc-igg tag:c-c|sufficient binding region:20-239|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42081-3	intact:EBI-16196843	intact:EBI-15945259|ensembl:ENSP00000377248	-	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:12c(display_short)|psi-mi:EBI-16196843(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16196952|imex:IM-26134-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	uniprotkb:P01552(see-also)	-	-	comment:"SEB derivative:P01552"	figure legend:3 A/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/13	2017/08/08	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rogid:4C3zGXLT0d+fM6Yj8AM08lOvvOQ-2	rigid:PS8VJpeUQcjTp5crMRNkmAPN9/Q	false	fc-igg tag:c-c|sufficient binding region:20-239|his tag:c-c	mutation decreasing interaction strength:2-2,4-4|mutation decreasing interaction strength:4-4,13-13	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01552	uniprotkb:P42081-3	intact:EBI-1027464	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:etxb_staau(display_long)|uniprotkb:entB(gene name)|psi-mi:entB(display_short)|uniprotkb:SEB(gene name synonym)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16201294|imex:IM-26134-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006177(Toxin, bacterial)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1GOZ|rcsb pdb:1SBB|rcsb pdb:1SE3|rcsb pdb:1SE4|rcsb pdb:1SEB|rcsb pdb:2SEB|rcsb pdb:3GP7|rcsb pdb:3R8B|rcsb pdb:3SEB|rcsb pdb:3W2D|rcsb pdb:4C56|rcsb pdb:4RGM|rcsb pdb:4RGN|rcsb pdb:4RGO|refseq:WP_000278085.1|dip:DIP-35541N	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:5A, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.32x10^-6(molar)	2017/06/13	2017/08/08	rogid:G84qGHuyDP7GpWBh5Jvkzra5PsA1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:mqAb7AnGLjjEqm0YiMMlaFHmXxM	false	sufficient binding region:177-188	sufficient binding region:67-77	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01552	uniprotkb:P42081-3	intact:EBI-1027464	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:etxb_staau(display_long)|uniprotkb:entB(gene name)|psi-mi:entB(display_short)|uniprotkb:SEB(gene name synonym)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16202325|imex:IM-26134-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006177(Toxin, bacterial)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1GOZ|rcsb pdb:1SBB|rcsb pdb:1SE3|rcsb pdb:1SE4|rcsb pdb:1SEB|rcsb pdb:2SEB|rcsb pdb:3GP7|rcsb pdb:3R8B|rcsb pdb:3SEB|rcsb pdb:3W2D|rcsb pdb:4C56|rcsb pdb:4RGM|rcsb pdb:4RGN|rcsb pdb:4RGO|refseq:WP_000278085.1|dip:DIP-35541N	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:5B, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.9x10^-6(molar)	2017/06/13	2017/08/08	rogid:G84qGHuyDP7GpWBh5Jvkzra5PsA1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:mqAb7AnGLjjEqm0YiMMlaFHmXxM	false	sufficient binding region:177-188	sufficient binding region:83-90	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06886-PRO_0000035619	uniprotkb:P42081-3	intact:EBI-16211350	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:p06886-pro_0000035619(display_long)|uniprotkb:tst(gene name)|psi-mi:tst(display_short)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16203758|imex:IM-26134-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7247529(chain-parent)	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	chain-seq-start:41|chain-seq-end:234	-	figure legend:Supp fig 4 A, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.8x10^-6(molar)	2017/06/13	2017/08/08	rogid:JrzpL5fnG5JJ/ZBFotqe84U32WQ1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:AzSjTHzpjvhcX8hmbJppyv5oTIo	false	his tag:n-n	sufficient binding region:67-77	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06886-PRO_0000035619	uniprotkb:P42081-3	intact:EBI-16211350	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:p06886-pro_0000035619(display_long)|uniprotkb:tst(gene name)|psi-mi:tst(display_short)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16211559|imex:IM-26134-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7247529(chain-parent)	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	chain-seq-start:41|chain-seq-end:234	-	figure legend:Supp fig 4B, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2017/06/13	2017/08/08	rogid:JrzpL5fnG5JJ/ZBFotqe84U32WQ1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:AzSjTHzpjvhcX8hmbJppyv5oTIo	false	his tag:n-n	sufficient binding region:83-90	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99XW1	uniprotkb:P42081-3	intact:EBI-16212640|ensemblbacteria:AAK34680|uniprotkb:Q48WF5	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:q99xw1_strp1(display_long)|uniprotkb:smeZ(gene name)|psi-mi:smeZ(display_short)|uniprotkb:SPy_1998(locus name)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16212631|imex:IM-26134-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK34680(transcript)|ensemblbacteria:SPy_1998(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0090729"(toxin activity)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006173(Staphylococcal/Streptococcal toxin, OB-fold)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|refseq:NP_269959.1	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:Supp fig 4 C, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.3x10^-6(molar)	2017/06/13	2017/08/08	rogid:IxDrRJRa8hPSVF/GuxWO1k8jHVc301447	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:qvDfMC9htQNU6jotebztIs4Bbx0	false	sufficient binding region:?-?|his tag:n-n	sufficient binding region:67-77	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99XW1	uniprotkb:P42081-3	intact:EBI-16212640|ensemblbacteria:AAK34680|uniprotkb:Q48WF5	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:q99xw1_strp1(display_long)|uniprotkb:smeZ(gene name)|psi-mi:smeZ(display_short)|uniprotkb:SPy_1998(locus name)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16212704|imex:IM-26134-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK34680(transcript)|ensemblbacteria:SPy_1998(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0090729"(toxin activity)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006173(Staphylococcal/Streptococcal toxin, OB-fold)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|refseq:NP_269959.1	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:Supp fig 4D, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.8x10^-6(molar)	2017/06/13	2017/08/08	rogid:IxDrRJRa8hPSVF/GuxWO1k8jHVc301447	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:qvDfMC9htQNU6jotebztIs4Bbx0	false	his tag:n-n|sufficient binding region:?-?	sufficient binding region:83-90	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01552	uniprotkb:P42081-3	intact:EBI-1027464	intact:EBI-15945259|ensembl:ENSP00000377248	psi-mi:etxb_staau(display_long)|uniprotkb:entB(gene name)|psi-mi:entB(display_short)|uniprotkb:SEB(gene name synonym)	psi-mi:p42081-3(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16192902|imex:IM-26134-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR006177(Toxin, bacterial)|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1GOZ|rcsb pdb:1SBB|rcsb pdb:1SE3|rcsb pdb:1SE4|rcsb pdb:1SEB|rcsb pdb:2SEB|rcsb pdb:3GP7|rcsb pdb:3R8B|rcsb pdb:3SEB|rcsb pdb:3W2D|rcsb pdb:4C56|rcsb pdb:4RGM|rcsb pdb:4RGN|rcsb pdb:4RGO|refseq:WP_000278085.1|dip:DIP-35541N	ensembl:ENSG00000114013(gene)|ensembl:ENST00000393627(transcript)|intact:EBI-1030956(isoform-parent)	-	-	-	figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.9x10^-6(molar)	2017/06/13	2017/08/08	rogid:G84qGHuyDP7GpWBh5Jvkzra5PsA1280	rogid:ip4sFEhQ26nzCxD3D8xF7wPkVUY9606	rigid:mqAb7AnGLjjEqm0YiMMlaFHmXxM	false	sufficient binding region:177-188|mutation disrupting interaction strength:177-177,179-179	fc-igg tag:c-c|sufficient binding region:20-239|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42081-1	uniprotkb:P10747-1	intact:EBI-16182989|ensembl:ENSP00000332049	intact:EBI-15945088|ensembl:ENSP00000324890	psi-mi:p42081-1(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:BU63(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:FUN-1(gene name synonym)	psi-mi:p10747-1(display_long)|uniprotkb:CD28(gene name)|psi-mi:CD28(display_short)|uniprotkb:TP44(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Levy et al. (2016)	pubmed:27708164|imex:IM-26134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16216809|imex:IM-26134-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114013(gene)|ensembl:ENST00000330540(transcript)|intact:EBI-1030956(isoform-parent)	intact:EBI-4314301(isoform-parent)|ensembl:ENSG00000178562(gene)|ensembl:ENST00000324106(transcript)	-	-	-	figure legend:7F-J, Supp fig 6|agonist:SEB; however the SEB tk2 mutant did not have any agonistic effect.|comment:"The B7-2C splice variant  did not bind CD28.  From Ref 18 Figure 1A, this variant is missing the first  \"Ig like domain\", so this variant  might correspond to  P42081-5."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/13	2017/08/09	rogid:VMDr9AcMwoSX2JyeGy7C0IcHXnY9606	rogid:hXXImyYy1G/3xoStJWpisi3sIWI9606	rigid:0a9gDgRYz6fvu6bJlj5TPfLWHvA	false	mcherry fluorescent protein tag:c-c|necessary binding region:25..25-133..133(IPR003599)	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)