#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P43629 uniprotkb:P30511 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 intact:EBI-2811134|uniprotkb:Q5SPT5|uniprotkb:Q9TP68|uniprotkb:Q8WLP5|uniprotkb:Q860R0|uniprotkb:Q5JQJ1|uniprotkb:Q8MGQ1|uniprotkb:Q95HC0|uniprotkb:Q5JQI8|ensembl:ENSP00000334263|ensembl:ENSP00000366057 psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:hlaf_human(display_long)|uniprotkb:HLA-F(gene name)|psi-mi:HLA-F(display_short)|uniprotkb:HLA-5.4(gene name synonym)|uniprotkb:HLAF(gene name synonym)|uniprotkb:CDA12(gene name synonym)|uniprotkb:HLA F antigen(gene name synonym)|uniprotkb:Leukocyte antigen F(gene name synonym)|uniprotkb:MHC class I antigen F(gene name synonym) psi-mi:"MI:0400"(affinity technology) Garcia-Beltran et al. (2016) pubmed:27455421|imex:IM-26130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483050|imex:IM-26130-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 refseq:NP_001091948.1|refseq:NP_001091949.1|refseq:NP_061823.2|ensembl:ENSG00000204642(gene)|ensembl:ENST00000334668(transcript)|ensembl:ENST00000376861(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002728"(negative regulation of natural killer cell cytokine production)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5IUE|rcsb pdb:5KNM|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - - - figure legend:1B-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/13 2017/07/18 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rogid:rbmQdah7wpa+IyDjP5vDlIA+heM9606 rigid:mmwFtLEVMEHbrQugOSW09QOVpIg false sufficient binding region:22-340|fc-igg tag:c-c biotin tag:?-?|sufficient binding region:22..22-305..305 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q14943 uniprotkb:P30511 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 intact:EBI-2811134|uniprotkb:Q5SPT5|uniprotkb:Q9TP68|uniprotkb:Q8WLP5|uniprotkb:Q860R0|uniprotkb:Q5JQJ1|uniprotkb:Q8MGQ1|uniprotkb:Q95HC0|uniprotkb:Q5JQI8|ensembl:ENSP00000334263|ensembl:ENSP00000366057 psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:hlaf_human(display_long)|uniprotkb:HLA-F(gene name)|psi-mi:HLA-F(display_short)|uniprotkb:HLA-5.4(gene name synonym)|uniprotkb:HLAF(gene name synonym)|uniprotkb:CDA12(gene name synonym)|uniprotkb:HLA F antigen(gene name synonym)|uniprotkb:Leukocyte antigen F(gene name synonym)|uniprotkb:MHC class I antigen F(gene name synonym) psi-mi:"MI:0400"(affinity technology) Garcia-Beltran et al. (2016) pubmed:27455421|imex:IM-26130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483081|imex:IM-26130-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 refseq:NP_001091948.1|refseq:NP_001091949.1|refseq:NP_061823.2|ensembl:ENSG00000204642(gene)|ensembl:ENST00000334668(transcript)|ensembl:ENST00000376861(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002728"(negative regulation of natural killer cell cytokine production)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5IUE|rcsb pdb:5KNM|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - - - figure legend:1 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/13 2017/07/18 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rogid:rbmQdah7wpa+IyDjP5vDlIA+heM9606 rigid:Lv5o+WKJzQLI1ONxbiIB7/b+CO4 false sufficient binding region:22-340|fc-igg tag:c-c biotin tag:?-?|sufficient binding region:22..22-305..305 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43630 uniprotkb:P30511 intact:EBI-6165894|ensembl:ENSP00000479425|ensembl:ENSP00000479772|ensembl:ENSP00000325525|ensembl:ENSP00000477516|ensembl:ENSP00000477519|ensembl:ENSP00000478251|ensembl:ENSP00000479299|ensembl:ENSP00000479903|ensembl:ENSP00000481209|ensembl:ENSP00000481579|ensembl:ENSP00000481662|ensembl:ENSP00000482110|ensembl:ENSP00000482301|ensembl:ENSP00000482565|ensembl:ENSP00000491183|ensembl:ENSP00000491303|ensembl:ENSP00000491436|ensembl:ENSP00000492261|uniprotkb:Q13238|uniprotkb:Q14947|uniprotkb:Q14948|uniprotkb:Q92684|uniprotkb:Q95367|uniprotkb:Q95368|uniprotkb:Q95366 intact:EBI-2811134|uniprotkb:Q5SPT5|uniprotkb:Q9TP68|uniprotkb:Q8WLP5|uniprotkb:Q860R0|uniprotkb:Q5JQJ1|uniprotkb:Q8MGQ1|uniprotkb:Q95HC0|uniprotkb:Q5JQI8|ensembl:ENSP00000334263|ensembl:ENSP00000366057 psi-mi:ki3l2_human(display_long)|uniprotkb:KIR3DL2(gene name)|psi-mi:KIR3DL2(display_short)|uniprotkb:CD158 antigen-like family member K(gene name synonym)|uniprotkb:CD158K(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:NKAT4(gene name synonym)|uniprotkb:Natural killer-associated transcript 4(gene name synonym)|uniprotkb:p70 natural killer cell receptor clone CL-5(gene name synonym) psi-mi:hlaf_human(display_long)|uniprotkb:HLA-F(gene name)|psi-mi:HLA-F(display_short)|uniprotkb:HLA-5.4(gene name synonym)|uniprotkb:HLAF(gene name synonym)|uniprotkb:CDA12(gene name synonym)|uniprotkb:HLA F antigen(gene name synonym)|uniprotkb:Leukocyte antigen F(gene name synonym)|uniprotkb:MHC class I antigen F(gene name synonym) psi-mi:"MI:0400"(affinity technology) Garcia-Beltran et al. (2016) pubmed:27455421|imex:IM-26130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483091|imex:IM-26130-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000240403(gene)|ensembl:ENSG00000274722(gene)|ensembl:ENSG00000275083(gene)|ensembl:ENSG00000275416(gene)|ensembl:ENSG00000275566(gene)|ensembl:ENSG00000275626(gene)|ensembl:ENSG00000276004(gene)|ensembl:ENSG00000276357(gene)|ensembl:ENSG00000276739(gene)|ensembl:ENSG00000277181(gene)|ensembl:ENSG00000278361(gene)|ensembl:ENSG00000278442(gene)|ensembl:ENSG00000278474(gene)|ensembl:ENSG00000278809(gene)|ensembl:ENSG00000283951(gene)|ensembl:ENSG00000283975(gene)|ensembl:ENSG00000284063(gene)|ensembl:ENSG00000284381(gene)|ensembl:ENST00000326321(transcript)|ensembl:ENST00000611608(transcript)|ensembl:ENST00000611628(transcript)|ensembl:ENST00000613610(transcript)|ensembl:ENST00000613612(transcript)|ensembl:ENST00000614753(transcript)|ensembl:ENST00000617354(transcript)|ensembl:ENST00000617666(transcript)|ensembl:ENST00000617957(transcript)|ensembl:ENST00000619683(transcript)|ensembl:ENST00000620817(transcript)|ensembl:ENST00000621155(transcript)|ensembl:ENST00000622024(transcript)|ensembl:ENST00000622453(transcript)|ensembl:ENST00000638330(transcript)|ensembl:ENST00000638891(transcript)|ensembl:ENST00000638970(transcript)|ensembl:ENST00000640782(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|refseq:NP_001229796.1|refseq:NP_006728.2 refseq:NP_001091948.1|refseq:NP_001091949.1|refseq:NP_061823.2|ensembl:ENSG00000204642(gene)|ensembl:ENST00000334668(transcript)|ensembl:ENST00000376861(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002728"(negative regulation of natural killer cell cytokine production)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5IUE|rcsb pdb:5KNM|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - - - figure legend:1 B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/13 2017/07/18 rogid:z6uiSVZQ/gMCPqiX5E6syx6t3jY9606 rogid:rbmQdah7wpa+IyDjP5vDlIA+heM9606 rigid:80RVzGMQu8U42MgMR7vODjkZvgY false sufficient binding region:22-339|fc-igg tag:c-c biotin tag:?-?|sufficient binding region:22..22-305..305 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43630 uniprotkb:P30511 intact:EBI-6165894|ensembl:ENSP00000479425|ensembl:ENSP00000479772|ensembl:ENSP00000325525|ensembl:ENSP00000477516|ensembl:ENSP00000477519|ensembl:ENSP00000478251|ensembl:ENSP00000479299|ensembl:ENSP00000479903|ensembl:ENSP00000481209|ensembl:ENSP00000481579|ensembl:ENSP00000481662|ensembl:ENSP00000482110|ensembl:ENSP00000482301|ensembl:ENSP00000482565|ensembl:ENSP00000491183|ensembl:ENSP00000491303|ensembl:ENSP00000491436|ensembl:ENSP00000492261|uniprotkb:Q13238|uniprotkb:Q14947|uniprotkb:Q14948|uniprotkb:Q92684|uniprotkb:Q95367|uniprotkb:Q95368|uniprotkb:Q95366 intact:EBI-2811134|uniprotkb:Q5SPT5|uniprotkb:Q9TP68|uniprotkb:Q8WLP5|uniprotkb:Q860R0|uniprotkb:Q5JQJ1|uniprotkb:Q8MGQ1|uniprotkb:Q95HC0|uniprotkb:Q5JQI8|ensembl:ENSP00000334263|ensembl:ENSP00000366057 psi-mi:ki3l2_human(display_long)|uniprotkb:KIR3DL2(gene name)|psi-mi:KIR3DL2(display_short)|uniprotkb:CD158 antigen-like family member K(gene name synonym)|uniprotkb:CD158K(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:NKAT4(gene name synonym)|uniprotkb:Natural killer-associated transcript 4(gene name synonym)|uniprotkb:p70 natural killer cell receptor clone CL-5(gene name synonym) psi-mi:hlaf_human(display_long)|uniprotkb:HLA-F(gene name)|psi-mi:HLA-F(display_short)|uniprotkb:HLA-5.4(gene name synonym)|uniprotkb:HLAF(gene name synonym)|uniprotkb:CDA12(gene name synonym)|uniprotkb:HLA F antigen(gene name synonym)|uniprotkb:Leukocyte antigen F(gene name synonym)|uniprotkb:MHC class I antigen F(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Garcia-Beltran et al. (2016) pubmed:27455421|imex:IM-26130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483130|imex:IM-26130-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000240403(gene)|ensembl:ENSG00000274722(gene)|ensembl:ENSG00000275083(gene)|ensembl:ENSG00000275416(gene)|ensembl:ENSG00000275566(gene)|ensembl:ENSG00000275626(gene)|ensembl:ENSG00000276004(gene)|ensembl:ENSG00000276357(gene)|ensembl:ENSG00000276739(gene)|ensembl:ENSG00000277181(gene)|ensembl:ENSG00000278361(gene)|ensembl:ENSG00000278442(gene)|ensembl:ENSG00000278474(gene)|ensembl:ENSG00000278809(gene)|ensembl:ENSG00000283951(gene)|ensembl:ENSG00000283975(gene)|ensembl:ENSG00000284063(gene)|ensembl:ENSG00000284381(gene)|ensembl:ENST00000326321(transcript)|ensembl:ENST00000611608(transcript)|ensembl:ENST00000611628(transcript)|ensembl:ENST00000613610(transcript)|ensembl:ENST00000613612(transcript)|ensembl:ENST00000614753(transcript)|ensembl:ENST00000617354(transcript)|ensembl:ENST00000617666(transcript)|ensembl:ENST00000617957(transcript)|ensembl:ENST00000619683(transcript)|ensembl:ENST00000620817(transcript)|ensembl:ENST00000621155(transcript)|ensembl:ENST00000622024(transcript)|ensembl:ENST00000622453(transcript)|ensembl:ENST00000638330(transcript)|ensembl:ENST00000638891(transcript)|ensembl:ENST00000638970(transcript)|ensembl:ENST00000640782(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|refseq:NP_001229796.1|refseq:NP_006728.2 refseq:NP_001091948.1|refseq:NP_001091949.1|refseq:NP_061823.2|ensembl:ENSG00000204642(gene)|ensembl:ENST00000334668(transcript)|ensembl:ENST00000376861(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002728"(negative regulation of natural killer cell cytokine production)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5IUE|rcsb pdb:5KNM|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - - - figure legend:2A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:118.0x10^-9(molar) 2017/07/13 2017/07/18 rogid:z6uiSVZQ/gMCPqiX5E6syx6t3jY9606 rogid:rbmQdah7wpa+IyDjP5vDlIA+heM9606 rigid:80RVzGMQu8U42MgMR7vODjkZvgY false sufficient binding region:22-339|fc-igg tag:c-c sufficient binding region:22..22-305..305|biotin tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14943 uniprotkb:P30511 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 intact:EBI-2811134|uniprotkb:Q5SPT5|uniprotkb:Q9TP68|uniprotkb:Q8WLP5|uniprotkb:Q860R0|uniprotkb:Q5JQJ1|uniprotkb:Q8MGQ1|uniprotkb:Q95HC0|uniprotkb:Q5JQI8|ensembl:ENSP00000334263|ensembl:ENSP00000366057 psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:hlaf_human(display_long)|uniprotkb:HLA-F(gene name)|psi-mi:HLA-F(display_short)|uniprotkb:HLA-5.4(gene name synonym)|uniprotkb:HLAF(gene name synonym)|uniprotkb:CDA12(gene name synonym)|uniprotkb:HLA F antigen(gene name synonym)|uniprotkb:Leukocyte antigen F(gene name synonym)|uniprotkb:MHC class I antigen F(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Garcia-Beltran et al. (2016) pubmed:27455421|imex:IM-26130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483120|imex:IM-26130-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 refseq:NP_001091948.1|refseq:NP_001091949.1|refseq:NP_061823.2|ensembl:ENSG00000204642(gene)|ensembl:ENST00000334668(transcript)|ensembl:ENST00000376861(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002728"(negative regulation of natural killer cell cytokine production)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5IUE|rcsb pdb:5KNM|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - - - figure legend:2A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:25.0x10^-9(molar) 2017/07/13 2017/07/13 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rogid:rbmQdah7wpa+IyDjP5vDlIA+heM9606 rigid:Lv5o+WKJzQLI1ONxbiIB7/b+CO4 false sufficient binding region:22-340|fc-igg tag:c-c sufficient binding region:22..22-305..305|biotin tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43629 uniprotkb:P30511 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 intact:EBI-2811134|uniprotkb:Q5SPT5|uniprotkb:Q9TP68|uniprotkb:Q8WLP5|uniprotkb:Q860R0|uniprotkb:Q5JQJ1|uniprotkb:Q8MGQ1|uniprotkb:Q95HC0|uniprotkb:Q5JQI8|ensembl:ENSP00000334263|ensembl:ENSP00000366057 psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:hlaf_human(display_long)|uniprotkb:HLA-F(gene name)|psi-mi:HLA-F(display_short)|uniprotkb:HLA-5.4(gene name synonym)|uniprotkb:HLAF(gene name synonym)|uniprotkb:CDA12(gene name synonym)|uniprotkb:HLA F antigen(gene name synonym)|uniprotkb:Leukocyte antigen F(gene name synonym)|uniprotkb:MHC class I antigen F(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Garcia-Beltran et al. (2016) pubmed:27455421|imex:IM-26130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483110|imex:IM-26130-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 refseq:NP_001091948.1|refseq:NP_001091949.1|refseq:NP_061823.2|ensembl:ENSG00000204642(gene)|ensembl:ENST00000334668(transcript)|ensembl:ENST00000376861(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002728"(negative regulation of natural killer cell cytokine production)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5IUE|rcsb pdb:5KNM|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - - - figure legend:2A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:157.0x10^-9(molar) 2017/07/13 2017/07/18 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rogid:rbmQdah7wpa+IyDjP5vDlIA+heM9606 rigid:mmwFtLEVMEHbrQugOSW09QOVpIg false sufficient binding region:22-340|fc-igg tag:c-c sufficient binding region:22..22-305..305|biotin tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)