#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208479|imex:IM-25452-1|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254|mutation disrupting interaction strength:148-148|mutation decreasing interaction strength:160-160|mutation decreasing interaction strength:160-160|mutation decreasing interaction strength:157-157|mutation decreasing interaction strength:71-71|mutation decreasing interaction strength:71-71	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208540|imex:IM-25452-3|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0826"(x ray scattering)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208561|imex:IM-25452-4|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0038"(dynamic light scattering)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208582|imex:IM-25452-5|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208603|imex:IM-25452-6|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228|mutation decreasing interaction strength:163-163|mutation decreasing interaction strength:163-163|mutation disrupting interaction strength:81-81|mutation decreasing interaction strength:62-62|mutation decreasing interaction strength:45-45|mutation decreasing interaction strength:45-45	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0944"(mass spectrometry study of hydrogen/deuterium exchange)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208642|imex:IM-25452-7|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208518|imex:IM-25452-2|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6ND01-1	uniprotkb:Q8IYV9-1	intact:EBI-16208304|ensembl:ENSP00000332963	intact:EBI-16208297|ensembl:ENSP00000327786	psi-mi:a6nd01-1(display_long)|uniprotkb:Folate receptor 4(gene name synonym)|uniprotkb:Folate receptor delta(gene name synonym)|uniprotkb:IZUMO1 receptor protein JUNO(gene name synonym)|uniprotkb:IZUMO1R(gene name)|psi-mi:IZUMO1R(display_short)|uniprotkb:FOLR4(gene name synonym)|uniprotkb:JUNO(gene name synonym)	psi-mi:q8iyv9-1(display_long)|uniprotkb:Oocyte binding/fusion factor(gene name synonym)|uniprotkb:Sperm-specific protein izumo(gene name synonym)|uniprotkb:IZUMO1(gene name)|psi-mi:IZUMO1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Aydin et al. (2016)	pubmed:27309818|doi:10.1038/nature18595|imex:IM-25452	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208663|imex:IM-25452-8|dip:DIP-201155E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183560(gene)|ensembl:ENST00000328458(transcript)|intact:EBI-16357235(isoform-parent)	ensembl:ENST00000332955(transcript)|ensembl:ENSG00000182264(gene)|intact:EBI-16357190(isoform-parent)	psi-mi:"MI:0465"(dip)	isoform-comment:No experimental confirmation available. Gene prediction based on EST data.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bQe2nhj4bV0mZpDGwm9zHASunx09606	rogid:q+Git0ldTz7n3ZomEAKVIQd5luo9606	rigid:3r+lN2l4oe0yD+K5zvH61fYtY/8	false	sufficient binding region:20-228	sufficient binding region:22-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)