#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9R186	uniprotkb:Q9R186	intact:EBI-7198720|intact:UNK-5555281	intact:EBI-7198720|intact:UNK-5555281	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Saotome et al. (2016)	pubmed:27296226|doi:10.1038/nature17975|imex:IM-25450	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208226|imex:IM-25450-1|dip:DIP-201154E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rigid:VnD+0nmUBszILhtZZRcLh/Oq5Hg	false	sufficient binding region:41-700	sufficient binding region:41-700	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9R186	uniprotkb:Q9R186	intact:EBI-7198720|intact:UNK-5555281	intact:EBI-7198720|intact:UNK-5555281	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Saotome et al. (2016)	pubmed:27296226|doi:10.1038/nature17975|imex:IM-25450	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208248|imex:IM-25450-2|dip:DIP-201154E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rigid:VnD+0nmUBszILhtZZRcLh/Oq5Hg	false	sufficient binding region:41-700	sufficient binding region:41-700	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9R186	uniprotkb:Q9R186	intact:EBI-7198720|intact:UNK-5555281	intact:EBI-7198720|intact:UNK-5555281	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:trpv6_rat(display_long)|uniprotkb:Trpv6(gene name)|psi-mi:Trpv6(display_short)|uniprotkb:Epithelial calcium channel 2(gene name synonym)|uniprotkb:Calcium transport protein 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Saotome et al. (2016)	pubmed:27296226|doi:10.1038/nature17975|imex:IM-25450	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16208266|imex:IM-25450-3|dip:DIP-201154E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N	mint:Q9R186|go:"GO:0005216"(ion channel activity)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008345(Epithelial calcium channel 1)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|rcsb pdb:5IWK|rcsb pdb:5IWP|rcsb pdb:5IWR|rcsb pdb:5IWT|rcsb pdb:5WO6|rcsb pdb:5WO7|rcsb pdb:5WO8|rcsb pdb:5WO9|rcsb pdb:5WOA|rcsb pdb:6BOB|rcsb pdb:6D7O|rcsb pdb:6D7P|rcsb pdb:6D7Q|rcsb pdb:6D7V|rcsb pdb:6D7X|rcsb pdb:6E2G|reactome:R-RNO-3295583|rgd:69335|refseq:NP_446138.1|dip:DIP-47769N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	comment:mint|function:"Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rogid:juqO6UkILpdNAuG+bhvVekrIFis10116	rigid:VnD+0nmUBszILhtZZRcLh/Oq5Hg	false	sufficient binding region:41-700|mutation:74-74,671-671	sufficient binding region:41-700|mutation:74-74,671-671	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)