#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P63000-1	uniprotkb:Q8TCU6	intact:EBI-7212896|uniprotkb:P15154-1|intact:MINT-124079|ensembl:ENSP00000258737	intact:EBI-1046542|uniprotkb:E1P5X9|uniprotkb:Q5JS95|uniprotkb:Q5JS96|uniprotkb:Q69YL2|uniprotkb:Q7Z2L9|uniprotkb:Q9BQH0|uniprotkb:Q9BX55|uniprotkb:Q9H4Q6|uniprotkb:Q9P2D2|uniprotkb:Q9UGQ4|ensembl:ENSP00000361009	psi-mi:p63000-1(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:TC25(gene name synonym)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:MIG5(orf name)|uniprotkb:Rac1A(isoform synonym)	psi-mi:prex1_human(display_long)|uniprotkb:PREX1(gene name)|psi-mi:PREX1(display_short)|uniprotkb:KIAA1415(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Cash et al. (2016)	pubmed:27150042|doi:10.1016/j.str.2016.02.022|imex:IM-25336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16206350|imex:IM-25336-1|dip:DIP-200880E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-413628(isoform-parent)|ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)	refseq:NP_065871.2|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QIK|rcsb pdb:4YON|rcsb pdb:5D27|rcsb pdb:5D3V|rcsb pdb:5D3W|rcsb pdb:5D3X|rcsb pdb:5D3Y|rcsb pdb:5FI0|rcsb pdb:5FI1|rcsb pdb:6PCV|rcsb pdb:6VSK|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensembl:ENSG00000124126(gene)|ensembl:ENST00000371941(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|dip:DIP-46975N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rogid:EvGaUJMrR5DD53V6bQIpocW1Ako9606	rigid:LzhOErk60cYY+lPaa7Xww+Jbzlw	false	-	sufficient binding region:38-408	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60953-2	uniprotkb:Q8TCU6	intact:EBI-287394|uniprotkb:P21181-4|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-1046542|uniprotkb:E1P5X9|uniprotkb:Q5JS95|uniprotkb:Q5JS96|uniprotkb:Q69YL2|uniprotkb:Q7Z2L9|uniprotkb:Q9BQH0|uniprotkb:Q9BX55|uniprotkb:Q9H4Q6|uniprotkb:Q9P2D2|uniprotkb:Q9UGQ4|ensembl:ENSP00000361009	psi-mi:p60953-2(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:prex1_human(display_long)|uniprotkb:PREX1(gene name)|psi-mi:PREX1(display_short)|uniprotkb:KIAA1415(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Cash et al. (2016)	pubmed:27150042|doi:10.1016/j.str.2016.02.022|imex:IM-25336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16206389|imex:IM-25336-3|dip:DIP-200881E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81752(cdc42_human)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)	refseq:NP_065871.2|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QIK|rcsb pdb:4YON|rcsb pdb:5D27|rcsb pdb:5D3V|rcsb pdb:5D3W|rcsb pdb:5D3X|rcsb pdb:5D3Y|rcsb pdb:5FI0|rcsb pdb:5FI1|rcsb pdb:6PCV|rcsb pdb:6VSK|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensembl:ENSG00000124126(gene)|ensembl:ENST00000371941(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|dip:DIP-46975N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:EvGaUJMrR5DD53V6bQIpocW1Ako9606	rigid:MjMDsMNocAQVFPcTtU04l5kPTEw	false	-	sufficient binding region:38-408	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60953-2	uniprotkb:Q8TCU6	intact:EBI-287394|uniprotkb:P21181-4|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-1046542|uniprotkb:E1P5X9|uniprotkb:Q5JS95|uniprotkb:Q5JS96|uniprotkb:Q69YL2|uniprotkb:Q7Z2L9|uniprotkb:Q9BQH0|uniprotkb:Q9BX55|uniprotkb:Q9H4Q6|uniprotkb:Q9P2D2|uniprotkb:Q9UGQ4|ensembl:ENSP00000361009	psi-mi:p60953-2(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:prex1_human(display_long)|uniprotkb:PREX1(gene name)|psi-mi:PREX1(display_short)|uniprotkb:KIAA1415(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Cash et al. (2016)	pubmed:27150042|doi:10.1016/j.str.2016.02.022|imex:IM-25336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16206369|imex:IM-25336-2|dip:DIP-200881E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81752(cdc42_human)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)	refseq:NP_065871.2|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QIK|rcsb pdb:4YON|rcsb pdb:5D27|rcsb pdb:5D3V|rcsb pdb:5D3W|rcsb pdb:5D3X|rcsb pdb:5D3Y|rcsb pdb:5FI0|rcsb pdb:5FI1|rcsb pdb:6PCV|rcsb pdb:6VSK|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensembl:ENSG00000124126(gene)|ensembl:ENST00000371941(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|dip:DIP-46975N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:EvGaUJMrR5DD53V6bQIpocW1Ako9606	rigid:MjMDsMNocAQVFPcTtU04l5kPTEw	false	-	sufficient binding region:38-408	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63000-1	uniprotkb:Q8TCU6	intact:EBI-7212896|uniprotkb:P15154-1|intact:MINT-124079|ensembl:ENSP00000258737	intact:EBI-1046542|uniprotkb:E1P5X9|uniprotkb:Q5JS95|uniprotkb:Q5JS96|uniprotkb:Q69YL2|uniprotkb:Q7Z2L9|uniprotkb:Q9BQH0|uniprotkb:Q9BX55|uniprotkb:Q9H4Q6|uniprotkb:Q9P2D2|uniprotkb:Q9UGQ4|ensembl:ENSP00000361009	psi-mi:p63000-1(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:TC25(gene name synonym)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:MIG5(orf name)|uniprotkb:Rac1A(isoform synonym)	psi-mi:prex1_human(display_long)|uniprotkb:PREX1(gene name)|psi-mi:PREX1(display_short)|uniprotkb:KIAA1415(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Cash et al. (2016)	pubmed:27150042|doi:10.1016/j.str.2016.02.022|imex:IM-25336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16206408|imex:IM-25336-4|dip:DIP-200880E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-413628(isoform-parent)|ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)	refseq:NP_065871.2|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QIK|rcsb pdb:4YON|rcsb pdb:5D27|rcsb pdb:5D3V|rcsb pdb:5D3W|rcsb pdb:5D3X|rcsb pdb:5D3Y|rcsb pdb:5FI0|rcsb pdb:5FI1|rcsb pdb:6PCV|rcsb pdb:6VSK|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|ensembl:ENSG00000124126(gene)|ensembl:ENST00000371941(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|dip:DIP-46975N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rogid:EvGaUJMrR5DD53V6bQIpocW1Ako9606	rigid:LzhOErk60cYY+lPaa7Xww+Jbzlw	false	-	sufficient binding region:38-408	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)