#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P60891-1	uniprotkb:P50053-2	intact:EBI-16205225|ensembl:ENSP00000361512	intact:EBI-12204387|ensembl:ENSP00000260599	psi-mi:p60891-1(display_long)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)	psi-mi:p50053-2(display_long)|uniprotkb:KHK(gene name)|psi-mi:KHK(display_short)|uniprotkb:Hepatic fructokinase(gene name synonym)|uniprotkb:Peripheral(isoform synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2016)	pubmed:27088854|doi:10.1038/ncb3338|imex:IM-25418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16205232|imex:IM-25418-1|dip:DIP-201121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|intact:EBI-749195(isoform-parent)|uniprotkb:P60891-1(isoform-parent)	intact:EBI-1053974(isoform-parent)|ensembl:ENSG00000138030(gene)|ensembl:ENST00000260599(transcript)|uniprotkb:P50053-2(isoform-parent)	psi-mi:"MI:0465"(dip)	-	isoform-comment:"More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1)."	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:+Hih2M7JLTsjEglauBlPj182h9M9606	rogid:7rpEtixaEeTXC8sLzUf7nHHD3d09606	rigid:rY4fu5vfygb7Nh0/lPklRzTIKx0	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60891-1	uniprotkb:P50053-2	intact:EBI-16205225|ensembl:ENSP00000361512	intact:EBI-12204387|ensembl:ENSP00000260599	psi-mi:p60891-1(display_long)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)	psi-mi:p50053-2(display_long)|uniprotkb:KHK(gene name)|psi-mi:KHK(display_short)|uniprotkb:Hepatic fructokinase(gene name synonym)|uniprotkb:Peripheral(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2016)	pubmed:27088854|doi:10.1038/ncb3338|imex:IM-25418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16205279|imex:IM-25418-3|dip:DIP-201121E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|intact:EBI-749195(isoform-parent)|uniprotkb:P60891-1(isoform-parent)	intact:EBI-1053974(isoform-parent)|ensembl:ENSG00000138030(gene)|ensembl:ENST00000260599(transcript)|uniprotkb:P50053-2(isoform-parent)	psi-mi:"MI:0465"(dip)	-	isoform-comment:"More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1)."	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:+Hih2M7JLTsjEglauBlPj182h9M9606	rogid:7rpEtixaEeTXC8sLzUf7nHHD3d09606	rigid:rY4fu5vfygb7Nh0/lPklRzTIKx0	false	O-phospho-L-threonine:225-225|mutation disrupting interaction rate:225-225|O-phospho-L-threonine:225-225	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P60891-1	uniprotkb:P50053-2	intact:EBI-16205225|ensembl:ENSP00000361512	intact:EBI-12204387|ensembl:ENSP00000260599	psi-mi:p60891-1(display_long)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)	psi-mi:p50053-2(display_long)|uniprotkb:KHK(gene name)|psi-mi:KHK(display_short)|uniprotkb:Hepatic fructokinase(gene name synonym)|uniprotkb:Peripheral(isoform synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2016)	pubmed:27088854|doi:10.1038/ncb3338|imex:IM-25418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16205305|imex:IM-25418-4|dip:DIP-201121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|intact:EBI-749195(isoform-parent)|uniprotkb:P60891-1(isoform-parent)	intact:EBI-1053974(isoform-parent)|ensembl:ENSG00000138030(gene)|ensembl:ENST00000260599(transcript)|uniprotkb:P50053-2(isoform-parent)	psi-mi:"MI:0465"(dip)	-	isoform-comment:"More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1)."	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:+Hih2M7JLTsjEglauBlPj182h9M9606	rogid:7rpEtixaEeTXC8sLzUf7nHHD3d09606	rigid:rY4fu5vfygb7Nh0/lPklRzTIKx0	false	his tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction strength:83-83	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60891	uniprotkb:P50053-2	intact:EBI-749195|uniprotkb:P09329|uniprotkb:B2R6T7|uniprotkb:B1ALA8|uniprotkb:B4DNL6|uniprotkb:D3DUX6|ensembl:ENSP00000361512	intact:EBI-12204387|ensembl:ENSP00000260599	psi-mi:prps1_human(display_long)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym)	psi-mi:p50053-2(display_long)|uniprotkb:KHK(gene name)|psi-mi:KHK(display_short)|uniprotkb:Hepatic fructokinase(gene name synonym)|uniprotkb:Peripheral(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2016)	pubmed:27088854|doi:10.1038/ncb3338|imex:IM-25418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16205257|imex:IM-25418-2|dip:DIP-201121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191331.1|refseq:NP_002755.1|ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006221"(pyrimidine nucleotide biosynthetic process)|go:"GO:0007399"(nervous system development)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046101"(hypoxanthine biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|go:"GO:0006144"(purine nucleobase metabolic process)|interpro:IPR029057|interpro:IPR029099|interpro:IPR037515|rcsb pdb:2H06|rcsb pdb:2H07|rcsb pdb:2H08|rcsb pdb:2HCR|rcsb pdb:3EFH|rcsb pdb:3S5J|rcsb pdb:4F8E|rcsb pdb:4LYG|rcsb pdb:4LZN|rcsb pdb:4LZO|rcsb pdb:4M0P|rcsb pdb:4M0U|reactome:R-HSA-73843|dip:DIP-61999N	intact:EBI-1053974(isoform-parent)|ensembl:ENSG00000138030(gene)|ensembl:ENST00000260599(transcript)|uniprotkb:P50053-2(isoform-parent)	psi-mi:"MI:0465"(dip)	-	isoform-comment:"More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1)."	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:+Hih2M7JLTsjEglauBlPj182h9M9606	rogid:7rpEtixaEeTXC8sLzUf7nHHD3d09606	rigid:rY4fu5vfygb7Nh0/lPklRzTIKx0	false	-	flag tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P60891-1	uniprotkb:P50053-2	intact:EBI-16205225|ensembl:ENSP00000361512	intact:EBI-12204387|ensembl:ENSP00000260599	psi-mi:p60891-1(display_long)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)	psi-mi:p50053-2(display_long)|uniprotkb:KHK(gene name)|psi-mi:KHK(display_short)|uniprotkb:Hepatic fructokinase(gene name synonym)|uniprotkb:Peripheral(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2016)	pubmed:27088854|doi:10.1038/ncb3338|imex:IM-25418	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16205333|imex:IM-25418-5|dip:DIP-201121E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|intact:EBI-749195(isoform-parent)|uniprotkb:P60891-1(isoform-parent)	intact:EBI-1053974(isoform-parent)|ensembl:ENSG00000138030(gene)|ensembl:ENST00000260599(transcript)|uniprotkb:P50053-2(isoform-parent)	psi-mi:"MI:0465"(dip)	-	isoform-comment:"More widely distributed but with a low expression level. KM=7 mM for D-fructose (at 25 degrees Celsius). KM=036 mM for Mg-ATP (at 25 degrees Celsius). kcat is 6.9 sec(-1)."	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:+Hih2M7JLTsjEglauBlPj182h9M9606	rogid:7rpEtixaEeTXC8sLzUf7nHHD3d09606	rigid:rY4fu5vfygb7Nh0/lPklRzTIKx0	false	O-phospho-L-threonine:225-225|O-phospho-L-threonine:225-225	mutation disrupting interaction rate:83-83|mutation disrupting interaction rate:257-257	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)