#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UL51	uniprotkb:Q4ACU6-1	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201995|imex:IM-25455-1|dip:DIP-201161E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:a29B29Bu/lQSnNUZ8NLi0/SviHk	false	ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60741	uniprotkb:Q4ACU6-1	intact:EBI-11173743|ensembl:ENSP00000307342	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn1_human(display_long)|uniprotkb:HCN1(gene name)|psi-mi:HCN1(display_short)|uniprotkb:BCNG1(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202018|imex:IM-25455-2|dip:DIP-201160E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066550.2|ensembl:ENSG00000164588(gene)|ensembl:ENST00000303230(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098855"(HCN channel complex)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:5U6O|rcsb pdb:5U6P|rcsb pdb:6UQF|rcsb pdb:6UQG|reactome:R-HSA-1296061|dip:DIP-62038N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:6sRqFrbAjwmHyMWh0FMXuCyuPe49606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:nuWI1pQ2NyYLR+EYDpLh8VycJQs	false	ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60741	uniprotkb:Q4ACU6-1	intact:EBI-11173743|ensembl:ENSP00000307342	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn1_human(display_long)|uniprotkb:HCN1(gene name)|psi-mi:HCN1(display_short)|uniprotkb:BCNG1(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202041|imex:IM-25455-3|dip:DIP-201160E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066550.2|ensembl:ENSG00000164588(gene)|ensembl:ENST00000303230(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098855"(HCN channel complex)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:5U6O|rcsb pdb:5U6P|rcsb pdb:6UQF|rcsb pdb:6UQG|reactome:R-HSA-1296061|dip:DIP-62038N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:6sRqFrbAjwmHyMWh0FMXuCyuPe49606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:nuWI1pQ2NyYLR+EYDpLh8VycJQs	false	ha tag:n-n	green fluorescent protein tag:?-?|sufficient binding region:1-345	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9P1Z3	uniprotkb:Q4ACU6-1	intact:EBI-11178054|uniprotkb:D3DV90|uniprotkb:Q4VX12|uniprotkb:Q8N6W6|uniprotkb:Q9BWQ2|ensembl:ENSP00000357342|ensembl:ENSP00000458364	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn3_human(display_long)|uniprotkb:HCN3(gene name)|psi-mi:HCN3(display_short)|uniprotkb:KIAA1535(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202066|imex:IM-25455-4|dip:DIP-201162E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065948.1|ensembl:ENSG00000143630(gene)|ensembl:ENSG00000263324(gene)|ensembl:ENST00000368358(transcript)|ensembl:ENST00000575670(transcript)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072718"(response to cisplatin)|go:"GO:1903351"(cellular response to dopamine)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|reactome:R-HSA-1296061|dip:DIP-62039N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:J4EVRCJJcyrbf0NonPXdqWzbd449606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:p+7wlPnX8Jd0cNL9XyDcaF2BAq8	false	ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9P1Z3	uniprotkb:Q4ACU6-1	intact:EBI-11178054|uniprotkb:D3DV90|uniprotkb:Q4VX12|uniprotkb:Q8N6W6|uniprotkb:Q9BWQ2|ensembl:ENSP00000357342|ensembl:ENSP00000458364	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn3_human(display_long)|uniprotkb:HCN3(gene name)|psi-mi:HCN3(display_short)|uniprotkb:KIAA1535(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202089|imex:IM-25455-5|dip:DIP-201162E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065948.1|ensembl:ENSG00000143630(gene)|ensembl:ENSG00000263324(gene)|ensembl:ENST00000368358(transcript)|ensembl:ENST00000575670(transcript)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072718"(response to cisplatin)|go:"GO:1903351"(cellular response to dopamine)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|reactome:R-HSA-1296061|dip:DIP-62039N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:J4EVRCJJcyrbf0NonPXdqWzbd449606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:p+7wlPnX8Jd0cNL9XyDcaF2BAq8	false	ha tag:n-n	green fluorescent protein tag:?-?|sufficient binding region:1-345	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UL51	uniprotkb:Q4ACU6-1	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202114|imex:IM-25455-6|dip:DIP-201161E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:a29B29Bu/lQSnNUZ8NLi0/SviHk	false	ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60741	uniprotkb:Q4ACU6-1	intact:EBI-11173743|ensembl:ENSP00000307342	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn1_human(display_long)|uniprotkb:HCN1(gene name)|psi-mi:HCN1(display_short)|uniprotkb:BCNG1(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0096"(pull down)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202137|imex:IM-25455-7|dip:DIP-201160E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066550.2|ensembl:ENSG00000164588(gene)|ensembl:ENST00000303230(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098855"(HCN channel complex)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:5U6O|rcsb pdb:5U6P|rcsb pdb:6UQF|rcsb pdb:6UQG|reactome:R-HSA-1296061|dip:DIP-62038N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6sRqFrbAjwmHyMWh0FMXuCyuPe49606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:nuWI1pQ2NyYLR+EYDpLh8VycJQs	false	ha tag:n-n	glutathione s tranferase tag:?-?|sufficient binding region:1-345	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UL51	uniprotkb:Q4ACU6-1	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202185|imex:IM-25455-9|dip:DIP-201161E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:a29B29Bu/lQSnNUZ8NLi0/SviHk	false	ha tag:n-n	green fluorescent protein tag:?-?|sufficient binding region:1-345	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60741	uniprotkb:Q4ACU6-1	intact:EBI-11173743|ensembl:ENSP00000307342	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn1_human(display_long)|uniprotkb:HCN1(gene name)|psi-mi:HCN1(display_short)|uniprotkb:BCNG1(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202162|imex:IM-25455-8|dip:DIP-201160E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066550.2|ensembl:ENSG00000164588(gene)|ensembl:ENST00000303230(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098855"(HCN channel complex)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:5U6O|rcsb pdb:5U6P|rcsb pdb:6UQF|rcsb pdb:6UQG|reactome:R-HSA-1296061|dip:DIP-62038N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:6sRqFrbAjwmHyMWh0FMXuCyuPe49606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:nuWI1pQ2NyYLR+EYDpLh8VycJQs	false	ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9P1Z3	uniprotkb:Q4ACU6-1	intact:EBI-11178054|uniprotkb:D3DV90|uniprotkb:Q4VX12|uniprotkb:Q8N6W6|uniprotkb:Q9BWQ2|ensembl:ENSP00000357342|ensembl:ENSP00000458364	intact:EBI-16201983|ensembl:ENSMUSP00000104932	psi-mi:hcn3_human(display_long)|uniprotkb:HCN3(gene name)|psi-mi:HCN3(display_short)|uniprotkb:KIAA1535(gene name synonym)	psi-mi:q4acu6-1(display_long)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yi et al. (2016)	pubmed:26966193|doi:10.1126/science.aaf2669|imex:IM-25455	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16202210|imex:IM-25455-10|dip:DIP-201162E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065948.1|ensembl:ENSG00000143630(gene)|ensembl:ENSG00000263324(gene)|ensembl:ENST00000368358(transcript)|ensembl:ENST00000575670(transcript)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072718"(response to cisplatin)|go:"GO:1903351"(cellular response to dopamine)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|reactome:R-HSA-1296061|dip:DIP-62039N	intact:EBI-771450(isoform-parent)|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:J4EVRCJJcyrbf0NonPXdqWzbd449606	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:p+7wlPnX8Jd0cNL9XyDcaF2BAq8	false	ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)