#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96P71 uniprotkb:O96018 intact:EBI-5773009|uniprotkb:Q9H433|uniprotkb:Q5JWF6|uniprotkb:Q5JWF5|uniprotkb:Q9HCQ9|uniprotkb:Q5JWF7|uniprotkb:Q9H8G8|uniprotkb:A8K780|uniprotkb:Q9HBW7|uniprotkb:E1P5N2|uniprotkb:Q86VV1|ensembl:ENSP00000246190 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:neca3_human(display_long)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym)|uniprotkb:XB51(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098801|imex:IM-25785-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112508.3|refseq:NP_112509.3|ensembl:ENSG00000125967(gene)|ensembl:ENST00000246190(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009306"(protein secretion)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q96P71 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:I2inlkjnL4kDeYl7geuy7tEaRI09606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:lWVwbmA05WQILObg0BZeCpHcT04 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8NCP5 uniprotkb:O96018 intact:EBI-5658292|uniprotkb:Q86VJ7|uniprotkb:Q6IPT8|uniprotkb:Q86XX5|intact:EBI-28972467 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:zbt44_human(display_long)|uniprotkb:BTB/POZ domain-containing protein 15(gene name synonym)|uniprotkb:BTBD15(gene name synonym)|uniprotkb:ZNF851(gene name synonym)|uniprotkb:Zinc finger protein 851(gene name synonym)|uniprotkb:ZBTB44(gene name)|psi-mi:ZBTB44(display_short) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098805|imex:IM-25785-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q8NCP5|ensembl:ENST00000445008|ensembl:ENSP00000408079|ensembl:ENSG00000196323|ensembl:ENST00000525842|ensembl:ENSP00000433457|ensembl:ENST00000530205|ensembl:ENSP00000434177|refseq:NP_001288027.1|refseq:NP_001288028.1|interpro:IPR036236|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0003677"(DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|refseq:NP_054874.3|refseq:XP_016873112.1 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:xewgUIEkS1YVch+LlFi+bSwFZ2Y9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:3QLbV84QsL7SCbiuSNI4f/QOFQU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q06481 uniprotkb:O96018 intact:EBI-79306|uniprotkb:Q13861|uniprotkb:Q14594|uniprotkb:Q14662|uniprotkb:Q71U10|uniprotkb:Q7M4L3|uniprotkb:Q9BT36|ensembl:ENSP00000263574|ensembl:ENSP00000497691|uniprotkb:B3KXX9|uniprotkb:H7BXI4 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:aplp2_human(display_long)|uniprotkb:APPH(gene name synonym)|uniprotkb:APPL2(gene name synonym)|uniprotkb:APLP2(gene name)|psi-mi:APLP2(display_short)|uniprotkb:Amyloid protein homolog(gene name synonym)|uniprotkb:CDEI box-binding protein(gene name synonym)|uniprotkb:"Amyloid beta (A4) precursor-like protein 2"(gene name synonym)|uniprotkb:Amyloid-like protein 2(gene name synonym)|uniprotkb:Sperm membrane protein YWK-II(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098809|imex:IM-25785-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135748.1|refseq:NP_001135749.1|refseq:NP_001135750.1|refseq:NP_001633.1|ensembl:ENSG00000084234(gene)|ensembl:ENST00000263574(transcript)|ensembl:ENST00000650012(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|interpro:IPR036880|mint:Q06481|rcsb pdb:5JBT|rcsb pdb:5TPT|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001230228.1|dip:DIP-31047N ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:WBmrQxD6+MjRPRNHt63XDIs9++o9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:BYcVJv6PENVRZKEKUElGb3VjXNk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P78545 uniprotkb:O96018 intact:EBI-1057285|uniprotkb:Q7Z3X2|uniprotkb:Q8NFG2|uniprotkb:Q99718|uniprotkb:Q6IAP8|uniprotkb:Q7RU03|uniprotkb:B2R5Q6|ensembl:ENSP00000352673|ensembl:ENSP00000356252|ensembl:ENSP00000356253 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:elf3_human(display_long)|uniprotkb:ELF3(gene name)|psi-mi:ELF3(display_short)|uniprotkb:ERT(gene name synonym)|uniprotkb:ESX(gene name synonym)|uniprotkb:JEN(gene name synonym)|uniprotkb:E74-like factor 3(gene name synonym)|uniprotkb:Epithelium-specific Ets transcription factor 1(gene name synonym)|uniprotkb:Epithelium-restricted Ets protein ESX(gene name synonym)|uniprotkb:Epithelial-restricted with serine box(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098813|imex:IM-25785-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107781.1|refseq:NP_004424.3|ensembl:ENSG00000163435(gene)|ensembl:ENST00000359651(transcript)|ensembl:ENST00000367283(transcript)|ensembl:ENST00000367284(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001824"(blastocyst development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060056"(mammary gland involution)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033074|interpro:IPR036388|interpro:IPR036390|interpro:IPR042693|rcsb pdb:2E8P|reactome:R-HSA-1912408 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:UR/FgxMk+J5InoP/6OCJTyCwM/s9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:wAhGswVJuZih15nxDd742d9j+Hs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P14061 uniprotkb:O96018 intact:EBI-12867244|ensembl:ENSP00000466799|uniprotkb:B3KXS1|uniprotkb:Q2M2L8 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:dhb1_human(display_long)|uniprotkb:Estradiol 17-beta-dehydrogenase 1(gene name synonym)|uniprotkb:HSD17B1(gene name)|psi-mi:HSD17B1(display_short)|uniprotkb:20 alpha-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:E17KSR(gene name synonym)|uniprotkb:E2DH(gene name synonym)|uniprotkb:EDH17B1(gene name synonym)|uniprotkb:EDH17B2(gene name synonym)|uniprotkb:EDHB17(gene name synonym)|uniprotkb:Placental 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:SDR28C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 28C member 1(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098817|imex:IM-25785-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000108786(gene)|ensembl:ENST00000585807(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0035410"(dihydrotestosterone 17-beta-dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|go:"GO:0050661"(NADP binding)|go:"GO:0060348"(bone development)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0070401"(NADP+ binding)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|go:"GO:1903924"(estradiol binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR011348(17beta-dehydrogenase)|interpro:IPR020904|interpro:IPR036291|rcsb pdb:1A27|rcsb pdb:1BHS|rcsb pdb:1DHT|rcsb pdb:1EQU|rcsb pdb:1FDS|rcsb pdb:1FDT|rcsb pdb:1FDU|rcsb pdb:1FDV|rcsb pdb:1FDW|rcsb pdb:1I5R|rcsb pdb:1IOL|rcsb pdb:1JTV|rcsb pdb:1QYV|rcsb pdb:1QYW|rcsb pdb:1QYX|rcsb pdb:3DEY|rcsb pdb:3DHE|rcsb pdb:3HB4|rcsb pdb:3HB5|rcsb pdb:3KLM|rcsb pdb:3KLP|rcsb pdb:3KM0|rcsb pdb:6CGC|rcsb pdb:6CGE|rcsb pdb:6DTP|rcsb pdb:6MNC|rcsb pdb:6MNE|reactome:R-HSA-193144|reactome:R-HSA-2453902|refseq:NP_000404.2 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:ih5Kou2xPEQL2xNJEXvwUkiPUkU9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:3Gw+ZRe/+2d2zmFiWW3H0nNbqds false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UN79 uniprotkb:O96018 intact:EBI-3928516|uniprotkb:B4E2B0|uniprotkb:O95275|uniprotkb:Q9UHW7|uniprotkb:Q5SXX1|uniprotkb:O95826|uniprotkb:Q3KQV7|ensembl:ENSP00000356172|ensembl:ENSP00000478239 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:sox13_human(display_long)|uniprotkb:SOX13(gene name)|psi-mi:SOX13(display_short)|uniprotkb:Islet cell antigen 12(gene name synonym)|uniprotkb:"SRY (Sex determining region Y)-box 13"(gene name synonym)|uniprotkb:Type 1 diabetes autoantigen ICA12(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098821|imex:IM-25785-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143842(gene)|ensembl:ENST00000367204(transcript)|ensembl:ENST00000618875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021529"(spinal cord oligodendrocyte cell differentiation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029547|interpro:IPR036910|reactome:R-HSA-3769402|go:"GO:0042492"(gamma-delta T cell differentiation)|refseq:NP_005677.2 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:TKVoZ+JHR+jS+TdNQzVlVXqjuyY9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:8NbIbX8noauTQPb7+w4LZmn+XMI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H6I2 uniprotkb:O96018 intact:EBI-9106753|ensembl:ENSP00000297316 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:sox17_human(display_long)|uniprotkb:SOX17(gene name)|psi-mi:SOX17(display_short) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098825|imex:IM-25785-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071899.1|ensembl:ENSG00000164736(gene)|ensembl:ENST00000297316(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003142"(cardiogenic plate morphogenesis)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007493"(endodermal cell fate determination)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031648"(protein destabilization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050821"(protein stabilization)|go:"GO:0060214"(endocardium formation)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060914"(heart formation)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061009"(common bile duct development)|go:"GO:0061010"(gall bladder development)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072189"(ureter development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000043"(regulation of cardiac cell fate specification)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR021934|interpro:IPR033392|interpro:IPR036910|rcsb pdb:2YUL|rcsb pdb:4A3N|reactome:R-HSA-3769402 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:ZYBklRsVPlbTrGQgxbqG7wEBNYk9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:pQr2v4TzCsojE2nBEys2y45xdSw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P52747 uniprotkb:O96018 intact:EBI-2849334|uniprotkb:O75559|uniprotkb:A8K518|uniprotkb:Q8WUK9|uniprotkb:B4DLY5|uniprotkb:E7ER34|ensembl:ENSP00000379847 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:zn143_human(display_long)|uniprotkb:ZNF143(gene name)|psi-mi:ZNF143(display_short)|uniprotkb:SBF(gene name synonym)|uniprotkb:STAF(gene name synonym)|uniprotkb:SPH-binding factor(gene name synonym)|uniprotkb:Selenocysteine tRNA gene transcription-activating factor(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098829|imex:IM-25785-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269585.1|refseq:NP_001269586.1|refseq:XP_011518651.1|refseq:NP_003433.3|refseq:XP_016873743.1|refseq:XP_016873744.1|ensembl:ENSG00000166478(gene)|ensembl:ENST00000396602(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046872"(metal ion binding)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-6807505|reactome:R-HSA-749476|reactome:R-HSA-76071 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/07 2017/06/07 rogid:UE8tZG7jHDlKiOlSfYC+TqImOX09606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:TInNm2uVnmoJFhoiuEtGMALNNcw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96P71-2 uniprotkb:O96018 intact:EBI-15098952|ensembl:ENSP00000364386 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:q96p71-2(display_long)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:XB51(gene name synonym)|uniprotkb:XB51-beta(isoform synonym)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098872|imex:IM-25785-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5773009(isoform-parent)|uniprotkb:Q96P71-2(isoform-parent)|ensembl:ENSG00000125967(gene)|ensembl:ENST00000375238(transcript) ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/06/07 2017/06/07 rogid:uhhE0J8fulclq9bippkbncAxmfA9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:J7ekNqqvGOVhay1Ufop30nj3YsM false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96P71-2 uniprotkb:O96018 intact:EBI-15098952|ensembl:ENSP00000364386 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:q96p71-2(display_long)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:XB51(gene name synonym)|uniprotkb:XB51-beta(isoform synonym)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098886|imex:IM-25785-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5773009(isoform-parent)|uniprotkb:Q96P71-2(isoform-parent)|ensembl:ENSG00000125967(gene)|ensembl:ENST00000375238(transcript) ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:1B, 5B, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/06/07 2017/06/07 rogid:uhhE0J8fulclq9bippkbncAxmfA9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:J7ekNqqvGOVhay1Ufop30nj3YsM false v5 tag:?-?|necessary binding region:181-190|mutation with no effect:324-324 sufficient binding region:215-364(IPR006020)|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NWT6 uniprotkb:Q96P71-2 intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69 intact:EBI-15098952|ensembl:ENSP00000364386 psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym) psi-mi:q96p71-2(display_long)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:XB51(gene name synonym)|uniprotkb:XB51-beta(isoform synonym)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-15099018|imex:IM-25785-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N intact:EBI-5773009(isoform-parent)|uniprotkb:Q96P71-2(isoform-parent)|ensembl:ENSG00000125967(gene)|ensembl:ENST00000375238(transcript) - - - figure legend:5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/06/07 2017/06/07 rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606 rogid:uhhE0J8fulclq9bippkbncAxmfA9606 rigid:cH1xl62VPDGxFDjyGnj4S+RCBgQ false flag tag:?-? v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NWT6 uniprotkb:O96018 intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-15099018|imex:IM-25785-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/06/07 2017/06/07 rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:cH1xl62VPDGxFDjyGnj4S+RCBgQ false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NWT6 uniprotkb:O96018 intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15099029|imex:IM-25785-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/06/07 2017/06/07 rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:5EL6vSof7xWdQ8SEB6Ji6UR7IwQ false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96P71 uniprotkb:O96018 intact:EBI-5773009|uniprotkb:Q9H433|uniprotkb:Q5JWF6|uniprotkb:Q5JWF5|uniprotkb:Q9HCQ9|uniprotkb:Q5JWF7|uniprotkb:Q9H8G8|uniprotkb:A8K780|uniprotkb:Q9HBW7|uniprotkb:E1P5N2|uniprotkb:Q86VV1|ensembl:ENSP00000246190 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:neca3_human(display_long)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym)|uniprotkb:XB51(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098928|imex:IM-25785-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112508.3|refseq:NP_112509.3|ensembl:ENSG00000125967(gene)|ensembl:ENST00000246190(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009306"(protein secretion)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q96P71 ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line) - 2017/06/07 2017/06/07 rogid:I2inlkjnL4kDeYl7geuy7tEaRI09606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:lWVwbmA05WQILObg0BZeCpHcT04 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NWT6 uniprotkb:Q96P71 intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69 intact:EBI-5773009|uniprotkb:Q9H433|uniprotkb:Q5JWF6|uniprotkb:Q5JWF5|uniprotkb:Q9HCQ9|uniprotkb:Q5JWF7|uniprotkb:Q9H8G8|uniprotkb:A8K780|uniprotkb:Q9HBW7|uniprotkb:E1P5N2|uniprotkb:Q86VV1|ensembl:ENSP00000246190 psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym) psi-mi:neca3_human(display_long)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym)|uniprotkb:XB51(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098946|imex:IM-25785-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N refseq:NP_112508.3|refseq:NP_112509.3|ensembl:ENSG00000125967(gene)|ensembl:ENST00000246190(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009306"(protein secretion)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q96P71 - - - figure legend:4A|comment:Depletion of NECAB3 abrogates the coprecipitation of APBA3/Mint3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line) - 2017/06/07 2017/06/07 rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606 rogid:I2inlkjnL4kDeYl7geuy7tEaRI09606 rigid:Nr20HHjAmorGfw7AbuFC1lDRvC8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NWT6 uniprotkb:O96018 intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-15098946|imex:IM-25785-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 - - - figure legend:4A|comment:Depletion of NECAB3 abrogates the coprecipitation of APBA3/Mint3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line) - 2017/06/07 2017/06/07 rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:Nr20HHjAmorGfw7AbuFC1lDRvC8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96P71-2 uniprotkb:O96018 intact:EBI-15098952|ensembl:ENSP00000364386 intact:EBI-6115839|uniprotkb:O60483|uniprotkb:Q9UPZ2|intact:EBI-28977865|ensembl:ENSP00000315136 psi-mi:q96p71-2(display_long)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:XB51(gene name synonym)|uniprotkb:XB51-beta(isoform synonym)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym) psi-mi:apba3_human(display_long)|uniprotkb:APBA3(gene name)|psi-mi:APBA3(display_short)|uniprotkb:MINT3(gene name synonym)|uniprotkb:X11L2(gene name synonym)|uniprotkb:Adapter protein X11gamma(gene name synonym)|uniprotkb:Neuron-specific X11L2 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 3(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Nakaoka et al. (2016) imex:IM-25785|pubmed:26948053 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-15098938|imex:IM-25785-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5773009(isoform-parent)|uniprotkb:Q96P71-2(isoform-parent)|ensembl:ENSG00000125967(gene)|ensembl:ENST00000375238(transcript) ensembl:ENSP00000315136|refseq:NP_004877.1|ensembl:ENSG00000011132(gene)|ensembl:ENST00000316757(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030531|interpro:IPR036034|rcsb pdb:2YT7|rcsb pdb:2YT8|rcsb pdb:5UWS|reactome:R-HSA-6794361 go:"GO:0005794"(Golgi apparatus) - - figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line) - 2017/06/07 2017/06/07 rogid:uhhE0J8fulclq9bippkbncAxmfA9606 rogid:9XKJCGIewG6Lx84WB+IkWXcDj3E9606 rigid:J7ekNqqvGOVhay1Ufop30nj3YsM false flag tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)