#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WTK8-1	uniprotkb:J3QMY9	intact:EBI-16201014|ensembl:ENSMUSP00000059056	intact:EBI-16200997|ensembl:ENSMUSP00000153439|uniprotkb:Q3UY62	psi-mi:q9wtk8-1(display_long)|uniprotkb:Spo11(gene name)|psi-mi:Spo11(display_short)|uniprotkb:Spo11beta(isoform synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:to6bl_mouse(display_long)|uniprotkb:Top6bl(gene name)|psi-mi:Top6bl(display_short)|uniprotkb:Gm960(gene name synonym)|uniprotkb:Type 2 DNA topoisomerase VI subunit B-like(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Robert et al. (2016)	pubmed:26917764|doi:10.1126/science.aad5309|imex:IM-25439	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201021|imex:IM-25439-1|dip:DIP-201138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000050442(transcript)|ensembl:ENSMUSG00000005883(gene)|intact:EBI-16357104(isoform-parent)	ensembl:ENSMUSG00000071691(gene)|ensembl:ENSMUST00000225896(transcript)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005694"(chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0042138"(meiotic DNA double-strand break formation)|interpro:IPR028040|dip:DIP-62005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:cwAqZKwGzA2CVMrMYrtsqhK5t6s10090	rogid:bo6dIgH7g7v3g0EsEcSVIdn5mAE10090	rigid:qOlRWYRarAXdq5+h8DfAGhGYtKQ	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WTK8-1	uniprotkb:J3QMY9	intact:EBI-16201014|ensembl:ENSMUSP00000059056	intact:EBI-16200997|ensembl:ENSMUSP00000153439|uniprotkb:Q3UY62	psi-mi:q9wtk8-1(display_long)|uniprotkb:Spo11(gene name)|psi-mi:Spo11(display_short)|uniprotkb:Spo11beta(isoform synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:to6bl_mouse(display_long)|uniprotkb:Top6bl(gene name)|psi-mi:Top6bl(display_short)|uniprotkb:Gm960(gene name synonym)|uniprotkb:Type 2 DNA topoisomerase VI subunit B-like(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Robert et al. (2016)	pubmed:26917764|doi:10.1126/science.aad5309|imex:IM-25439	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201065|imex:IM-25439-3|dip:DIP-201138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000050442(transcript)|ensembl:ENSMUSG00000005883(gene)|intact:EBI-16357104(isoform-parent)	ensembl:ENSMUSG00000071691(gene)|ensembl:ENSMUST00000225896(transcript)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005694"(chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0042138"(meiotic DNA double-strand break formation)|interpro:IPR028040|dip:DIP-62005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:cwAqZKwGzA2CVMrMYrtsqhK5t6s10090	rogid:bo6dIgH7g7v3g0EsEcSVIdn5mAE10090	rigid:qOlRWYRarAXdq5+h8DfAGhGYtKQ	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WTK8-1	uniprotkb:J3QMY9	intact:EBI-16201014|ensembl:ENSMUSP00000059056	intact:EBI-16200997|ensembl:ENSMUSP00000153439|uniprotkb:Q3UY62	psi-mi:q9wtk8-1(display_long)|uniprotkb:Spo11(gene name)|psi-mi:Spo11(display_short)|uniprotkb:Spo11beta(isoform synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:to6bl_mouse(display_long)|uniprotkb:Top6bl(gene name)|psi-mi:Top6bl(display_short)|uniprotkb:Gm960(gene name synonym)|uniprotkb:Type 2 DNA topoisomerase VI subunit B-like(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Robert et al. (2016)	pubmed:26917764|doi:10.1126/science.aad5309|imex:IM-25439	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201086|imex:IM-25439-4|dip:DIP-201138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000050442(transcript)|ensembl:ENSMUSG00000005883(gene)|intact:EBI-16357104(isoform-parent)	ensembl:ENSMUSG00000071691(gene)|ensembl:ENSMUST00000225896(transcript)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005694"(chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0042138"(meiotic DNA double-strand break formation)|interpro:IPR028040|dip:DIP-62005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:cwAqZKwGzA2CVMrMYrtsqhK5t6s10090	rogid:bo6dIgH7g7v3g0EsEcSVIdn5mAE10090	rigid:qOlRWYRarAXdq5+h8DfAGhGYtKQ	false	-	sufficient binding region:?-?|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WTK8-1	uniprotkb:J3QMY9	intact:EBI-16201014|ensembl:ENSMUSP00000059056	intact:EBI-16200997|ensembl:ENSMUSP00000153439|uniprotkb:Q3UY62	psi-mi:q9wtk8-1(display_long)|uniprotkb:Spo11(gene name)|psi-mi:Spo11(display_short)|uniprotkb:Spo11beta(isoform synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:to6bl_mouse(display_long)|uniprotkb:Top6bl(gene name)|psi-mi:Top6bl(display_short)|uniprotkb:Gm960(gene name synonym)|uniprotkb:Type 2 DNA topoisomerase VI subunit B-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Robert et al. (2016)	pubmed:26917764|doi:10.1126/science.aad5309|imex:IM-25439	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201109|imex:IM-25439-5|dip:DIP-201138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000050442(transcript)|ensembl:ENSMUSG00000005883(gene)|intact:EBI-16357104(isoform-parent)	ensembl:ENSMUSG00000071691(gene)|ensembl:ENSMUST00000225896(transcript)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005694"(chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0042138"(meiotic DNA double-strand break formation)|interpro:IPR028040|dip:DIP-62005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:cwAqZKwGzA2CVMrMYrtsqhK5t6s10090	rogid:bo6dIgH7g7v3g0EsEcSVIdn5mAE10090	rigid:qOlRWYRarAXdq5+h8DfAGhGYtKQ	false	-	sufficient binding region:?-?|his tag:n-n|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WTK8-1	uniprotkb:J3QMY9	intact:EBI-16201014|ensembl:ENSMUSP00000059056	intact:EBI-16200997|ensembl:ENSMUSP00000153439|uniprotkb:Q3UY62	psi-mi:q9wtk8-1(display_long)|uniprotkb:Spo11(gene name)|psi-mi:Spo11(display_short)|uniprotkb:Spo11beta(isoform synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:to6bl_mouse(display_long)|uniprotkb:Top6bl(gene name)|psi-mi:Top6bl(display_short)|uniprotkb:Gm960(gene name synonym)|uniprotkb:Type 2 DNA topoisomerase VI subunit B-like(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Robert et al. (2016)	pubmed:26917764|doi:10.1126/science.aad5309|imex:IM-25439	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201042|imex:IM-25439-2|dip:DIP-201138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000050442(transcript)|ensembl:ENSMUSG00000005883(gene)|intact:EBI-16357104(isoform-parent)	ensembl:ENSMUSG00000071691(gene)|ensembl:ENSMUST00000225896(transcript)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005694"(chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0042138"(meiotic DNA double-strand break formation)|interpro:IPR028040|dip:DIP-62005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:cwAqZKwGzA2CVMrMYrtsqhK5t6s10090	rogid:bo6dIgH7g7v3g0EsEcSVIdn5mAE10090	rigid:qOlRWYRarAXdq5+h8DfAGhGYtKQ	false	-	sufficient binding region:?-?|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WTK8-1	uniprotkb:J3QMY9	intact:EBI-16201014|ensembl:ENSMUSP00000059056	intact:EBI-16200997|ensembl:ENSMUSP00000153439|uniprotkb:Q3UY62	psi-mi:q9wtk8-1(display_long)|uniprotkb:Spo11(gene name)|psi-mi:Spo11(display_short)|uniprotkb:Spo11beta(isoform synonym)|uniprotkb:Beta(isoform synonym)	psi-mi:to6bl_mouse(display_long)|uniprotkb:Top6bl(gene name)|psi-mi:Top6bl(display_short)|uniprotkb:Gm960(gene name synonym)|uniprotkb:Type 2 DNA topoisomerase VI subunit B-like(gene name synonym)	psi-mi:"MI:0096"(pull down)	Robert et al. (2016)	pubmed:26917764|doi:10.1126/science.aad5309|imex:IM-25439	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16201135|imex:IM-25439-6|dip:DIP-201138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000050442(transcript)|ensembl:ENSMUSG00000005883(gene)|intact:EBI-16357104(isoform-parent)	ensembl:ENSMUSG00000071691(gene)|ensembl:ENSMUST00000225896(transcript)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005694"(chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0042138"(meiotic DNA double-strand break formation)|interpro:IPR028040|dip:DIP-62005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:cwAqZKwGzA2CVMrMYrtsqhK5t6s10090	rogid:bo6dIgH7g7v3g0EsEcSVIdn5mAE10090	rigid:qOlRWYRarAXdq5+h8DfAGhGYtKQ	false	-	sufficient binding region:?-?|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)