#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9LZ03	uniprotkb:Q5Q0E6	intact:EBI-1772104|ensemblplants:AT5G02820.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200387|imex:IM-25438-1|dip:DIP-201137E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xqnzaeI4iP9NTsmYksimbqQjKs0	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q5Q0E6	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200408|imex:IM-25438-2|dip:DIP-201134E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:mqvjtg0NRg1SylG/tfgb2k8OrR0	false	cYFP:c-c|sufficient binding region:1-180	nYFP:n-n|sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C5V6	uniprotkb:Q9LZ03	intact:EBI-1772132|uniprotkb:Q9LT43|ensemblplants:AT3G20780.1	intact:EBI-1772104|ensemblplants:AT5G02820.1	psi-mi:top6b_arath(display_long)|uniprotkb:TOP6B(gene name)|psi-mi:TOP6B(display_short)|uniprotkb:At3g20780(locus name)|uniprotkb:BIN3(gene name synonym)|uniprotkb:HYP6(gene name synonym)|uniprotkb:RHL3(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 3(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 3(gene name synonym)|uniprotkb:Protein ELONGATED HYPOCOTYL 6(gene name synonym)|uniprotkb:MOE17.8(orf name)	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200435|imex:IM-25438-3|dip:DIP-68234E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_188714.2|dip:DIP-40170N|ensemblplants:AT3G20780(gene)|ensemblplants:AT3G20780.1(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006265"(DNA topological change)|go:"GO:0007389"(pattern specification process)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009741"(response to brassinosteroid)|go:"GO:0010026"(trichome differentiation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005734(DNA topoisomerase VI, subunit B)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015320(DNA topoisomerase VI, subunit B, transducer)|interpro:IPR020568|interpro:IPR036890	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:zOeXKnRBz0sLLYMuVcan+0grUq83702	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rigid:JIS256tJMxiCCrT5c600OXn3tqg	false	sufficient binding region:321-670	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200532|imex:IM-25438-8|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	cYFP:n-n	nYFP:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C5V6	uniprotkb:Q9LZ03	intact:EBI-1772132|uniprotkb:Q9LT43|ensemblplants:AT3G20780.1	intact:EBI-1772104|ensemblplants:AT5G02820.1	psi-mi:top6b_arath(display_long)|uniprotkb:TOP6B(gene name)|psi-mi:TOP6B(display_short)|uniprotkb:At3g20780(locus name)|uniprotkb:BIN3(gene name synonym)|uniprotkb:HYP6(gene name synonym)|uniprotkb:RHL3(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 3(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 3(gene name synonym)|uniprotkb:Protein ELONGATED HYPOCOTYL 6(gene name synonym)|uniprotkb:MOE17.8(orf name)	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200513|imex:IM-25438-7|dip:DIP-68234E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_188714.2|dip:DIP-40170N|ensemblplants:AT3G20780(gene)|ensemblplants:AT3G20780.1(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006265"(DNA topological change)|go:"GO:0007389"(pattern specification process)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009741"(response to brassinosteroid)|go:"GO:0010026"(trichome differentiation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005734(DNA topoisomerase VI, subunit B)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015320(DNA topoisomerase VI, subunit B, transducer)|interpro:IPR020568|interpro:IPR036890	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:zOeXKnRBz0sLLYMuVcan+0grUq83702	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rigid:JIS256tJMxiCCrT5c600OXn3tqg	false	-	sufficient binding region:1-248	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9LZ03	uniprotkb:Q5Q0E6	intact:EBI-1772104|ensemblplants:AT5G02820.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200494|imex:IM-25438-6|dip:DIP-201137E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xqnzaeI4iP9NTsmYksimbqQjKs0	false	sufficient binding region:1-248	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q9M4A1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200475|imex:IM-25438-5|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	necessary binding region:1-54	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9LZ03	uniprotkb:Q5Q0E6	intact:EBI-1772104|ensemblplants:AT5G02820.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200454|imex:IM-25438-4|dip:DIP-201137E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xqnzaeI4iP9NTsmYksimbqQjKs0	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q5Q0E6	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200633|imex:IM-25438-13|dip:DIP-201134E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:mqvjtg0NRg1SylG/tfgb2k8OrR0	false	nYFP:n-n	cYFP:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q9M4A2	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200612|imex:IM-25438-12|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	nYFP:n-n	cYFP:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9LZ03	uniprotkb:Q9LZ03	intact:EBI-1772104|ensemblplants:AT5G02820.1	intact:EBI-1772104|ensemblplants:AT5G02820.1	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200595|imex:IM-25438-11|dip:DIP-68232E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rigid:zT0uDvcfaOYIV8VRaDW9scFbSTs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q5Q0E6	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200574|imex:IM-25438-10|dip:DIP-201134E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:mqvjtg0NRg1SylG/tfgb2k8OrR0	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200553|imex:IM-25438-9|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C5V6	uniprotkb:Q9LZ03	intact:EBI-1772132|uniprotkb:Q9LT43|ensemblplants:AT3G20780.1	intact:EBI-1772104|ensemblplants:AT5G02820.1	psi-mi:top6b_arath(display_long)|uniprotkb:TOP6B(gene name)|psi-mi:TOP6B(display_short)|uniprotkb:At3g20780(locus name)|uniprotkb:BIN3(gene name synonym)|uniprotkb:HYP6(gene name synonym)|uniprotkb:RHL3(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 3(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 3(gene name synonym)|uniprotkb:Protein ELONGATED HYPOCOTYL 6(gene name synonym)|uniprotkb:MOE17.8(orf name)	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200654|imex:IM-25438-14|dip:DIP-68234E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_188714.2|dip:DIP-40170N|ensemblplants:AT3G20780(gene)|ensemblplants:AT3G20780.1(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006265"(DNA topological change)|go:"GO:0007389"(pattern specification process)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009741"(response to brassinosteroid)|go:"GO:0010026"(trichome differentiation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005734(DNA topoisomerase VI, subunit B)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015320(DNA topoisomerase VI, subunit B, transducer)|interpro:IPR020568|interpro:IPR036890	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:zOeXKnRBz0sLLYMuVcan+0grUq83702	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rigid:JIS256tJMxiCCrT5c600OXn3tqg	false	-	sufficient binding region:1-248	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q5Q0E6	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200673|imex:IM-25438-15|dip:DIP-201134E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:mqvjtg0NRg1SylG/tfgb2k8OrR0	false	sufficient binding region:1-180|necessary binding region:1-54	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q9M4A1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200694|imex:IM-25438-16|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	necessary binding region:1-54	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q9M4A1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200713|imex:IM-25438-17|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	-	necessary binding region:1-77	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q5Q0E6	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200732|imex:IM-25438-18|dip:DIP-201134E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:mqvjtg0NRg1SylG/tfgb2k8OrR0	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q9M4A1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200753|imex:IM-25438-19|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	-	necessary binding region:1-77	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200799|imex:IM-25438-21|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	sufficient binding region:1-208|necessary binding region:1-22	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200772|imex:IM-25438-20|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	cYFP:c-c|sufficient binding region:1-208	nYFP:n-n|sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C5V6	uniprotkb:Q9LZ03	intact:EBI-1772132|uniprotkb:Q9LT43|ensemblplants:AT3G20780.1	intact:EBI-1772104|ensemblplants:AT5G02820.1	psi-mi:top6b_arath(display_long)|uniprotkb:TOP6B(gene name)|psi-mi:TOP6B(display_short)|uniprotkb:At3g20780(locus name)|uniprotkb:BIN3(gene name synonym)|uniprotkb:HYP6(gene name synonym)|uniprotkb:RHL3(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 3(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 3(gene name synonym)|uniprotkb:Protein ELONGATED HYPOCOTYL 6(gene name synonym)|uniprotkb:MOE17.8(orf name)	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200820|imex:IM-25438-22|dip:DIP-68234E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_188714.2|dip:DIP-40170N|ensemblplants:AT3G20780(gene)|ensemblplants:AT3G20780.1(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006265"(DNA topological change)|go:"GO:0007389"(pattern specification process)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009741"(response to brassinosteroid)|go:"GO:0010026"(trichome differentiation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005734(DNA topoisomerase VI, subunit B)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015320(DNA topoisomerase VI, subunit B, transducer)|interpro:IPR020568|interpro:IPR036890	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:zOeXKnRBz0sLLYMuVcan+0grUq83702	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rigid:JIS256tJMxiCCrT5c600OXn3tqg	false	sufficient binding region:321-670	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200860|imex:IM-25438-24|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q9M4A2	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200881|imex:IM-25438-25|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	cYFP:n-n	nYFP:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200839|imex:IM-25438-23|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	nYFP:n-n	cYFP:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9LZ03	uniprotkb:Q5Q0E6	intact:EBI-1772104|ensemblplants:AT5G02820.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:top6a_arath(display_long)|uniprotkb:TOP6A(gene name)|psi-mi:TOP6A(display_short)|uniprotkb:SPO11-3(gene name synonym)|uniprotkb:BIN5(gene name synonym)|uniprotkb:At5g02820(locus name)|uniprotkb:RHL2(gene name synonym)|uniprotkb:Protein BRASSINOSTEROID INSENSITIVE 5(gene name synonym)|uniprotkb:Protein ROOT HAIRLESS 2(gene name synonym)|uniprotkb:Meiotic recombination protein SPO11-3(gene name synonym)|uniprotkb:F9G14.130(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200923|imex:IM-25438-27|dip:DIP-201137E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195902.1|dip:DIP-40169N|ensemblplants:AT5G02820(gene)|ensemblplants:AT5G02820.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:BgtabRKCz0PwBnIDn58Z1JcFrxk3702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xqnzaeI4iP9NTsmYksimbqQjKs0	false	sufficient binding region:1-248	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A2	uniprotkb:Q5Q0E6	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200902|imex:IM-25438-26|dip:DIP-201134E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:mqvjtg0NRg1SylG/tfgb2k8OrR0	false	sufficient binding region:1-180|necessary binding region:1-54	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q9M4A2	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-1540725|uniprotkb:Q9C5S3|uniprotkb:Q9LK56|ensemblplants:AT3G13170.1	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:spo11_arath(display_long)|uniprotkb:SPO11-1(gene name)|psi-mi:SPO11-1(display_short)|uniprotkb:MJG19.19(orf name)|uniprotkb:At3g13170(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200942|imex:IM-25438-28|dip:DIP-201136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	refseq:NP_187923.1|dip:DIP-62004N|mint:Q9M4A2|ensemblplants:AT3G13170(gene)|ensemblplants:AT3G13170.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051026"(chiasma assembly)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013048(Meiotic recombination Spo11)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4100(nicbe)|taxid:4100(Nicotiana benthamiana)	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid:3tnPNMj3oTh6SQdYMJ1nrWIeS003702	rigid:xXkPlWJheQApdb9LCICdz3MmMvs	false	nYFP:n-n	cYFP:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9M4A1	uniprotkb:Q5Q0E6	intact:EBI-1772309|uniprotkb:Q9SH50|ensemblplants:AT1G63990.1	intact:EBI-16200362|ensemblplants:AT1G60460.3|uniprotkb:O22692|uniprotkb:Q5Q0E4|uniprotkb:Q5Q0E5	psi-mi:spo12_arath(display_long)|uniprotkb:SPO11-2(gene name)|psi-mi:SPO11-2(display_short)|uniprotkb:At1g63990(locus name)|uniprotkb:F22C12.24(orf name)	psi-mi:to6bl_arath(display_long)|uniprotkb:MTOPVIB(gene name)|psi-mi:MTOPVIB(display_short)|uniprotkb:Meiotic topoisomerase VIB-like(gene name synonym)|uniprotkb:F8A5.1(orf name)|uniprotkb:At1g60460(locus name)	psi-mi:"MI:0018"(two hybrid)	Vrielynck et al. (2016)	pubmed:26917763|doi:10.1126/science.aad5196|imex:IM-25438	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16200963|imex:IM-25438-29|dip:DIP-201135E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_176582.2|dip:DIP-40433N|ensemblplants:AT1G63990(gene)|ensemblplants:AT1G63990.1(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009553"(embryo sac development)|go:"GO:0009555"(pollen development)|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048316"(seed development)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388	ensemblplants:AT1G60460(gene)|ensemblplants:AT1G60460.3(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0048235"(pollen sperm cell differentiation)|go:"GO:0048314"(embryo sac morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR034566|refseq:NP_001031210.1|refseq:NP_001031211.1|refseq:NP_176249.2|dip:DIP-62003N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:509E9B3E2EA77328	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:Hl7zf8ZHvnTLLjda4KZZghuvrx03702	rogid://37kQFEs5I6gUgoOzfbgrqHIDY3702	rigid:xJ8ZuJ7dI/C4xhCRLq8aoSKi+1g	false	sufficient binding region:1-208|necessary binding region:1-22	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)