#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9USP0 uniprotkb:Q9UT76 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198574|imex:IM-25364-1|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:19F324EF0135628B full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9USP0 uniprotkb:Q09924 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198531|ensemblfungi:"SPAC21E11.06.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2bd_schpo(display_long)|uniprotkb:tif224(gene name)|psi-mi:tif224(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:SPAC21E11.06(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198574|imex:IM-25364-1|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC21E11.06(gene)|ensemblfungi:SPAC21E11.06.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61961N|reactome:R-SPO-72731|refseq:NP_594503.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:3C7029EBDFEF6EAF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:Aks4E/RvLZMqA0n5KidtcX9m5KQ284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9USP0 uniprotkb:P56287 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198550|ensemblfungi:"SPAC8C9.15c.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2be_schpo(display_long)|uniprotkb:tif225(gene name)|psi-mi:tif225(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)|uniprotkb:SPAC8C9.15c(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198574|imex:IM-25364-1|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC8C9.15c(gene)|ensemblfungi:SPAC8C9.15c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61962N|reactome:R-SPO-72731|refseq:NP_594285.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:D399547CBD82C4BC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:u2wJRy6HbBwJAiu7vj8mrMncIpc284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9USP0 uniprotkb:P56288 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198511|ensemblfungi:"SPAC4D7.09.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2bg_schpo(display_long)|uniprotkb:tif223(gene name)|psi-mi:tif223(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:SPAC4D7.09(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198574|imex:IM-25364-1|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC4D7.09(gene)|ensemblfungi:SPAC4D7.09.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR029044|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61960N|reactome:R-SPO-72731|refseq:NP_594962.2 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:242987543BE43021 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:EXcyv765uE6fEfVJSuVYPQFWPy4284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4R5Q4 uniprotkb:P56287 intact:EBI-16198691|ensemblfungi:CAY70890 intact:EBI-16198550|ensemblfungi:"SPAC8C9.15c.1:pep" psi-mi:c4r5q4_kompg(display_long)|uniprotkb:PAS_chr3_0839(locus name) psi-mi:ei2be_schpo(display_long)|uniprotkb:tif225(gene name)|psi-mi:tif225(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)|uniprotkb:SPAC8C9.15c(orf name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198734|imex:IM-25364-4|dip:DIP-200970E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY70890(transcript)|ensemblfungi:PAS_chr3_0839(gene)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:1990856"(methionyl-initiator methionine tRNA binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|dip:DIP-61966N|refseq:XP_002493069.1 ensemblfungi:SPAC8C9.15c(gene)|ensemblfungi:SPAC8C9.15c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61962N|reactome:R-SPO-72731|refseq:NP_594285.1 psi-mi:"MI:0465"(dip) - crc64:D399547CBD82C4BC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:IDELK1hAQL6wQyotkss8cJ2cZNA644223 rogid:u2wJRy6HbBwJAiu7vj8mrMncIpc284812 rigid:r1U7q6ql+0OtizvhqD9Z3gKyiik false flag tag:c-c unnatural residue:115-115|unnatural residue:116-116|unnatural residue:117-117|unnatural residue:204-204|unnatural residue:257-257 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:C4QXJ0 uniprotkb:C4R3H4 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198651|ensemblfungi:CAY70009 psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:c4r3h4_kompg(display_long)|uniprotkb:PAS_chr3_0077(locus name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198716|imex:IM-25364-3|dip:DIP-200971E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:CAY70009(transcript)|ensemblfungi:PAS_chr3_0077(gene)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:1990856"(methionyl-initiator methionine tRNA binding)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61964N|refseq:XP_002492289.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:ZaN4pA2cPuCmx1cZu2ez8M0AwlY644223 rigid:B+V/NXeV4iQJbLXFuF9UkAvnzl4 false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:C4R5Q4 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198691|ensemblfungi:CAY70890 psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:c4r5q4_kompg(display_long)|uniprotkb:PAS_chr3_0839(locus name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198716|imex:IM-25364-3|dip:DIP-200971E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:CAY70890(transcript)|ensemblfungi:PAS_chr3_0839(gene)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:1990856"(methionyl-initiator methionine tRNA binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|dip:DIP-61966N|refseq:XP_002493069.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:IDELK1hAQL6wQyotkss8cJ2cZNA644223 rigid:B+V/NXeV4iQJbLXFuF9UkAvnzl4 false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q09924 uniprotkb:P56286 intact:EBI-16198531|ensemblfungi:"SPAC21E11.06.1:pep" intact:EBI-16198594|ensemblfungi:"SPAC3G9.09c.1:pep" psi-mi:ei2bd_schpo(display_long)|uniprotkb:tif224(gene name)|psi-mi:tif224(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:SPAC21E11.06(orf name) psi-mi:if2a_schpo(display_long)|uniprotkb:tif211(gene name)|psi-mi:tif211(display_short)|uniprotkb:SPAC3G9.09c(orf name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198626|imex:IM-25364-2|dip:DIP-200975E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC21E11.06(gene)|ensemblfungi:SPAC21E11.06.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61961N|reactome:R-SPO-72731|refseq:NP_594503.1 reactome:R-SPO-72649|reactome:R-SPO-72706|ensemblfungi:SPAC3G9.09c(gene)|ensemblfungi:SPAC3G9.09c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61963N|reactome:R-SPO-156827|reactome:R-SPO-72695|reactome:R-SPO-72702|reactome:R-SPO-72731|refseq:NP_594081.1 psi-mi:"MI:0465"(dip) crc64:3C7029EBDFEF6EAF crc64:6C967FF2C3BD0D1E full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:Aks4E/RvLZMqA0n5KidtcX9m5KQ284812 rogid:jFvkwZdJKnwrdM0IFriu2gPqpYk284812 rigid:pilcDmJDWw4OIz0PIj2DqU+hn8I false unnatural residue:247-247|unnatural residue:248-248|unnatural residue:256-256 flag tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UT76 uniprotkb:P56286 intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep" intact:EBI-16198594|ensemblfungi:"SPAC3G9.09c.1:pep" psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name) psi-mi:if2a_schpo(display_long)|uniprotkb:tif211(gene name)|psi-mi:tif211(display_short)|uniprotkb:SPAC3G9.09c(orf name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198861|imex:IM-25364-9|dip:DIP-200974E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1 reactome:R-SPO-72649|reactome:R-SPO-72706|ensemblfungi:SPAC3G9.09c(gene)|ensemblfungi:SPAC3G9.09c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61963N|reactome:R-SPO-156827|reactome:R-SPO-72695|reactome:R-SPO-72702|reactome:R-SPO-72731|refseq:NP_594081.1 psi-mi:"MI:0465"(dip) crc64:19F324EF0135628B crc64:6C967FF2C3BD0D1E full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812 rogid:jFvkwZdJKnwrdM0IFriu2gPqpYk284812 rigid:o2I8u43UKZmuGJ5zaZ6DrztlBCg false ha tag:n-n unnatural residue:16-16|unnatural residue:88-88|unnatural residue:90-90 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9USP0 uniprotkb:Q9UT76 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name) psi-mi:"MI:0114"(x-ray crystallography) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198841|imex:IM-25364-8|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:19F324EF0135628B full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9USP0 uniprotkb:Q09924 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198531|ensemblfungi:"SPAC21E11.06.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2bd_schpo(display_long)|uniprotkb:tif224(gene name)|psi-mi:tif224(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:SPAC21E11.06(orf name) psi-mi:"MI:0114"(x-ray crystallography) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198841|imex:IM-25364-8|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC21E11.06(gene)|ensemblfungi:SPAC21E11.06.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61961N|reactome:R-SPO-72731|refseq:NP_594503.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:3C7029EBDFEF6EAF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:Aks4E/RvLZMqA0n5KidtcX9m5KQ284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9USP0 uniprotkb:P56287 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198550|ensemblfungi:"SPAC8C9.15c.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2be_schpo(display_long)|uniprotkb:tif225(gene name)|psi-mi:tif225(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)|uniprotkb:SPAC8C9.15c(orf name) psi-mi:"MI:0114"(x-ray crystallography) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198841|imex:IM-25364-8|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC8C9.15c(gene)|ensemblfungi:SPAC8C9.15c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61962N|reactome:R-SPO-72731|refseq:NP_594285.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:D399547CBD82C4BC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:u2wJRy6HbBwJAiu7vj8mrMncIpc284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9USP0 uniprotkb:P56288 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198511|ensemblfungi:"SPAC4D7.09.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:ei2bg_schpo(display_long)|uniprotkb:tif223(gene name)|psi-mi:tif223(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:SPAC4D7.09(orf name) psi-mi:"MI:0114"(x-ray crystallography) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198841|imex:IM-25364-8|dip:DIP-200968E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 ensemblfungi:SPAC4D7.09(gene)|ensemblfungi:SPAC4D7.09.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR029044|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61960N|reactome:R-SPO-72731|refseq:NP_594962.2 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:242987543BE43021 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:EXcyv765uE6fEfVJSuVYPQFWPy4284812 rigid:xYxejKi5xXFmJVy2AZuUjR41XdU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C4QXJ0 uniprotkb:C4R3H4 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198651|ensemblfungi:CAY70009 psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:c4r3h4_kompg(display_long)|uniprotkb:PAS_chr3_0077(locus name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:CAY70009(transcript)|ensemblfungi:PAS_chr3_0077(gene)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:1990856"(methionyl-initiator methionine tRNA binding)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61964N|refseq:XP_002492289.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:ZaN4pA2cPuCmx1cZu2ez8M0AwlY644223 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:C4R5Q4 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198691|ensemblfungi:CAY70890 psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:c4r5q4_kompg(display_long)|uniprotkb:PAS_chr3_0839(locus name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:CAY70890(transcript)|ensemblfungi:PAS_chr3_0839(gene)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:1990856"(methionyl-initiator methionine tRNA binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|dip:DIP-61966N|refseq:XP_002493069.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:IDELK1hAQL6wQyotkss8cJ2cZNA644223 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:Q9USP0 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 psi-mi:"MI:0465"(dip) - crc64:6FAACEBEBD50995A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:Q9UT76 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep" psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1 psi-mi:"MI:0465"(dip) - crc64:19F324EF0135628B full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:Q09924 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198531|ensemblfungi:"SPAC21E11.06.1:pep" psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:ei2bd_schpo(display_long)|uniprotkb:tif224(gene name)|psi-mi:tif224(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:SPAC21E11.06(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:SPAC21E11.06(gene)|ensemblfungi:SPAC21E11.06.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61961N|reactome:R-SPO-72731|refseq:NP_594503.1 psi-mi:"MI:0465"(dip) - crc64:3C7029EBDFEF6EAF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:Aks4E/RvLZMqA0n5KidtcX9m5KQ284812 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:P56287 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198550|ensemblfungi:"SPAC8C9.15c.1:pep" psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:ei2be_schpo(display_long)|uniprotkb:tif225(gene name)|psi-mi:tif225(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)|uniprotkb:SPAC8C9.15c(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:SPAC8C9.15c(gene)|ensemblfungi:SPAC8C9.15c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61962N|reactome:R-SPO-72731|refseq:NP_594285.1 psi-mi:"MI:0465"(dip) - crc64:D399547CBD82C4BC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:u2wJRy6HbBwJAiu7vj8mrMncIpc284812 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C4QXJ0 uniprotkb:P56288 intact:EBI-16198674|ensemblfungi:CAY67963 intact:EBI-16198511|ensemblfungi:"SPAC4D7.09.1:pep" psi-mi:c4qxj0_kompg(display_long)|uniprotkb:PAS_chr1-4_0135(locus name) psi-mi:ei2bg_schpo(display_long)|uniprotkb:tif223(gene name)|psi-mi:tif223(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:SPAC4D7.09(orf name) psi-mi:"MI:0071"(molecular sieving) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198817|imex:IM-25364-7|dip:DIP-200969E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:CAY67963(transcript)|ensemblfungi:PAS_chr1-4_0135(gene)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|dip:DIP-61965N|refseq:XP_002490244.1 ensemblfungi:SPAC4D7.09(gene)|ensemblfungi:SPAC4D7.09.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR029044|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61960N|reactome:R-SPO-72731|refseq:NP_594962.2 psi-mi:"MI:0465"(dip) - crc64:242987543BE43021 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:LXdatHGuMWVGq3ouH0ccNH4cE5A644223 rogid:EXcyv765uE6fEfVJSuVYPQFWPy4284812 rigid:hOjObXEDPJoDm4RjHD6Pls/JX9Q false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P56288 uniprotkb:C4R5Q4 intact:EBI-16198511|ensemblfungi:"SPAC4D7.09.1:pep" intact:EBI-16198691|ensemblfungi:CAY70890 psi-mi:ei2bg_schpo(display_long)|uniprotkb:tif223(gene name)|psi-mi:tif223(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:SPAC4D7.09(orf name) psi-mi:c4r5q4_kompg(display_long)|uniprotkb:PAS_chr3_0839(locus name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:644223(picpg)|taxid:644223("Komagataella pastoris (strain GS115 / ATCC 20864)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198788|imex:IM-25364-6|dip:DIP-200972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC4D7.09(gene)|ensemblfungi:SPAC4D7.09.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR029044|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61960N|reactome:R-SPO-72731|refseq:NP_594962.2 ensemblfungi:CAY70890(transcript)|ensemblfungi:PAS_chr3_0839(gene)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:1990856"(methionyl-initiator methionine tRNA binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|dip:DIP-61966N|refseq:XP_002493069.1 psi-mi:"MI:0465"(dip) crc64:242987543BE43021 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:EXcyv765uE6fEfVJSuVYPQFWPy4284812 rogid:IDELK1hAQL6wQyotkss8cJ2cZNA644223 rigid:TTXJw2rm9iq0RwhCqgYKSZxTTbI false unnatural residue:124-124|unnatural residue:126-126|unnatural residue:191-191|unnatural residue:213-213|unnatural residue:258-258 flag tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9USP0 uniprotkb:P56286 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198594|ensemblfungi:"SPAC3G9.09c.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:if2a_schpo(display_long)|uniprotkb:tif211(gene name)|psi-mi:tif211(display_short)|uniprotkb:SPAC3G9.09c(orf name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198886|imex:IM-25364-10|dip:DIP-200973E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 reactome:R-SPO-72649|reactome:R-SPO-72706|ensemblfungi:SPAC3G9.09c(gene)|ensemblfungi:SPAC3G9.09c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61963N|reactome:R-SPO-156827|reactome:R-SPO-72695|reactome:R-SPO-72702|reactome:R-SPO-72731|refseq:NP_594081.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:6C967FF2C3BD0D1E full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:jFvkwZdJKnwrdM0IFriu2gPqpYk284812 rigid:zzDoenln+RzBS52r1OItY5e+3pY false unnatural residue:56-56|unnatural residue:63-63|unnatural residue:87-87|unnatural residue:92-92|unnatural residue:95-95|unnatural residue:97-97|unnatural residue:338-338|unnatural residue:341-341 flag tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9USP0 uniprotkb:P56286 intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep" intact:EBI-16198594|ensemblfungi:"SPAC3G9.09c.1:pep" psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym) psi-mi:if2a_schpo(display_long)|uniprotkb:tif211(gene name)|psi-mi:tif211(display_short)|uniprotkb:SPAC3G9.09c(orf name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198763|imex:IM-25364-5|dip:DIP-200973E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731 reactome:R-SPO-72649|reactome:R-SPO-72706|ensemblfungi:SPAC3G9.09c(gene)|ensemblfungi:SPAC3G9.09c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61963N|reactome:R-SPO-156827|reactome:R-SPO-72695|reactome:R-SPO-72702|reactome:R-SPO-72731|refseq:NP_594081.1 psi-mi:"MI:0465"(dip) crc64:6FAACEBEBD50995A crc64:6C967FF2C3BD0D1E full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812 rogid:jFvkwZdJKnwrdM0IFriu2gPqpYk284812 rigid:zzDoenln+RzBS52r1OItY5e+3pY false myc tag:n-n unnatural residue:28-28|unnatural residue:74-74|unnatural residue:88-88 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UT76 uniprotkb:P56286 intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep" intact:EBI-16198594|ensemblfungi:"SPAC3G9.09c.1:pep" psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name) psi-mi:if2a_schpo(display_long)|uniprotkb:tif211(gene name)|psi-mi:tif211(display_short)|uniprotkb:SPAC3G9.09c(orf name) psi-mi:"MI:0030"(cross-linking study) Kashiwagi et al. (2016) pubmed:26901872|doi:10.1038/nature16991|imex:IM-25364 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16198921|imex:IM-25364-11|dip:DIP-200974E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1 reactome:R-SPO-72649|reactome:R-SPO-72706|ensemblfungi:SPAC3G9.09c(gene)|ensemblfungi:SPAC3G9.09c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|dip:DIP-61963N|reactome:R-SPO-156827|reactome:R-SPO-72695|reactome:R-SPO-72702|reactome:R-SPO-72731|refseq:NP_594081.1 psi-mi:"MI:0465"(dip) crc64:19F324EF0135628B crc64:6C967FF2C3BD0D1E full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812 rogid:jFvkwZdJKnwrdM0IFriu2gPqpYk284812 rigid:o2I8u43UKZmuGJ5zaZ6DrztlBCg false unnatural residue:95-95|unnatural residue:100-100|unnatural residue:91-91|unnatural residue:84-84 flag tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)