#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40969	uniprotkb:P22216	intact:EBI-4077|uniprotkb:D6VZZ0|ensemblfungi:YMR168C	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	psi-mi:cbf3b_yeast(display_long)|uniprotkb:CEP3(gene name)|psi-mi:CEP3(display_short)|uniprotkb:CBF3(gene name synonym)|uniprotkb:YMR168C(locus name)|uniprotkb:YM8520.17C(orf name)|uniprotkb:CBF3B(gene name synonym)|uniprotkb:CSL1(gene name synonym)	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Strecker et al. (2016)	pubmed:26829389|doi:10.1038/ncb3308|imex:IM-25412	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16194715|imex:IM-25412-1|dip:DIP-201106E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013891.1|sgd:S000004778|dip:DIP-5956N|ensemblfungi:YMR168C(gene)|ensemblfungi:YMR168C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0031518"(CBF3 complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR001138(Fungal transcriptional regulatory protein, N-terminal)|interpro:IPR031760|interpro:IPR036864|rcsb pdb:2QUQ|rcsb pdb:2VEQ|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYS|rcsb pdb:7K79|rcsb pdb:7K7G	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216	psi-mi:"MI:0465"(dip)	crc64:2E24A0508080A09B	crc64:84A9612229CA72D1	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:fX2WF64mv3m8KsmULd7CJVp9cOo559292	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rigid:Qd9WudNLOcJnR3+NSWF+fWT6JcY	false	sufficient binding region:563-608	mutation disrupting interaction rate:339-339	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P40969	uniprotkb:P22216	intact:EBI-4077|uniprotkb:D6VZZ0|ensemblfungi:YMR168C	intact:EBI-17843|uniprotkb:D6W3L5|uniprotkb:Q6B1S1|ensemblfungi:YPL153C	psi-mi:cbf3b_yeast(display_long)|uniprotkb:CEP3(gene name)|psi-mi:CEP3(display_short)|uniprotkb:CBF3(gene name synonym)|uniprotkb:YMR168C(locus name)|uniprotkb:YM8520.17C(orf name)|uniprotkb:CBF3B(gene name synonym)|uniprotkb:CSL1(gene name synonym)	psi-mi:rad53_yeast(display_long)|uniprotkb:RAD53(gene name)|psi-mi:RAD53(display_short)|uniprotkb:MEC2(gene name synonym)|uniprotkb:SAD1(gene name synonym)|uniprotkb:Serine-protein kinase 1(gene name synonym)|uniprotkb:SPK1(gene name synonym)|uniprotkb:P2588(orf name)|uniprotkb:YPL153C(locus name)|uniprotkb:CHEK2 homolog(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Strecker et al. (2016)	pubmed:26829389|doi:10.1038/ncb3308|imex:IM-25412	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16194737|imex:IM-25412-2|dip:DIP-201106E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013891.1|sgd:S000004778|dip:DIP-5956N|ensemblfungi:YMR168C(gene)|ensemblfungi:YMR168C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0031518"(CBF3 complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR001138(Fungal transcriptional regulatory protein, N-terminal)|interpro:IPR031760|interpro:IPR036864|rcsb pdb:2QUQ|rcsb pdb:2VEQ|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYS|rcsb pdb:7K79|rcsb pdb:7K7G	refseq:NP_015172.1|sgd:S000006074|ensemblfungi:YPL153C(gene)|ensemblfungi:YPL153C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0009202"(deoxyribonucleoside triphosphate biosynthetic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016256(Serine/threonine-protein kinase RAD53)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1DMZ|rcsb pdb:1FHQ|rcsb pdb:1FHR|rcsb pdb:1G3G|rcsb pdb:1G6G|rcsb pdb:1J4K|rcsb pdb:1J4L|rcsb pdb:1J4O|rcsb pdb:1J4P|rcsb pdb:1J4Q|rcsb pdb:1K2M|rcsb pdb:1K2N|rcsb pdb:1K3J|rcsb pdb:1K3N|rcsb pdb:1K3Q|rcsb pdb:1QU5|rcsb pdb:2A0T|rcsb pdb:2JQI|rcsb pdb:2JQL|rcsb pdb:2YGV|rcsb pdb:4PDP|rcsb pdb:4PDS|rcsb pdb:5T2F|rcsb pdb:5T2S|rcsb pdb:5XZV|rcsb pdb:5XZW|rcsb pdb:6C4U|dip:DIP-2322N|mint:P22216	psi-mi:"MI:0465"(dip)	crc64:2E24A0508080A09B	crc64:84A9612229CA72D1	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:fX2WF64mv3m8KsmULd7CJVp9cOo559292	rogid:OU8gjvSvTtvDvk+en1y8hyEjFhI559292	rigid:Qd9WudNLOcJnR3+NSWF+fWT6JcY	false	mutation disrupting interaction rate:575-575|sufficient binding region:563-608	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)