#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A6NFY7 uniprotkb:Q9H1K1 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059655|imex:IM-26139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) go:"GO:0005739"(mitochondrion) - - figure legend:1A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:P38646 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059655|imex:IM-26139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N go:"GO:0005739"(mitochondrion) - - figure legend:1A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:Q8IWL3 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059655|imex:IM-26139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) go:"GO:0005739"(mitochondrion) - - figure legend:1A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:P21912 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059655|imex:IM-26139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N go:"GO:0005739"(mitochondrion) - - figure legend:1A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:Q9H1K1 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059686|imex:IM-26139-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) go:"GO:0005739"(mitochondrion) - - figure legend:1B, 2C, Supp 2D, Supp 3 B/D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false flag tag:c-c|myc tag:c-c|mutation decreasing interaction strength:53-55|mutation decreasing interaction strength:55-55|mutation disrupting interaction strength:57-57|mutation decreasing interaction strength:61-61,64-65|mutation decreasing interaction strength:56-59|mutation disrupting interaction strength:53-55,61-61,64-65|mutation decreasing interaction strength:61-61,64-65|mutation disrupting interaction strength:53-55,61-61,64-65|mutation disrupting interaction strength:56-59,61-61,64-65|sufficient binding region:1-70(IPR008011)|mutation disrupting interaction strength:53-59 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:P38646 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059686|imex:IM-26139-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N go:"GO:0005739"(mitochondrion) - - figure legend:1B, 2C, Supp 2D, Supp 3 B/D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false flag tag:c-c|myc tag:c-c|mutation decreasing interaction strength:53-55|mutation decreasing interaction strength:55-55|mutation disrupting interaction strength:57-57|mutation decreasing interaction strength:61-61,64-65|mutation decreasing interaction strength:56-59|mutation disrupting interaction strength:53-55,61-61,64-65|mutation decreasing interaction strength:61-61,64-65|mutation disrupting interaction strength:53-55,61-61,64-65|mutation disrupting interaction strength:56-59,61-61,64-65|sufficient binding region:1-70(IPR008011)|mutation disrupting interaction strength:53-59 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:Q8IWL3 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059686|imex:IM-26139-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) go:"GO:0005739"(mitochondrion) - - figure legend:1B, 2C, Supp 2D, Supp 3 B/D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false flag tag:c-c|myc tag:c-c|mutation decreasing interaction strength:53-55|mutation decreasing interaction strength:55-55|mutation disrupting interaction strength:57-57|mutation decreasing interaction strength:61-61,64-65|mutation decreasing interaction strength:56-59|mutation disrupting interaction strength:53-55,61-61,64-65|mutation decreasing interaction strength:61-61,64-65|mutation disrupting interaction strength:53-55,61-61,64-65|mutation disrupting interaction strength:56-59,61-61,64-65|sufficient binding region:1-70(IPR008011)|mutation disrupting interaction strength:53-59 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6NFY7 uniprotkb:P21912 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059686|imex:IM-26139-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N go:"GO:0005739"(mitochondrion) - - figure legend:1B, 2C, Supp 2D, Supp 3 B/D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:n1pVmOE41XN9ToTI8OvO4NFVgEY false flag tag:c-c|myc tag:c-c|mutation decreasing interaction strength:53-55|mutation decreasing interaction strength:55-55|mutation disrupting interaction strength:57-57|mutation decreasing interaction strength:61-61,64-65|mutation decreasing interaction strength:56-59|mutation disrupting interaction strength:53-55,61-61,64-65|mutation decreasing interaction strength:61-61,64-65|mutation disrupting interaction strength:53-55,61-61,64-65|mutation disrupting interaction strength:56-59,61-61,64-65|sufficient binding region:1-70(IPR008011)|mutation disrupting interaction strength:53-59 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14059735|imex:IM-26139-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 go:"GO:0005739"(mitochondrion) - - figure legend:1Bi, Supp 2D|comment:weak interaction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:sDLwmKPtY56NcbnTT8ETRDfyN9E false - mutation:14-16|flag tag:c-c|myc tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060168|imex:IM-26139-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:3 B/D|comment:"R46Q mutation/variant (VAR_054377) corresponds to variant dbSNP:rs772551056"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:JQCE6dVYa2mcC8hSxuNT9wju+tI false mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:200-200|mutation decreasing interaction strength:146-146|mutation decreasing interaction strength:183-185|mutation decreasing interaction strength:198-202|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060168|imex:IM-26139-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:3 B/D|comment:"R46Q mutation/variant (VAR_054377) corresponds to variant dbSNP:rs772551056"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:JQCE6dVYa2mcC8hSxuNT9wju+tI false mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:200-200|mutation decreasing interaction strength:146-146|mutation decreasing interaction strength:183-185|mutation decreasing interaction strength:198-202|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q9H1K1 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060168|imex:IM-26139-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) - - - figure legend:3 B/D|comment:"R46Q mutation/variant (VAR_054377) corresponds to variant dbSNP:rs772551056"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:JQCE6dVYa2mcC8hSxuNT9wju+tI false mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:200-200|mutation decreasing interaction strength:146-146|mutation decreasing interaction strength:183-185|mutation decreasing interaction strength:198-202|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060168|imex:IM-26139-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N - - - figure legend:3 B/D|comment:"R46Q mutation/variant (VAR_054377) corresponds to variant dbSNP:rs772551056"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:JQCE6dVYa2mcC8hSxuNT9wju+tI false mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:200-200|mutation decreasing interaction strength:146-146|mutation decreasing interaction strength:183-185|mutation decreasing interaction strength:198-202|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060168|imex:IM-26139-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) - - - figure legend:3 B/D|comment:"R46Q mutation/variant (VAR_054377) corresponds to variant dbSNP:rs772551056"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:JQCE6dVYa2mcC8hSxuNT9wju+tI false mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:200-200|mutation decreasing interaction strength:146-146|mutation decreasing interaction strength:183-185|mutation decreasing interaction strength:198-202|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q9H1K1 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060214|imex:IM-26139-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) - - - figure legend:3Bi|comment:weak interaction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false mutation:146-147,149-151,153-153|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060214|imex:IM-26139-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N - - - figure legend:3Bi|comment:weak interaction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false mutation:146-147,149-151,153-153|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060214|imex:IM-26139-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) - - - figure legend:3Bi|comment:weak interaction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false mutation:146-147,149-151,153-153|flag tag:c-c|myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060243|imex:IM-26139-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:3C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:ILQ30qMVMKLtfllyrKw4S2ln4aM false mutation decreasing interaction strength:146-146|flag tag:c-c|myc tag:c-c|mutation disrupting interaction strength:149-151,153-153,146-147|mutation with no effect:171-173,179-181,177-177|mutation with no effect:171-173 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060243|imex:IM-26139-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:3C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:ILQ30qMVMKLtfllyrKw4S2ln4aM false mutation decreasing interaction strength:146-146|flag tag:c-c|myc tag:c-c|mutation disrupting interaction strength:149-151,153-153,146-147|mutation with no effect:171-173,179-181,177-177|mutation with no effect:171-173 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:A6NFY7 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14059886|imex:IM-26139-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:2A, Supp 1C, Supp 2 A/B/E|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/02 2017/05/09 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:2V7f3B4lpyg70OmMD6L1h3WHNpY false 35s radiolabel:?-? mutation disrupting interaction strength:13-13,17-17|flag tag:c-c|myc tag:c-c|35s radiolabel:?-?|sufficient binding region:1-35|mutation with no effect:53-55|mutation disrupting interaction strength:14-16|mutation with no effect:55-55|mutation with no effect:57-57|mutation with no effect:14-16|mutation decreasing interaction strength:52-52,56-56 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14059900|imex:IM-26139-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:2B, Supp Fig 1D,|comment:"Fig 2B:It is stated:- \"clones 2, 4, and 5 bound to SDHB in vitro\"."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:sDLwmKPtY56NcbnTT8ETRDfyN9E false 35s radiolabel:?-? flag tag:c-c|myc tag:c-c|35s radiolabel:?-?|sufficient binding region:61-115|mutation disrupting interaction strength:57-57|mutation decreasing interaction strength:53-55|mutation with no effect:14-16|mutation decreasing interaction strength:55-55 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14060040|imex:IM-26139-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 go:"GO:0005739"(mitochondrion) - - figure legend:2 D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:sDLwmKPtY56NcbnTT8ETRDfyN9E false sufficient binding region:146-218|35s radiolabel:?-? flag tag:c-c|myc tag:c-c|mutation decreasing interaction strength:61-61,64-65|mutation decreasing interaction strength:56-59|mutation disrupting interaction strength:53-55,61-61,64-65|mutation disrupting interaction strength:53-59|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14060116|imex:IM-26139-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:3A, Supp 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/05/02 2017/05/09 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:sDLwmKPtY56NcbnTT8ETRDfyN9E false 35s radiolabel:?-?|sufficient binding region:146-218|mutation decreasing interaction strength:146-146|mutation disrupting interaction strength:146-147,149-151,153-153|mutation increasing interaction strength:171-173|mutation increasing interaction strength:177-177,179-181|mutation disrupting interaction strength:183-185|mutation disrupting interaction strength:198-202|flag tag:c-c|myc tag:c-c 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) chebi:"CHEBI:18248" uniprotkb:P21912 intact:EBI-1252632 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:iron(display_short)|psi-mi:"CHEBI:18248"(display_long) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060380|imex:IM-26139-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N - - - figure legend:6B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2017/05/02 2017/11/03 - rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 - false radiolabel:?-? flag tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060380|imex:IM-26139-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:6B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2017/05/02 2017/11/03 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 - false flag tag:c-c necessary binding region:36-115|mutation disrupting interaction strength:57-57 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:18248" uniprotkb:P21912 intact:EBI-1252632 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:iron(display_short)|psi-mi:"CHEBI:18248"(display_long) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060484|imex:IM-26139-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N - - - figure legend:Supp 5|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2017/05/02 2017/05/10 - rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 - false radiolabel:?-? flag tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2016) pubmed:26749241|imex:IM-26139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14060484|imex:IM-26139-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 - - - figure legend:Supp 5|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0") - 2017/05/02 2017/05/10 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 - false flag tag:c-c necessary binding region:36-115|mutation disrupting interaction strength:57-57 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation)