#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q12860 uniprotkb:Q9UHC6 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 intact:EBI-310892|uniprotkb:Q14DG2|uniprotkb:Q52LV1|uniprotkb:Q5H9Q7|uniprotkb:Q9UQ12|uniprotkb:D3DWG2|ensembl:ENSP00000354778 psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:cntp2_human(display_long)|uniprotkb:CNTNAP2(gene name)|psi-mi:CNTNAP2(display_short)|uniprotkb:CASPR2(gene name synonym)|uniprotkb:KIAA0868(gene name synonym)|uniprotkb:Cell recognition molecule Caspr2(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Rubio-Marrero et al. (2016) pubmed:26721881|imex:IM-26233 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16589566|imex:IM-26233-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2 refseq:NP_054860.1|ensembl:ENSG00000174469(gene)|ensembl:ENST00000361727(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008038"(neuron recognition)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019899"(enzyme binding)|go:"GO:0021756"(striatum development)|go:"GO:0021761"(limbic system development)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0030673"(axolemma)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0071625"(vocalization behavior)|go:"GO:1903598"(positive regulation of gap junction assembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR029831|interpro:IPR036056|rcsb pdb:5Y4M|go:"GO:0044224"(juxtaparanode region of axon) - - - figure legend:5A, 6A, 8A|comment:"Text above Figure 5 states:- \"When the phases were reversed by immobilizing CASPR2-Fc to the sensor tip and using purified CNTN1–993 (Fig. 5B), similar results were obtained.\" However the image and image legend for Figure 5B shows a SEC (molecular sieving) experiment."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:14.0x10^-6(molar) 2017/10/16 2017/12/20 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rogid:lxU5rHVgSUp+Mf/i+BQYKZZqn+Q9606 rigid:obJ4Nip9AYrOcuv24JeRXvnT0Ao false sufficient binding region:396-704|fc-igg tag:c-c sufficient binding region:28-1261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHC6 uniprotkb:Q12860 intact:EBI-310892|uniprotkb:Q14DG2|uniprotkb:Q52LV1|uniprotkb:Q5H9Q7|uniprotkb:Q9UQ12|uniprotkb:D3DWG2|ensembl:ENSP00000354778 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 psi-mi:cntp2_human(display_long)|uniprotkb:CNTNAP2(gene name)|psi-mi:CNTNAP2(display_short)|uniprotkb:CASPR2(gene name synonym)|uniprotkb:KIAA0868(gene name synonym)|uniprotkb:Cell recognition molecule Caspr2(gene name synonym) psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Rubio-Marrero et al. (2016) pubmed:26721881|imex:IM-26233 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16591258|imex:IM-26233-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054860.1|ensembl:ENSG00000174469(gene)|ensembl:ENST00000361727(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008038"(neuron recognition)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019899"(enzyme binding)|go:"GO:0021756"(striatum development)|go:"GO:0021761"(limbic system development)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0030673"(axolemma)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0071625"(vocalization behavior)|go:"GO:1903598"(positive regulation of gap junction assembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR029831|interpro:IPR036056|rcsb pdb:5Y4M|go:"GO:0044224"(juxtaparanode region of axon) refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2 go:"GO:0009986"(cell surface) - - figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/16 2017/12/20 rogid:lxU5rHVgSUp+Mf/i+BQYKZZqn+Q9606 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rigid:obJ4Nip9AYrOcuv24JeRXvnT0Ao false fc-igg tag:c-c|sufficient binding region:28-962 sufficient binding region:21..21-933 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12860 uniprotkb:Q12860 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Rubio-Marrero et al. (2016) pubmed:26721881|imex:IM-26233 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16590381|imex:IM-26233-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2 refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2 - - - figure legend:5B|comment:CNTN1 is likely a dimer in solution.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/16 2017/12/20 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rigid:pnnZmgDJ/UeejzFCjmdQOkFOH6U false sufficient binding region:21..21-993|fc-igg tag:c-c sufficient binding region:21..21-993|fc-igg tag:c-c 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHC6 uniprotkb:Q12860 intact:EBI-310892|uniprotkb:Q14DG2|uniprotkb:Q52LV1|uniprotkb:Q5H9Q7|uniprotkb:Q9UQ12|uniprotkb:D3DWG2|ensembl:ENSP00000354778 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 psi-mi:cntp2_human(display_long)|uniprotkb:CNTNAP2(gene name)|psi-mi:CNTNAP2(display_short)|uniprotkb:CASPR2(gene name synonym)|uniprotkb:KIAA0868(gene name synonym)|uniprotkb:Cell recognition molecule Caspr2(gene name synonym) psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Rubio-Marrero et al. (2016) pubmed:26721881|imex:IM-26233 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16590466|imex:IM-26233-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054860.1|ensembl:ENSG00000174469(gene)|ensembl:ENST00000361727(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008038"(neuron recognition)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019899"(enzyme binding)|go:"GO:0021756"(striatum development)|go:"GO:0021761"(limbic system development)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0030673"(axolemma)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0071625"(vocalization behavior)|go:"GO:1903598"(positive regulation of gap junction assembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR029831|interpro:IPR036056|rcsb pdb:5Y4M|go:"GO:0044224"(juxtaparanode region of axon) refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2|interpro:IPR013783(Immunoglobulin-like fold) go:"GO:0009986"(cell surface) - - figure legend:5C, 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/16 2017/12/20 rogid:lxU5rHVgSUp+Mf/i+BQYKZZqn+Q9606 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rigid:obJ4Nip9AYrOcuv24JeRXvnT0Ao false ha tag:n-n sufficient binding region:396-704|fc-igg tag:c-c - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q12860 uniprotkb:Q9UHC6 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 intact:EBI-310892|uniprotkb:Q14DG2|uniprotkb:Q52LV1|uniprotkb:Q5H9Q7|uniprotkb:Q9UQ12|uniprotkb:D3DWG2|ensembl:ENSP00000354778 psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:cntp2_human(display_long)|uniprotkb:CNTNAP2(gene name)|psi-mi:CNTNAP2(display_short)|uniprotkb:CASPR2(gene name synonym)|uniprotkb:KIAA0868(gene name synonym)|uniprotkb:Cell recognition molecule Caspr2(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Rubio-Marrero et al. (2016) pubmed:26721881|imex:IM-26233 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16591370|imex:IM-26233-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2|interpro:IPR013783(Immunoglobulin-like fold) refseq:NP_054860.1|ensembl:ENSG00000174469(gene)|ensembl:ENST00000361727(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008038"(neuron recognition)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019899"(enzyme binding)|go:"GO:0021756"(striatum development)|go:"GO:0021761"(limbic system development)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0030673"(axolemma)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0071625"(vocalization behavior)|go:"GO:1903598"(positive regulation of gap junction assembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR029831|interpro:IPR036056|rcsb pdb:5Y4M|go:"GO:0044224"(juxtaparanode region of axon) go:"GO:0009986"(cell surface) - - figure legend:6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/16 2017/12/20 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rogid:lxU5rHVgSUp+Mf/i+BQYKZZqn+Q9606 rigid:obJ4Nip9AYrOcuv24JeRXvnT0Ao false flag tag:n-n sufficient binding region:28-962|fc-igg tag:c-c - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q12860 uniprotkb:Q9UHC6 intact:EBI-5564336|uniprotkb:A8K0H9|uniprotkb:A8K0Y3|uniprotkb:Q12861|uniprotkb:Q14030|uniprotkb:Q7M4P0|uniprotkb:Q8N466|ensembl:ENSP00000325660|ensembl:ENSP00000447006 intact:EBI-310892|uniprotkb:Q14DG2|uniprotkb:Q52LV1|uniprotkb:Q5H9Q7|uniprotkb:Q9UQ12|uniprotkb:D3DWG2|ensembl:ENSP00000354778 psi-mi:cntn1_human(display_long)|uniprotkb:CNTN1(gene name)|psi-mi:CNTN1(display_short)|uniprotkb:Glycoprotein gp135(gene name synonym)|uniprotkb:Neural cell surface protein F3(gene name synonym) psi-mi:cntp2_human(display_long)|uniprotkb:CNTNAP2(gene name)|psi-mi:CNTNAP2(display_short)|uniprotkb:CASPR2(gene name synonym)|uniprotkb:KIAA0868(gene name synonym)|uniprotkb:Cell recognition molecule Caspr2(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Rubio-Marrero et al. (2016) pubmed:26721881|imex:IM-26233 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16591388|imex:IM-26233-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011536228.1|refseq:XP_011536229.1|refseq:NP_001242992.1|refseq:NP_001242993.1|refseq:NP_001834.2|refseq:NP_778203.1|refseq:XP_005268708.1|refseq:XP_006719304.1|refseq:XP_016874314.1|refseq:XP_016874315.1|refseq:XP_016874316.1|dip:DIP-59714N|ensembl:ENSG00000018236(gene)|ensembl:ENST00000347616(transcript)|ensembl:ENST00000551295(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|rcsb pdb:3S97|reactome:R-HSA-2122948|reactome:R-HSA-2979096|reactome:R-HSA-373760|reactome:R-HSA-447043|rcsb pdb:2EE2|interpro:IPR013783(Immunoglobulin-like fold) refseq:NP_054860.1|ensembl:ENSG00000174469(gene)|ensembl:ENST00000361727(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008038"(neuron recognition)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019899"(enzyme binding)|go:"GO:0021756"(striatum development)|go:"GO:0021761"(limbic system development)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0030673"(axolemma)|go:"GO:0031175"(neuron projection development)|go:"GO:0033010"(paranodal junction)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0071625"(vocalization behavior)|go:"GO:1903598"(positive regulation of gap junction assembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR029831|interpro:IPR036056|rcsb pdb:5Y4M|go:"GO:0044224"(juxtaparanode region of axon) go:"GO:0009986"(cell surface) - - figure legend:7C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/16 2017/12/20 rogid:wkqpI3hRQ1Y/Q6JeasMbZYYIWWY9606 rogid:lxU5rHVgSUp+Mf/i+BQYKZZqn+Q9606 rigid:obJ4Nip9AYrOcuv24JeRXvnT0Ao false flag tag:n-n sufficient binding region:28-1261|fc-igg tag:c-c - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)