#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P13806 uniprotkb:P07293 intact:EBI-9683767 intact:EBI-8613624|intact:MINT-8146707 psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:cac1s_rabit(display_long)|uniprotkb:CACNA1S(gene name)|psi-mi:CACNA1S(display_short)|uniprotkb:CACH1(gene name synonym)|uniprotkb:CACNL1A3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.1(gene name synonym)|uniprotkb:Dihydropyridine receptor alpha-1S subunit(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16188679|imex:IM-25194-1|dip:DIP-200684E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005450(Voltage-dependent calcium channel, L-type, alpha-1S subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR031649|go:"GO:0030315"(T-tubule)|interpro:IPR031688|rcsb pdb:1DU1|rcsb pdb:1JZP|rcsb pdb:1T3L|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6BYO|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:7JPK|rcsb pdb:7JPL|go:"GO:0046872"(metal ion binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX|refseq:NP_001095190.1|dip:DIP-61879N psi-mi:"MI:0465"(dip) - comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rogid:NgP9i0nXQqgnDJVy4Pz55Aq+rzI9986 rigid:DYCgGWQcscZ+MCEjAze7iL7rBq0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13806 uniprotkb:P19517 intact:EBI-9683767 intact:EBI-978604 psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:cacb1_rabit(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:CACNB1(gene name)|psi-mi:CACNB1(display_short)|uniprotkb:CACNLB1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16188679|imex:IM-25194-1|dip:DIP-200684E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|refseq:NP_001075748.1|dip:DIP-37525N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rogid:Mq4Dw4XO0eiM/Bd5gXr/RNpcyGA9986 rigid:DYCgGWQcscZ+MCEjAze7iL7rBq0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13806 uniprotkb:P19518 intact:EBI-9683767 intact:EBI-9683808|ensembl:ENSOCUP00000007638 psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:ccg1_rabit(display_long)|uniprotkb:CACNG1(gene name)|psi-mi:CACNG1(display_short)|uniprotkb:CACNLG(gene name synonym)|uniprotkb:Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16188679|imex:IM-25194-1|dip:DIP-200684E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX refseq:XP_008269323.1|refseq:NP_001075862.1|dip:DIP-61881N|ensembl:ENSOCUG00000008850(gene)|ensembl:ENSOCUT00000008846(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR005421(Voltage-dependent calcium channel, gamma-1 subunit)|interpro:IPR008368(Voltage-dependent calcium channel, gamma subunit)|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rogid:zdb6V48xKHtxy+A2wJ4220G7Wng9986 rigid:DYCgGWQcscZ+MCEjAze7iL7rBq0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07293 uniprotkb:P19517 intact:EBI-8613624|intact:MINT-8146707 intact:EBI-978604 psi-mi:cac1s_rabit(display_long)|uniprotkb:CACNA1S(gene name)|psi-mi:CACNA1S(display_short)|uniprotkb:CACH1(gene name synonym)|uniprotkb:CACNL1A3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.1(gene name synonym)|uniprotkb:Dihydropyridine receptor alpha-1S subunit(gene name synonym) psi-mi:cacb1_rabit(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:CACNB1(gene name)|psi-mi:CACNB1(display_short)|uniprotkb:CACNLB1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16188720|imex:IM-25194-3|dip:DIP-200687E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005450(Voltage-dependent calcium channel, L-type, alpha-1S subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR031649|go:"GO:0030315"(T-tubule)|interpro:IPR031688|rcsb pdb:1DU1|rcsb pdb:1JZP|rcsb pdb:1T3L|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6BYO|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:7JPK|rcsb pdb:7JPL|go:"GO:0046872"(metal ion binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX|refseq:NP_001095190.1|dip:DIP-61879N go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|refseq:NP_001075748.1|dip:DIP-37525N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:NgP9i0nXQqgnDJVy4Pz55Aq+rzI9986 rogid:Mq4Dw4XO0eiM/Bd5gXr/RNpcyGA9986 rigid:b6R8MgsbzJNVADl/PyJmIFsfr1s false crosslinked residues:693-693 crosslinked residues:151-151 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13806 uniprotkb:P07293 intact:EBI-9683767 intact:EBI-8613624|intact:MINT-8146707 psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:cac1s_rabit(display_long)|uniprotkb:CACNA1S(gene name)|psi-mi:CACNA1S(display_short)|uniprotkb:CACH1(gene name synonym)|uniprotkb:CACNL1A3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.1(gene name synonym)|uniprotkb:Dihydropyridine receptor alpha-1S subunit(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16188742|imex:IM-25194-4|dip:DIP-200684E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005450(Voltage-dependent calcium channel, L-type, alpha-1S subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR031649|go:"GO:0030315"(T-tubule)|interpro:IPR031688|rcsb pdb:1DU1|rcsb pdb:1JZP|rcsb pdb:1T3L|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6BYO|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:7JPK|rcsb pdb:7JPL|go:"GO:0046872"(metal ion binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX|refseq:NP_001095190.1|dip:DIP-61879N psi-mi:"MI:0465"(dip) - comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rogid:NgP9i0nXQqgnDJVy4Pz55Aq+rzI9986 rigid:DYCgGWQcscZ+MCEjAze7iL7rBq0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13806 uniprotkb:P19517 intact:EBI-9683767 intact:EBI-978604 psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:cacb1_rabit(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:CACNB1(gene name)|psi-mi:CACNB1(display_short)|uniprotkb:CACNLB1(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16188742|imex:IM-25194-4|dip:DIP-200684E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|refseq:NP_001075748.1|dip:DIP-37525N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rogid:Mq4Dw4XO0eiM/Bd5gXr/RNpcyGA9986 rigid:DYCgGWQcscZ+MCEjAze7iL7rBq0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13806 uniprotkb:P19518 intact:EBI-9683767 intact:EBI-9683808|ensembl:ENSOCUP00000007638 psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:ccg1_rabit(display_long)|uniprotkb:CACNG1(gene name)|psi-mi:CACNG1(display_short)|uniprotkb:CACNLG(gene name synonym)|uniprotkb:Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16188742|imex:IM-25194-4|dip:DIP-200684E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX refseq:XP_008269323.1|refseq:NP_001075862.1|dip:DIP-61881N|ensembl:ENSOCUG00000008850(gene)|ensembl:ENSOCUT00000008846(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR005421(Voltage-dependent calcium channel, gamma-1 subunit)|interpro:IPR008368(Voltage-dependent calcium channel, gamma subunit)|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rogid:zdb6V48xKHtxy+A2wJ4220G7Wng9986 rigid:DYCgGWQcscZ+MCEjAze7iL7rBq0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07293 uniprotkb:P19518 intact:EBI-8613624|intact:MINT-8146707 intact:EBI-9683808|ensembl:ENSOCUP00000007638 psi-mi:cac1s_rabit(display_long)|uniprotkb:CACNA1S(gene name)|psi-mi:CACNA1S(display_short)|uniprotkb:CACH1(gene name synonym)|uniprotkb:CACNL1A3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.1(gene name synonym)|uniprotkb:Dihydropyridine receptor alpha-1S subunit(gene name synonym) psi-mi:ccg1_rabit(display_long)|uniprotkb:CACNG1(gene name)|psi-mi:CACNG1(display_short)|uniprotkb:CACNLG(gene name synonym)|uniprotkb:Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16188761|imex:IM-25194-5|dip:DIP-200686E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005450(Voltage-dependent calcium channel, L-type, alpha-1S subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR031649|go:"GO:0030315"(T-tubule)|interpro:IPR031688|rcsb pdb:1DU1|rcsb pdb:1JZP|rcsb pdb:1T3L|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6BYO|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:7JPK|rcsb pdb:7JPL|go:"GO:0046872"(metal ion binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX|refseq:NP_001095190.1|dip:DIP-61879N refseq:XP_008269323.1|refseq:NP_001075862.1|dip:DIP-61881N|ensembl:ENSOCUG00000008850(gene)|ensembl:ENSOCUT00000008846(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0042383"(sarcolemma)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR005421(Voltage-dependent calcium channel, gamma-1 subunit)|interpro:IPR008368(Voltage-dependent calcium channel, gamma subunit)|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:NgP9i0nXQqgnDJVy4Pz55Aq+rzI9986 rogid:zdb6V48xKHtxy+A2wJ4220G7Wng9986 rigid:tJYdeNm9xCyJrdRvpNgDDt/ygDM false crosslinked residues:1414-1414,1094-1094 crosslinked residues:1-1 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07293 uniprotkb:P13806 intact:EBI-8613624|intact:MINT-8146707 intact:EBI-9683767 psi-mi:cac1s_rabit(display_long)|uniprotkb:CACNA1S(gene name)|psi-mi:CACNA1S(display_short)|uniprotkb:CACH1(gene name synonym)|uniprotkb:CACNL1A3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.1(gene name synonym)|uniprotkb:Dihydropyridine receptor alpha-1S subunit(gene name synonym) psi-mi:ca2d1_rabit(display_long)|uniprotkb:CACNA2D1(gene name)|psi-mi:CACNA2D1(display_short)|uniprotkb:CACNL2A(gene name synonym)|uniprotkb:CCHL2A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16188699|imex:IM-25194-2|dip:DIP-200685E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005450(Voltage-dependent calcium channel, L-type, alpha-1S subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR031649|go:"GO:0030315"(T-tubule)|interpro:IPR031688|rcsb pdb:1DU1|rcsb pdb:1JZP|rcsb pdb:1T3L|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6BYO|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:7JPK|rcsb pdb:7JPL|go:"GO:0046872"(metal ion binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX|refseq:NP_001095190.1|dip:DIP-61879N refseq:NP_001075745.1|dip:DIP-61880N|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|rcsb pdb:7JPK|rcsb pdb:7JPL|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:NgP9i0nXQqgnDJVy4Pz55Aq+rzI9986 rogid:D9VMzYzxldNOyc68IHuGkBTIPec9986 rigid:Au4Fwka2aNs3zqXCSpXGggYB0Yw false crosslinked residues:976-976 crosslinked residues:234-234 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07293 uniprotkb:P19517 intact:EBI-8613624|intact:MINT-8146707 intact:EBI-978604 psi-mi:cac1s_rabit(display_long)|uniprotkb:CACNA1S(gene name)|psi-mi:CACNA1S(display_short)|uniprotkb:CACH1(gene name synonym)|uniprotkb:CACNL1A3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.1(gene name synonym)|uniprotkb:Dihydropyridine receptor alpha-1S subunit(gene name synonym) psi-mi:cacb1_rabit(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:CACNB1(gene name)|psi-mi:CACNB1(display_short)|uniprotkb:CACNLB1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Wu et al. (2015) pubmed:26680202|doi:10.1126/science.aad2395|imex:IM-25194 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16188783|imex:IM-25194-6|dip:DIP-200687E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005450(Voltage-dependent calcium channel, L-type, alpha-1S subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR031649|go:"GO:0030315"(T-tubule)|interpro:IPR031688|rcsb pdb:1DU1|rcsb pdb:1JZP|rcsb pdb:1T3L|rcsb pdb:3JBR|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6BYO|rcsb pdb:6JP5|rcsb pdb:6JP8|rcsb pdb:6JPA|rcsb pdb:6JPB|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:7JPK|rcsb pdb:7JPL|go:"GO:0046872"(metal ion binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|rcsb pdb:7JPV|rcsb pdb:7JPW|rcsb pdb:7JPX|refseq:NP_001095190.1|dip:DIP-61879N go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0030315"(T-tubule)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|rcsb pdb:5GJV|rcsb pdb:5GJW|rcsb pdb:6JP5|rcsb pdb:6JP8|refseq:NP_001075748.1|dip:DIP-37525N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:NgP9i0nXQqgnDJVy4Pz55Aq+rzI9986 rogid:Mq4Dw4XO0eiM/Bd5gXr/RNpcyGA9986 rigid:b6R8MgsbzJNVADl/PyJmIFsfr1s false crosslinked residues:352-352 crosslinked residues:395-395 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)