#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99ZV9	uniprotkb:Q99ZW1	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0096"(pull down)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188014|imex:IM-25267-1|dip:DIP-199493E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:MYZL5VMMGYGYapQabDDXy37njsM	false	-	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ZW1	uniprotkb:Q99ZW1	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188050|imex:IM-25267-3|dip:DIP-200861E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:xjBLR2CWR6q+sbDEDpYXOSA+lPc	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ZV9	uniprotkb:Q99ZW1	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0071"(molecular sieving)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188066|imex:IM-25267-4|dip:DIP-199493E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:MYZL5VMMGYGYapQabDDXy37njsM	false	-	mutation disrupting interaction strength:14-14|mutation disrupting interaction strength:25-25	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ZV9	uniprotkb:Q99ZW1	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188089|imex:IM-25267-5|dip:DIP-199493E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:MYZL5VMMGYGYapQabDDXy37njsM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ZV9	uniprotkb:Q99ZV9	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:"MI:0071"(molecular sieving)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188106|imex:IM-25267-6|dip:DIP-200862E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rigid:EP8rJQiSffAnrNDjFKpqyjaUg5U	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ZW1	uniprotkb:Q99ZW1	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0071"(molecular sieving)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188033|imex:IM-25267-2|dip:DIP-200861E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:xjBLR2CWR6q+sbDEDpYXOSA+lPc	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ZV9	uniprotkb:Q99ZW1	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0071"(molecular sieving)	Ka et al. (2016)	pubmed:26671707|doi:10.1016/j.str.2015.10.019|imex:IM-25267	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16188122|imex:IM-25267-7|dip:DIP-199493E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:MYZL5VMMGYGYapQabDDXy37njsM	false	mutation decreasing interaction strength:23-23	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)