#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C0S1	uniprotkb:P0C0S1	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:"MI:0071"(molecular sieving)	Pliotas et al. (2015)	pubmed:26551077|doi:10.1038/nsmb.3120|imex:IM-25150	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16183975|imex:IM-25150-1|dip:DIP-80218E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rigid:Knto8BoljtW2ZSY3A/eDXyFuTEQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S1	uniprotkb:P0C0S1	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Pliotas et al. (2015)	pubmed:26551077|doi:10.1038/nsmb.3120|imex:IM-25150	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16183991|imex:IM-25150-2|dip:DIP-80218E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rigid:Knto8BoljtW2ZSY3A/eDXyFuTEQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S1	uniprotkb:P0C0S1	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Pliotas et al. (2015)	pubmed:26551077|doi:10.1038/nsmb.3120|imex:IM-25150	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16184008|imex:IM-25150-3|dip:DIP-80218E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rigid:Knto8BoljtW2ZSY3A/eDXyFuTEQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S1	uniprotkb:P0C0S1	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	intact:EBI-554616|uniprotkb:P11666|uniprotkb:Q2M9R8|ensemblbacteria:AAC75961|ensemblbacteria:BAE76988	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:mscs_ecoli(display_long)|uniprotkb:yggB(gene name synonym)|uniprotkb:mscS(gene name)|psi-mi:mscS(display_short)|uniprotkb:b2924(locus name)|uniprotkb:JW2891(locus name)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Pliotas et al. (2015)	pubmed:26551077|doi:10.1038/nsmb.3120|imex:IM-25150	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16184024|imex:IM-25150-4|dip:DIP-80218E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	refseq:NP_417399.1|refseq:WP_000389818.1|dip:DIP-36192N|ensemblbacteria:AAC75961(transcript)|ensemblbacteria:b2924(gene)|ensemblbacteria:BAE76988(gene)|ensemblbacteria:BAE76988(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008381"(mechanosensitive ion channel activity)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR008910(Conserved TM helix)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:2OAU|rcsb pdb:2VV5|rcsb pdb:3UDC|rcsb pdb:4AGE|rcsb pdb:4AGF|rcsb pdb:4HWA|rcsb pdb:5AJI|rcsb pdb:6PWN|rcsb pdb:6PWO|rcsb pdb:6PWP|rcsb pdb:6RLD|rcsb pdb:6UZH	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rogid:almpxY5F3EuqrQBMciA6kLz9/LQ83333	rigid:Knto8BoljtW2ZSY3A/eDXyFuTEQ	false	his tag:n-n	his tag:n-n	-	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)