#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-4399559 uniprotkb:Q8IYW5 dip:DIP-24261N intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16182463|imex:IM-24936-1|dip:DIP-65427E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) no-uniprot-update: - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:zgESqo4Ki+X7r5LHOdqmYvW6QVk false ubiquitinylated lysine:63-63 sufficient binding region:110-201|strep tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-4399559 uniprotkb:Q92522 dip:DIP-24261N intact:EBI-876335|ensembl:ENSP00000329662 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:h1x_human(display_long)|uniprotkb:H1-10(gene name)|psi-mi:H1-10(display_short)|uniprotkb:H1FX(gene name synonym)|uniprotkb:Histone H1x(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16182486|imex:IM-24936-2|dip:DIP-199961E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 ensembl:ENSG00000184897(gene)|ensembl:ENST00000333762(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045296"(cadherin binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q92522|refseq:NP_006017.1|dip:DIP-36358N|rcsb pdb:2LSO|rcsb pdb:6L9Z|rcsb pdb:7K60|rcsb pdb:7K63 psi-mi:"MI:0465"(dip) no-uniprot-update: - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:T+NweCoHXj0rYsS6gJ4V42R9MpA9606 rigid:zjON6wbJDnPf5sc9oAAFsNjiwyg false strep tag:0-0 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L7L0 uniprotkb:Q8IYW5 intact:EBI-5325551|ensembl:ENSP00000355656|ensembl:ENSP00000493926|uniprotkb:B2R4S4 intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:h2a3_human(display_long)|uniprotkb:H2AW(gene name)|psi-mi:H2AW(display_short)|uniprotkb:HIST3H2A(gene name synonym) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16182505|imex:IM-24936-3|dip:DIP-199958E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000181218(gene)|ensembl:ENSG00000284841(gene)|ensembl:ENST00000366695(transcript)|refseq:NP_254280.1|ensembl:ENST00000645741(transcript)|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-5689603|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:Q7L7L0|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|go:"GO:0000786"(nucleosome)|dip:DIP-48936N go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:t0RdR1SmUtmwRjtCS3uTyLGqSUI9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:Z3qk/dSrLY5chc38TzeMd9NKbOo false - sufficient binding region:419-487|strep tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-4399559 uniprotkb:Q8IYW5 dip:DIP-24261N intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16182526|imex:IM-24936-4|dip:DIP-65427E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) no-uniprot-update: - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:zgESqo4Ki+X7r5LHOdqmYvW6QVk false ubiquitinylated lysine:63-63|ubiquitinylated lysine:27-27|ubiquitinylated lysine:29-29|ubiquitinylated lysine:33-33 sufficient binding region:419-487|strep tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92522 uniprotkb:Q8IYW5 intact:EBI-876335|ensembl:ENSP00000329662 intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:h1x_human(display_long)|uniprotkb:H1-10(gene name)|psi-mi:H1-10(display_short)|uniprotkb:H1FX(gene name synonym)|uniprotkb:Histone H1x(gene name synonym) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16182555|imex:IM-24936-5|dip:DIP-199960E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184897(gene)|ensembl:ENST00000333762(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045296"(cadherin binding)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:Q92522|refseq:NP_006017.1|dip:DIP-36358N|rcsb pdb:2LSO|rcsb pdb:6L9Z|rcsb pdb:7K60|rcsb pdb:7K63 go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:T+NweCoHXj0rYsS6gJ4V42R9MpA9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:qNMaNvP0GGUKHdQ0GGBdT058u10 false - sufficient binding region:110-201|strep tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P07305 uniprotkb:Q8IYW5 intact:EBI-725224|uniprotkb:Q6FG88|uniprotkb:Q8N6R3|uniprotkb:B4DRD6|uniprotkb:B2R6I0|ensembl:ENSP00000344504 intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:h10_human(display_long)|uniprotkb:H1-0(gene name)|psi-mi:H1-0(display_short)|uniprotkb:H1F0(gene name synonym)|uniprotkb:H1FV(gene name synonym)|uniprotkb:Histone H1'(gene name synonym)|uniprotkb:"Histone H1(0)"(gene name synonym) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16182576|imex:IM-24936-6|dip:DIP-199957E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005309.1|ensembl:ENSG00000189060(gene)|ensembl:ENST00000340857(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016604"(nuclear body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P07305|rcsb pdb:6HQ1|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6N88|rcsb pdb:6N89|rcsb pdb:7DBP|rcsb pdb:7K5X|reactome:R-HSA-140342|reactome:R-HSA-2559584|dip:DIP-41775N go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:7ir9Jz/gNZypmWkTopCusDQFEhs9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:8yxMLlfBFB2ZD11rQM44nC2Hg5s false - sufficient binding region:110-128|strep tag:n-n - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P16403 uniprotkb:Q8IYW5 intact:EBI-358372|ensembl:ENSP00000339566|uniprotkb:A8K4I2 intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:h12_human(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:H1F2(gene name synonym)|uniprotkb:HIST1H1C(gene name synonym)|uniprotkb:Histone H1c(gene name synonym)|uniprotkb:Histone H1d(gene name synonym)|uniprotkb:Histone H1s-1(gene name synonym) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16182618|imex:IM-24936-8|dip:DIP-199962E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005310.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P16403|reactome:R-HSA-140342|reactome:R-HSA-2559584|ensembl:ENSG00000187837(gene)|ensembl:ENST00000343677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-36359N go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:eRT5bTyBJUg6nRANMRYZekT4N+g9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:EZDTaZZN7ycn9YxwgvBvLTJuhXg false - sufficient binding region:110-201|strep tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P07305 uniprotkb:Q8IYW5 intact:EBI-725224|uniprotkb:Q6FG88|uniprotkb:Q8N6R3|uniprotkb:B4DRD6|uniprotkb:B2R6I0|ensembl:ENSP00000344504 intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898 psi-mi:h10_human(display_long)|uniprotkb:H1-0(gene name)|psi-mi:H1-0(display_short)|uniprotkb:H1F0(gene name synonym)|uniprotkb:H1FV(gene name synonym)|uniprotkb:Histone H1'(gene name synonym)|uniprotkb:"Histone H1(0)"(gene name synonym) psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym) psi-mi:"MI:0096"(pull down) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16182597|imex:IM-24936-7|dip:DIP-199957E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005309.1|ensembl:ENSG00000189060(gene)|ensembl:ENST00000340857(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016604"(nuclear body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P07305|rcsb pdb:6HQ1|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6N88|rcsb pdb:6N89|rcsb pdb:7DBP|rcsb pdb:7K5X|reactome:R-HSA-140342|reactome:R-HSA-2559584|dip:DIP-41775N go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:7ir9Jz/gNZypmWkTopCusDQFEhs9606 rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606 rigid:8yxMLlfBFB2ZD11rQM44nC2Hg5s false - sufficient binding region:110-201|strep tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O76064-1 uniprotkb:Q92889 intact:EBI-15964690|ensembl:ENSP00000362578 intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520 psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym) psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16182639|imex:IM-24936-9|dip:DIP-199959E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent) refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606 rogid:A42t082dZNQH72TF3QRa+Msuoms9606 rigid:vYLlCFqQPxutTeKG1gTo0v2C0e8 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O76064-1 uniprotkb:P07992 intact:EBI-15964690|ensembl:ENSP00000362578 intact:EBI-750962|ensembl:ENSP00000300853|ensembl:ENSP00000468035|uniprotkb:B2RC01|uniprotkb:B3KRR0|uniprotkb:Q7Z7F5|uniprotkb:Q96S40 psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym) psi-mi:ercc1_human(display_long)|uniprotkb:ERCC1(gene name)|psi-mi:ERCC1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16182639|imex:IM-24936-9|dip:DIP-199959E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent) refseq:NP_001974.1|ensembl:ENSG00000012061(gene)|ensembl:ENST00000300853(transcript)|ensembl:ENST00000589165(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|refseq:XP_011524912.1|refseq:NP_001159521.1|refseq:NP_973730.1|refseq:XP_005258691.1|refseq:XP_005258692.1|refseq:XP_005258693.1|refseq:XP_016881948.1|refseq:XP_016881949.1|refseq:XP_016881950.1|refseq:XP_016881951.1|refseq:XP_016881952.1|refseq:XP_016881953.1|refseq:XP_016881954.1|refseq:XP_016881955.1|dip:DIP-24235N|reactome:R-HSA-6783310|reactome:R-HSA-6782135|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006949"(syncytium formation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009650"(UV protection)|go:"GO:0009744"(response to sucrose)|go:"GO:0010165"(response to X-ray)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045190"(isotype switching)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048477"(oogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:1904431"(positive regulation of t-circle formation)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004579(DNA repair protein rad10)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|rcsb pdb:1Z00|rcsb pdb:2A1I|rcsb pdb:2A1J|rcsb pdb:2JNW|rcsb pdb:2JPD|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606 rogid:wgacfBH+F2NRhpzRsTChE4zSPho9606 rigid:vYLlCFqQPxutTeKG1gTo0v2C0e8 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O76064-1 uniprotkb:Q9Y230 intact:EBI-15964690|ensembl:ENSP00000362578 intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527 psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym) psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16182639|imex:IM-24936-9|dip:DIP-199959E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent) go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606 rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606 rigid:vYLlCFqQPxutTeKG1gTo0v2C0e8 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O76064-1 uniprotkb:P12270 intact:EBI-15964690|ensembl:ENSP00000362578 intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448 psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym) psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16182639|imex:IM-24936-9|dip:DIP-199959E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent) ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606 rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606 rigid:vYLlCFqQPxutTeKG1gTo0v2C0e8 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O76064-1 uniprotkb:Q9UMS4 intact:EBI-15964690|ensembl:ENSP00000362578 intact:EBI-395746|ensembl:ENSP00000227524 psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym) psi-mi:prp19_human(display_long)|uniprotkb:PRPF19(gene name)|psi-mi:PRPF19(display_short)|uniprotkb:PRP19/PSO4 homolog(gene name synonym)|uniprotkb:Nuclear matrix protein 200(gene name synonym)|uniprotkb:Senescence evasion factor(gene name synonym)|uniprotkb:NMP200(gene name synonym)|uniprotkb:PRP19(gene name synonym)|uniprotkb:SNEV(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PRP19(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16182639|imex:IM-24936-9|dip:DIP-199959E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent) ensembl:ENSG00000110107(gene)|ensembl:ENST00000227524(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005819"(spindle)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_055317.1|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001680(WD40 repeat)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013915(Pre-mRNA-splicing factor 19)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR038959|mint:Q9UMS4|rcsb pdb:4LG8|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:7A5P|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-72163|dip:DIP-32978N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606 rogid:5TseaFcCOVVWjJeMF/H7k29nd3c9606 rigid:vYLlCFqQPxutTeKG1gTo0v2C0e8 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O76064-1 uniprotkb:O95714 intact:EBI-15964690|ensembl:ENSP00000362578 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Thorslund et al. (2015) pubmed:26503038|doi:10.1038/nature15401|imex:IM-24936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16182639|imex:IM-24936-9|dip:DIP-199959E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent) ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 rigid:vYLlCFqQPxutTeKG1gTo0v2C0e8 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry)