#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24863	uniprotkb:P49336	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Dale et al. (2015)	pubmed:26502155|doi:10.1038/nchembio.1952|imex:IM-25182	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16182414|imex:IM-25182-1|dip:DIP-66328E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	rigid:j2upJguPtHaQkz9e1LS4qokdaAw	false	-	sufficient binding region:1-403	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24863	uniprotkb:P49336	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Dale et al. (2015)	pubmed:26502155|doi:10.1038/nchembio.1952|imex:IM-25182	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16182433|imex:IM-25182-2|dip:DIP-66328E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	rigid:j2upJguPtHaQkz9e1LS4qokdaAw	false	-	sufficient binding region:1-403	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)