#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P58004	uniprotkb:Q96S15	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16179865|imex:IM-25460-1|dip:DIP-201194E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:iWah43a5/PXKGTYnmvWu1zDrRNE	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q9NXC5	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16179884|imex:IM-25460-2|dip:DIP-201192E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:P58004	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16179884|imex:IM-25460-2|dip:DIP-201192E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q9NXC5	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180118|imex:IM-25460-10|dip:DIP-201192E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:P58004	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180118|imex:IM-25460-10|dip:DIP-201192E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58005	uniprotkb:Q96S15	intact:EBI-16179942|ensembl:ENSP00000441927|uniprotkb:B7Z7P9|uniprotkb:Q96AD1	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn3_human(display_long)|uniprotkb:SESN3(gene name)|psi-mi:SESN3(display_short)|uniprotkb:SEST3(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180037|imex:IM-25460-6|dip:DIP-201196E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000149212(gene)|ensembl:ENST00000536441(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|refseq:NP_001258523.1|refseq:NP_653266.2|dip:DIP-62045N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:9MxzlQ+s+B26xLkf1UiqekFclcE9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:FkeBsPxZ9PsYJnA814WchX9Wj0s	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9W1K5	uniprotkb:Q96S15	intact:EBI-212765|uniprotkb:A8DYN7|uniprotkb:Q9I7V1|ensemblmetazoa:FBpp0071996|ensemblmetazoa:FBpp0112026|ensemblmetazoa:FBpp0112027	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn_drome(display_long)|uniprotkb:CG11299(orf name)|uniprotkb:Sesn(gene name)|psi-mi:Sesn(display_short)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180056|imex:IM-25460-7|dip:DIP-201197E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001097437.1|refseq:NP_001097438.1|refseq:NP_611821.1|flybase:FBgn0034897|dip:DIP-19601N|ensemblmetazoa:FBgn0034897(gene)|ensemblmetazoa:FBtr0072087(transcript)|ensemblmetazoa:FBtr0113113(transcript)|ensemblmetazoa:FBtr0113114(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-DME-5628897	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:Eh7qgPa95i5eCgSoTeZ/MB4m8YI7227	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:iM4PNGxI+NptkfSxhEsIJrPXHaQ	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P58004	uniprotkb:Q96S15	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180077|imex:IM-25460-8|dip:DIP-201194E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:iWah43a5/PXKGTYnmvWu1zDrRNE	false	mutation disrupting interaction strength:190-190|flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NXC5	uniprotkb:Q96S15	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180099|imex:IM-25460-9|dip:DIP-201193E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:M4ptwb03xF6rOvCJshO5aLgdNxA	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:Q96S15	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16179925|imex:IM-25460-4|dip:DIP-201193E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:M4ptwb03xF6rOvCJshO5aLgdNxA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q96S15	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16179904|imex:IM-25460-3|dip:DIP-201194E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:iWah43a5/PXKGTYnmvWu1zDrRNE	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96S15	uniprotkb:Q9Y6P5	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-16179977|ensembl:ENSP00000349061|uniprotkb:Q2M2B7|uniprotkb:Q5T316|uniprotkb:Q9NV00|uniprotkb:Q9UPD5|uniprotkb:Q9Y6P6	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:sesn1_human(display_long)|uniprotkb:SESN1(gene name)|psi-mi:SESN1(display_short)|uniprotkb:PA26(gene name synonym)|uniprotkb:SEST1(gene name synonym)|uniprotkb:p53-regulated protein PA26(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180016|imex:IM-25460-5|dip:DIP-201195E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000080546(gene)|ensembl:ENST00000356644(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|reactome:R-HSA-9639288|refseq:NP_001186862.1|refseq:NP_001186863.1|refseq:NP_055269.1|dip:DIP-62046N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:g6P/Kjg8YHAxSKbdpe7K5kx16B89606	rigid:dC0TFHkH1oNwo0ns57zW7EcYEto	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:P58005	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-16179942|ensembl:ENSP00000441927|uniprotkb:B7Z7P9|uniprotkb:Q96AD1	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:sesn3_human(display_long)|uniprotkb:SESN3(gene name)|psi-mi:SESN3(display_short)|uniprotkb:SEST3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180016|imex:IM-25460-5|dip:DIP-201195E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000149212(gene)|ensembl:ENST00000536441(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|refseq:NP_001258523.1|refseq:NP_653266.2|dip:DIP-62045N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:9MxzlQ+s+B26xLkf1UiqekFclcE9606	rigid:dC0TFHkH1oNwo0ns57zW7EcYEto	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:P58004	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180016|imex:IM-25460-5|dip:DIP-201195E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rigid:dC0TFHkH1oNwo0ns57zW7EcYEto	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q96S15	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolfson et al. (2016)	pubmed:26449471|doi:10.1126/science.aab2674|imex:IM-25460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16180136|imex:IM-25460-11|dip:DIP-201194E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:iWah43a5/PXKGTYnmvWu1zDrRNE	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)