#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8TAF3-1 uniprotkb:O94782 intact:EBI-16178048|ensembl:ENSP00000307491 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 psi-mi:q8taf3-1(display_long)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym) psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yin et al. (2015) pubmed:26388029|doi:10.1016/j.str.2015.08.010|imex:IM-25123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16178058|imex:IM-25123-1|dip:DIP-177844E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|intact:EBI-1045469(isoform-parent) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rigid:qc9BLulPb+PVH2Xwbk2KNfbUIkQ false mutation disrupting interaction strength:272-272,256-256,214-214|ha tag:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P62068-1 uniprotkb:Q8TAF3-1 intact:EBI-16178086|ensembl:ENSP00000407818 intact:EBI-16178048|ensembl:ENSP00000307491 psi-mi:p62068-1(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym) psi-mi:q8taf3-1(display_long)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Yin et al. (2015) pubmed:26388029|doi:10.1016/j.str.2015.08.010|imex:IM-25123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16178094|imex:IM-25123-2|dip:DIP-177743E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2512753(isoform-parent)|ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript) ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|intact:EBI-1045469(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rigid:JUoMcprFE4vMMm87VROXG27qHNc false - mutation decreasing interaction strength:170-170|mutation disrupting interaction strength:272-272,256-256,214-214 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TAF3-1 uniprotkb:O94782 intact:EBI-16178048|ensembl:ENSP00000307491 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 psi-mi:q8taf3-1(display_long)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym) psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yin et al. (2015) pubmed:26388029|doi:10.1016/j.str.2015.08.010|imex:IM-25123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16178119|imex:IM-25123-3|dip:DIP-177844E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|intact:EBI-1045469(isoform-parent) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rigid:qc9BLulPb+PVH2Xwbk2KNfbUIkQ false - mutation disrupting interaction strength:444-444|flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-4399559 uniprotkb:Q02363 dip:DIP-24261N intact:EBI-713450|ensembl:ENSP00000234091|ensembl:ENSP00000379585|ensembl:ENSP00000385465 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:id2_human(display_long)|uniprotkb:Inhibitor of DNA binding 2(gene name synonym)|uniprotkb:ID2(gene name)|psi-mi:ID2(display_short)|uniprotkb:BHLHB26(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 26(gene name synonym)|uniprotkb:Inhibitor of differentiation 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yin et al. (2015) pubmed:26388029|doi:10.1016/j.str.2015.08.010|imex:IM-25123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16178141|imex:IM-25123-4|dip:DIP-200086E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 ensembl:ENSG00000115738(gene)|ensembl:ENST00000234091(transcript)|ensembl:ENST00000331129(transcript)|ensembl:ENST00000396290(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0003166"(bundle of His development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030154"(cell differentiation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061031"(endodermal digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071931"(positive regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR026052|interpro:IPR036638|mint:Q02363|rcsb pdb:4AYA|reactome:R-HSA-9031628|refseq:NP_002157.2|dip:DIP-46874N psi-mi:"MI:0465"(dip) no-uniprot-update: - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:zKX4mIq64fyS8DVPGQNeL7+c50w9606 rigid:tuoBo/p7FB1E5gBJfLrRJhSABiQ false ha tag:0-0 flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)