#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9D8T2	uniprotkb:P70343	intact:EBI-16177955|ensembl:ENSMUSP00000023238|uniprotkb:Q3TBD9	intact:EBI-16177872|ensembl:ENSMUSP00000027012|uniprotkb:C6L648|uniprotkb:O08735|uniprotkb:Q3TAF3|uniprotkb:Q6P8H1	psi-mi:gsdmd_mouse(display_long)|uniprotkb:Gsdmd(gene name)|psi-mi:Gsdmd(display_short)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:Gsdmdc1(gene name synonym)	psi-mi:casp4_mouse(display_long)|uniprotkb:Casp4(gene name)|psi-mi:Casp4(display_short)|uniprotkb:Casp11(gene name synonym)|uniprotkb:Caspl(gene name synonym)|uniprotkb:Ich3(gene name synonym)|uniprotkb:Caspase-11(gene name synonym)|uniprotkb:Protease ICH-3(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Kayagaki et al. (2015)	pubmed:26375259|doi:10.1038/nature15541|imex:IM-24917	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16177991|imex:IM-24917-1|dip:DIP-199911E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:6AO3|rcsb pdb:6KMV|rcsb pdb:6N9N|rcsb pdb:6VIE|reactome:R-MMU-111457|reactome:R-MMU-448706|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|go:"GO:0035915"(pore formation in membrane of another organism)|ensembl:ENSMUSG00000022575(gene)|ensembl:ENSMUST00000023238(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|refseq:NP_081236.1|dip:DIP-61777N	ensembl:ENSMUSG00000033538(gene)|ensembl:ENSMUST00000027012(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007015"(actin filament organization)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:6KMT|rcsb pdb:6KMU|rcsb pdb:6KMV|rcsb pdb:6KN1|rcsb pdb:6NS7|reactome:R-MMU-168638|reactome:R-MMU-5620971|refseq:NP_031635.2|dip:DIP-61776N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:pLM7kb37QmbkWdISHgXm1UtRV9U10090	rogid:uEjXZY+TtiNIdUWg8/FHUioXtT810090	rigid:CShZmui3mu6pFni9xGrE5FRvNEM	false	sufficient binding region:2-487	sufficient binding region:2-373	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)