#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49662	uniprotkb:P57764	intact:EBI-1057327|uniprotkb:A2NHL8|uniprotkb:A2NHM0|uniprotkb:A2NHL9|uniprotkb:B3KPZ9|uniprotkb:B4DJH5|uniprotkb:B4E2D2|uniprotkb:O95601|uniprotkb:Q7KYX7|uniprotkb:Q9UG96|ensembl:ENSP00000388566	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	psi-mi:casp4_human(display_long)|uniprotkb:ICH2(gene name synonym)|uniprotkb:CASP4(gene name)|psi-mi:CASP4(display_short)|uniprotkb:Protease TX(gene name synonym)|uniprotkb:"ICE(rel)-II"(gene name synonym)|uniprotkb:ICE and Ced-3 homolog 2(gene name synonym)|uniprotkb:Mih1(gene name synonym)	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:"MI:0435"(protease assay)	Shi et al. (2015)	pubmed:26375003|doi:10.1038/nature15514|imex:IM-24916	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16177855|imex:IM-24916-1|dip:DIP-199909E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541321.1|refseq:NP_001216.1|refseq:NP_150649.1|ensembl:ENSG00000196954(gene)|ensembl:ENST00000444739(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P49662|rcsb pdb:6KMZ|rcsb pdb:6NRY|reactome:R-HSA-168638|reactome:R-HSA-5620971|refseq:XP_016873886.1|dip:DIP-44806N	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GAgsHH5G984opk7ar2CzWDsDhWA9606	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rigid:qCqso0DpTufxpDZR6nWagcIjRcg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70343	uniprotkb:P57764	intact:EBI-16177872|ensembl:ENSMUSP00000027012|uniprotkb:C6L648|uniprotkb:O08735|uniprotkb:Q3TAF3|uniprotkb:Q6P8H1	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	psi-mi:casp4_mouse(display_long)|uniprotkb:Casp4(gene name)|psi-mi:Casp4(display_short)|uniprotkb:Casp11(gene name synonym)|uniprotkb:Caspl(gene name synonym)|uniprotkb:Ich3(gene name synonym)|uniprotkb:Caspase-11(gene name synonym)|uniprotkb:Protease ICH-3(gene name synonym)	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:"MI:0435"(protease assay)	Shi et al. (2015)	pubmed:26375003|doi:10.1038/nature15514|imex:IM-24916	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16177929|imex:IM-24916-2|dip:DIP-199910E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000033538(gene)|ensembl:ENSMUST00000027012(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007015"(actin filament organization)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:6KMT|rcsb pdb:6KMU|rcsb pdb:6KMV|rcsb pdb:6KN1|rcsb pdb:6NS7|reactome:R-MMU-168638|reactome:R-MMU-5620971|refseq:NP_031635.2|dip:DIP-61776N	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:uEjXZY+TtiNIdUWg8/FHUioXtT810090	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rigid:LKef5Kv3VkJtsNWNVnYGjvVEzko	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)