#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99AU3 uniprotkb:Q99AU3 intact:EBI-6150155 intact:EBI-6150155 psi-mi:ns1_i18a0(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ns1_i18a0(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Jureka et al. (2015) pubmed:26365801|doi:10.1016/j.str.2015.08.007|imex:IM-25120 taxid:88776(i18a0)|taxid:88776("Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)") taxid:88776(i18a0)|taxid:88776("Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16177465|imex:IM-25120-1|dip:DIP-200078E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61813N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2N74|rcsb pdb:5UL6|rcsb pdb:6ATV|rcsb pdb:6DGK|rcsb pdb:6NU0|rcsb pdb:6OX7|rcsb pdb:6U28 dip:DIP-61813N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2N74|rcsb pdb:5UL6|rcsb pdb:6ATV|rcsb pdb:6DGK|rcsb pdb:6NU0|rcsb pdb:6OX7|rcsb pdb:6U28 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:A0wZuIW8uezDFqFkBcQ7yDrVj6Q88776 rogid:A0wZuIW8uezDFqFkBcQ7yDrVj6Q88776 rigid:Gx5K4qwdmkOOxS4dH9fXB/YNupc false sufficient binding region:1-73 sufficient binding region:1-73 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95786-1 uniprotkb:Q99AU3 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-6150155 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:ns1_i18a0(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Jureka et al. (2015) pubmed:26365801|doi:10.1016/j.str.2015.08.007|imex:IM-25120 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:88776(i18a0)|taxid:88776("Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16177483|imex:IM-25120-2|dip:DIP-200079E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) dip:DIP-61813N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2N74|rcsb pdb:5UL6|rcsb pdb:6ATV|rcsb pdb:6DGK|rcsb pdb:6NU0|rcsb pdb:6OX7|rcsb pdb:6U28 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:A0wZuIW8uezDFqFkBcQ7yDrVj6Q88776 rigid:kg0NmpgNPnMWWEp1kvLUWG5S99I false sufficient binding region:90-188 sufficient binding region:1-73|mutation disrupting interaction strength:17-17 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95786-1 uniprotkb:Q99AU3 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-6150155 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:ns1_i18a0(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Jureka et al. (2015) pubmed:26365801|doi:10.1016/j.str.2015.08.007|imex:IM-25120 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:88776(i18a0)|taxid:88776("Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16177507|imex:IM-25120-3|dip:DIP-200079E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) dip:DIP-61813N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2N74|rcsb pdb:5UL6|rcsb pdb:6ATV|rcsb pdb:6DGK|rcsb pdb:6NU0|rcsb pdb:6OX7|rcsb pdb:6U28 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:A0wZuIW8uezDFqFkBcQ7yDrVj6Q88776 rigid:kg0NmpgNPnMWWEp1kvLUWG5S99I false sufficient binding region:90-188 sufficient binding region:1-73 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)