#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-4399559	uniprotkb:P60484-1	dip:DIP-24261N	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170586|imex:IM-24757-2|dip:DIP-189520E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:bYAhzAtKdVQn5j7EcvtPkaEBZfA	false	ha tag:0-0	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5T2D3	uniprotkb:Q5T2D3	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170565|imex:IM-24757-1|dip:DIP-199649E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rigid:ZzT5dzbhipKVFwUBvR2KG2eHmrk	false	glutathione s tranferase tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T2D3	uniprotkb:P60484-1	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170645|imex:IM-24757-5|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60484-1	uniprotkb:Q5T2D3	intact:EBI-15722967|ensembl:ENSP00000361021	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170662|imex:IM-24757-6|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	myc tag:n-n	flag tag:n-n|mutation disrupting interaction strength:96-96|mutation disrupting interaction strength:144-144|mutation decreasing interaction strength:180-180	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60484-1	uniprotkb:Q5T2D3	intact:EBI-15722967|ensembl:ENSP00000361021	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170624|imex:IM-24757-4|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	flag tag:n-n|sufficient binding region:188-403	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5T2D3	uniprotkb:P60484-1	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170607|imex:IM-24757-3|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:B1AZ99	uniprotkb:O08586	intact:EBI-16170692|ensembl:ENSMUSP00000095441	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	psi-mi:otud3_mouse(display_long)|uniprotkb:Otud3(gene name)|psi-mi:Otud3(display_short)	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170712|imex:IM-24757-7|dip:DIP-199648E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000041161(gene)|ensembl:ENSMUST00000097830(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|reactome:R-MMU-5689896|reactome:R-MMU-8948751|refseq:NP_082729.1|dip:DIP-61703N	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/08	2017/08/10	rogid:ttolgcIMu+R/93RprjLK0vjHpNI10090	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	rigid:TSPz+PyBpvcQ3+YfopfzJ0xjZYA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92995	uniprotkb:P60484-1	intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170729|imex:IM-24757-8|dip:DIP-199650E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:Gwb/hCRaBHXUOhBW3J2xxqSAEJ4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60484-1	uniprotkb:Q5T2D3	intact:EBI-15722967|ensembl:ENSP00000361021	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170746|imex:IM-24757-9|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	glutathione s tranferase tag:n-n	myc tag:n-n|sufficient binding region:1-183	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-4399559	uniprotkb:P60484-1	dip:DIP-24261N	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170769|imex:IM-24757-10|dip:DIP-189520E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:bYAhzAtKdVQn5j7EcvtPkaEBZfA	false	his tag:0-0	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-4399559	uniprotkb:P60484-1	dip:DIP-24261N	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170790|imex:IM-24757-11|dip:DIP-189520E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:bYAhzAtKdVQn5j7EcvtPkaEBZfA	false	his tag:0-0	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:B1AZ99	uniprotkb:O08586	intact:EBI-16170692|ensembl:ENSMUSP00000095441	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	psi-mi:otud3_mouse(display_long)|uniprotkb:Otud3(gene name)|psi-mi:Otud3(display_short)	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170811|imex:IM-24757-12|dip:DIP-199648E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000041161(gene)|ensembl:ENSMUST00000097830(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|reactome:R-MMU-5689896|reactome:R-MMU-8948751|refseq:NP_082729.1|dip:DIP-61703N	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/08	2017/08/10	rogid:ttolgcIMu+R/93RprjLK0vjHpNI10090	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	rigid:TSPz+PyBpvcQ3+YfopfzJ0xjZYA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T2D3	uniprotkb:P60484-1	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170828|imex:IM-24757-13|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P60484-1	uniprotkb:Q5T2D3	intact:EBI-15722967|ensembl:ENSP00000361021	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170847|imex:IM-24757-14|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	flag tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-4399559	uniprotkb:P60484-1	dip:DIP-24261N	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170906|imex:IM-24757-17|dip:DIP-189520E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:bYAhzAtKdVQn5j7EcvtPkaEBZfA	false	ha tag:0-0	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62991	uniprotkb:O08586	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	intact:EBI-1186266|uniprotkb:Q542G1|uniprotkb:Q3UFB0|ensembl:ENSMUSP00000013807	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:pten_mouse(display_long)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Pten(gene name)|psi-mi:Pten(display_short)|uniprotkb:Mmac1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170889|imex:IM-24757-16|dip:DIP-87943E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	refseq:NP_032986.1|ensembl:ENSMUSG00000013663(gene)|ensembl:ENSMUST00000013807(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:O08586|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-199418|reactome:R-MMU-202424|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-8948747|reactome:R-MMU-8948751|dip:DIP-38740N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rogid:aYdg7gklHYpORXuGG/JEOr/l/uo10090	rigid:4pqsij+2wLXHu36xgAI+Y5k8kAo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T2D3	uniprotkb:P60484-1	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	intact:EBI-15722967|ensembl:ENSP00000361021	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170868|imex:IM-24757-15|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	myc tag:n-n|sufficient binding region:1-183	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P60484-1	uniprotkb:Q5T2D3	intact:EBI-15722967|ensembl:ENSP00000361021	intact:EBI-16170539|ensembl:ENSP00000364261|uniprotkb:O75047	psi-mi:p60484-1(display_long)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)|uniprotkb:55kDa(isoform synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)	psi-mi:otud3_human(display_long)|uniprotkb:OTUD3(gene name)|psi-mi:OTUD3(display_short)|uniprotkb:KIAA0459(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yuan et al. (2015)	pubmed:26280536|doi:10.1038/ncb3218|imex:IM-24757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16170925|imex:IM-24757-18|dip:DIP-199647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-696162(isoform-parent)|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)	ensembl:ENSG00000169914(gene)|ensembl:ENST00000375120(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990167"(protein K27-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOU|reactome:R-HSA-5689896|reactome:R-HSA-8948751|refseq:NP_056022.1|dip:DIP-61702N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:9L0E5zODyxUFPNJGXEE9vbAZBMY9606	rigid:FtjWZMsKpRun5REB/DzBat4gtOM	false	sufficient binding region:188-403|flag tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)