#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61221-1	uniprotkb:P53762	intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167415|imex:IM-24584-2|dip:DIP-65646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:8DH0CLqO4ZKhCz0suiZLgp9JW9c	false	sufficient binding region:13-357|his tag:?-?	sufficient binding region:82-464	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61221-1	uniprotkb:P53762	intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167382|imex:IM-24584-1|dip:DIP-65646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:8DH0CLqO4ZKhCz0suiZLgp9JW9c	false	myc tag:?-?|mutation decreasing interaction strength:170-170|mutation decreasing interaction strength:191-191|mutation decreasing interaction strength:191-191,170-170	flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97481	uniprotkb:P53762	intact:EBI-15704570|ensembl:ENSMUSP00000024954|uniprotkb:O08787|uniprotkb:O55046	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:epas1_mouse(display_long)|uniprotkb:Epas1(gene name)|psi-mi:Epas1(display_short)|uniprotkb:Hif2a(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:HIF-related factor(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167617|imex:IM-24584-9|dip:DIP-199263E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024140(gene)|ensembl:ENSMUST00000024954(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0016607"(nuclear speck)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZQD|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-1234174|reactome:R-MMU-1234176|reactome:R-MMU-8951664|refseq:NP_034267.3|dip:DIP-46109N	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:7ig5kjgoBYsU14OAS9Fr5gDaQ3Q10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:/jxk4VKKxwREzmjcOfhy8K0DXOg	false	myc tag:c-c|mutation decreasing interaction strength:169-169|mutation decreasing interaction strength:171-171|mutation decreasing interaction strength:192-192|mutation decreasing interaction strength:194-194|mutation disrupting interaction strength:192-192,171-171	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97481	uniprotkb:P53762	intact:EBI-15704570|ensembl:ENSMUSP00000024954|uniprotkb:O08787|uniprotkb:O55046	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:epas1_mouse(display_long)|uniprotkb:Epas1(gene name)|psi-mi:Epas1(display_short)|uniprotkb:Hif2a(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:HIF-related factor(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167554|imex:IM-24584-6|dip:DIP-199263E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024140(gene)|ensembl:ENSMUST00000024954(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0016607"(nuclear speck)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZQD|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-1234174|reactome:R-MMU-1234176|reactome:R-MMU-8951664|refseq:NP_034267.3|dip:DIP-46109N	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:7ig5kjgoBYsU14OAS9Fr5gDaQ3Q10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:/jxk4VKKxwREzmjcOfhy8K0DXOg	false	sufficient binding region:3-361	sufficient binding region:82-464	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61221-1	uniprotkb:P53762	intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167575|imex:IM-24584-7|dip:DIP-65646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:8DH0CLqO4ZKhCz0suiZLgp9JW9c	false	sufficient binding region:13-357	sufficient binding region:82-464	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97481	uniprotkb:P53762	intact:EBI-15704570|ensembl:ENSMUSP00000024954|uniprotkb:O08787|uniprotkb:O55046	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:epas1_mouse(display_long)|uniprotkb:Epas1(gene name)|psi-mi:Epas1(display_short)|uniprotkb:Hif2a(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:HIF-related factor(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167596|imex:IM-24584-8|dip:DIP-199263E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024140(gene)|ensembl:ENSMUST00000024954(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0016607"(nuclear speck)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZQD|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-1234174|reactome:R-MMU-1234176|reactome:R-MMU-8951664|refseq:NP_034267.3|dip:DIP-46109N	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:7ig5kjgoBYsU14OAS9Fr5gDaQ3Q10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:/jxk4VKKxwREzmjcOfhy8K0DXOg	false	sufficient binding region:3-361	sufficient binding region:82-464	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97481	uniprotkb:P53762	intact:EBI-15704570|ensembl:ENSMUSP00000024954|uniprotkb:O08787|uniprotkb:O55046	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:epas1_mouse(display_long)|uniprotkb:Epas1(gene name)|psi-mi:Epas1(display_short)|uniprotkb:Hif2a(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:HIF-related factor(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167460|imex:IM-24584-4|dip:DIP-199263E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024140(gene)|ensembl:ENSMUST00000024954(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0016607"(nuclear speck)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZQD|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-1234174|reactome:R-MMU-1234176|reactome:R-MMU-8951664|refseq:NP_034267.3|dip:DIP-46109N	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:7ig5kjgoBYsU14OAS9Fr5gDaQ3Q10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:/jxk4VKKxwREzmjcOfhy8K0DXOg	false	sufficient binding region:3-361|his tag:?-?	sufficient binding region:82-464	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61221-1	uniprotkb:P53762	intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167439|imex:IM-24584-3|dip:DIP-65646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:8DH0CLqO4ZKhCz0suiZLgp9JW9c	false	sufficient binding region:13-357	sufficient binding region:82-464	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97481	uniprotkb:P53762	intact:EBI-15704570|ensembl:ENSMUSP00000024954|uniprotkb:O08787|uniprotkb:O55046	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:epas1_mouse(display_long)|uniprotkb:Epas1(gene name)|psi-mi:Epas1(display_short)|uniprotkb:Hif2a(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:HIF-related factor(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167483|imex:IM-24584-5|dip:DIP-199263E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024140(gene)|ensembl:ENSMUST00000024954(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0016607"(nuclear speck)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZQD|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-1234174|reactome:R-MMU-1234176|reactome:R-MMU-8951664|refseq:NP_034267.3|dip:DIP-46109N	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:7ig5kjgoBYsU14OAS9Fr5gDaQ3Q10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:/jxk4VKKxwREzmjcOfhy8K0DXOg	false	myc tag:c-c	flag tag:c-c|mutation disrupting interaction strength:112-112|mutation disrupting interaction strength:132-132|mutation disrupting interaction strength:136-136|mutation disrupting interaction strength:168-168|mutation disrupting interaction strength:132-132,112-112|mutation disrupting interaction strength:448-448,366-366|mutation disrupting interaction strength:167-167|mutation disrupting interaction strength:171-171|mutation disrupting interaction strength:264-264|mutation decreasing interaction strength:305-305|mutation decreasing interaction strength:366-366|mutation disrupting interaction strength:171-171,167-167|mutation decreasing interaction strength:305-305,264-264|mutation decreasing interaction strength:266-266	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q61221-1	uniprotkb:P53762	intact:EBI-8549331|ensembl:ENSMUSP00000021530|intact:MINT-2635005	intact:EBI-78852|uniprotkb:Q921F3|uniprotkb:Q60661|ensembl:ENSMUSP00000099810	psi-mi:q61221-1(display_long)|uniprotkb:Hif1a(gene name)|psi-mi:Hif1a(display_short)|uniprotkb:ARNT-interacting protein(gene name synonym)	psi-mi:arnt_mouse(display_long)|uniprotkb:Arnt(gene name)|psi-mi:Arnt(display_short)|uniprotkb:Dioxin receptor, nuclear translocator(gene name synonym)|uniprotkb:Hypoxia-inducible factor 1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wu et al. (2015)	pubmed:26245371|doi:10.1038/nature14883|imex:IM-24584	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167654|imex:IM-24584-10|dip:DIP-65646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021109(gene)|ensembl:ENSMUST00000021530(transcript)|intact:EBI-298954(isoform-parent)	refseq:NP_001032826.1|ensembl:ENSMUSG00000015522(gene)|ensembl:ENSMUST00000102749(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016604"(nuclear body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4ZP4|rcsb pdb:4ZPH|rcsb pdb:4ZPK|rcsb pdb:4ZPR|rcsb pdb:4ZQD|rcsb pdb:5NJ8|rcsb pdb:5SY5|rcsb pdb:5SY7|rcsb pdb:6E3S|rcsb pdb:6E3T|rcsb pdb:6E3U|reactome:R-MMU-1234158|reactome:R-MMU-211945|reactome:R-MMU-211976|reactome:R-MMU-211981|reactome:R-MMU-8937144|dip:DIP-280N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:1jBCL7bIWP7x+b9k/mCB131AQuA10090	rogid:NYJuNrii1HcGy0q0T0NDNXiPiKE10090	rigid:8DH0CLqO4ZKhCz0suiZLgp9JW9c	false	myc tag:?-?	flag tag:c-c|mutation disrupting interaction strength:112-112|mutation disrupting interaction strength:132-132|mutation disrupting interaction strength:136-136|mutation disrupting interaction strength:168-168|mutation disrupting interaction strength:132-132,112-112|mutation disrupting interaction strength:448-448,366-366|mutation decreasing interaction strength:167-167|mutation decreasing interaction strength:171-171|mutation decreasing interaction strength:264-264|mutation decreasing interaction strength:305-305|mutation decreasing interaction strength:366-366|mutation decreasing interaction strength:171-171,167-167|mutation decreasing interaction strength:305-305,264-264	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)