#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O05443	uniprotkb:O05442	intact:EBI-16167151|uniprotkb:F2GDR3|uniprotkb:I6YDB2|uniprotkb:Q7D4M5	intact:EBI-16167127|uniprotkb:F2GDR4|uniprotkb:I6Y4T3|uniprotkb:Q7D4M4	psi-mi:iftnt_myctu(display_long)|uniprotkb:Tuberculosis necrotizing toxin antitoxin(gene name synonym)|uniprotkb:LH57_21250(locus name)|uniprotkb:Rv3902c(locus name)	psi-mi:cpnt_myctu(display_long)|uniprotkb:cpnT(gene name)|psi-mi:cpnT(display_short)|uniprotkb:Channel protein with necrosis-inducing toxin(gene name synonym)|uniprotkb:Rv3903c(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	Sun et al. (2015)	pubmed:26237511|doi:10.1038/nsmb.3064|imex:IM-24763	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167165|imex:IM-24763-1|dip:DIP-199671E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_218419.1|refseq:WP_003400086.1|rcsb pdb:4QLP|interpro:IPR028953	go:"GO:0001907"(killing by symbiont of host cells)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006811"(ion transport)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015288"(porin activity)|go:"GO:0044164"(host cell cytosol)|go:"GO:0046930"(pore complex)|go:"GO:0061810"(NAD glycohydrolase activity)|go:"GO:0090729"(toxin activity)|refseq:NP_218420.1|refseq:WP_003899759.1|rcsb pdb:4QLP|interpro:IPR025331|reactome:R-HSA-9637698	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:QuK6k+VxdF6ghEcEBMhJ0XNpfrA83332	rogid:Q/WH4P9AIV2b87iFrLBeKm8pPyU83332	rigid:PqDftWwaJJugmoPr1sp5LQ7+ljU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O05443	uniprotkb:O05442	intact:EBI-16167151|uniprotkb:F2GDR3|uniprotkb:I6YDB2|uniprotkb:Q7D4M5	intact:EBI-16167127|uniprotkb:F2GDR4|uniprotkb:I6Y4T3|uniprotkb:Q7D4M4	psi-mi:iftnt_myctu(display_long)|uniprotkb:Tuberculosis necrotizing toxin antitoxin(gene name synonym)|uniprotkb:LH57_21250(locus name)|uniprotkb:Rv3902c(locus name)	psi-mi:cpnt_myctu(display_long)|uniprotkb:cpnT(gene name)|psi-mi:cpnT(display_short)|uniprotkb:Channel protein with necrosis-inducing toxin(gene name synonym)|uniprotkb:Rv3903c(locus name)	psi-mi:"MI:0071"(molecular sieving)	Sun et al. (2015)	pubmed:26237511|doi:10.1038/nsmb.3064|imex:IM-24763	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167201|imex:IM-24763-3|dip:DIP-199671E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_218419.1|refseq:WP_003400086.1|rcsb pdb:4QLP|interpro:IPR028953	go:"GO:0001907"(killing by symbiont of host cells)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006811"(ion transport)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015288"(porin activity)|go:"GO:0044164"(host cell cytosol)|go:"GO:0046930"(pore complex)|go:"GO:0061810"(NAD glycohydrolase activity)|go:"GO:0090729"(toxin activity)|refseq:NP_218420.1|refseq:WP_003899759.1|rcsb pdb:4QLP|interpro:IPR025331|reactome:R-HSA-9637698	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:QuK6k+VxdF6ghEcEBMhJ0XNpfrA83332	rogid:Q/WH4P9AIV2b87iFrLBeKm8pPyU83332	rigid:PqDftWwaJJugmoPr1sp5LQ7+ljU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O05443	uniprotkb:O05442	intact:EBI-16167151|uniprotkb:F2GDR3|uniprotkb:I6YDB2|uniprotkb:Q7D4M5	intact:EBI-16167127|uniprotkb:F2GDR4|uniprotkb:I6Y4T3|uniprotkb:Q7D4M4	psi-mi:iftnt_myctu(display_long)|uniprotkb:Tuberculosis necrotizing toxin antitoxin(gene name synonym)|uniprotkb:LH57_21250(locus name)|uniprotkb:Rv3902c(locus name)	psi-mi:cpnt_myctu(display_long)|uniprotkb:cpnT(gene name)|psi-mi:cpnT(display_short)|uniprotkb:Channel protein with necrosis-inducing toxin(gene name synonym)|uniprotkb:Rv3903c(locus name)	psi-mi:"MI:0415"(enzymatic study)	Sun et al. (2015)	pubmed:26237511|doi:10.1038/nsmb.3064|imex:IM-24763	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167218|imex:IM-24763-4|dip:DIP-199671E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_218419.1|refseq:WP_003400086.1|rcsb pdb:4QLP|interpro:IPR028953	go:"GO:0001907"(killing by symbiont of host cells)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006811"(ion transport)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015288"(porin activity)|go:"GO:0044164"(host cell cytosol)|go:"GO:0046930"(pore complex)|go:"GO:0061810"(NAD glycohydrolase activity)|go:"GO:0090729"(toxin activity)|refseq:NP_218420.1|refseq:WP_003899759.1|rcsb pdb:4QLP|interpro:IPR025331|reactome:R-HSA-9637698	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:QuK6k+VxdF6ghEcEBMhJ0XNpfrA83332	rogid:Q/WH4P9AIV2b87iFrLBeKm8pPyU83332	rigid:PqDftWwaJJugmoPr1sp5LQ7+ljU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O05443	uniprotkb:O05442	intact:EBI-16167151|uniprotkb:F2GDR3|uniprotkb:I6YDB2|uniprotkb:Q7D4M5	intact:EBI-16167127|uniprotkb:F2GDR4|uniprotkb:I6Y4T3|uniprotkb:Q7D4M4	psi-mi:iftnt_myctu(display_long)|uniprotkb:Tuberculosis necrotizing toxin antitoxin(gene name synonym)|uniprotkb:LH57_21250(locus name)|uniprotkb:Rv3902c(locus name)	psi-mi:cpnt_myctu(display_long)|uniprotkb:cpnT(gene name)|psi-mi:cpnT(display_short)|uniprotkb:Channel protein with necrosis-inducing toxin(gene name synonym)|uniprotkb:Rv3903c(locus name)	psi-mi:"MI:0096"(pull down)	Sun et al. (2015)	pubmed:26237511|doi:10.1038/nsmb.3064|imex:IM-24763	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167182|imex:IM-24763-2|dip:DIP-199671E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_218419.1|refseq:WP_003400086.1|rcsb pdb:4QLP|interpro:IPR028953	go:"GO:0001907"(killing by symbiont of host cells)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006811"(ion transport)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015288"(porin activity)|go:"GO:0044164"(host cell cytosol)|go:"GO:0046930"(pore complex)|go:"GO:0061810"(NAD glycohydrolase activity)|go:"GO:0090729"(toxin activity)|refseq:NP_218420.1|refseq:WP_003899759.1|rcsb pdb:4QLP|interpro:IPR025331|reactome:R-HSA-9637698	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:QuK6k+VxdF6ghEcEBMhJ0XNpfrA83332	rogid:Q/WH4P9AIV2b87iFrLBeKm8pPyU83332	rigid:PqDftWwaJJugmoPr1sp5LQ7+ljU	false	maltose binding protein tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O05443	uniprotkb:O05442	intact:EBI-16167151|uniprotkb:F2GDR3|uniprotkb:I6YDB2|uniprotkb:Q7D4M5	intact:EBI-16167127|uniprotkb:F2GDR4|uniprotkb:I6Y4T3|uniprotkb:Q7D4M4	psi-mi:iftnt_myctu(display_long)|uniprotkb:Tuberculosis necrotizing toxin antitoxin(gene name synonym)|uniprotkb:LH57_21250(locus name)|uniprotkb:Rv3902c(locus name)	psi-mi:cpnt_myctu(display_long)|uniprotkb:cpnT(gene name)|psi-mi:cpnT(display_short)|uniprotkb:Channel protein with necrosis-inducing toxin(gene name synonym)|uniprotkb:Rv3903c(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Sun et al. (2015)	pubmed:26237511|doi:10.1038/nsmb.3064|imex:IM-24763	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167236|imex:IM-24763-5|dip:DIP-199671E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_218419.1|refseq:WP_003400086.1|rcsb pdb:4QLP|interpro:IPR028953	go:"GO:0001907"(killing by symbiont of host cells)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006811"(ion transport)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015288"(porin activity)|go:"GO:0044164"(host cell cytosol)|go:"GO:0046930"(pore complex)|go:"GO:0061810"(NAD glycohydrolase activity)|go:"GO:0090729"(toxin activity)|refseq:NP_218420.1|refseq:WP_003899759.1|rcsb pdb:4QLP|interpro:IPR025331|reactome:R-HSA-9637698	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:QuK6k+VxdF6ghEcEBMhJ0XNpfrA83332	rogid:Q/WH4P9AIV2b87iFrLBeKm8pPyU83332	rigid:PqDftWwaJJugmoPr1sp5LQ7+ljU	false	-	sufficient binding region:648-846	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)