#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8BGT1 uniprotkb:Q80TS3 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-770665|uniprotkb:Q3UHI7|uniprotkb:Q3UM79|uniprotkb:Q504Z9|uniprotkb:Q5HZJ6|uniprotkb:Q80T56 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:agrl3_mouse(display_long)|uniprotkb:Adgrl3(gene name)|psi-mi:Adgrl3(display_short)|uniprotkb:Kiaa0768(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lec3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym)|uniprotkb:Lphn3(gene name synonym) psi-mi:"MI:0944"(mass spectrometry study of hydrogen/deuterium exchange) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166959|imex:IM-24949-1|dip:DIP-199972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N refseq:NP_941991.1|refseq:XP_011247767.1|refseq:XP_011247768.1|refseq:XP_011247773.1|refseq:NP_001334298.1|refseq:XP_017176402.1|dip:DIP-32218N|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:4RMK|rcsb pdb:4RML|rcsb pdb:4YEB|rcsb pdb:5AFB|rcsb pdb:5FTT|rcsb pdb:5FTU|rcsb pdb:6JBU psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CzKvwTjsU4Ho2zkQ+aG9PGBgMRE10090 rigid:TN87aW12RN/MjMLOnZfVArPgZU4 false sufficient binding region:29-386 sufficient binding region:199-495 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGT1 uniprotkb:Q80TS3 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-770665|uniprotkb:Q3UHI7|uniprotkb:Q3UM79|uniprotkb:Q504Z9|uniprotkb:Q5HZJ6|uniprotkb:Q80T56 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:agrl3_mouse(display_long)|uniprotkb:Adgrl3(gene name)|psi-mi:Adgrl3(display_short)|uniprotkb:Kiaa0768(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lec3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym)|uniprotkb:Lphn3(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166980|imex:IM-24949-2|dip:DIP-199972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N refseq:NP_941991.1|refseq:XP_011247767.1|refseq:XP_011247768.1|refseq:XP_011247773.1|refseq:NP_001334298.1|refseq:XP_017176402.1|dip:DIP-32218N|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:4RMK|rcsb pdb:4RML|rcsb pdb:4YEB|rcsb pdb:5AFB|rcsb pdb:5FTT|rcsb pdb:5FTU|rcsb pdb:6JBU psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CzKvwTjsU4Ho2zkQ+aG9PGBgMRE10090 rigid:TN87aW12RN/MjMLOnZfVArPgZU4 false sufficient binding region:29-386 sufficient binding region:199-495|mutation decreasing interaction strength:332-332|mutation disrupting interaction strength:323-323 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGT1 uniprotkb:Q80TS3 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-770665|uniprotkb:Q3UHI7|uniprotkb:Q3UM79|uniprotkb:Q504Z9|uniprotkb:Q5HZJ6|uniprotkb:Q80T56 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:agrl3_mouse(display_long)|uniprotkb:Adgrl3(gene name)|psi-mi:Adgrl3(display_short)|uniprotkb:Kiaa0768(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lec3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym)|uniprotkb:Lphn3(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16167008|imex:IM-24949-3|dip:DIP-199972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N refseq:NP_941991.1|refseq:XP_011247767.1|refseq:XP_011247768.1|refseq:XP_011247773.1|refseq:NP_001334298.1|refseq:XP_017176402.1|dip:DIP-32218N|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:4RMK|rcsb pdb:4RML|rcsb pdb:4YEB|rcsb pdb:5AFB|rcsb pdb:5FTT|rcsb pdb:5FTU|rcsb pdb:6JBU psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CzKvwTjsU4Ho2zkQ+aG9PGBgMRE10090 rigid:TN87aW12RN/MjMLOnZfVArPgZU4 false sufficient binding region:29-386 sufficient binding region:199-495 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGT1 uniprotkb:Q80TS3 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-770665|uniprotkb:Q3UHI7|uniprotkb:Q3UM79|uniprotkb:Q504Z9|uniprotkb:Q5HZJ6|uniprotkb:Q80T56 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:agrl3_mouse(display_long)|uniprotkb:Adgrl3(gene name)|psi-mi:Adgrl3(display_short)|uniprotkb:Kiaa0768(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lec3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym)|uniprotkb:Lphn3(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16167029|imex:IM-24949-4|dip:DIP-199972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N refseq:NP_941991.1|refseq:XP_011247767.1|refseq:XP_011247768.1|refseq:XP_011247773.1|refseq:NP_001334298.1|refseq:XP_017176402.1|dip:DIP-32218N|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:4RMK|rcsb pdb:4RML|rcsb pdb:4YEB|rcsb pdb:5AFB|rcsb pdb:5FTT|rcsb pdb:5FTU|rcsb pdb:6JBU psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CzKvwTjsU4Ho2zkQ+aG9PGBgMRE10090 rigid:TN87aW12RN/MjMLOnZfVArPgZU4 false sufficient binding region:29-386 sufficient binding region:199-495 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGT1 uniprotkb:Q80TS3 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-770665|uniprotkb:Q3UHI7|uniprotkb:Q3UM79|uniprotkb:Q504Z9|uniprotkb:Q5HZJ6|uniprotkb:Q80T56 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:agrl3_mouse(display_long)|uniprotkb:Adgrl3(gene name)|psi-mi:Adgrl3(display_short)|uniprotkb:Kiaa0768(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lec3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym)|uniprotkb:Lphn3(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16167050|imex:IM-24949-5|dip:DIP-199972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N refseq:NP_941991.1|refseq:XP_011247767.1|refseq:XP_011247768.1|refseq:XP_011247773.1|refseq:NP_001334298.1|refseq:XP_017176402.1|dip:DIP-32218N|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:4RMK|rcsb pdb:4RML|rcsb pdb:4YEB|rcsb pdb:5AFB|rcsb pdb:5FTT|rcsb pdb:5FTU|rcsb pdb:6JBU psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CzKvwTjsU4Ho2zkQ+aG9PGBgMRE10090 rigid:TN87aW12RN/MjMLOnZfVArPgZU4 false sufficient binding region:29-386 sufficient binding region:199-495 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGT1 uniprotkb:Q80TS3 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-770665|uniprotkb:Q3UHI7|uniprotkb:Q3UM79|uniprotkb:Q504Z9|uniprotkb:Q5HZJ6|uniprotkb:Q80T56 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:agrl3_mouse(display_long)|uniprotkb:Adgrl3(gene name)|psi-mi:Adgrl3(display_short)|uniprotkb:Kiaa0768(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lec3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym)|uniprotkb:Lphn3(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16167071|imex:IM-24949-6|dip:DIP-199972E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N refseq:NP_941991.1|refseq:XP_011247767.1|refseq:XP_011247768.1|refseq:XP_011247773.1|refseq:NP_001334298.1|refseq:XP_017176402.1|dip:DIP-32218N|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:4RMK|rcsb pdb:4RML|rcsb pdb:4YEB|rcsb pdb:5AFB|rcsb pdb:5FTT|rcsb pdb:5FTU|rcsb pdb:6JBU psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CzKvwTjsU4Ho2zkQ+aG9PGBgMRE10090 rigid:TN87aW12RN/MjMLOnZfVArPgZU4 false sufficient binding region:29-386|mutation decreasing interaction strength:117-117|mutation decreasing interaction strength:160-160|mutation disrupting interaction strength:160-160 sufficient binding region:199-495 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGT1 uniprotkb:Q8BGT1 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 intact:EBI-16166902|ensembl:ENSMUSP00000053399|ensembl:ENSMUSP00000105684|uniprotkb:Q6ZPQ1 psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:flrt3_mouse(display_long)|uniprotkb:Flrt3(gene name)|psi-mi:Flrt3(display_short)|uniprotkb:Kiaa1469(gene name synonym)|uniprotkb:Fibronectin leucine rich transmembrane protein 3(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Ranaivoson et al. (2015) pubmed:26235031|doi:10.1016/j.str.2015.06.022|imex:IM-24949 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16167101|imex:IM-24949-7|dip:DIP-199973E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N ensembl:ENSMUSG00000051379(gene)|ensembl:ENSMUST00000056760(transcript)|ensembl:ENSMUST00000110057(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR032675|rcsb pdb:4V2E|rcsb pdb:4YEB|reactome:R-MMU-5654687|refseq:NP_001165631.1|refseq:NP_848469.1|dip:DIP-61803N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rogid:CltF9mLDTwheq4rEWdg4FbWgPIQ10090 rigid:7VR2Zr0PT3PBualMHBMq74TDbrc false sufficient binding region:29-386 sufficient binding region:29-386 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)