#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9HAR2 uniprotkb:Q9NZU0 intact:EBI-2689295|uniprotkb:O94867|uniprotkb:Q9NWK5|intact:EBI-28975732|uniprotkb:E9PE04 intact:EBI-1057092|uniprotkb:Q96K39|uniprotkb:Q96K42|uniprotkb:Q96KB1|uniprotkb:Q9P259|uniprotkb:Q542Z9|uniprotkb:D3DW20|ensembl:ENSP00000339912|ensembl:ENSP00000367292 psi-mi:agrl3_human(display_long)|uniprotkb:ADGRL3(gene name)|psi-mi:ADGRL3(display_short)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 3(gene name synonym)|uniprotkb:KIAA0768(gene name synonym)|uniprotkb:LEC3(gene name synonym)|uniprotkb:LPHN3(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym) psi-mi:flrt3_human(display_long)|uniprotkb:FLRT3(gene name)|psi-mi:FLRT3(display_short)|uniprotkb:KIAA1469(gene name synonym)|uniprotkb:UNQ856/PRO1865(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 3(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Lu et al. (2015) pubmed:26235030|doi:10.1016/j.str.2015.06.024|imex:IM-24948 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166785|imex:IM-24948-1|dip:DIP-199970E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000512091|ensembl:ENSP00000423388|ensembl:ENSG00000150471|ensembl:ENST00000514591|ensembl:ENSP00000422533|refseq:NP_056051.2|refseq:NP_001309175.1|refseq:NP_001309331.1|dip:DIP-56228N|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:5CMN|rcsb pdb:6VHH|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway) refseq:XP_011527506.1|refseq:XP_011527507.1|refseq:NP_037413.1|refseq:NP_938205.1|refseq:XP_005260739.1|ensembl:ENSG00000125848(gene)|ensembl:ENST00000341420(transcript)|ensembl:ENST00000378053(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|rcsb pdb:5CMN|rcsb pdb:5CMP|rcsb pdb:6JBU|reactome:R-HSA-376176|reactome:R-HSA-5654687|dip:DIP-50407N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:Nn+3IhWv11bzTP93F2VViiOLe3I9606 rogid:9lRMRN7fMySPLxHExhs6xSXE8E49606 rigid:tYLAd9BfWwIg3HIaSec5Rrgg8AE false sufficient binding region:132-392 sufficient binding region:29-357 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZU0 uniprotkb:Q9NZU0 intact:EBI-1057092|uniprotkb:Q96K39|uniprotkb:Q96K42|uniprotkb:Q96KB1|uniprotkb:Q9P259|uniprotkb:Q542Z9|uniprotkb:D3DW20|ensembl:ENSP00000339912|ensembl:ENSP00000367292 intact:EBI-1057092|uniprotkb:Q96K39|uniprotkb:Q96K42|uniprotkb:Q96KB1|uniprotkb:Q9P259|uniprotkb:Q542Z9|uniprotkb:D3DW20|ensembl:ENSP00000339912|ensembl:ENSP00000367292 psi-mi:flrt3_human(display_long)|uniprotkb:FLRT3(gene name)|psi-mi:FLRT3(display_short)|uniprotkb:KIAA1469(gene name synonym)|uniprotkb:UNQ856/PRO1865(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 3(gene name synonym) psi-mi:flrt3_human(display_long)|uniprotkb:FLRT3(gene name)|psi-mi:FLRT3(display_short)|uniprotkb:KIAA1469(gene name synonym)|uniprotkb:UNQ856/PRO1865(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 3(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lu et al. (2015) pubmed:26235030|doi:10.1016/j.str.2015.06.024|imex:IM-24948 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166828|imex:IM-24948-3|dip:DIP-199971E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011527506.1|refseq:XP_011527507.1|refseq:NP_037413.1|refseq:NP_938205.1|refseq:XP_005260739.1|ensembl:ENSG00000125848(gene)|ensembl:ENST00000341420(transcript)|ensembl:ENST00000378053(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|rcsb pdb:5CMN|rcsb pdb:5CMP|rcsb pdb:6JBU|reactome:R-HSA-376176|reactome:R-HSA-5654687|dip:DIP-50407N refseq:XP_011527506.1|refseq:XP_011527507.1|refseq:NP_037413.1|refseq:NP_938205.1|refseq:XP_005260739.1|ensembl:ENSG00000125848(gene)|ensembl:ENST00000341420(transcript)|ensembl:ENST00000378053(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|rcsb pdb:5CMN|rcsb pdb:5CMP|rcsb pdb:6JBU|reactome:R-HSA-376176|reactome:R-HSA-5654687|dip:DIP-50407N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:9lRMRN7fMySPLxHExhs6xSXE8E49606 rogid:9lRMRN7fMySPLxHExhs6xSXE8E49606 rigid:LranKX8yPnvksUQ9bby6IOLx1kc false sufficient binding region:29-357|mutation decreasing interaction strength:183-183,181-181 sufficient binding region:29-357|mutation decreasing interaction strength:183-183,181-181 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAR2 uniprotkb:Q9NZU0 intact:EBI-2689295|uniprotkb:O94867|uniprotkb:Q9NWK5|intact:EBI-28975732|uniprotkb:E9PE04 intact:EBI-1057092|uniprotkb:Q96K39|uniprotkb:Q96K42|uniprotkb:Q96KB1|uniprotkb:Q9P259|uniprotkb:Q542Z9|uniprotkb:D3DW20|ensembl:ENSP00000339912|ensembl:ENSP00000367292 psi-mi:agrl3_human(display_long)|uniprotkb:ADGRL3(gene name)|psi-mi:ADGRL3(display_short)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 3(gene name synonym)|uniprotkb:KIAA0768(gene name synonym)|uniprotkb:LEC3(gene name synonym)|uniprotkb:LPHN3(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym) psi-mi:flrt3_human(display_long)|uniprotkb:FLRT3(gene name)|psi-mi:FLRT3(display_short)|uniprotkb:KIAA1469(gene name synonym)|uniprotkb:UNQ856/PRO1865(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 3(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Lu et al. (2015) pubmed:26235030|doi:10.1016/j.str.2015.06.024|imex:IM-24948 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166850|imex:IM-24948-4|dip:DIP-199970E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000512091|ensembl:ENSP00000423388|ensembl:ENSG00000150471|ensembl:ENST00000514591|ensembl:ENSP00000422533|refseq:NP_056051.2|refseq:NP_001309175.1|refseq:NP_001309331.1|dip:DIP-56228N|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:5CMN|rcsb pdb:6VHH|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway) refseq:XP_011527506.1|refseq:XP_011527507.1|refseq:NP_037413.1|refseq:NP_938205.1|refseq:XP_005260739.1|ensembl:ENSG00000125848(gene)|ensembl:ENST00000341420(transcript)|ensembl:ENST00000378053(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|rcsb pdb:5CMN|rcsb pdb:5CMP|rcsb pdb:6JBU|reactome:R-HSA-376176|reactome:R-HSA-5654687|dip:DIP-50407N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:Nn+3IhWv11bzTP93F2VViiOLe3I9606 rogid:9lRMRN7fMySPLxHExhs6xSXE8E49606 rigid:tYLAd9BfWwIg3HIaSec5Rrgg8AE false sufficient binding region:132-392 sufficient binding region:29-357 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAR2 uniprotkb:Q9NZU0 intact:EBI-2689295|uniprotkb:O94867|uniprotkb:Q9NWK5|intact:EBI-28975732|uniprotkb:E9PE04 intact:EBI-1057092|uniprotkb:Q96K39|uniprotkb:Q96K42|uniprotkb:Q96KB1|uniprotkb:Q9P259|uniprotkb:Q542Z9|uniprotkb:D3DW20|ensembl:ENSP00000339912|ensembl:ENSP00000367292 psi-mi:agrl3_human(display_long)|uniprotkb:ADGRL3(gene name)|psi-mi:ADGRL3(display_short)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 3(gene name synonym)|uniprotkb:KIAA0768(gene name synonym)|uniprotkb:LEC3(gene name synonym)|uniprotkb:LPHN3(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym) psi-mi:flrt3_human(display_long)|uniprotkb:FLRT3(gene name)|psi-mi:FLRT3(display_short)|uniprotkb:KIAA1469(gene name synonym)|uniprotkb:UNQ856/PRO1865(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 3(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Lu et al. (2015) pubmed:26235030|doi:10.1016/j.str.2015.06.024|imex:IM-24948 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166807|imex:IM-24948-2|dip:DIP-199970E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000512091|ensembl:ENSP00000423388|ensembl:ENSG00000150471|ensembl:ENST00000514591|ensembl:ENSP00000422533|refseq:NP_056051.2|refseq:NP_001309175.1|refseq:NP_001309331.1|dip:DIP-56228N|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:5CMN|rcsb pdb:6VHH|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway) refseq:XP_011527506.1|refseq:XP_011527507.1|refseq:NP_037413.1|refseq:NP_938205.1|refseq:XP_005260739.1|ensembl:ENSG00000125848(gene)|ensembl:ENST00000341420(transcript)|ensembl:ENST00000378053(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|rcsb pdb:5CMN|rcsb pdb:5CMP|rcsb pdb:6JBU|reactome:R-HSA-376176|reactome:R-HSA-5654687|dip:DIP-50407N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:Nn+3IhWv11bzTP93F2VViiOLe3I9606 rogid:9lRMRN7fMySPLxHExhs6xSXE8E49606 rigid:tYLAd9BfWwIg3HIaSec5Rrgg8AE false sufficient binding region:132-392 sufficient binding region:29-357 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAR2 uniprotkb:Q9NZU0 intact:EBI-2689295|uniprotkb:O94867|uniprotkb:Q9NWK5|intact:EBI-28975732|uniprotkb:E9PE04 intact:EBI-1057092|uniprotkb:Q96K39|uniprotkb:Q96K42|uniprotkb:Q96KB1|uniprotkb:Q9P259|uniprotkb:Q542Z9|uniprotkb:D3DW20|ensembl:ENSP00000339912|ensembl:ENSP00000367292 psi-mi:agrl3_human(display_long)|uniprotkb:ADGRL3(gene name)|psi-mi:ADGRL3(display_short)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 3(gene name synonym)|uniprotkb:KIAA0768(gene name synonym)|uniprotkb:LEC3(gene name synonym)|uniprotkb:LPHN3(gene name synonym)|uniprotkb:Latrophilin-3(gene name synonym)|uniprotkb:Lectomedin-3(gene name synonym) psi-mi:flrt3_human(display_long)|uniprotkb:FLRT3(gene name)|psi-mi:FLRT3(display_short)|uniprotkb:KIAA1469(gene name synonym)|uniprotkb:UNQ856/PRO1865(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 3(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lu et al. (2015) pubmed:26235030|doi:10.1016/j.str.2015.06.024|imex:IM-24948 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16166871|imex:IM-24948-5|dip:DIP-199970E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000512091|ensembl:ENSP00000423388|ensembl:ENSG00000150471|ensembl:ENST00000514591|ensembl:ENSP00000422533|refseq:NP_056051.2|refseq:NP_001309175.1|refseq:NP_001309331.1|dip:DIP-56228N|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR015630(GPCR, family 2, latrophilin, type 3)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|rcsb pdb:5CMN|rcsb pdb:6VHH|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway) refseq:XP_011527506.1|refseq:XP_011527507.1|refseq:NP_037413.1|refseq:NP_938205.1|refseq:XP_005260739.1|ensembl:ENSG00000125848(gene)|ensembl:ENST00000341420(transcript)|ensembl:ENST00000378053(transcript)|go:"GO:0003345"(proepicardium cell migration involved in pericardium morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060322"(head development)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|rcsb pdb:5CMN|rcsb pdb:5CMP|rcsb pdb:6JBU|reactome:R-HSA-376176|reactome:R-HSA-5654687|dip:DIP-50407N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:Nn+3IhWv11bzTP93F2VViiOLe3I9606 rogid:9lRMRN7fMySPLxHExhs6xSXE8E49606 rigid:tYLAd9BfWwIg3HIaSec5Rrgg8AE false sufficient binding region:132-392 sufficient binding region:29-357 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)