#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A1T557	uniprotkb:A1T557	intact:EBI-16163958|ensemblbacteria:ABM12307	intact:EBI-16163958|ensemblbacteria:ABM12307	psi-mi:insig_mycvp(display_long)|uniprotkb:Mvan_1475(locus name)	psi-mi:insig_mycvp(display_long)|uniprotkb:Mvan_1475(locus name)	psi-mi:"MI:0071"(molecular sieving)	Ren et al. (2015)	pubmed:26160948|doi:10.1126/science.aab1091|imex:IM-24670	taxid:350058(mycvp)|taxid:350058("Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)")	taxid:350058(mycvp)|taxid:350058("Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16163969|imex:IM-24670-1|dip:DIP-199420E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ABM12307(transcript)|ensemblbacteria:Mvan_1475(gene)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|rcsb pdb:4XU4|rcsb pdb:4XU5|rcsb pdb:4XU6|refseq:WP_011778733.1|dip:DIP-61665N	ensemblbacteria:ABM12307(transcript)|ensemblbacteria:Mvan_1475(gene)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|rcsb pdb:4XU4|rcsb pdb:4XU5|rcsb pdb:4XU6|refseq:WP_011778733.1|dip:DIP-61665N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:v382bSesCkDYR1eYI6MMKJcBDnQ350058	rogid:v382bSesCkDYR1eYI6MMKJcBDnQ350058	rigid:wYv/zZJECZXIMb6gvDE1od+EmlE	false	-	-	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:A1T557	uniprotkb:A1T557	intact:EBI-16163958|ensemblbacteria:ABM12307	intact:EBI-16163958|ensemblbacteria:ABM12307	psi-mi:insig_mycvp(display_long)|uniprotkb:Mvan_1475(locus name)	psi-mi:insig_mycvp(display_long)|uniprotkb:Mvan_1475(locus name)	psi-mi:"MI:0030"(cross-linking study)	Ren et al. (2015)	pubmed:26160948|doi:10.1126/science.aab1091|imex:IM-24670	taxid:350058(mycvp)|taxid:350058("Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)")	taxid:350058(mycvp)|taxid:350058("Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16163985|imex:IM-24670-2|dip:DIP-199420E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ABM12307(transcript)|ensemblbacteria:Mvan_1475(gene)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|rcsb pdb:4XU4|rcsb pdb:4XU5|rcsb pdb:4XU6|refseq:WP_011778733.1|dip:DIP-61665N	ensemblbacteria:ABM12307(transcript)|ensemblbacteria:Mvan_1475(gene)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|rcsb pdb:4XU4|rcsb pdb:4XU5|rcsb pdb:4XU6|refseq:WP_011778733.1|dip:DIP-61665N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:v382bSesCkDYR1eYI6MMKJcBDnQ350058	rogid:v382bSesCkDYR1eYI6MMKJcBDnQ350058	rigid:wYv/zZJECZXIMb6gvDE1od+EmlE	false	mutation:77-77	mutation:77-77	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:A1T557	uniprotkb:A1T557	intact:EBI-16163958|ensemblbacteria:ABM12307	intact:EBI-16163958|ensemblbacteria:ABM12307	psi-mi:insig_mycvp(display_long)|uniprotkb:Mvan_1475(locus name)	psi-mi:insig_mycvp(display_long)|uniprotkb:Mvan_1475(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2015)	pubmed:26160948|doi:10.1126/science.aab1091|imex:IM-24670	taxid:350058(mycvp)|taxid:350058("Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)")	taxid:350058(mycvp)|taxid:350058("Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16164007|imex:IM-24670-3|dip:DIP-199420E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ABM12307(transcript)|ensemblbacteria:Mvan_1475(gene)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|rcsb pdb:4XU4|rcsb pdb:4XU5|rcsb pdb:4XU6|refseq:WP_011778733.1|dip:DIP-61665N	ensemblbacteria:ABM12307(transcript)|ensemblbacteria:Mvan_1475(gene)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|rcsb pdb:4XU4|rcsb pdb:4XU5|rcsb pdb:4XU6|refseq:WP_011778733.1|dip:DIP-61665N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:v382bSesCkDYR1eYI6MMKJcBDnQ350058	rogid:v382bSesCkDYR1eYI6MMKJcBDnQ350058	rigid:wYv/zZJECZXIMb6gvDE1od+EmlE	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y5U4	uniprotkb:Q6GQT6	intact:EBI-8503746|intact:MINT-8431157|uniprotkb:Q8TBI8|uniprotkb:A8K5W8|ensembl:ENSP00000245787	intact:EBI-16164023|ensembl:ENSMUSP00000095953|uniprotkb:Q6A0A6|uniprotkb:Q6NS67|uniprotkb:Q7TNG7|uniprotkb:Q80UI6	psi-mi:insi2_human(display_long)|uniprotkb:INSIG2(gene name)|psi-mi:INSIG2(display_short)	psi-mi:scap_mouse(display_long)|uniprotkb:Scap(gene name)|psi-mi:Scap(display_short)|uniprotkb:Kiaa0199(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2015)	pubmed:26160948|doi:10.1126/science.aab1091|imex:IM-24670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16164065|imex:IM-24670-4|dip:DIP-199421E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001308259.1|refseq:NP_001308260.1|refseq:NP_001308261.1|refseq:NP_001308262.1|refseq:NP_001308258.1|refseq:NP_057217.2|dip:DIP-60913N|ensembl:ENSG00000125629(gene)|ensembl:ENST00000245787(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0070542"(response to fatty acid)|interpro:IPR025929|rcsb pdb:4J82|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829	ensembl:ENSMUSG00000032485(gene)|ensembl:ENSMUST00000098350(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045540"(regulation of cholesterol biosynthetic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|reactome:R-MMU-1655829|refseq:NP_001001144.2|refseq:NP_001096632.1|refseq:XP_006512146.1|refseq:XP_006512147.1|refseq:XP_006512148.1|dip:DIP-61666N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/08	2017/08/10	rogid:u6hydxrFnhRfWQ4LuogzQ+P/S1I9606	rogid:sxiY5c4XMoAwORZyXnA4qiN0kIk10090	rigid:xwh+St6N6m7sS+FWPaJkV57qLnw	false	his tag:n-n|mutation disrupting interaction strength:115-115|mutation disrupting interaction strength:145-145|mutation disrupting interaction strength:149-149|mutation disrupting interaction strength:113-113|mutation disrupting interaction strength:120-120|mutation decreasing interaction strength:117-117|mutation decreasing interaction strength:132-132|mutation decreasing interaction strength:39-39|mutation decreasing interaction strength:77-77|mutation decreasing interaction strength:200-200|mutation decreasing interaction strength:203-203|mutation decreasing interaction strength:50-50,47-47,119-119	sufficient binding region:1-741|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)