#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8R1H0 uniprotkb:Q924K8 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-3043925|ensembl:ENSMUSP00000068931|uniprotkb:Q8VC18 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:mta3_mouse(display_long)|uniprotkb:Mta3(gene name)|psi-mi:Mta3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N mint:Q924K8|rcsb pdb:2CRG|reactome:R-MMU-3214815|reactome:R-MMU-73762|reactome:R-MMU-8943724|interpro:IPR043151|ensembl:ENSMUSG00000055817(gene)|ensembl:ENSMUST00000067826(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR035170|interpro:IPR040138|refseq:NP_001164525.1|refseq:NP_473423.1|dip:DIP-61664N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:ZZYvhY+qLqElWJBgG3u/PyEOrco10090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:Q9R190 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-904134|uniprotkb:Q3TVT8|ensembl:ENSMUSP00000093959 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:mta2_mouse(display_long)|uniprotkb:Mta2(gene name)|psi-mi:Mta2(display_short)|uniprotkb:Mta1l1(gene name synonym)|uniprotkb:Metastasis-associated 1-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N refseq:NP_035972.3|dip:DIP-36630N|ensembl:ENSMUSG00000071646(gene)|ensembl:ENSMUST00000096240(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006306"(DNA methylation)|go:"GO:0006323"(DNA packaging)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR035170|interpro:IPR037964|interpro:IPR040138|interpro:IPR043151|mint:Q9R190|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:iHG+WZKTCRwTvC7LdS7OayvcEuA10090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:Q8K4B0 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-1216353|uniprotkb:Q80UI1|uniprotkb:Q8K4D4|uniprotkb:Q924K9|ensembl:ENSMUSP00000009099 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:mta1_mouse(display_long)|uniprotkb:Mta1(gene name)|psi-mi:Mta1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N refseq:XP_006515485.1|dip:DIP-38226N|ensembl:ENSMUSG00000021144(gene)|ensembl:ENSMUST00000009099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|reactome:R-MMU-3214815|reactome:R-MMU-3232118|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033363"(secretory granule organization)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|mint:Q8K4B0|reactome:R-MMU-73762|reactome:R-MMU-8943724 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:5DvgpUkohteacGjUvdFq7C+fU2w10090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:Q60973 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-302297|ensembl:ENSMUSP00000033720|uniprotkb:Q3UX20|uniprotkb:A2AFJ0 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:rbbp7_mouse(display_long)|uniprotkb:Rbbp7(gene name)|psi-mi:Rbbp7(display_short)|uniprotkb:Rbap46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60973|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8951664|reactome:R-MMU-8953750|ensembl:ENSMUSG00000031353(gene)|ensembl:ENSMUST00000033720(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006338"(chromatin remodeling)|refseq:NP_033057.3|dip:DIP-32856N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:+OV9hWS13A8fAypZJAXf656Z25U10090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:Q60972 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:P70288 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-302251|uniprotkb:B2RRP3 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:bGLIDKTlyhBz40NViC8calRacZ010090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:O09106 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-301912|uniprotkb:P97476|ensembl:ENSMUSP00000099657 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:hdac1_mouse(display_long)|uniprotkb:Hdac1(gene name)|psi-mi:Hdac1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N dip:DIP-31499N|ensembl:ENSMUSG00000028800(gene)|ensembl:ENSMUST00000102597(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_032254.1|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O09106|reactome:R-MMU-1538133|reactome:R-MMU-201722|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-3769402|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8936459|reactome:R-MMU-8943724|reactome:R-MMU-9018519|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031000"(response to caffeine)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007492"(endoderm development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0001046"(core promoter sequence-specific DNA binding) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:P7QV++FiMiNcabUkswbnNhGVU3410090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8R1H0 uniprotkb:P97471 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589 psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16162578|imex:IM-24669-1|dip:DIP-199417E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090 rigid:LpzOWu/N6uiIsBg+q8cml9c7H+s false flag tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P97471 uniprotkb:Q8R1H0 intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym) psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16162604|imex:IM-24669-2|dip:DIP-199418E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828 ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rigid:9HxE5/C67/VT3rGcYKb9AyQDh3A false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13485 uniprotkb:Q8R1H0 intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452 intact:EBI-6913924|ensembl:ENSMUSP00000080630|ensembl:ENSMUSP00000109080|ensembl:ENSMUSP00000113295|uniprotkb:Q8C1N5|uniprotkb:Q8CJ22 psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym) psi-mi:hop_mouse(display_long)|uniprotkb:Hopx(gene name)|psi-mi:Hopx(display_short)|uniprotkb:Hod(gene name synonym)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ob1(gene name synonym)|uniprotkb:Homeobox-only protein(gene name synonym)|uniprotkb:Odd homeobox protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jain et al. (2015) pubmed:26113728|doi:10.1126/science.aaa6071|imex:IM-24669 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16162623|imex:IM-24669-3|dip:DIP-199419E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N ensembl:ENSMUSG00000059325(gene)|ensembl:ENSMUST00000081964(transcript)|ensembl:ENSMUST00000113453(transcript)|ensembl:ENSMUST00000120827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR039162|mint:Q8R1H0|rcsb pdb:1UHS|rcsb pdb:2HI3|go:"GO:0008016"(regulation of heart contraction)|refseq:NP_001153372.1|refseq:NP_001153373.1|refseq:NP_783199.1|dip:DIP-61663N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:mPu190hmySGV54KAtldys/IHuo89606 rogid:4HaZ3XSA5PaOEUQNjnRXYp8NCsc10090 rigid:lvIoV15+HgrthMj2D/budYlr+Lw false myc tag:c-c flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)