#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P59158	uniprotkb:Q61098	intact:EBI-8366645|intact:MINT-4133700|ensembl:ENSMUSP00000034218	intact:EBI-13612516|ensembl:ENSMUSP00000085298|ensembl:ENSMUSP00000103679|ensembl:ENSMUSP00000142070	psi-mi:s12a3_mouse(display_long)|uniprotkb:Slc12a3(gene name)|psi-mi:Slc12a3(display_short)|uniprotkb:Tsc(gene name synonym)|uniprotkb:Thiazide-sensitive sodium-chloride cotransporter(gene name synonym)|uniprotkb:Na-Cl symporter(gene name synonym)|uniprotkb:Ncc(gene name synonym)	psi-mi:il18r_mouse(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)|uniprotkb:Il18r1(gene name)|psi-mi:Il18r1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2015)	pubmed:26099046|imex:IM-25625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13612547|imex:IM-25625-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192240.1|ensembl:ENSMUSG00000031766(gene)|ensembl:ENSMUST00000034218(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015378"("sodium:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031982"(vesicle)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002948(Thiazide-sensitive Na-K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P59158|reactome:R-MMU-426117	refseq:NP_032391.1|refseq:XP_006495790.1|refseq:XP_006495791.1|refseq:XP_006495792.1|refseq:XP_006495793.1|refseq:XP_006495795.1|refseq:XP_006495797.1|ensembl:ENSMUSG00000026070(gene)|ensembl:ENSMUST00000087983(transcript)|ensembl:ENSMUST00000108044(transcript)|ensembl:ENSMUST00000195684(transcript)|go:"GO:0006954"(inflammatory response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR035897	-	comment:mint|function:Electrically silent transporter system. Mediates sodium and chloride reabsorption	-	figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2017/01/20	2017/01/20	rogid:7wnHFkJ30DHkzijfKA9yHZrF4eU10090	rogid:VgHRtQwLnvxGGQzkyqTEtdxTdgo10090	rigid:F14Mu/+CXsCA1CVTZju2tPgaENA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P59158	uniprotkb:Q61098	intact:EBI-8366645|intact:MINT-4133700|ensembl:ENSMUSP00000034218	intact:EBI-13612516|ensembl:ENSMUSP00000085298|ensembl:ENSMUSP00000103679|ensembl:ENSMUSP00000142070	psi-mi:s12a3_mouse(display_long)|uniprotkb:Slc12a3(gene name)|psi-mi:Slc12a3(display_short)|uniprotkb:Tsc(gene name synonym)|uniprotkb:Thiazide-sensitive sodium-chloride cotransporter(gene name synonym)|uniprotkb:Na-Cl symporter(gene name synonym)|uniprotkb:Ncc(gene name synonym)	psi-mi:il18r_mouse(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)|uniprotkb:Il18r1(gene name)|psi-mi:Il18r1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2015)	pubmed:26099046|imex:IM-25625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13612571|imex:IM-25625-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192240.1|ensembl:ENSMUSG00000031766(gene)|ensembl:ENSMUST00000034218(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015378"("sodium:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031982"(vesicle)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002948(Thiazide-sensitive Na-K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P59158|reactome:R-MMU-426117	refseq:NP_032391.1|refseq:XP_006495790.1|refseq:XP_006495791.1|refseq:XP_006495792.1|refseq:XP_006495793.1|refseq:XP_006495795.1|refseq:XP_006495797.1|ensembl:ENSMUSG00000026070(gene)|ensembl:ENSMUST00000087983(transcript)|ensembl:ENSMUST00000108044(transcript)|ensembl:ENSMUST00000195684(transcript)|go:"GO:0006954"(inflammatory response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR035897	-	comment:mint|function:Electrically silent transporter system. Mediates sodium and chloride reabsorption	-	figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2017/01/20	2017/01/20	rogid:7wnHFkJ30DHkzijfKA9yHZrF4eU10090	rogid:VgHRtQwLnvxGGQzkyqTEtdxTdgo10090	rigid:F14Mu/+CXsCA1CVTZju2tPgaENA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P59158	uniprotkb:Q61098	intact:EBI-8366645|intact:MINT-4133700|ensembl:ENSMUSP00000034218	intact:EBI-13612516|ensembl:ENSMUSP00000085298|ensembl:ENSMUSP00000103679|ensembl:ENSMUSP00000142070	psi-mi:s12a3_mouse(display_long)|uniprotkb:Slc12a3(gene name)|psi-mi:Slc12a3(display_short)|uniprotkb:Tsc(gene name synonym)|uniprotkb:Thiazide-sensitive sodium-chloride cotransporter(gene name synonym)|uniprotkb:Na-Cl symporter(gene name synonym)|uniprotkb:Ncc(gene name synonym)	psi-mi:il18r_mouse(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)|uniprotkb:Il18r1(gene name)|psi-mi:Il18r1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2015)	pubmed:26099046|imex:IM-25625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13612584|imex:IM-25625-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192240.1|ensembl:ENSMUSG00000031766(gene)|ensembl:ENSMUST00000034218(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015378"("sodium:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031982"(vesicle)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002948(Thiazide-sensitive Na-K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P59158|reactome:R-MMU-426117	refseq:NP_032391.1|refseq:XP_006495790.1|refseq:XP_006495791.1|refseq:XP_006495792.1|refseq:XP_006495793.1|refseq:XP_006495795.1|refseq:XP_006495797.1|ensembl:ENSMUSG00000026070(gene)|ensembl:ENSMUST00000087983(transcript)|ensembl:ENSMUST00000108044(transcript)|ensembl:ENSMUST00000195684(transcript)|go:"GO:0006954"(inflammatory response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR035897	-	comment:mint|function:Electrically silent transporter system. Mediates sodium and chloride reabsorption	-	figure legend:2D|comment:Atheroslerotic lesions tissue has been analyzed|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-arterial_smooth_muscle)|taxid:10090(mouse)	-	2017/01/20	2017/01/20	rogid:7wnHFkJ30DHkzijfKA9yHZrF4eU10090	rogid:VgHRtQwLnvxGGQzkyqTEtdxTdgo10090	rigid:F14Mu/+CXsCA1CVTZju2tPgaENA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P59158	uniprotkb:Q61098	intact:EBI-8366645|intact:MINT-4133700|ensembl:ENSMUSP00000034218	intact:EBI-13612516|ensembl:ENSMUSP00000085298|ensembl:ENSMUSP00000103679|ensembl:ENSMUSP00000142070	psi-mi:s12a3_mouse(display_long)|uniprotkb:Slc12a3(gene name)|psi-mi:Slc12a3(display_short)|uniprotkb:Tsc(gene name synonym)|uniprotkb:Thiazide-sensitive sodium-chloride cotransporter(gene name synonym)|uniprotkb:Na-Cl symporter(gene name synonym)|uniprotkb:Ncc(gene name synonym)	psi-mi:il18r_mouse(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)|uniprotkb:Il18r1(gene name)|psi-mi:Il18r1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2015)	pubmed:26099046|imex:IM-25625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13612598|imex:IM-25625-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192240.1|ensembl:ENSMUSG00000031766(gene)|ensembl:ENSMUST00000034218(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015378"("sodium:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031982"(vesicle)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002948(Thiazide-sensitive Na-K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P59158|reactome:R-MMU-426117	refseq:NP_032391.1|refseq:XP_006495790.1|refseq:XP_006495791.1|refseq:XP_006495792.1|refseq:XP_006495793.1|refseq:XP_006495795.1|refseq:XP_006495797.1|ensembl:ENSMUSG00000026070(gene)|ensembl:ENSMUST00000087983(transcript)|ensembl:ENSMUST00000108044(transcript)|ensembl:ENSMUST00000195684(transcript)|go:"GO:0006954"(inflammatory response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR035897	-	comment:mint|function:Electrically silent transporter system. Mediates sodium and chloride reabsorption	-	figure legend:2g|agonist:IL18|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2017/01/20	2017/01/20	rogid:7wnHFkJ30DHkzijfKA9yHZrF4eU10090	rogid:VgHRtQwLnvxGGQzkyqTEtdxTdgo10090	rigid:F14Mu/+CXsCA1CVTZju2tPgaENA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P59158	uniprotkb:Q61098	intact:EBI-8366645|intact:MINT-4133700|ensembl:ENSMUSP00000034218	intact:EBI-13612516|ensembl:ENSMUSP00000085298|ensembl:ENSMUSP00000103679|ensembl:ENSMUSP00000142070	psi-mi:s12a3_mouse(display_long)|uniprotkb:Slc12a3(gene name)|psi-mi:Slc12a3(display_short)|uniprotkb:Tsc(gene name synonym)|uniprotkb:Thiazide-sensitive sodium-chloride cotransporter(gene name synonym)|uniprotkb:Na-Cl symporter(gene name synonym)|uniprotkb:Ncc(gene name synonym)	psi-mi:il18r_mouse(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)|uniprotkb:Il18r1(gene name)|psi-mi:Il18r1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2015)	pubmed:26099046|imex:IM-25625	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13636958|imex:IM-25625-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192240.1|ensembl:ENSMUSG00000031766(gene)|ensembl:ENSMUST00000034218(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015378"("sodium:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031982"(vesicle)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002948(Thiazide-sensitive Na-K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P59158|reactome:R-MMU-426117	refseq:NP_032391.1|refseq:XP_006495790.1|refseq:XP_006495791.1|refseq:XP_006495792.1|refseq:XP_006495793.1|refseq:XP_006495795.1|refseq:XP_006495797.1|ensembl:ENSMUSG00000026070(gene)|ensembl:ENSMUST00000087983(transcript)|ensembl:ENSMUST00000108044(transcript)|ensembl:ENSMUST00000195684(transcript)|go:"GO:0006954"(inflammatory response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR035897	-	comment:mint|function:Electrically silent transporter system. Mediates sodium and chloride reabsorption	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2017/01/20	2017/01/25	rogid:7wnHFkJ30DHkzijfKA9yHZrF4eU10090	rogid:VgHRtQwLnvxGGQzkyqTEtdxTdgo10090	rigid:F14Mu/+CXsCA1CVTZju2tPgaENA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)