#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P13500 uniprotkb:Q2F862 intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831 intact:EBI-16161937 psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0114"(x-ray crystallography) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16161966|imex:IM-24563-2|dip:DIP-199196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:gZGW+fBpgy0bi5YRkibJXwsdgeQ false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2F862 uniprotkb:Q2F862 intact:EBI-16161937 intact:EBI-16161937 psi-mi:q2f862_orfv(display_long) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0071"(molecular sieving) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:10258(Orf virus)|taxid:10258(Orf virus) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16161947|imex:IM-24563-1|dip:DIP-199195E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:hAzDvqZHmJvgAHbrbVHY+s9tHV4 false sufficient binding region:17-286 sufficient binding region:17-286 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2F862 uniprotkb:Q2F862 intact:EBI-16161937 intact:EBI-16161937 psi-mi:q2f862_orfv(display_long) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0067"(light scattering) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:10258(Orf virus)|taxid:10258(Orf virus) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162030|imex:IM-24563-5|dip:DIP-199195E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:hAzDvqZHmJvgAHbrbVHY+s9tHV4 false sufficient binding region:17-286 sufficient binding region:17-286 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10889 uniprotkb:Q2F862 intact:EBI-16162048|ensembl:ENSMUSP00000074885 intact:EBI-16161937 psi-mi:cxcl2_mouse(display_long)|uniprotkb:Cxcl2(gene name)|psi-mi:Cxcl2(display_short)|uniprotkb:Mip-2(gene name synonym)|uniprotkb:Mip2(gene name synonym)|uniprotkb:Scyb2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0892"(solid phase assay) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162094|imex:IM-24563-6|dip:DIP-199203E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070997"(neuron death)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1MI2|rcsb pdb:3N52|reactome:R-MMU-380108|reactome:R-MMU-418594|reactome:R-MMU-6798695|ensembl:ENSMUSG00000058427(gene)|ensembl:ENSMUST00000075433(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008009"(chemokine activity)|go:"GO:0009408"(response to heat)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0030593"(neutrophil chemotaxis)|refseq:NP_033166.1|dip:DIP-61570N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:/GTJ8gusrFUl0i/DkTFjImYOwAU10090 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:l7EVkYccJJyquEK620eaK7lW1hQ false sufficient binding region:28-100 sufficient binding region:17-286 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P47992 uniprotkb:Q2F862 intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792 intact:EBI-16161937 psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162009|imex:IM-24563-4|dip:DIP-199199E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:Og1ArOw0yFU8VbXL6KtKgff0/p8 false sufficient binding region:22-114 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P80098 uniprotkb:Q2F862 intact:EBI-718759|uniprotkb:Q569J6|ensembl:ENSP00000367832 intact:EBI-16161937 psi-mi:ccl7_human(display_long)|uniprotkb:Small-inducible cytokine A7(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 3(gene name synonym)|uniprotkb:Monocyte chemotactic protein 3(gene name synonym)|uniprotkb:NC28(gene name synonym)|uniprotkb:CCL7(gene name)|psi-mi:CCL7(display_short)|uniprotkb:MCP3(gene name synonym)|uniprotkb:SCYA7(gene name synonym)|uniprotkb:SCYA6(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0114"(x-ray crystallography) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16161988|imex:IM-24563-3|dip:DIP-199198E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006264.2|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010332"(response to gamma radiation)|ensembl:ENSG00000108688(gene)|ensembl:ENST00000378569(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1BO0|rcsb pdb:1NCV|rcsb pdb:4ZKC|reactome:R-HSA-380108|dip:DIP-5847N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:xYXxbcu9VsvZbbq8sKBLe7zH0bg9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:kmYqnGgDnISrWrbqATbUPOqgtTI false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10147 uniprotkb:Q2F862 intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712 intact:EBI-16161937 psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0114"(x-ray crystallography) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162116|imex:IM-24563-7|dip:DIP-199197E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783 go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:T1Lk3F7zmosCGz+aw53M6eCRLU0 false sufficient binding region:24-92 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2F862 uniprotkb:Q2F862 intact:EBI-16161937 intact:EBI-16161937 psi-mi:q2f862_orfv(display_long) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0114"(x-ray crystallography) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:10258(Orf virus)|taxid:10258(Orf virus) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162138|imex:IM-24563-8|dip:DIP-199195E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:hAzDvqZHmJvgAHbrbVHY+s9tHV4 false sufficient binding region:17-286 sufficient binding region:17-286 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13500 uniprotkb:Q2F862 intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831 intact:EBI-16161937 psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162156|imex:IM-24563-9|dip:DIP-199196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:gZGW+fBpgy0bi5YRkibJXwsdgeQ false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z126 uniprotkb:Q2F862 intact:EBI-8350471|intact:MINT-4107892|ensembl:ENSMUSP00000031320 intact:EBI-16161937 psi-mi:plf4_mouse(display_long)|uniprotkb:Pf4(gene name)|psi-mi:Pf4(display_short)|uniprotkb:Cxcl4(gene name synonym)|uniprotkb:Scyb4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162177|imex:IM-24563-10|dip:DIP-199200E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064316.1|dip:DIP-61569N|ensembl:ENSMUSG00000029373(gene)|ensembl:ENSMUST00000031320(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q9Z126|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-202733|reactome:R-MMU-380108|reactome:R-MMU-418594|interpro:IPR027222 go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) comment:mint|function:Platelet factor 4, non-covalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:JD52RS18yY8b3TsxwpYzY0g3YSg10090 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:CHLv1m4TGzGa3muAKcEjmrXBh7Y false sufficient binding region:30-105 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13500 uniprotkb:Q2F862 intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831 intact:EBI-16161937 psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0071"(molecular sieving) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162198|imex:IM-24563-11|dip:DIP-199196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:gZGW+fBpgy0bi5YRkibJXwsdgeQ false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10147 uniprotkb:Q2F862 intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712 intact:EBI-16161937 psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0071"(molecular sieving) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162219|imex:IM-24563-12|dip:DIP-199197E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783 go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:T1Lk3F7zmosCGz+aw53M6eCRLU0 false sufficient binding region:24-92 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13500 uniprotkb:Q2F862 intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831 intact:EBI-16161937 psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162240|imex:IM-24563-13|dip:DIP-199196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:gZGW+fBpgy0bi5YRkibJXwsdgeQ false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P80098 uniprotkb:Q2F862 intact:EBI-718759|uniprotkb:Q569J6|ensembl:ENSP00000367832 intact:EBI-16161937 psi-mi:ccl7_human(display_long)|uniprotkb:Small-inducible cytokine A7(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 3(gene name synonym)|uniprotkb:Monocyte chemotactic protein 3(gene name synonym)|uniprotkb:NC28(gene name synonym)|uniprotkb:CCL7(gene name)|psi-mi:CCL7(display_short)|uniprotkb:MCP3(gene name synonym)|uniprotkb:SCYA7(gene name synonym)|uniprotkb:SCYA6(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0071"(molecular sieving) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162303|imex:IM-24563-16|dip:DIP-199198E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006264.2|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010332"(response to gamma radiation)|ensembl:ENSG00000108688(gene)|ensembl:ENST00000378569(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1BO0|rcsb pdb:1NCV|rcsb pdb:4ZKC|reactome:R-HSA-380108|dip:DIP-5847N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:xYXxbcu9VsvZbbq8sKBLe7zH0bg9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:kmYqnGgDnISrWrbqATbUPOqgtTI false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13500 uniprotkb:Q2F862 intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831 intact:EBI-16161937 psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0067"(light scattering) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162282|imex:IM-24563-15|dip:DIP-199196E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:gZGW+fBpgy0bi5YRkibJXwsdgeQ false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13501 uniprotkb:Q2F862 intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921 intact:EBI-16161937 psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0892"(solid phase assay) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162261|imex:IM-24563-14|dip:DIP-199201E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:/3P2YlGewkvq1PHDr+iNXsrM4vE false sufficient binding region:24-91 sufficient binding region:17-286 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P80098 uniprotkb:Q2F862 intact:EBI-718759|uniprotkb:Q569J6|ensembl:ENSP00000367832 intact:EBI-16161937 psi-mi:ccl7_human(display_long)|uniprotkb:Small-inducible cytokine A7(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 3(gene name synonym)|uniprotkb:Monocyte chemotactic protein 3(gene name synonym)|uniprotkb:NC28(gene name synonym)|uniprotkb:CCL7(gene name)|psi-mi:CCL7(display_short)|uniprotkb:MCP3(gene name synonym)|uniprotkb:SCYA7(gene name synonym)|uniprotkb:SCYA6(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162324|imex:IM-24563-17|dip:DIP-199198E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006264.2|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010332"(response to gamma radiation)|ensembl:ENSG00000108688(gene)|ensembl:ENST00000378569(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1BO0|rcsb pdb:1NCV|rcsb pdb:4ZKC|reactome:R-HSA-380108|dip:DIP-5847N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:xYXxbcu9VsvZbbq8sKBLe7zH0bg9606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:kmYqnGgDnISrWrbqATbUPOqgtTI false sufficient binding region:24-99 sufficient binding region:17-286 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P02776 uniprotkb:Q2F862 intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029 intact:EBI-16161937 psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym) psi-mi:q2f862_orfv(display_long) psi-mi:"MI:0892"(solid phase assay) Couñago et al. (2015) pubmed:26095031|doi:10.1016/j.str.2015.04.023|imex:IM-24563 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10258(Orf virus)|taxid:10258(Orf virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16162345|imex:IM-24563-18|dip:DIP-199202E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N go:"GO:0042802"(identical protein binding)|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|rcsb pdb:4P5I|rcsb pdb:4ZK9|rcsb pdb:4ZKB|rcsb pdb:4ZKC|dip:DIP-61568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606 rogid:+WfG/Mb9CVTsnfoaylqYUP92rV010258 rigid:S984cv8XLybUIV+8nVSEZRcPr1I false sufficient binding region:32-101 sufficient binding region:17-286 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)