#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49023 uniprotkb:P12003 intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307 intact:EBI-1039563|uniprotkb:Q91024|ensembl:ENSGALP00000008131 psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short) psi-mi:vinc_chick(display_long)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)|uniprotkb:VINC1(gene name synonym)|uniprotkb:Metavinculin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Case et al. (2015) pubmed:26053221|doi:10.1038/ncb3180|imex:IM-24646 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16161010|imex:IM-24646-1|dip:DIP-199370E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471 refseq:XP_015143689.1|refseq:NP_990772.1|ensembl:ENSGALG00000005079(gene)|ensembl:ENSGALT00000008145(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|rcsb pdb:1QKR|rcsb pdb:1ST6|rcsb pdb:1T01|rcsb pdb:1U6H|rcsb pdb:1XWJ|rcsb pdb:1ZVZ|rcsb pdb:1ZW2|rcsb pdb:1ZW3|rcsb pdb:2GDC|rcsb pdb:3JBI|rcsb pdb:3ZDL|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:6FQ4|rcsb pdb:6NR7|reactome:R-GGA-114608|reactome:R-GGA-445355|reactome:R-GGA-5674135|reactome:R-GGA-6798695|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098723"(skeletal muscle myofibril)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P12003|dip:DIP-35191N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606 rogid:94z6CivjYryFIKVVE4dRTbssflA9031 rigid:HVMVt7yRuVaU2z8P+77SLoVNg70 false - green fluorescent protein tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)