#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03281	uniprotkb:Q02821	intact:EBI-22131|uniprotkb:D6VT82|ensemblfungi:YDR458C	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:heh2_yeast(display_long)|uniprotkb:YDR458C(locus name)|uniprotkb:D8035.2(orf name)|uniprotkb:HEH2(gene name)|psi-mi:HEH2(display_short)|uniprotkb:Helix-extension-helix domain-containing protein 2(gene name synonym)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159719|imex:IM-24556-1|dip:DIP-191613E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010746.1|sgd:S000002866|dip:DIP-7259N|ensemblfungi:YDR458C(gene)|ensemblfungi:YDR458C_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034399"(nuclear periphery)|interpro:IPR011015(LEM-like fold)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4PVZ	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	crc64:1E11821F2542723E	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:I4nGsbLmzE8RLfZDB9Dosyx+ugM559292	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:QrN5P+fsV0lGO0uww3LaC1ietlg	false	sufficient binding region:100-137	sufficient binding region:88-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03281	uniprotkb:Q02821	intact:EBI-22131|uniprotkb:D6VT82|ensemblfungi:YDR458C	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:heh2_yeast(display_long)|uniprotkb:YDR458C(locus name)|uniprotkb:D8035.2(orf name)|uniprotkb:HEH2(gene name)|psi-mi:HEH2(display_short)|uniprotkb:Helix-extension-helix domain-containing protein 2(gene name synonym)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159794|imex:IM-24556-4|dip:DIP-191613E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010746.1|sgd:S000002866|dip:DIP-7259N|ensemblfungi:YDR458C(gene)|ensemblfungi:YDR458C_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034399"(nuclear periphery)|interpro:IPR011015(LEM-like fold)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4PVZ	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	crc64:1E11821F2542723E	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:I4nGsbLmzE8RLfZDB9Dosyx+ugM559292	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:QrN5P+fsV0lGO0uww3LaC1ietlg	false	sufficient binding region:100-137|glutathione s tranferase tag:n-n	sufficient binding region:88-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02821	uniprotkb:Q03707	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	intact:EBI-18064|uniprotkb:Q03712|uniprotkb:D6VZE1|ensemblfungi:YML034W	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:src1_yeast(display_long)|uniprotkb:YML033W(orf name)|uniprotkb:YML034W(locus name)|uniprotkb:SRC1(gene name)|psi-mi:SRC1(display_short)|uniprotkb:HEH1(gene name synonym)|uniprotkb:Helix-extension-helix domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159762|imex:IM-24556-3|dip:DIP-199177E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	refseq:NP_013679.1|sgd:S000004497|ensemblfungi:YML034W(gene)|ensemblfungi:YML034W_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043007"(maintenance of rDNA)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4XZR|dip:DIP-4546N|mint:Q03707	psi-mi:"MI:0465"(dip)	crc64:8D3A0CB76F2E7C00	crc64:214CA064ECE160F4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rogid:YeIyXOJ+hN9AMRaZKqLZVXjv9p4559292	rigid:bX3o8uq17Ome73HObfrLEiW/bV8	false	sufficient binding region:88-530|glutathione s tranferase tag:n-n	sufficient binding region:171-221|mutation decreasing interaction strength:190-190,176-176|mutation decreasing interaction strength:176-176|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q02821	uniprotkb:Q03707	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	intact:EBI-18064|uniprotkb:Q03712|uniprotkb:D6VZE1|ensemblfungi:YML034W	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:src1_yeast(display_long)|uniprotkb:YML033W(orf name)|uniprotkb:YML034W(locus name)|uniprotkb:SRC1(gene name)|psi-mi:SRC1(display_short)|uniprotkb:HEH1(gene name synonym)|uniprotkb:Helix-extension-helix domain-containing protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159741|imex:IM-24556-2|dip:DIP-199177E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	refseq:NP_013679.1|sgd:S000004497|ensemblfungi:YML034W(gene)|ensemblfungi:YML034W_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043007"(maintenance of rDNA)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4XZR|dip:DIP-4546N|mint:Q03707	psi-mi:"MI:0465"(dip)	crc64:8D3A0CB76F2E7C00	crc64:214CA064ECE160F4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rogid:YeIyXOJ+hN9AMRaZKqLZVXjv9p4559292	rigid:bX3o8uq17Ome73HObfrLEiW/bV8	false	sufficient binding region:88-530	sufficient binding region:171-221	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02821	uniprotkb:Q03707	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	intact:EBI-18064|uniprotkb:Q03712|uniprotkb:D6VZE1|ensemblfungi:YML034W	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:src1_yeast(display_long)|uniprotkb:YML033W(orf name)|uniprotkb:YML034W(locus name)|uniprotkb:SRC1(gene name)|psi-mi:SRC1(display_short)|uniprotkb:HEH1(gene name synonym)|uniprotkb:Helix-extension-helix domain-containing protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159817|imex:IM-24556-5|dip:DIP-199177E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	refseq:NP_013679.1|sgd:S000004497|ensemblfungi:YML034W(gene)|ensemblfungi:YML034W_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043007"(maintenance of rDNA)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4XZR|dip:DIP-4546N|mint:Q03707	psi-mi:"MI:0465"(dip)	crc64:8D3A0CB76F2E7C00	crc64:214CA064ECE160F4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rogid:YeIyXOJ+hN9AMRaZKqLZVXjv9p4559292	rigid:bX3o8uq17Ome73HObfrLEiW/bV8	false	sufficient binding region:88-530	sufficient binding region:171-221	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05221	uniprotkb:Q02821	intact:EBI-7261813|intact:MINT-6623126	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:nupl_xenla(display_long)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159838|imex:IM-24556-6|dip:DIP-199178E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P05221|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035041"(sperm DNA decondensation)|go:"GO:0051312"(chromosome decondensation)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR036824|rcsb pdb:1EE5|rcsb pdb:1EJY|rcsb pdb:1K5J|rcsb pdb:2VTX|rcsb pdb:3UL1|rcsb pdb:4BPL|dip:DIP-48470N	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	function:Nucleoplasmin is an acidic protein which is able to assemble nucleosomes by binding histones and transferring them to DNA|comment:mint	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:KNzoCOMDA3W19S6MLyKxUTSgRmE8355	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:q34mFRbokavLYq/9jDN7UwN51RE	false	sufficient binding region:151-172	sufficient binding region:88-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02821	uniprotkb:Q03707	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	intact:EBI-18064|uniprotkb:Q03712|uniprotkb:D6VZE1|ensemblfungi:YML034W	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:src1_yeast(display_long)|uniprotkb:YML033W(orf name)|uniprotkb:YML034W(locus name)|uniprotkb:SRC1(gene name)|psi-mi:SRC1(display_short)|uniprotkb:HEH1(gene name synonym)|uniprotkb:Helix-extension-helix domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159859|imex:IM-24556-7|dip:DIP-199177E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	refseq:NP_013679.1|sgd:S000004497|ensemblfungi:YML034W(gene)|ensemblfungi:YML034W_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043007"(maintenance of rDNA)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4XZR|dip:DIP-4546N|mint:Q03707	psi-mi:"MI:0465"(dip)	crc64:8D3A0CB76F2E7C00	crc64:214CA064ECE160F4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rogid:YeIyXOJ+hN9AMRaZKqLZVXjv9p4559292	rigid:bX3o8uq17Ome73HObfrLEiW/bV8	false	sufficient binding region:88-530	sufficient binding region:171-221|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02821	uniprotkb:Q03707	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	intact:EBI-18064|uniprotkb:Q03712|uniprotkb:D6VZE1|ensemblfungi:YML034W	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:src1_yeast(display_long)|uniprotkb:YML033W(orf name)|uniprotkb:YML034W(locus name)|uniprotkb:SRC1(gene name)|psi-mi:SRC1(display_short)|uniprotkb:HEH1(gene name synonym)|uniprotkb:Helix-extension-helix domain-containing protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159882|imex:IM-24556-8|dip:DIP-199177E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	refseq:NP_013679.1|sgd:S000004497|ensemblfungi:YML034W(gene)|ensemblfungi:YML034W_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043007"(maintenance of rDNA)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4XZR|dip:DIP-4546N|mint:Q03707	psi-mi:"MI:0465"(dip)	crc64:8D3A0CB76F2E7C00	crc64:214CA064ECE160F4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rogid:YeIyXOJ+hN9AMRaZKqLZVXjv9p4559292	rigid:bX3o8uq17Ome73HObfrLEiW/bV8	false	sufficient binding region:88-530	sufficient binding region:171-221|mutation decreasing interaction strength:190-190,176-176|mutation decreasing interaction strength:176-176|mutation decreasing interaction strength:190-190	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03281	uniprotkb:Q02821	intact:EBI-22131|uniprotkb:D6VT82|ensemblfungi:YDR458C	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:heh2_yeast(display_long)|uniprotkb:YDR458C(locus name)|uniprotkb:D8035.2(orf name)|uniprotkb:HEH2(gene name)|psi-mi:HEH2(display_short)|uniprotkb:Helix-extension-helix domain-containing protein 2(gene name synonym)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159983|imex:IM-24556-12|dip:DIP-191613E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010746.1|sgd:S000002866|dip:DIP-7259N|ensemblfungi:YDR458C(gene)|ensemblfungi:YDR458C_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034399"(nuclear periphery)|interpro:IPR011015(LEM-like fold)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4PVZ	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	crc64:1E11821F2542723E	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:I4nGsbLmzE8RLfZDB9Dosyx+ugM559292	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:QrN5P+fsV0lGO0uww3LaC1ietlg	false	sufficient binding region:97-137|mutation decreasing interaction strength:126-126,103-103|mutation decreasing interaction strength:103-103|mutation decreasing interaction strength:126-126	sufficient binding region:88-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03281	uniprotkb:Q02821	intact:EBI-22131|uniprotkb:D6VT82|ensemblfungi:YDR458C	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:heh2_yeast(display_long)|uniprotkb:YDR458C(locus name)|uniprotkb:D8035.2(orf name)|uniprotkb:HEH2(gene name)|psi-mi:HEH2(display_short)|uniprotkb:Helix-extension-helix domain-containing protein 2(gene name synonym)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159962|imex:IM-24556-11|dip:DIP-191613E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010746.1|sgd:S000002866|dip:DIP-7259N|ensemblfungi:YDR458C(gene)|ensemblfungi:YDR458C_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034399"(nuclear periphery)|interpro:IPR011015(LEM-like fold)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4PVZ	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	crc64:1E11821F2542723E	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:I4nGsbLmzE8RLfZDB9Dosyx+ugM559292	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:QrN5P+fsV0lGO0uww3LaC1ietlg	false	sufficient binding region:100-137	sufficient binding region:88-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03281	uniprotkb:Q02821	intact:EBI-22131|uniprotkb:D6VT82|ensemblfungi:YDR458C	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:heh2_yeast(display_long)|uniprotkb:YDR458C(locus name)|uniprotkb:D8035.2(orf name)|uniprotkb:HEH2(gene name)|psi-mi:HEH2(display_short)|uniprotkb:Helix-extension-helix domain-containing protein 2(gene name synonym)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159938|imex:IM-24556-10|dip:DIP-191613E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010746.1|sgd:S000002866|dip:DIP-7259N|ensemblfungi:YDR458C(gene)|ensemblfungi:YDR458C_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034399"(nuclear periphery)|interpro:IPR011015(LEM-like fold)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4PVZ	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	crc64:1E11821F2542723E	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:I4nGsbLmzE8RLfZDB9Dosyx+ugM559292	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:QrN5P+fsV0lGO0uww3LaC1ietlg	false	sufficient binding region:97-137|glutathione s tranferase tag:n-n	sufficient binding region:88-530	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05221	uniprotkb:Q02821	intact:EBI-7261813|intact:MINT-6623126	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:nupl_xenla(display_long)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16159913|imex:IM-24556-9|dip:DIP-199178E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P05221|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035041"(sperm DNA decondensation)|go:"GO:0051312"(chromosome decondensation)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR036824|rcsb pdb:1EE5|rcsb pdb:1EJY|rcsb pdb:1K5J|rcsb pdb:2VTX|rcsb pdb:3UL1|rcsb pdb:4BPL|dip:DIP-48470N	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	function:Nucleoplasmin is an acidic protein which is able to assemble nucleosomes by binding histones and transferring them to DNA|comment:mint	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:KNzoCOMDA3W19S6MLyKxUTSgRmE8355	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:q34mFRbokavLYq/9jDN7UwN51RE	false	sufficient binding region:151-172|maltose binding protein tag:n-n	sufficient binding region:88-530|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q03281	uniprotkb:Q02821	intact:EBI-22131|uniprotkb:D6VT82|ensemblfungi:YDR458C	intact:EBI-1797|uniprotkb:D6W0Z8|ensemblfungi:YNL189W	psi-mi:heh2_yeast(display_long)|uniprotkb:YDR458C(locus name)|uniprotkb:D8035.2(orf name)|uniprotkb:HEH2(gene name)|psi-mi:HEH2(display_short)|uniprotkb:Helix-extension-helix domain-containing protein 2(gene name synonym)	psi-mi:ima1_yeast(display_long)|uniprotkb:SRP1(gene name)|psi-mi:SRP1(display_short)|uniprotkb:KAP60(gene name synonym)|uniprotkb:YNL189W(locus name)|uniprotkb:N1606(orf name)|uniprotkb:Karyopherin subunit alpha(gene name synonym)|uniprotkb:Karyopherin-60(gene name synonym)|uniprotkb:Serine-rich RNA polymerase I suppressor protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lokareddy et al. (2015)	pubmed:26051712|doi:10.1016/j.str.2015.04.017|imex:IM-24556	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16160014|imex:IM-24556-13|dip:DIP-191613E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010746.1|sgd:S000002866|dip:DIP-7259N|ensemblfungi:YDR458C(gene)|ensemblfungi:YDR458C_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034399"(nuclear periphery)|interpro:IPR011015(LEM-like fold)|interpro:IPR018996|interpro:IPR025856|interpro:IPR041885|interpro:IPR044780|rcsb pdb:4PVZ	refseq:NP_014210.1|sgd:S000005133|dip:DIP-728N|mint:Q02821|ensemblfungi:YNL189W(gene)|ensemblfungi:YNL189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031144"(proteasome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|rcsb pdb:1BK5|rcsb pdb:1BK6|rcsb pdb:1EE4|rcsb pdb:1EE5|rcsb pdb:1UN0|rcsb pdb:1WA5|rcsb pdb:2C1T|rcsb pdb:4PVZ|rcsb pdb:4XZR|rcsb pdb:5H2W|rcsb pdb:5H2X|rcsb pdb:5T94	psi-mi:"MI:0465"(dip)	crc64:1E11821F2542723E	crc64:8D3A0CB76F2E7C00	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:I4nGsbLmzE8RLfZDB9Dosyx+ugM559292	rogid:NyzC93xnBCb8DX/AH346lwg4u2A559292	rigid:QrN5P+fsV0lGO0uww3LaC1ietlg	false	sufficient binding region:97-137|mutation decreasing interaction strength:126-126,103-103|mutation decreasing interaction strength:103-103|maltose binding protein tag:n-n	sufficient binding region:88-530|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)