#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05019	uniprotkb:P08069	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Menting et al. (2015)	pubmed:26027733|doi:10.1016/j.str.2015.04.016|imex:IM-24555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16158445|imex:IM-24555-1|dip:DIP-199176E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	psi-mi:"MI:0465"(dip)	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	rigid:CUpDcpRuc57mTfjBrLwgvTJi67o	false	sufficient binding region:49-118	sufficient binding region:721-736	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05019	uniprotkb:P06213-1	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Menting et al. (2015)	pubmed:26027733|doi:10.1016/j.str.2015.04.016|imex:IM-24555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16158445|imex:IM-24555-1|dip:DIP-199176E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:CUpDcpRuc57mTfjBrLwgvTJi67o	false	sufficient binding region:49-118	sufficient binding region:28-377	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15127	uniprotkb:P06213-1	intact:EBI-7472166|intact:MINT-1348005|uniprotkb:P97681	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:insr_rat(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Menting et al. (2015)	pubmed:26027733|doi:10.1016/j.str.2015.04.016|imex:IM-24555	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16158470|imex:IM-24555-2|dip:DIP-90319E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P15127|rgd:2917|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032094"(response to food)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033280"(response to vitamin D)|go:"GO:0033574"(response to testosterone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097421"(liver regeneration)|go:"GO:1902438"("response to vanadate(3-)")|go:"GO:1904638"(response to resveratrol)|go:"GO:1990402"(embryonic liver development)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|rcsb pdb:4XST|rcsb pdb:5TQ1|reactome:R-RNO-6811558|reactome:R-RNO-74713|reactome:R-RNO-74749|reactome:R-RNO-74751|reactome:R-RNO-74752|reactome:R-RNO-77387|go:"GO:0051384"(response to glucocorticoid)|dip:DIP-42209N	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ldt21SpdR80CvCb99s38/rfnIZs10116	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:nB5q80oPMfbJjmIdGNzklLQpotE	false	sufficient binding region:726-748	sufficient binding region:28-377	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)