#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12643	uniprotkb:Q96B86-1	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-16155394	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:q96b86-1(display_long)|uniprotkb:RGMA(gene name)|psi-mi:RGMA(display_short)|uniprotkb:RGM(gene name synonym)|uniprotkb:RGM domain family member A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155401|imex:IM-24599-1|dip:DIP-199290E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	intact:EBI-722102(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:07HgG1R+n1EUHt+CKdCJbhMb3ns9606	rigid:1kAKQ8wdvNfxb0tKmtKwQQedEi4	false	sufficient binding region:283-396	sufficient binding region:45-139	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P12643	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155443|imex:IM-24599-3|dip:DIP-10071E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:uOjo+k6ntioajh3WtYrnaTHK4Ts	false	sufficient binding region:49-141	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P12643	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155422|imex:IM-24599-2|dip:DIP-10071E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:uOjo+k6ntioajh3WtYrnaTHK4Ts	false	sufficient binding region:49-141	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:P97798	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-774991	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155518|imex:IM-24599-5|dip:DIP-199293E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090	rigid:NAI7N2Hl9oDaFJbQ3g4R7tkdfIk	false	sufficient binding region:283-396	sufficient binding region:883-1083	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q6NW40	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155518|imex:IM-24599-5|dip:DIP-199293E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rigid:NAI7N2Hl9oDaFJbQ3g4R7tkdfIk	false	sufficient binding region:283-396	sufficient binding region:53-412	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZVN8-1	uniprotkb:P12643	intact:EBI-16155543|ensembl:ENSP00000337014	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:q6zvn8-1(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155552|imex:IM-24599-6|dip:DIP-199291E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|intact:EBI-10900704(isoform-parent)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:bmK4ChaEpDbBh65hE8bleNrbDuU	false	sufficient binding region:36-147	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97798	uniprotkb:Q6NW40	intact:EBI-774991	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym)	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155497|imex:IM-24599-4|dip:DIP-199294E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane)	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rigid:Dgv14n1GjPj3fXHV5/5AIQHBEp0	false	sufficient binding region:883-1083	sufficient binding region:53-412	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13873	uniprotkb:P12643	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155573|imex:IM-24599-7|dip:DIP-10073E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:oPFJYJywL0i1h8tPt+yKRHyK4Ds	false	sufficient binding region:33-132	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6NW40	uniprotkb:P12643	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155594|imex:IM-24599-8|dip:DIP-199292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:nVW4YbzShYZzI9v6gTDIPDAMWBA	false	sufficient binding region:53-136	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:P97798	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-774991	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155615|imex:IM-24599-9|dip:DIP-199293E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090	rigid:NAI7N2Hl9oDaFJbQ3g4R7tkdfIk	false	sufficient binding region:283-396	sufficient binding region:883-1083	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q6NW40	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155615|imex:IM-24599-9|dip:DIP-199293E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rigid:NAI7N2Hl9oDaFJbQ3g4R7tkdfIk	false	sufficient binding region:283-396	sufficient binding region:53-412	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q96B86-1	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-16155394	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:q96b86-1(display_long)|uniprotkb:RGMA(gene name)|psi-mi:RGMA(display_short)|uniprotkb:RGM(gene name synonym)|uniprotkb:RGM domain family member A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155639|imex:IM-24599-10|dip:DIP-199290E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	intact:EBI-722102(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:07HgG1R+n1EUHt+CKdCJbhMb3ns9606	rigid:1kAKQ8wdvNfxb0tKmtKwQQedEi4	false	sufficient binding region:283-396	sufficient binding region:45-139	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6NW40	uniprotkb:P12643	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155662|imex:IM-24599-11|dip:DIP-199292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:nVW4YbzShYZzI9v6gTDIPDAMWBA	false	sufficient binding region:53-136	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27037-1	uniprotkb:P12643	intact:EBI-16012625|ensembl:ENSP00000241416|ensembl:ENSP00000384338	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:p27037-1(display_long)|uniprotkb:ACVR2A(gene name)|psi-mi:ACVR2A(display_short)|uniprotkb:ACVR2(gene name synonym)|uniprotkb:Activin receptor type IIA(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155683|imex:IM-24599-12|dip:DIP-10672E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121989(gene)|ensembl:ENST00000241416(transcript)|ensembl:ENST00000404590(transcript)|intact:EBI-296189(isoform-parent)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:JWP9gi/caaa3Tpin8YoeVC7K1nM9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:0SAkQZV0MV0vBA6zIEIDiB/W5g0	false	sufficient binding region:27-118	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6NW40	uniprotkb:P12643	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155704|imex:IM-24599-13|dip:DIP-199292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:nVW4YbzShYZzI9v6gTDIPDAMWBA	false	sufficient binding region:53-136|mutation decreasing interaction strength:106-106	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P12643	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155795|imex:IM-24599-17|dip:DIP-10071E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:uOjo+k6ntioajh3WtYrnaTHK4Ts	false	sufficient binding region:49-141	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6NW40	uniprotkb:P12643	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155774|imex:IM-24599-16|dip:DIP-199292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:nVW4YbzShYZzI9v6gTDIPDAMWBA	false	sufficient binding region:53-136	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97798	uniprotkb:Q6NW40	intact:EBI-774991	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym)	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155753|imex:IM-24599-15|dip:DIP-199294E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane)	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rigid:Dgv14n1GjPj3fXHV5/5AIQHBEp0	false	sufficient binding region:883-1083	sufficient binding region:53-412	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:P97798	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-774991	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155729|imex:IM-24599-14|dip:DIP-199293E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090	rigid:NAI7N2Hl9oDaFJbQ3g4R7tkdfIk	false	sufficient binding region:283-396	sufficient binding region:883-1083	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q6NW40	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-16155464|ensembl:ENSP00000423256|uniprotkb:D6R9A0|uniprotkb:Q8NC92	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:rgmb_human(display_long)|uniprotkb:RGMB(gene name)|psi-mi:RGMB(display_short)|uniprotkb:DRG11-responsive axonal guidance and outgrowth of neurite(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155729|imex:IM-24599-14|dip:DIP-199293E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	ensembl:ENSG00000174136(gene)|ensembl:ENST00000513185(transcript)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046658"(anchored component of plasma membrane)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033608|interpro:IPR040287|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:6Z3M|reactome:R-HSA-373752|rcsb pdb:4BQ8|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI2|rcsb pdb:6Z3H|rcsb pdb:6Z3J|refseq:NP_001012779.2|dip:DIP-61607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:ENuJnfOmC8wO6i/r7XkyjPmsHMY9606	rigid:NAI7N2Hl9oDaFJbQ3g4R7tkdfIk	false	sufficient binding region:283-396	sufficient binding region:53-412	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZVN8-1	uniprotkb:P12643	intact:EBI-16155543|ensembl:ENSP00000337014	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:q6zvn8-1(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Healey et al. (2015)	pubmed:25938661|doi:"https://doi.org/10.1038/nsmb.3016"|imex:IM-24599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16155816|imex:IM-24599-18|dip:DIP-199291E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|intact:EBI-10900704(isoform-parent)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rigid:bmK4ChaEpDbBh65hE8bleNrbDuU	false	sufficient binding region:36-147|mutation decreasing interaction strength:99-99|mutation decreasing interaction strength:101-101	sufficient binding region:283-396	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)