#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BYX4	uniprotkb:O14730	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737975|imex:IM-25663-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/12	2017/01/12	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:17U7926IPhTNI980cZT422EqEGE	false	sufficient binding region:731-1025	sufficient binding region:1-291	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYX4	uniprotkb:O14730	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12738019|imex:IM-25663-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/12	2017/01/12	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:17U7926IPhTNI980cZT422EqEGE	false	sufficient binding region:731-1025	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYX4	uniprotkb:O14730	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12738035|imex:IM-25663-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:1E, F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2017/01/12	2017/01/12	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:17U7926IPhTNI980cZT422EqEGE	false	flag tag:n-n|sufficient binding region:731-1025	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYX4	uniprotkb:O14730	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13642754|imex:IM-25663-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2017/01/12	2017/02/07	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:17U7926IPhTNI980cZT422EqEGE	false	flag tag:n-n	ha tag:c-c|sufficient binding region:1-291	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYX4	uniprotkb:O14730	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12738054|imex:IM-25663-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:1G|comment:"Observed before and after polyI:C stimulation"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2017/01/12	2017/01/12	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:17U7926IPhTNI980cZT422EqEGE	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BYX4	uniprotkb:O14730	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12738102|imex:IM-25663-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	go:"GO:0005737"(cytoplasm)	-	-	figure legend:1K|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2017/01/12	2017/02/07	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:17U7926IPhTNI980cZT422EqEGE	false	flag tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9BYX4	uniprotkb:Q9BYX4	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12738141|imex:IM-25663-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:4B-E, S4A-B|comment:"Multinerization observed in resting and polyI:C stimulated cells"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line)	-	2017/01/12	2017/01/12	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rigid:I9ZLjeg93N9OTmxGAhboMbwfwsw	false	flag tag:n-n|mutation increasing interaction strength:828-828|mutation decreasing interaction strength:828-828	flag tag:n-n|mutation increasing interaction strength:828-828|mutation decreasing interaction strength:828-828	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYX4	uniprotkb:Q9BYX4	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Takashima et al. (2015)	imex:IM-25663|pubmed:25865883	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12738160|imex:IM-25663-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:4F-I|comment:"Multinerization observed in resting and polyI:C stimulated cells"|antagonist:RIOK3. RIOK3 knock-out increases multimer formation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/01/12	2017/01/12	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rigid:I9ZLjeg93N9OTmxGAhboMbwfwsw	false	flag tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)