#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0071"(molecular sieving) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150847|imex:IM-24223-3|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640 sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150798|imex:IM-24223-1|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:608-608 sufficient binding region:223-303|r1 spin label:261-261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150823|imex:IM-24223-2|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:635-635,563-563 sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150868|imex:IM-24223-4|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:537-537 sufficient binding region:223-303|r1 spin label:248-248 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y3Q4 uniprotkb:Q8IYB4-6 intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150943|imex:IM-24223-7|dip:DIP-198758E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:ImaA7OJBZvWImbNnW1jpnCcQO30 false sufficient binding region:563-727 sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150918|imex:IM-24223-6|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:537-537 sufficient binding region:223-303|r1 spin label:261-261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150893|imex:IM-24223-5|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:563-563 sufficient binding region:223-303|r1 spin label:261-261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150964|imex:IM-24223-8|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:570-570 r1 spin label:261-261|sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151037|imex:IM-24223-11|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:635-635,537-537 sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151014|imex:IM-24223-10|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:635-635 sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16150989|imex:IM-24223-9|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:624-624 sufficient binding region:223-303|r1 spin label:261-261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151061|imex:IM-24223-12|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:563-563 sufficient binding region:223-303|r1 spin label:248-248 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151136|imex:IM-24223-15|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:608-608 sufficient binding region:223-303|r1 spin label:248-248 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151111|imex:IM-24223-14|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:616-616 sufficient binding region:223-303|r1 spin label:261-261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151086|imex:IM-24223-13|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:635-635 sufficient binding region:223-303|r1 spin label:248-248 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151161|imex:IM-24223-16|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:616-616 sufficient binding region:223-303|r1 spin label:248-248 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151210|imex:IM-24223-18|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:635-635 sufficient binding region:223-303|r1 spin label:261-261 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151186|imex:IM-24223-17|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:624-624,537-537 sufficient binding region:223-303 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:Q8IYB4-6 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-16150786|ensembl:ENSP00000419348 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:q8iyb4-6(display_long)|uniprotkb:PEX5L(gene name)|psi-mi:PEX5L(display_short)|uniprotkb:PEX5R(gene name synonym)|uniprotkb:PXR2(gene name synonym)|uniprotkb:PEX2-related protein(gene name synonym)|uniprotkb:PEX5-like protein(gene name synonym)|uniprotkb:Peroxin-5-related protein(gene name synonym)|uniprotkb:Peroxisome biogenesis factor 5-like(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing Rab8b-interacting protein(gene name synonym) psi-mi:"MI:0042"(electron paramagnetic resonance) DeBerg et al. (2015) pubmed:25800552|doi:10.1016/j.str.2015.02.007|imex:IM-24223 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16151235|imex:IM-24223-19|dip:DIP-198757E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061 ensembl:ENSG00000114757(gene)|ensembl:ENST00000465751(transcript)|intact:EBI-15749355(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:CRU/bU2bonqkLqX/ZNZimKvJiUk9606 rigid:jN3SGrrrf2XOhV5S13AcLS4Ih4U false sufficient binding region:488-640|r1 spin label:570-570 sufficient binding region:223-303|r1 spin label:248-248 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)