#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16628797|imex:IM-26314-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false enhanced green fluorescent protein tag:n-n red fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16628842|imex:IM-26314-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:1A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16628893|imex:IM-26314-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:1A-3|caution:"Image text states that:- \"Beads that bind mRFP and mCherry were used to immunoprecipitate (IP) mRFP-HAS3, mCherry-HAS2, and mCherry-HAS1 from COS1 cultures co-transfected with EGFP-HAS1.\". However the image labels give two instances of mcherry-HAS2 transfection and NO instance of mcherry-HAS1. It has been assumed that the second instance of mcherry-HAS2 is meant to be mcherry-HAS1."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16628904|imex:IM-26314-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false enhanced green fluorescent protein tag:n-n red fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16628914|imex:IM-26314-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:1B-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00219 uniprotkb:Q92819 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16629623|imex:IM-26314-79 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/22 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false enhanced green fluorescent protein tag:n-n|sufficient binding region:1-86|sufficient binding region:87-553 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628933|imex:IM-26314-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane) - - figure legend:2-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92839 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628946|imex:IM-26314-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane) - - figure legend:2-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:Q92839 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628956|imex:IM-26314-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane) - - figure legend:2-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0663"(confocal microscopy) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628966|imex:IM-26314-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane) - - figure legend:2-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0663"(confocal microscopy) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628976|imex:IM-26314-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane) - - figure legend:2-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:Q92819 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0663"(confocal microscopy) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628986|imex:IM-26314-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane) - - figure legend:2-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629008|imex:IM-26314-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629018|imex:IM-26314-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629026|imex:IM-26314-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629034|imex:IM-26314-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629043|imex:IM-26314-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629051|imex:IM-26314-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629083|imex:IM-26314-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 3A, top right image;figure 4C, top right image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629075|imex:IM-26314-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 3A, top middle image;figure 4B, top middle image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629099|imex:IM-26314-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 3B, lower right image;figure 4F, lower right image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629107|imex:IM-26314-103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 3B, lower middle image;figure 4E, middle image-left hand side|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629067|imex:IM-26314-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:Figure 3A, top left image; figure 4A, top left image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629091|imex:IM-26314-101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 3B, lower left image; figure 4D, lower left image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629230|imex:IM-26314-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:Figure 4A, top left image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:aVprLN+wOoaFE8+IZOSFDwDUEGk false myc tag:?-? venus fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629230|imex:IM-26314-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:Figure 4A, top left image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:aVprLN+wOoaFE8+IZOSFDwDUEGk false myc tag:?-? cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629241|imex:IM-26314-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 4B, top middle image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:mEshKHcCKP21zfj2HJ5HeG+mV14 false ha tag:?-? venus fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629241|imex:IM-26314-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 4B, top middle image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:mEshKHcCKP21zfj2HJ5HeG+mV14 false ha tag:?-? cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629253|imex:IM-26314-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 4C, top right image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:Cc+guOALEZ7AalMp3UPwxkbKDOg false myc tag:?-? venus fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629253|imex:IM-26314-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 4C, top right image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:Cc+guOALEZ7AalMp3UPwxkbKDOg false myc tag:?-? cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629266|imex:IM-26314-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 4D, lower left image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false fluorescent protein tag:c-c ha tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629266|imex:IM-26314-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 4D, lower left image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629277|imex:IM-26314-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:Figure 4E, lower middle image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false myc tag:?-? fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629277|imex:IM-26314-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 4E, lower middle image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false myc tag:?-? fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629288|imex:IM-26314-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 4E, right hand side image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false fluorescent protein tag:c-c myc tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629288|imex:IM-26314-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 4E, right hand side image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629299|imex:IM-26314-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:Figure 4F, lower right image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false ha tag:?-? fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629299|imex:IM-26314-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:Figure 4F, lower right image|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false ha tag:?-? fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629164|imex:IM-26314-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629156|imex:IM-26314-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629124|imex:IM-26314-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629140|imex:IM-26314-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629132|imex:IM-26314-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629148|imex:IM-26314-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629221|imex:IM-26314-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629213|imex:IM-26314-95 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629181|imex:IM-26314-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629197|imex:IM-26314-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629189|imex:IM-26314-105 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629205|imex:IM-26314-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:3-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false fluorescent protein tag:c-c fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629352|imex:IM-26314-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:5A-1/5B, 7A-LHS|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false necessary binding region:13-143|enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:O00219 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629362|imex:IM-26314-97 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:5A-2/5B,|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:6F3/Zk4ESSox+JEfg2xm4hbPg5M false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629370|imex:IM-26314-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 go:"GO:0005886"(plasma membrane) - - figure legend:5A-3/5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92839 uniprotkb:Q92839 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629467|imex:IM-26314-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 - - - figure legend:5B-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rigid:2y4d8b4kyJfYIpHSDwdaorMCw5c false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629475|imex:IM-26314-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:5B-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false enhanced green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629483|imex:IM-26314-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 - - - figure legend:5B-3, 7A-RHSi|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false enhanced green fluorescent protein tag:n-n|sufficient binding region:1-166 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:O00219 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629580|imex:IM-26314-107 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 go:"GO:0005886"(plasma membrane) - - figure legend:7A-RHSii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/22 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false mcherry fluorescent protein tag:n-n enhanced green fluorescent protein tag:n-n|sufficient binding region:1-166 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O00219 uniprotkb:O00219 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629607|imex:IM-26314-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 go:"GO:0005886"(plasma membrane) - - figure legend:7A-RHSiii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/10/18 2017/11/22 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rigid:EN1Kbgu71ktYoTKqUgm3BvDTNdM false mcherry fluorescent protein tag:n-n|sufficient binding region:1-220 enhanced green fluorescent protein tag:n-n|sufficient binding region:1-166 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92819 uniprotkb:Q92819 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0813"(proximity ligation assay) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629523|imex:IM-26314-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:figure 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mesothelium)|taxid:9606(human-mesothelium) - 2017/10/18 2017/11/21 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:LSazxzm3q5hKp59g5NpcJE0upN4 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q92839 uniprotkb:Q92819 intact:EBI-1052423|uniprotkb:Q14470|uniprotkb:Q9NS49|ensembl:ENSP00000222115 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas1_human(display_long)|uniprotkb:Hyaluronate synthase 1(gene name synonym)|uniprotkb:Hyaluronic acid synthase 1(gene name synonym)|uniprotkb:HAS1(gene name)|psi-mi:HAS1(display_short)|uniprotkb:HAS(gene name synonym) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0813"(proximity ligation assay) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629530|imex:IM-26314-99 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001514.2|ensembl:ENSG00000105509(gene)|ensembl:ENST00000222115(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR028385|interpro:IPR029044|reactome:R-HSA-2142850 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:figure 6i|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mesothelium)|taxid:9606(human-mesothelium) - 2017/10/18 2017/11/21 rogid:mTWVDChwbwSGH1gISnASTCQJdTM9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:1ZRG7BELsTIPztbYClgEMfNiMbY false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O00219 uniprotkb:Q92819 intact:EBI-16628799|ensembl:ENSP00000304440|ensembl:ENSP00000454731|uniprotkb:A8K5T5|uniprotkb:Q8WTZ0|uniprotkb:Q9NYP0 intact:EBI-16628852|ensembl:ENSP00000306991|uniprotkb:Q32MM3 psi-mi:hyas3_human(display_long)|uniprotkb:Hyaluronate synthase 3(gene name synonym)|uniprotkb:Hyaluronic acid synthase 3(gene name synonym)|uniprotkb:HAS3(gene name)|psi-mi:HAS3(display_short) psi-mi:hyas2_human(display_long)|uniprotkb:Hyaluronate synthase 2(gene name synonym)|uniprotkb:Hyaluronic acid synthase 2(gene name synonym)|uniprotkb:HAS2(gene name)|psi-mi:HAS2(display_short) psi-mi:"MI:0813"(proximity ligation assay) Bart et al. (2015) imex:IM-26314|pubmed:25795779 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16629535|imex:IM-26314-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103044(gene)|ensembl:ENST00000306560(transcript)|ensembl:ENST00000569188(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0036117"(hyaluranon cable)|go:"GO:0042802"(identical protein binding)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_001186209.1|refseq:NP_005320.2|refseq:NP_619515.1|refseq:XP_005255978.1|refseq:XP_011521363.1 ensembl:ENSG00000170961(gene)|ensembl:ENST00000303924(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0044849"(estrous cycle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045226"(extracellular polysaccharide biosynthetic process)|go:"GO:0050501"(hyaluronan synthase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090500"(endocardial cushion to mesenchymal transition)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR028371|interpro:IPR029044|reactome:R-HSA-2142850|refseq:NP_005319.1 - - - figure legend:figure 6ii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mesothelium)|taxid:9606(human-mesothelium) - 2017/10/18 2017/11/21 rogid:N35RQvlNri+6wbwfYlwgncUlzIU9606 rogid:CZv6sWwVxXJSOCxG41j9jLTd2ls9606 rigid:vSbqUolC00UYDOm/q8ckBeVQliI false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)