#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60337	uniprotkb:P41220-1	intact:EBI-2684600|uniprotkb:A5PKZ4|uniprotkb:O14670|uniprotkb:Q86X77|uniprotkb:D3DTC8|intact:EBI-28971061|ensembl:ENSP00000274140|uniprotkb:B4DKJ2|uniprotkb:B4DT33	intact:EBI-16037474|ensembl:ENSP00000235382	psi-mi:marh6_human(display_long)|uniprotkb:MARCHF6(gene name)|psi-mi:MARCHF6(display_short)|uniprotkb:Doa10 homolog(gene name synonym)|uniprotkb:KIAA0597(gene name synonym)|uniprotkb:MARCH6(gene name synonym)|uniprotkb:Membrane-associated RING finger protein 6(gene name synonym)|uniprotkb:Membrane-associated RING-CH protein VI(gene name synonym)|uniprotkb:Protein TEB-4(gene name synonym)|uniprotkb:RING finger protein 176(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MARCHF6(gene name synonym)|uniprotkb:RNF176(gene name synonym)|uniprotkb:TEB4(gene name synonym)	psi-mi:p41220-1(display_long)|uniprotkb:RGS2(gene name)|psi-mi:RGS2(display_short)|uniprotkb:G0S8(gene name synonym)|uniprotkb:GIG31(orf name)|uniprotkb:Cell growth-inhibiting gene 31 protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Park et al. (2015)	pubmed:25766235|doi:10.1126/science.aaa3844|imex:IM-24337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16149631|imex:IM-24337-1|dip:DIP-198967E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000274140|ensembl:ENST00000449913|ensembl:ENSP00000414643|ensembl:ENST00000503788|ensembl:ENSP00000425930|refseq:NP_005876.2|ensembl:ENSG00000145495(gene)|ensembl:ENST00000274140(transcript)|go:"GO:0000835"(ER ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|refseq:NP_001257589.1|refseq:NP_001257590.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:O60337|reactome:R-HSA-901032|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|dip:DIP-56134N	ensembl:ENST00000235382(transcript)|ensembl:ENSG00000116741(gene)|intact:EBI-712388(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:ow2W2xIcL82tgIHRS0SxlY4Ffjs9606	rogid:7tdfhNRRyaPKS2taH6iurdHCZ+s9606	rigid:UBrcX74YleHq15HRW/pvEKVIfaQ	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60337	uniprotkb:P41220-1	intact:EBI-2684600|uniprotkb:A5PKZ4|uniprotkb:O14670|uniprotkb:Q86X77|uniprotkb:D3DTC8|intact:EBI-28971061|ensembl:ENSP00000274140|uniprotkb:B4DKJ2|uniprotkb:B4DT33	intact:EBI-16037474|ensembl:ENSP00000235382	psi-mi:marh6_human(display_long)|uniprotkb:MARCHF6(gene name)|psi-mi:MARCHF6(display_short)|uniprotkb:Doa10 homolog(gene name synonym)|uniprotkb:KIAA0597(gene name synonym)|uniprotkb:MARCH6(gene name synonym)|uniprotkb:Membrane-associated RING finger protein 6(gene name synonym)|uniprotkb:Membrane-associated RING-CH protein VI(gene name synonym)|uniprotkb:Protein TEB-4(gene name synonym)|uniprotkb:RING finger protein 176(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MARCHF6(gene name synonym)|uniprotkb:RNF176(gene name synonym)|uniprotkb:TEB4(gene name synonym)	psi-mi:p41220-1(display_long)|uniprotkb:RGS2(gene name)|psi-mi:RGS2(display_short)|uniprotkb:G0S8(gene name synonym)|uniprotkb:GIG31(orf name)|uniprotkb:Cell growth-inhibiting gene 31 protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Park et al. (2015)	pubmed:25766235|doi:10.1126/science.aaa3844|imex:IM-24337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16149655|imex:IM-24337-2|dip:DIP-198967E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000274140|ensembl:ENST00000449913|ensembl:ENSP00000414643|ensembl:ENST00000503788|ensembl:ENSP00000425930|refseq:NP_005876.2|ensembl:ENSG00000145495(gene)|ensembl:ENST00000274140(transcript)|go:"GO:0000835"(ER ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|refseq:NP_001257589.1|refseq:NP_001257590.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:O60337|reactome:R-HSA-901032|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|dip:DIP-56134N	ensembl:ENST00000235382(transcript)|ensembl:ENSG00000116741(gene)|intact:EBI-712388(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ow2W2xIcL82tgIHRS0SxlY4Ffjs9606	rogid:7tdfhNRRyaPKS2taH6iurdHCZ+s9606	rigid:UBrcX74YleHq15HRW/pvEKVIfaQ	false	flag tag:c-c	glutathione s tranferase tag:?-?|sufficient binding region:1-10|N-acetyl-L-methionine:1-1	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60337	uniprotkb:P41220-1	intact:EBI-2684600|uniprotkb:A5PKZ4|uniprotkb:O14670|uniprotkb:Q86X77|uniprotkb:D3DTC8|intact:EBI-28971061|ensembl:ENSP00000274140|uniprotkb:B4DKJ2|uniprotkb:B4DT33	intact:EBI-16037474|ensembl:ENSP00000235382	psi-mi:marh6_human(display_long)|uniprotkb:MARCHF6(gene name)|psi-mi:MARCHF6(display_short)|uniprotkb:Doa10 homolog(gene name synonym)|uniprotkb:KIAA0597(gene name synonym)|uniprotkb:MARCH6(gene name synonym)|uniprotkb:Membrane-associated RING finger protein 6(gene name synonym)|uniprotkb:Membrane-associated RING-CH protein VI(gene name synonym)|uniprotkb:Protein TEB-4(gene name synonym)|uniprotkb:RING finger protein 176(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MARCHF6(gene name synonym)|uniprotkb:RNF176(gene name synonym)|uniprotkb:TEB4(gene name synonym)	psi-mi:p41220-1(display_long)|uniprotkb:RGS2(gene name)|psi-mi:RGS2(display_short)|uniprotkb:G0S8(gene name synonym)|uniprotkb:GIG31(orf name)|uniprotkb:Cell growth-inhibiting gene 31 protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Park et al. (2015)	pubmed:25766235|doi:10.1126/science.aaa3844|imex:IM-24337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16149683|imex:IM-24337-3|dip:DIP-198967E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000274140|ensembl:ENST00000449913|ensembl:ENSP00000414643|ensembl:ENST00000503788|ensembl:ENSP00000425930|refseq:NP_005876.2|ensembl:ENSG00000145495(gene)|ensembl:ENST00000274140(transcript)|go:"GO:0000835"(ER ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|refseq:NP_001257589.1|refseq:NP_001257590.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:O60337|reactome:R-HSA-901032|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|dip:DIP-56134N	ensembl:ENST00000235382(transcript)|ensembl:ENSG00000116741(gene)|intact:EBI-712388(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:ow2W2xIcL82tgIHRS0SxlY4Ffjs9606	rogid:7tdfhNRRyaPKS2taH6iurdHCZ+s9606	rigid:UBrcX74YleHq15HRW/pvEKVIfaQ	false	flag tag:c-c	ha tag:?-?|mutation disrupting interaction strength:1-1	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-4399559	uniprotkb:P41220-1	dip:DIP-24261N	intact:EBI-16037474|ensembl:ENSP00000235382	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p41220-1(display_long)|uniprotkb:RGS2(gene name)|psi-mi:RGS2(display_short)|uniprotkb:G0S8(gene name synonym)|uniprotkb:GIG31(orf name)|uniprotkb:Cell growth-inhibiting gene 31 protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Park et al. (2015)	pubmed:25766235|doi:10.1126/science.aaa3844|imex:IM-24337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16149709|imex:IM-24337-4|dip:DIP-198968E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENST00000235382(transcript)|ensembl:ENSG00000116741(gene)|intact:EBI-712388(isoform-parent)	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:7tdfhNRRyaPKS2taH6iurdHCZ+s9606	rigid:0IHItPc1Ho8vmp8Vn/fQYObA/q4	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)