#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97953-1	uniprotkb:O60462	intact:EBI-16148671|ensembl:ENSMUSP00000033919	intact:EBI-12586256|ensembl:ENSP00000353582|uniprotkb:E9PF66|uniprotkb:O14820|uniprotkb:O14821|uniprotkb:Q53TQ4|uniprotkb:Q53TS3|uniprotkb:Q7LBX7|uniprotkb:Q9H2D4|uniprotkb:Q9H2D5|uniprotkb:Q9H2E2|uniprotkb:Q9H2E3|uniprotkb:Q9H2E4|uniprotkb:A0A024R3W6|uniprotkb:A0A024R412|uniprotkb:Q7LBX6|uniprotkb:X5D2Q8	psi-mi:p97953-1(display_long)|uniprotkb:Vegfc(gene name)|psi-mi:Vegfc(display_short)|uniprotkb:Vascular endothelial growth factor-related protein(gene name synonym)|uniprotkb:Vegf-C(isoform synonym)|uniprotkb:Flt4 ligand(gene name synonym)	psi-mi:nrp2_human(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:1235"(thermal shift binding)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148679|imex:IM-24221-1|dip:DIP-198753E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031520(gene)|ensembl:ENSMUST00000033919(transcript)|intact:EBI-16356985(isoform-parent)	refseq:XP_016860674.1|ensembl:ENSG00000118257(gene)|ensembl:ENST00000360409(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030424"(axon)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027143|interpro:IPR035914|rcsb pdb:2QQJ|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQO|rcsb pdb:4QDQ|rcsb pdb:4QDR|rcsb pdb:4QDS|rcsb pdb:5DN2|rcsb pdb:5DQ0|rcsb pdb:6GH8|rcsb pdb:6TDB|rcsb pdb:6TJT|reactome:R-HSA-194306|reactome:R-HSA-447038|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|refseq:NP_003863.2|refseq:NP_061004.3|refseq:NP_957716.1|refseq:NP_957718.1|refseq:NP_957719.1|refseq:NP_958436.1|refseq:XP_005246990.2|refseq:XP_005246991.2|refseq:XP_016860675.1|dip:DIP-5745N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2018/04/06	rogid:tXMtikW0IQobxEQuXLYm3sYSnlg10090	rogid:AYb/eGPmTRm0687zHDz85Tlj3SI9606	rigid:DLXYhp1pORN/P9XLH/fgxL6bz+8	false	sufficient binding region:215-223	sufficient binding region:279-595	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60462-6	uniprotkb:O60462-6	intact:EBI-16148700|ensembl:ENSP00000387519	intact:EBI-16148700|ensembl:ENSP00000387519	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0408"(disulfide bond)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148729|imex:IM-24221-3|dip:DIP-196785E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2018/04/06	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rigid:9DPqbQ2ZE0MP0xgHCCy4F17SQxw	false	sufficient binding region:275-555	sufficient binding region:275-555	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O60462-6	uniprotkb:O60462-6	intact:EBI-16148700|ensembl:ENSP00000387519	intact:EBI-16148700|ensembl:ENSP00000387519	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0408"(disulfide bond)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148707|imex:IM-24221-2|dip:DIP-196785E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/08	2018/04/06	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rigid:9DPqbQ2ZE0MP0xgHCCy4F17SQxw	false	sufficient binding region:275-555|fusion protein:?-?	sufficient binding region:275-555|fusion protein:?-?	-	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60462-6	uniprotkb:O60462-6	intact:EBI-16148700|ensembl:ENSP00000387519	intact:EBI-16148700|ensembl:ENSP00000387519	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148817|imex:IM-24221-7|dip:DIP-196785E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2018/04/06	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rigid:9DPqbQ2ZE0MP0xgHCCy4F17SQxw	false	sufficient binding region:275-555	sufficient binding region:275-555	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97953-1	uniprotkb:O60462	intact:EBI-16148671|ensembl:ENSMUSP00000033919	intact:EBI-12586256|ensembl:ENSP00000353582|uniprotkb:E9PF66|uniprotkb:O14820|uniprotkb:O14821|uniprotkb:Q53TQ4|uniprotkb:Q53TS3|uniprotkb:Q7LBX7|uniprotkb:Q9H2D4|uniprotkb:Q9H2D5|uniprotkb:Q9H2E2|uniprotkb:Q9H2E3|uniprotkb:Q9H2E4|uniprotkb:A0A024R3W6|uniprotkb:A0A024R412|uniprotkb:Q7LBX6|uniprotkb:X5D2Q8	psi-mi:p97953-1(display_long)|uniprotkb:Vegfc(gene name)|psi-mi:Vegfc(display_short)|uniprotkb:Vascular endothelial growth factor-related protein(gene name synonym)|uniprotkb:Vegf-C(isoform synonym)|uniprotkb:Flt4 ligand(gene name synonym)	psi-mi:nrp2_human(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148792|imex:IM-24221-6|dip:DIP-198753E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031520(gene)|ensembl:ENSMUST00000033919(transcript)|intact:EBI-16356985(isoform-parent)	refseq:XP_016860674.1|ensembl:ENSG00000118257(gene)|ensembl:ENST00000360409(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030424"(axon)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027143|interpro:IPR035914|rcsb pdb:2QQJ|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQO|rcsb pdb:4QDQ|rcsb pdb:4QDR|rcsb pdb:4QDS|rcsb pdb:5DN2|rcsb pdb:5DQ0|rcsb pdb:6GH8|rcsb pdb:6TDB|rcsb pdb:6TJT|reactome:R-HSA-194306|reactome:R-HSA-447038|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|refseq:NP_003863.2|refseq:NP_061004.3|refseq:NP_957716.1|refseq:NP_957718.1|refseq:NP_957719.1|refseq:NP_958436.1|refseq:XP_005246990.2|refseq:XP_005246991.2|refseq:XP_016860675.1|dip:DIP-5745N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2018/04/06	rogid:tXMtikW0IQobxEQuXLYm3sYSnlg10090	rogid:AYb/eGPmTRm0687zHDz85Tlj3SI9606	rigid:DLXYhp1pORN/P9XLH/fgxL6bz+8	false	sufficient binding region:108-223|mutation decreasing interaction strength:223-223	sufficient binding region:279-595	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35916	uniprotkb:P97953-1	intact:EBI-1005467|uniprotkb:Q16067|uniprotkb:Q86W07|uniprotkb:A8K6L4|uniprotkb:B5A926|uniprotkb:Q86W08|ensembl:ENSP00000261937	intact:EBI-16148671|ensembl:ENSMUSP00000033919	psi-mi:vgfr3_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor FLT4(gene name synonym)|uniprotkb:FLT4(gene name)|psi-mi:FLT4(display_short)|uniprotkb:Fms-like tyrosine kinase 4(gene name synonym)|uniprotkb:VEGFR3(gene name synonym)	psi-mi:p97953-1(display_long)|uniprotkb:Vegfc(gene name)|psi-mi:Vegfc(display_short)|uniprotkb:Vascular endothelial growth factor-related protein(gene name synonym)|uniprotkb:Vegf-C(isoform synonym)|uniprotkb:Flt4 ligand(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148771|imex:IM-24221-5|dip:DIP-198754E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002011.2|refseq:NP_891555.2|dip:DIP-5739N|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009137(Vascular endothelial growth factor receptor 3, VEGFR3, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|mint:P35916|rcsb pdb:4BSJ|rcsb pdb:4BSK|reactome:R-HSA-195399|reactome:R-HSA-9013695|ensembl:ENSG00000037280(gene)|ensembl:ENST00000261937(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)	ensembl:ENSMUSG00000031520(gene)|ensembl:ENSMUST00000033919(transcript)|intact:EBI-16356985(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:daBgkt907Q/5VJ/nuDyeSNZMNf09606	rogid:tXMtikW0IQobxEQuXLYm3sYSnlg10090	rigid:24MEcu5TFsSijdMGAhonkq4vgR0	false	sufficient binding region:21-776	sufficient binding region:108-223	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97953-1	uniprotkb:O60462	intact:EBI-16148671|ensembl:ENSMUSP00000033919	intact:EBI-12586256|ensembl:ENSP00000353582|uniprotkb:E9PF66|uniprotkb:O14820|uniprotkb:O14821|uniprotkb:Q53TQ4|uniprotkb:Q53TS3|uniprotkb:Q7LBX7|uniprotkb:Q9H2D4|uniprotkb:Q9H2D5|uniprotkb:Q9H2E2|uniprotkb:Q9H2E3|uniprotkb:Q9H2E4|uniprotkb:A0A024R3W6|uniprotkb:A0A024R412|uniprotkb:Q7LBX6|uniprotkb:X5D2Q8	psi-mi:p97953-1(display_long)|uniprotkb:Vegfc(gene name)|psi-mi:Vegfc(display_short)|uniprotkb:Vascular endothelial growth factor-related protein(gene name synonym)|uniprotkb:Vegf-C(isoform synonym)|uniprotkb:Flt4 ligand(gene name synonym)	psi-mi:nrp2_human(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148747|imex:IM-24221-4|dip:DIP-198753E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031520(gene)|ensembl:ENSMUST00000033919(transcript)|intact:EBI-16356985(isoform-parent)	refseq:XP_016860674.1|ensembl:ENSG00000118257(gene)|ensembl:ENST00000360409(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030424"(axon)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027143|interpro:IPR035914|rcsb pdb:2QQJ|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQO|rcsb pdb:4QDQ|rcsb pdb:4QDR|rcsb pdb:4QDS|rcsb pdb:5DN2|rcsb pdb:5DQ0|rcsb pdb:6GH8|rcsb pdb:6TDB|rcsb pdb:6TJT|reactome:R-HSA-194306|reactome:R-HSA-447038|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|refseq:NP_003863.2|refseq:NP_061004.3|refseq:NP_957716.1|refseq:NP_957718.1|refseq:NP_957719.1|refseq:NP_958436.1|refseq:XP_005246990.2|refseq:XP_005246991.2|refseq:XP_016860675.1|dip:DIP-5745N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2018/04/06	rogid:tXMtikW0IQobxEQuXLYm3sYSnlg10090	rogid:AYb/eGPmTRm0687zHDz85Tlj3SI9606	rigid:DLXYhp1pORN/P9XLH/fgxL6bz+8	false	sufficient binding region:108-223	sufficient binding region:279-595|mutation disrupting interaction strength:319-319	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60462-6	uniprotkb:O60462-6	intact:EBI-16148700|ensembl:ENSP00000387519	intact:EBI-16148700|ensembl:ENSP00000387519	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:o60462-6(display_long)|uniprotkb:NRP2(gene name)|psi-mi:NRP2(display_short)|uniprotkb:VEGF165R2(gene name synonym)|uniprotkb:Vascular endothelial cell growth factor 165 receptor 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Parker et al. (2015)	pubmed:25752543|doi:10.1016/j.str.2015.01.018|imex:IM-24221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16148835|imex:IM-24221-8|dip:DIP-196785E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	ensembl:ENSG00000118257(gene)|ensembl:ENST00000417189(transcript)|intact:EBI-12586256(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2018/04/06	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rogid:GbadTyRqLigQwChQKuNz1h8RGUc9606	rigid:9DPqbQ2ZE0MP0xgHCCy4F17SQxw	false	sufficient binding region:275-555	sufficient binding region:275-555	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)