#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P46675 uniprotkb:P53267 intact:EBI-18471|uniprotkb:D6VY47|ensemblfungi:YLR045C intact:EBI-23268|uniprotkb:Q9P422|uniprotkb:D6VUP6|ensemblfungi:YGR113W psi-mi:stu2_yeast(display_long)|uniprotkb:STU2(gene name)|psi-mi:STU2(display_short)|uniprotkb:YLR045C(locus name)|uniprotkb:L2108(orf name)|uniprotkb:Suppressor of tubulin 2(gene name synonym) psi-mi:dam1_yeast(display_long)|uniprotkb:YGR113W(locus name)|uniprotkb:G6153(orf name)|uniprotkb:DAM1(gene name)|psi-mi:DAM1(display_short)|uniprotkb:Outer kinetochore protein DAM1(gene name synonym)|uniprotkb:DUO1 and MPS1-interacting protein 1(gene name synonym)|uniprotkb:Kinetochore assembly protein DAM1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kalantzaki et al. (2015) pubmed:25751138|doi:10.1038/ncb3128|imex:IM-24636 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16147959|imex:IM-24636-1|dip:DIP-79020E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005938"(cell cortex)|refseq:NP_013146.1|sgd:S000004035|ensemblfungi:YLR045C(gene)|ensemblfungi:YLR045C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005816"(spindle pole body)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0061863"(microtubule plus end polymerase)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|rcsb pdb:2QK1|rcsb pdb:4FFB|rcsb pdb:4U3J|rcsb pdb:6BL7|rcsb pdb:7KDF|dip:DIP-2462N|mint:P46675 sgd:S000003345|refseq:NP_011628.4|dip:DIP-1286N|mint:P53267|ensemblfungi:YGR113W(gene)|ensemblfungi:YGR113W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042729"(DASH complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:1990537"(mitotic spindle polar microtubule)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR013962(DASH complex, subunit Dam1) psi-mi:"MI:0465"(dip) crc64:7A49C3702E21C7BF crc64:F02DB6EE09BC2284 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/08 2017/08/10 rogid:MZSvgMGh+d1BYxGm4AEptyNQRfk559292 rogid:1U/NNQaGUzoddr+E0JlnygELpCc559292 rigid:fXpzCoU6kZ9MlV7ZfDdDPw6C1/4 false sufficient binding region:550-888 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40460 uniprotkb:P53267 intact:EBI-25247|uniprotkb:D6VVE3|ensemblfungi:YIL144W intact:EBI-23268|uniprotkb:Q9P422|uniprotkb:D6VUP6|ensemblfungi:YGR113W psi-mi:ndc80_yeast(display_long)|uniprotkb:NDC80(gene name)|psi-mi:NDC80(display_short)|uniprotkb:80 kDa spindle component protein(gene name synonym)|uniprotkb:HEC1(gene name synonym)|uniprotkb:Nuclear division cycle protein 80(gene name synonym)|uniprotkb:TID3(gene name synonym)|uniprotkb:Two-hybrid interaction with DMC1 protein 3(gene name synonym)|uniprotkb:YIL144W(locus name) psi-mi:dam1_yeast(display_long)|uniprotkb:YGR113W(locus name)|uniprotkb:G6153(orf name)|uniprotkb:DAM1(gene name)|psi-mi:DAM1(display_short)|uniprotkb:Outer kinetochore protein DAM1(gene name synonym)|uniprotkb:DUO1 and MPS1-interacting protein 1(gene name synonym)|uniprotkb:Kinetochore assembly protein DAM1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kalantzaki et al. (2015) pubmed:25751138|doi:10.1038/ncb3128|imex:IM-24636 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16147978|imex:IM-24636-2|dip:DIP-9265E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001406|refseq:NP_012122.3|mint:P40460|dip:DIP-818N|ensemblfungi:YIL144W(gene)|ensemblfungi:YIL144W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|interpro:IPR040967|rcsb pdb:5TCS|rcsb pdb:5TD8|rcsb pdb:7KDF sgd:S000003345|refseq:NP_011628.4|dip:DIP-1286N|mint:P53267|ensemblfungi:YGR113W(gene)|ensemblfungi:YGR113W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042729"(DASH complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:1990537"(mitotic spindle polar microtubule)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR013962(DASH complex, subunit Dam1) psi-mi:"MI:0465"(dip) crc64:7DBC492227A80093 crc64:F02DB6EE09BC2284 comment:Deletion of region 206-343 decreased the interaction rate/strength.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/08 2017/08/10 rogid:ZrT7N4pBKz6upSglhGhOqgeoAYw559292 rogid:1U/NNQaGUzoddr+E0JlnygELpCc559292 rigid:qc7j+krUw4axKum5ftvaywYAMLw false - mutation decreasing interaction strength:327-327,292-292,265-265,257-257 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P53168 uniprotkb:P53267 intact:EBI-23800|uniprotkb:D6VU80|ensemblfungi:YGL061C intact:EBI-23268|uniprotkb:Q9P422|uniprotkb:D6VUP6|ensemblfungi:YGR113W psi-mi:duo1_yeast(display_long)|uniprotkb:YGL061C(locus name)|uniprotkb:DUO1(gene name)|psi-mi:DUO1(display_short)|uniprotkb:Outer kinetochore protein DUO1(gene name synonym)|uniprotkb:Death upon overproduction protein 1(gene name synonym) psi-mi:dam1_yeast(display_long)|uniprotkb:YGR113W(locus name)|uniprotkb:G6153(orf name)|uniprotkb:DAM1(gene name)|psi-mi:DAM1(display_short)|uniprotkb:Outer kinetochore protein DAM1(gene name synonym)|uniprotkb:DUO1 and MPS1-interacting protein 1(gene name synonym)|uniprotkb:Kinetochore assembly protein DAM1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kalantzaki et al. (2015) pubmed:25751138|doi:10.1038/ncb3128|imex:IM-24636 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16148002|imex:IM-24636-3|dip:DIP-1467E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011454.1|sgd:S000003029|dip:DIP-1287N|mint:P53168|ensemblfungi:YGL061C(gene)|ensemblfungi:YGL061C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042729"(DASH complex)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|interpro:IPR013960(DASH complex, subunit Duo1) sgd:S000003345|refseq:NP_011628.4|dip:DIP-1286N|mint:P53267|ensemblfungi:YGR113W(gene)|ensemblfungi:YGR113W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042729"(DASH complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:1990537"(mitotic spindle polar microtubule)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR013962(DASH complex, subunit Dam1) psi-mi:"MI:0465"(dip) crc64:787F8AF869E3C978 crc64:F02DB6EE09BC2284 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/08 2017/08/10 rogid:uD838V20+p0YnjGgph8EZsT8/VE559292 rogid:1U/NNQaGUzoddr+E0JlnygELpCc559292 rigid:QA5zUpNhJ0eTNotL/DXWYEpzYAQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P46675 uniprotkb:P53267 intact:EBI-18471|uniprotkb:D6VY47|ensemblfungi:YLR045C intact:EBI-23268|uniprotkb:Q9P422|uniprotkb:D6VUP6|ensemblfungi:YGR113W psi-mi:stu2_yeast(display_long)|uniprotkb:STU2(gene name)|psi-mi:STU2(display_short)|uniprotkb:YLR045C(locus name)|uniprotkb:L2108(orf name)|uniprotkb:Suppressor of tubulin 2(gene name synonym) psi-mi:dam1_yeast(display_long)|uniprotkb:YGR113W(locus name)|uniprotkb:G6153(orf name)|uniprotkb:DAM1(gene name)|psi-mi:DAM1(display_short)|uniprotkb:Outer kinetochore protein DAM1(gene name synonym)|uniprotkb:DUO1 and MPS1-interacting protein 1(gene name synonym)|uniprotkb:Kinetochore assembly protein DAM1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kalantzaki et al. (2015) pubmed:25751138|doi:10.1038/ncb3128|imex:IM-24636 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16148019|imex:IM-24636-4|dip:DIP-79020E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005938"(cell cortex)|refseq:NP_013146.1|sgd:S000004035|ensemblfungi:YLR045C(gene)|ensemblfungi:YLR045C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005816"(spindle pole body)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0061863"(microtubule plus end polymerase)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|rcsb pdb:2QK1|rcsb pdb:4FFB|rcsb pdb:4U3J|rcsb pdb:6BL7|rcsb pdb:7KDF|dip:DIP-2462N|mint:P46675 sgd:S000003345|refseq:NP_011628.4|dip:DIP-1286N|mint:P53267|ensemblfungi:YGR113W(gene)|ensemblfungi:YGR113W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042729"(DASH complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:1990537"(mitotic spindle polar microtubule)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR013962(DASH complex, subunit Dam1) psi-mi:"MI:0465"(dip) crc64:7A49C3702E21C7BF crc64:F02DB6EE09BC2284 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/08 2017/08/10 rogid:MZSvgMGh+d1BYxGm4AEptyNQRfk559292 rogid:1U/NNQaGUzoddr+E0JlnygELpCc559292 rigid:fXpzCoU6kZ9MlV7ZfDdDPw6C1/4 false - mutation disrupting interaction strength:327-327,292-292,265-265,257-257|necessary binding region:206-343 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)